abc’s of hepatitis c treatment readiness and follow-up
DESCRIPTION
ABC’s Of Hepatitis C Treatment Readiness and Follow-up. Geri Hirsch RN-NP Nurse Practitioner Hepatology [email protected]. Overview of Presentation. HCV screening/testing Pretreatment counseling Encouraging adherence Managing adverse events. Screening. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/1.jpg)
ABC’s Of Hepatitis C Treatment Readiness and
Follow-up Geri Hirsch RN-NP
Nurse Practitioner Hepatology
![Page 2: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/2.jpg)
Overview of Presentation
• HCV screening/testing
• Pretreatment counseling
• Encouraging adherence
• Managing adverse events
![Page 3: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/3.jpg)
Screening
![Page 4: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/4.jpg)
![Page 5: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/5.jpg)
(1) Anyone with RISK BEHAVIOURS/POTENTIAL EXPOSURES
to HCV • High Risk
– Injection drug use (IDU)– Incarceration– Born, traveled, or resided in a region in which HCV
infection is more common– Receipt of health care where there is a lack of
universal precautions (nosocomial transmission)– Blood transfusion, blood products, or organ transplant
before 1992 in Canada
http://www.phac-aspc.gc.ca/hepc/pubs/pdf/hepc_guide-eng.pdf
![Page 6: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/6.jpg)
(1) Anyone with RISK BEHAVIOURS/POTENTIAL EXPOSURES to
HCV• Intermediate Risk
– Hemodialysis– Infant born to mother with HCV infection– Needle stick injuries
• Other Risks Associated With HCV EXPOSURE– Sharing sharp instruments/personal hygiene materials– with HCV+ person (e.g., razors, scissors, nail clippers,
toothbrush)– Tattooing, body piercing, scarification, female genital mutilation
or other ceremonial rituals– Intranasal (snorting) & inhalation drug use– Homelessness, residency in group homes or shelters– Higher-risk sexual behaviour
http://www.phac-aspc.gc.ca/hepc/pubs/pdf/hepc_guide-eng.pdf
![Page 7: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/7.jpg)
(2) Anyone with CLINICAL CLUES suspicious for hepatitis C infection (and
above risk factors)
• Abnormal liver biochemistry (e.g., ALT)
• Drug and/or alcohol dependency (past or present)
• Blood diseases requiring multiple transfusions of blood products (e.g., hemophilia, thalassemia, sickle cell
• anemia)
• HBV infection
• HIV infection
• Signs of chronic liver disease (e.g., hepatomegaly +/-
• splenomegaly, spider nevi, palmar erythema, jaundice)
• Vasculitis (due to associated cryoglobulinemia)
• History of unexplained renal impairment
• Non-Hodgkin’s lymphoma
http://www.phac-aspc.gc.ca/hepc/pubs/pdf/hepc_guide-eng.pdf
![Page 8: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/8.jpg)
Hepatitis C Treatment
![Page 9: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/9.jpg)
Medication HCV Genotypes 1 or 4 HCV Genotypes 2 or 3
PegIFN alfa-2a[1] 180 μg/wk SQ (hemodialysis: reduce to 135 μg/wk SQ)
• Ribavirin[2] 200 mg tablets in 2 divided doses/day
• 1000 mg/day (< 75 kg)• 1200 mg/day (≥ 75 kg)
• 800 mg/day
PegIFN alfa-2b[3] 1.5 μg/kg/wk SQ (If CrCl 30-50 mL/min: reduce dose by 25%;if CrCl 10-29 mL/min: reduce dose by 50%)
• Ribavirin[4] 200 mg capsules in 2 divided doses/day
• ≤ 65 kg: 800 mg/day• 66-80 kg: 1000 mg/day• > 80-105 kg: 1200 mg/day• > 105 kg: 1400 mg/day
• ≤ 65 kg: 800 mg/day• 66-80 kg: 1000 mg/day• > 80-105 kg: 1200 mg/day• > 105 kg: 1400 mg/day
1. Peginterferon alfa-2a [package insert]. 2010. 2. Ribavirin tablets [package insert]. 2010. 3. Peginterferon alfa-2b [package insert]. 2010. 4. Ribavirin capsules [package insert]. 2010.
HCV Standard of Care Therapy: Dosing Recommendations
![Page 10: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/10.jpg)
HCV Genotype and Response
0
10
20
30
40
50
60
70
80
90
Geno 1 Geno 2+3 Geno1 Geno 2+3
24 wksRBV800mg/day+pegIFN alfa2a
24 wks of RBV 1000/1200mg/day +pegIFN alfa 2a
48 wksRBV800mg/day+pegIFN alfa2a
48 wks of RBV 1000/1200mg/day +pegIFN alfa 2a
Advanced Fibrosis Minimal Fibrosis
Hadziyannis SJ, et al. Ann Intern Med. 2004;140:346-355.
SV
R (
%)
![Page 11: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/11.jpg)
Current and Future Treatments
0
10
20
30
40
50
60
70
80
SV
R (
%)
Current treatment
Future treatment
1. Poordad F, et al. AASLD 2010. Abstract LB-4. 2. Jacobson IM, et al. AASLD 2010. Abstract 211. 3. Bacon BR, et al. AASLD 2010. Abstract 216. 4. These data are available in press release format only, have not been peer reviewed, may be incomplete, and we await presentation or publication in a peer-reviewed format before conclusions should be made from these data.
Naïve non responders Naïve non responders
![Page 12: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/12.jpg)
Predictors of Treatment Response
Patient Factors• Age
• Sex
• Race
• Weight
• Insulin resistance
• Fatty liver disease
• Mental health
• Drug/alcohol use
• Cirrhosis
• HIV coinfection
• IL28B status
Virus Factors• Genotype
• HCV RNA level
Regimen Factors• Adherence to pegIFN/RBV
• Weight-based RBV dosing (genotypes 1/4)
• Reported improved response rates with protease inhibitors (in the future, for genotype 1 patients only)
![Page 13: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/13.jpg)
Response Definitions in Patients
Receiving HCV Therapy
Response definitions Time Point HCV RNA Level
Rapid virologic response - RVR
4 wks into therapy Undetectable
Early virologic response - EVR
12 wks into therapy Undetectable (complete)≥ 2 log decrease from baseline (partial)
End of treatment response - EOT
End of therapy Undetectable
Sustained virologic response - SVR
6 mos post therapy Undetectable
Ghany MG, et al. Hepatology. 2009;49:1335-1374.
![Page 14: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/14.jpg)
Preparing the Patient for HCV Therapy
• Provide and verify patient’s/family’s understanding of basic information about– HCV transmission, – prognosis,– treatment, – adverse event management
• Obtain and discuss– patient’s /family’s willingness – adherence to medications – need for visits/lab follow-ups
![Page 15: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/15.jpg)
Preparing the Patient for HCV Therapy• Social assessment
– housing, – disability, – social supports, – transportation, finances, drug plan
• Educate – alcohol, herbals,– hepatotoxins,– safe injection techniques*
• Ensure immunizations for HAV, HBV, pneumococcal, and seasonal influenza
![Page 16: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/16.jpg)
Preparing the Patient for HCV Therapy• Cautionary Uses
– Cardiovascular disease– Autoimmune disease
• Cryoglobulinemia related symptoms
– Psychiatry history/suicide– Alcohols and substance misue– Other
• DM,seziure disorder,decomplenstated liver disease ,renal diseasem lung disease, retinopathy, hemoglobinopathies
![Page 17: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/17.jpg)
Preparing the Patient for HCV Therapy• Provide and verify patient’s understanding of basic
information of side effect management • Encourage patient’s/family’s active participation in
treatment decisions and ability to ask questions• Review laboratory parameters and urine pregnancy test*
– Serum ALT, AST, bilirubin, alkaline phosphatase, albumin,
serum creatinine / BUN, TSH, glucose, urinalysis– prothrombin time/INR,CBC with differential and platelet
count,HIV and hepatitis B surface antigen – ANA*,genotype, viral load**,occular exam*– weight
![Page 18: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/18.jpg)
Preparing the Patient for HCV Therapy• Additional Tests
– Chest x ray, PA and LAT– Cardiac assessment - EKG and in consultations with
MD consider a cardiology consult– Mental Health Assessment – Abdominal ultrasound– Iron saturations (and hemochromatosis gene test if
indicated – Serum cooper, ceruloplasmin, and alpha 1 if indicated
![Page 19: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/19.jpg)
Preparing the Patient for HCV Therapy• Assure effective contraception and
reinforce issue of contraception
• Administer/demonstrate techniques for pegIFN injections
• Provide information on safe disposal of needles
![Page 20: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/20.jpg)
PegIFN Administration
• PegIFN alfa-2a[1]
– Premixed vials/prefilled syringes
– Dose is not weight adjusted: 180 μg SQ every wk
– Syringes are overfilled; ensure correct dose before administration
• PegIFN alfa-2b[2]
– Vials/syringes need to be reconstituted before use
– Redipen
– Weight-adjusted dose: 1.5 μg/kg per dose every wk
• Allow to come to room temperature before use
1. Peginterferon alfa-2a [package insert]. 2010. 2. Peginterferon alfa-2b [package insert]. 2010.
![Page 21: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/21.jpg)
Encouraging Adherence
![Page 22: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/22.jpg)
Adherence to PegIFN/RBV
• Not all patients take al their medication.
– In one US study 60% were adherent [1]
• 80/80/80 phenomenon– taking > 80 % of medications correlates with SVR[2,3]
• Remember patients may overestimate adherence [4]
• For some individuals a multidisciplinary team may be beneficial for adherence
1. Mitra D, et al. Value Health. 2010;13:479-486. 2. McHutchison JG, et al. Gastroenterology. 2002;123:1061-1069. 3. Raptopoulou M, et al. J Viral Hepat. 2005;12:91-95. 4. Smith SR, et al. Ann Pharmacother. 2007;41:1116-1123.
![Page 23: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/23.jpg)
Major Predictors of Poor Adherence to Medication
Patient and Treatment Factors•Treatment of asymptomatic disease•Presence of psychological comorbidities, especially depression•Patient’s lack of belief in treatment benefit •Treatment complexity•Adverse events of medication
Other Factors• Poor relationship
between the patient and provider
• Inadequate follow-up or discharge preparation
• Missed appointments• Cost of copayment,
medication, or both
Osterberg L, et al. N Engl J Med. 2005;353:487-497.
![Page 24: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/24.jpg)
Strategies for Improving Adherence to a Medication Regimen
• Identify risk factors for poor adherence early– Look for strategies to mitigate some of the factors
• Emphasize value of regimen and potential results to pts– Some patients are asymptomatic
• Provide simple, clear instructions and simplified regimen
• Encourage the use of medication-dispensing packaging– Blister packs may be helpful
Osterberg L, et al. N Engl J Med. 2005;353:487-497.
![Page 25: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/25.jpg)
Strategies for Improving Adherence to a Medication Regimen
• Customize regimen to pt lifestyle when possible– Injection days – weekend
• Support from family members, friends, and community
• Consider more “forgiving” medications– Medications with long half-lives, sustained release, or
depot
![Page 26: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/26.jpg)
Managing Adverse Events
![Page 27: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/27.jpg)
PegIFN Adverse EventsAE Occurring in > 20% of Pts, %
PegIFN alfa-2a/RBV (n = 1035)
PegIFN alfa-2b/RBV (n = 1019)
Fatigue/insomnia 64/41 67/38
Headache 41 50
Nausea 34 40
Anemia 34 35
Rash 34 29
Neutropenia 31 26
Irritability/depression 25/20 25/25
Chills 23 39
Injection-site reactions 23 34
Myalgia/arthralgia 22/22 27/21
Dyspnea 22 21
Pyrexia 21 35
Anorexia 21 29
Alopecia 17 23
Peginterferon alfa-2b [package insert]. 2010.
![Page 28: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/28.jpg)
RBV Adverse Effects
• Adverse events occurring more frequently when RBV added to pegIFN vs pegIFN alone– Hemolytic anemia– Headache– Cough/SOB– Gastrointestinal upset– Rash– Insomnia– Teratogenicity
Peginterferon alfa-2b [package insert]. 2010. Peginterferon alfa-2a [package insert]. 2010.
![Page 29: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/29.jpg)
Adverse Event Management• Anticipate adverse events
– Common and occur in nearly all patients
– Severity and nature of toxicity is highly variable
– If events are not managed well result …Negative impact on treatment outcome and quality of life
– Adverse event management starts before treatment begins
• Preemptive measures
– Chronic health conditions are stable
– Assess chronic health conditions to ensure they will not be significantly impacted with treatment side effects
– Provide supportive care during therapy
• During current treatment with pegIFN/RBV[1]
– 10% to 14% of patients discontinue treatment due to adverse event
• Monitor closely since fatalities can occur
1. Seeff LB, et al. Semin Liver Dis. 2010;30:348-360.
![Page 30: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/30.jpg)
Adverse Event Potential Interventions
Flulike symptoms (fever, chills, HA, myalgias, arthralgias, fatigue)
• Acetaminophen (≤ 2 grams/day) *• Bed rest• Fluids (noncaffeinated) 8-10 glasses/day
Fatigue • Administer IFN at bedtime• Low-impact exercise• Short naps, adjust work schedule• Assess for anemia, TSH..
Mood changes (depression, suicidal/ homicidal tendencies, anxiety, irritability)
• Avoid stimulants like caffeine, Ck TSH • Antidepressants (eg, SSRI), psych referral*• Short-acting benzodiazepines may help
Insomnia • Develop good sleep patterns *• Limit fluid intake/caffeine before bedtime• Consider sleep aids (eg, diphenhydramine,
trazodone, zolpidem)
Supportive Therapy for HCV Treatment-Related Adverse Events
![Page 31: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/31.jpg)
Adverse Event Potential Interventions
Nausea/vomiting/anorexia • Take RBV with food• Eat 6-8 small meals per day• Ginger may help: tea, ale, syrup• Carbonated fluids, jello drinks• Provide prophylactic antiemetics (eg, prochlorperazine)
Diarrhea • Drink noncaffeinated fluids • Increase fiber in diet (cereal, toast, rice), BRAT diet• Avoid foods that are spicy, greasy, acidic• Consider antidiarrheals or psyllium
Skin irritation (injection-site reactions, dry skin, rashes)
• Rotate injection sites• Take cool baths and use moisturizing soaps• Consider topical steroid cream or oral antihistamines
Hair loss/thinning Education, wigs; reversible/temporary as hair grows back
Supportive Therapy for HCV Treatment-Related Adverse Events
![Page 32: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/32.jpg)
RBV-Induced Anemia
• RBV-induced anemia correlates with achieving RVR/SVR– Mean maximum Hb decrease of 2.9-3.1 g/dL in first
6-8 wks[1,2]
– Occurs early within first 1-2 wks and remains low– Anemia during the first 4-8 wks associated with
improved probability of achieving RVR and/or SVR[3]
– Can worsen fatigue, SOB, CV, quality of life, and lead to discontinuation of treatment
– Follow product monograph for dose modification
1. Ribavirin tablets [package insert]. 2010. 2. Ribavirin capsules [package insert]. 2010. 3. Sulkowski MS, et al. Gastroenterology. 2010;139:1602-1611.
![Page 33: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/33.jpg)
Managing Hematologic Adverse Events
• Anemia– Specific thresholds for considering RBV dose
reduction, discontinuation, and/or EPO *– Note FDA warnings regarding risks associated with
ESAs• Neutropenia
– Specific thresholds for considering pegIFN dose reduction, therapy discontinuation, and/or G-CSF*
• Thrombocytopenia– Specific thresholds for considering pegIFN dose
reduction, therapy discontinuation
See package inserts for details
![Page 34: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/34.jpg)
Laboratory monitoring for efficacy and treatment toxicity
• Patients on PEG-Interferon combination therapy should have:– hematology and blood chemistry testing before the
start of treatment and then periodically thereafter. – In the clinical trials CBC (including hemoglobin,
neutrophil and platelet counts) and chemistries (including AST, ALT, bilirubin, and uric acid) were measured during the treatment period at weeks 2, 4, 8, 12, and then at 6-week intervals or more frequently if abnormalities developed.
– TSH levels were measured every 12 weeks during the treatment period.
See package inserts for details
![Page 35: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/35.jpg)
Laboratory monitoring for efficacy and treatment toxicity
• Genotype non 2,3– HCV viral load
baseline– HCV viral load week
12– HCV RNA week 24 *– HCV RNA week 48– HCV RNA week 72
• Genotype non 2,3– HCV RNA baseline– HCV RNA week 12– HCV RNA at the end
of treatment*– HCV RNA 24 week
after completing treatment
![Page 36: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/36.jpg)
Laboratory monitoring for efficacy and treatment toxicity
• Patients on PEG-Interferon combination therapy should have:– HCV RNA/VL at baseline– HCV RNA VL at week 12 ( non genotype 2,3)– HCV PCR at week 12 (genotype 2 and 3)– HCV PCR at week 24 ( non genotype 2,3)– HCV PCR at week 24 ( non genotype 2,3)– HCV PCR at week 48( non genotype 2,3)– HCV PCR at week 48( non genotype 2,3)– HCV PCR at week 72 ( non genotype 2,3)
See package inserts for details
![Page 37: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/37.jpg)
Canadian Consensus Guidelines-Management of Hepatitis C , 2007
![Page 38: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/38.jpg)
Canadian Consensus Guidelines-Management of Hepatitis C , 2007
![Page 39: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/39.jpg)
Nursing Role in Patient Education and HCV Drug Therapy Management
Patient Education Drug Therapy Management
Anticipated benefits and risks of treatment
Baseline assessment for contraindications to therapy
Lifestyle changes Injection training and/or administration of injections
Anticipated treatment duration/FU and need for adherence
Laboratory monitoring for efficacy and treatment toxicity
Prevention of disease progression•Avoid hepatotoxins—Acetaminophen, alcohol, herbals, NSAIDs•Vaccine advocates—hepatitis A and B, influenza, pneumococcal
Assessment and evaluation of adherence
Reduce risk of HCV transmission Management of treatment toxicity
Marino EL, et al. J Manag Care Pharm. 2009;15:147-150. Smith JP, et al. Am J Health Syst Pharm. 2007;64:632-636.
![Page 40: ABC’s Of Hepatitis C Treatment Readiness and Follow-up](https://reader035.vdocuments.us/reader035/viewer/2022062500/56814fca550346895dbd88d0/html5/thumbnails/40.jpg)
Success is dependent on effort and teamwork .