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S1 A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines Ke Chen and Sumod A. Pullarkat* Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore, E-mail: [email protected] ; Tel: +65-63168906 Supporting Information Contents 1 H and 13 C NMR Spectra for 8, 10, 11, 12 S2-S25 Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is © The Royal Society of Chemistry 2012

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Page 1: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

S1

A Tandem Heck- aza-Michael Addition Protocol for the One-Pot

Synthesis of Isoindolines from Unprotected Amines

Ke Chen and Sumod A. Pullarkat*

Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang

Technological University, Singapore 637371, Singapore, E-mail: [email protected] ; Tel: +65-63168906

Supporting Information

Contents 1H and 13C NMR Spectra for 8, 10, 11, 12 S2-S25

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 2: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

S2

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 3: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 4: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 5: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 6: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 7: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 11: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 12: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 23: A Tandem Heck- aza-Michael Addition Protocol for the One-Pot … · A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

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Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012