Horizon 2020FET Open

New technologies for cancer monitoring

and therapy

A paradigm shift in oncology research via externally controllable

molecular communications for "bio-nano-machine diagnostics"

This project has received funding from the European Union’s Horizon 2020 programmeunder Grant Agreement No. 828837.

Project CoordinatorDr. Constantinos PitrisAssociate ProfessorUniversity of CyprusTel: +357 22 892297Email: cpitris@ucy.ac.cy

Scientific CoordinatorDr. Andreani OdysseosDirector of ResearchEPOS-Iasis R&D, LtdTel: +357 22 373089Email: andreani@epos-

iasis.com

Contact Information

www.fet-gladiator.eu

FETOpenGladiator

fet-gladiator

@FET_Gladiator

GLADIATOR brings together high-calibre European andglobal experts in a collaborative effort from diversescientific fields and sub-disciplines. It is a truly trans-disciplinary team bringing together all the necessaryexpertise to achieve the visionary and ambitious goals ofthe proposal.

A Trans-Disciplinary, Global Network

Univ. of Cyprus, CY

EPOS-IasisR&D, Ltd, CY

Osaka Univ., JP

NTNU, NO

Univ. of Oulu, FI

WIT, IE

FraunhoferIBMT, DE

Next-generation theranostics of brain pathologies with autonomous externally

controllable nanonetworks: a transdisciplinary approach with

bio-nanodevice interfaces

A significant societal challenge

Brain pathologies are highly complex disorders

Despite recent progress, their prognosis is grim

A significant medical challengeAutonomously monitor the spatiotemporal tumour evolution and recurrence and generate, on demand,appropriate reprogramming interventions

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Measurement Communication Central Unit

Hybrid sensing and reporting device

Implantables

1

Processing, Storage, Display and Comm

(WBAN)

Computer3

Information

Transcranial (Power, Comm, RF) and Long

Range (WBAN)

Patches2

Information

Molecular CommunicationsAn emerging discipline

The transmission of encoded messages via molecularchannels, in solutions, cells or entire living organisms.MCs is the backbone of forming networks of bio-nano-machines

When externally controlled, they can be interrogated toextract information on the status of the disease but alsomanipulate the malignant cells to affect the diseaseprogression

Externally Controllable Molecular Communications (ECMC)

Rationally designed reprograming (therapeutic) bio-nano-machines will interfere with the underlyingbiological environment, form nano-networks, andprovide a revolutionary intervention.

A hybrid bio-electronic interface with coupled externaland implantable devices will enable communicationchannels integrated into a wireless ECMC network

Bio-nano-machine (Transmitter)

Bio-nano-machine (Receiver)

Molecular Communication Environment

External Environment

Molecules or Cells

Molecular Communication

Channel

External Device

Develop a vanguard & comprehensive theranostic (therapeutic + diagnostic)

platform

Bridging life sciences, bio-nano-technology, engineering and information communication technologies (ICT)

Improve patient prognosis

Minimize recurrences and reduce drug toxicity.

Positively affect the already overstrained Health Care Systems

Extend life expectancy and productivity, reduce sick-leaves, shorten hospitalizations, reduce return visits, anddecrease personnel and caregiver involvement

Yield a substantial economic impact

GLADIATOR will develop pioneering biological andnanotechnology-based innovations and develop methods,computational and analytical tools which can enter intosignificant market segments