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Your Partner in Chemical Development

automatically better

SYSTAG

SYSTAG - Your Partner


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SYSTAG Situation

SYSTAGIs situated in the historical

centre of Rüschlikon, close to the railwaystation. Rüschlikon, a village 8 km fromZurich downtown, is located in thebeautiful landscape of lake Zurich. Thepicture above shows the building with theconstruction, development and finalassembly departments to the left and thebuilding with administration and salesdepartment to the right.



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SYSTAG - Your PartnerEditorialSYSTAG, System Technik AG has been

the preferred partner of the chemical industry since1965, thanks to its consistent solutions whichencompass all phases from development to pilotingand process control engineering.

Our objective is to offer our customersconceptual and solution-orientated automationsolutions & services from a single provider, addressingall chemical process development aspects, associatedthermal safety inspections and scale-up. In additionto supplying turnkey applications, SYSTAG alsofrequently integrates existing peripheries or developscustomized solutions for a variety of specialapplications in cooperation with its partners.

Our products are subject to continuousdevelopment based on the latest technologicalknowledge and cognitions, thus generating a highdegree of added value for our clientele. We guaranteeinvestment protection through sustainability andintegration.

As an international player, weendeavour at all times to provide optimised solutionscharacterised by economic practicability, flexibility anda capacity for expansion. SYSTAG continuouslydevelops necessary hardware & software componentswith this in mind.

We identify with our customers in themost varied markets and enjoy close collaboration withour partners which has been carefully cultivated overmany years. A partnership of over 45 years durationwith the chemical industry, the know-how gained andtypical Swiss quality awareness all vouch for maximumreliability from the planning phase to commissioning.

Our close collaboration over many yearswith the pharmaceutical industry in particular hascrystallised into the following 3 business divisions:

CLR – stands for Controlled LabReactors and encompasses conventional singlereactor systems (ALR’s) and multi-reactor applicationsfor parallel process optimisation. SYSTAG products inthe CLR business division support personnel inchemical development laboratories and enable therealisation of more efficient and practice-orientatedtrials and logging. Integration of diverse analyticalmethods (also provided by other manufacturers) orspecial process techniques complement the CLRsegment.

TPS – the Thermal Process Safetybusiness division is dedicated exclusively to theinspection and qualification of the thermal risk poten-tial in a chemical process.

SYSTAG reaction calorimetry delivers thereaction output and heat of a synthetic reaction,whereas SYSTAG thermal analysis with FlexyTSCidentifies further data on undesired decompositionreactions (including storage & transportation tests) ofchemicals and their products.

The combination of reaction calorimetryand thermal analysis employed delivers part of thethermal risk analysis from time to time.

PCS – Plant Control Systems arespecific customer solutions involving automated kilo-lab & pilot plants up to 250 l reactor volume.Consistency from development to production improvesthe knowledge transfer and understanding of theprocess. Turnkey plants from a single provider enableus to provide support from engineering andprofessional system integration to IQ/OQ andassistance during validation.

Why not try us too! We look forward toa successful collaboration!

SYSTAG - automatically betterMike Mandlehr, Managing Director



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FlexyConcept - a name that representsstructured consistency and a sophisticated automation conceptin the laboratory and during piloting

Whether conventional laboratory reactors,multi-reactor systems or reaction calorimetry applications areinvolved, all SYSTAG applications can be integrated andcombined within the FlexyConcept platform with a few clicksof the mouse. A standard reactor is transformed in next to notime into a heat flow calorimeter, or a single reactor systemconverted into a multi-reactor application for processoptimisation and DoE (design of experiments).

However, the concept and, consequently, themethod of operation remain the same. No additional trainingis necessary. Durability and investment protection are onceagain guaranteed.

The core element of FlexyConcept is theFlexySys software. Implemented options, such as distillation,pressure/vacuum controls and many more can be importedwith ease into new applications. FlexyConcept enables you totransform yesterday’s application into a future-orientatedsolution.- Modular structure for changing requirements- Simple planning of human resources- Complete documentation- Maximum possible flexibility- Intuitive and, consequently, rapidly readied for operation

Your advantage is reflected in consistentlaboratory automation of process development, from kilo-labto pilot plant.

See for yourself….... and enthuse and inspire your colleagues!

FlexyConcept – developed withour customers for our customers



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Operation, Recipe, Protocol

FlexySys Uniform Software Platform

Synoptic PresentationThe illustration on the left shows the system

diagram together with the most important system values inthe yellow fields. On the right (partially covered by twooperating windows) freely selectable graphics are provided toallow the user a full view of the operation and the graphicsdisplay.

Manual OperationThe keys in the main display window will open

a number of additional windows; temperature control andDosing 1 are currently displayed. Through these windows,complete groups can be manually operated, includingparameter and limit setting.

Recipe ControlThe required operational steps can be

obtained from Basic Operations (left illustration). They canbe opened with a double-click, parameters are set similar toa manual operation.

Graphic Presentations andEvaluationsGraphic presentations and calculations can

be prepared after the completion of experiments. They canbe exported into the protocol.

Automatic ProtocolAll important steps of an experiment (selection

and templates are user selectable) can be entered and printedas Word documents.



Parallel Process Development (PPD)

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FlexyCUBE Controlled Lab Reactors

High level of productivity, accurateexperiments, ideally suitable for DoE

Operating close to actual productionconditions – perfect for Scale-up

Robust solution for routine applications,a real workhorse

Your trump card for rapid and quality focused process development

Our new concept for process development- Up to 6 reactor units controllable from a single PC- Parallel (DoE) or individual operation possible- Compact construction- Reactor capacity 10 ml to 400 ml- Manual and recipe modes

Standard Functions- Gravimetric or volumetric dosage capabilities available- Temperature control for jacket or reactor- Control of stirrer speed- Data capture and automatic Laboratory Report- Remote Support and Alarm Event File

Flexibility- pH Control, Standard single sided (acidic or alkaline)- Expansion with additional reactor units always possible- 70, 100, 250 or 400 ml reactors- Pressure reactors - glass or metal (SS/Hastelloy)- Height adjustable types of stirrer seals- Automated distillation with boiling point detection- Isothermal Heat Flow Calorimetry, On-line Analysis- System Qualification IQ/OQ

Temperature Range- -80 ... 280°C, Subzero range capability, dependent on thermostat type



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Reactors can be automated individually

FlexyALR Controlled Lab Reactors

Minimum Training Requirements, easyAcceptance by Personnel

Incorporation of Customer-OwnedInstruments

Up to 6 FlexyALR controllable from asingle PC

Flexible Automation for Syntheses, Lab Scale and Pilot Plant Applications

Functions- Gravimetric and Volumetric Dosing facilities- Temperature control for Jacket or Reactor- Stirrer control includes speed and torque measurements- pH Measurement- Manual and Recipe Control- Data capture and automatic Laboratory Report

Incorporation of Customer-OwnedInstrumentsThe FlexyALR Concept even allows the integration ofexisting customer-owned hardware. This will not onlyreduce costs dramatically but speeds up the automationprocess substantially.

ALR Options- Distillation with Reflux Splitter- Pressure and Vacuum measurement and Control- Hydrogenation capabilities- Isothermal Heat Flow Calorimetry- Turbidity measurement, midIR FTIR Integration- Particle size measuring instruments can be integrated- pH Control- CFR21 part 11

Operating Several ReactorsA number of ALR’s can be operated from a single PC.SYSTAG will provide optimal advice.



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The new Calo Family to meet all Requirements

The ”Blue Window“ provides a real-timeonline view of process behaviour

Three classes of instruments can besupplied. Each one is suitable for SafetyEvaluations and for Scale-Up procedures

Thermal Process SafetyCalo2310

The New Generation of Reaction Calorimeters

Calo2310 ecoThe classic economical Heat Flow instrumentAn Isothermal heat flow calorimeter, the best available atentry-level for safety evaluations and Scale-up operations.Complete with online display of A, U, cp utilising the ”BlueWindow“ facility.

Calo2310 baseThe powerful Heat Flow CalorimeterUniversally applicable, non-isothermal Heat Flowcalorimeter with automatic base line capability for the

experienced user suitable for complex tasks. Incorporatesonline display of output and heat from Heatflow, as well asA, U, cp display in the ”Blue Window“.

Calo2310 proThe professional Universal CalorimeterCombined Heat Flow and Heat Balance calorimeter withautomatic baseline and non-isothermal operations mode.This is the professional calorimeter for all types of reactions.Online display of output and heat from heat flow and heatbalance as well as A, U, and cp display via the ”BlueWindow“.



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Process Safety with RADEX and SEDEX

FlexyTSC Thermal Process Safety

Thermal Safety Evaluations under Real Conditions

Methods- Scanning- Isoperibolic- Adiabatic- IsoArc

Vessel Types- Glass, open, also gas purged- Glass, up to 6 bar- Steel, to 150 bar or 200 bar- Steel, with glass liner

Volumes- Radex 0.5 to 2.5 ml- Sedex 50 to 1000 ml

Temperature Ranges- Standard 20 ... +400°C- Optional -20 ... +500°C

Calibration- Scanning calibration- Isothermal calibration

Capabilities- High Sensitivity- Simple, intuitive operation- TMR, SHR, Arrhenius plot

Options- Control unit expandable to up to 6 systems per PC- Each system can handle totally independent experiments- Measurement of evolved gas volume



Automated turnkey Pilot Plant

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Specific customer solutions for theautomation of kilo lab and pilot plantswith reactor volumes up to 250 l

FlexyPlant is a logical progression ofprocess development – via FlexyLab andFlexyALR

FlexyPlant Plant Control Systems

A universal control concept fromlaboratory to pilot plantInterchangeability of recipesAutomatic data acquisition and log-gingcGMP-compliant qualificationCompliance with CFR 21 Part 11

Your advantagesGeneral information

FlexySys is an automation concept speciallydeveloped for chemical process researchThe FlexySys process control system combinesthe flexibility of manual operation with thereliability and reproducibility of a recipe-controlled systemThe system is also suitable for special problemsencountered in chemical process engineering(e.g. polymerization, hydrogenation and thermalseparation)



Flexible Production Automation

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Our PCS offers:Continuity from development to productionImproved technology transfer based on ourphilosophy of continuitySimilar structures reduce training effortUnlimited parallel processesCustomer specific, economically acceptablesystems solutionsRemote control via Modem and InternetRecipe control

Your Advantage:Everything from a single sourceTurnkey systemsProfessional system integrationIQ/OQ and FAT/SAT on request

Additional Benefits:Holistic problem coverage for optimum solutionsEngineering from A - ZIndividual attention during project phase,commissioning and maintenance

Conceptional Automation of Chemical Processes

Experience in application integration intohigher level systems

Support for FDA audits

Solutions for complex problems usingSiemens S7 PLC Systems

Pilot/Process Plant Control Systems



Technical details are subject to change without notice Filename: A4d_Prog6_FlxConc_1y12.pmdCopyright by SYSTAG (2005 - 2009, 2010)

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SYSTAG, System Technik AGBahnhofstrasse 76, CH-8803 Ruschlikon/ZHTel +41 (0)44 704 54 54 Fax +41 (0)44 704 54 55E-mail [email protected] Internet: www.systag.ch

System Technik Deutschland GmbHRodheimerstrasse 63, D-61191 Rosbach/Frankfurt a.M.Tel +49 (0)6003 93 50 50 Fax +49 (0)6003 93 50 522E-mail [email protected] Internet: www.systag.ch

Your Partner in Chemical DevelopmentSYSTAG

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