a single maximal exercise test improves lung function in ...... · the purpose of this study was to...
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Change in Additional Lung Function Variables
Following a Single Bout of Exercise. *Significant change after exercise.
Significant Improvement in Spirometric Variables
Following a Single Bout of Exercise
*Significant change after exercise
These data support that one session of maximal exercise can significantly
improve lung function in patients with CF. In addition, higher peak work
rates and ventilation during exercise both predict a greater improvement in
post exercise lung function. Future studies are warranted to determine the
most effective dose of exercise to improve lung function in CF.
Patients with Cystic Fibrosis (CF) typically have a progressive decrease in
lung function over time.
Exercise capacity has been shown to predict mortality in CF, independent
of lung function
Evidence suggests that chronic participation in an aerobic exercise
program can improve lung function in the CF population.
A Single Maximal Exercise Test improves Lung Function in Patients with
Cystic FibrosisReva H Crandall1,2, Nichole Seigler2, Paula Rodriguez-Miguelez2, Katie T McKie3,
Caralee Forseen4, Ryan A Harris2,5
1Georgia Regents University, Respiratory Care, Augusta GA 2Georgia Regents University, Georgia Prevention Institute, Augusta GA 3Georgia Regents University, Pediatric Pulmonology, Augusta GA 4Georgia Regents University, Pulmonary and Critical Care Medicine, Augusta GA
5University of Ulster, Sport and Exercise Research Institute, Jordanstown, Northern Ireland, UK
Laboratory of Integrative
Vascular & Exercise Physiology
This project was supported in part
by NIH/NIDDK R21DK100783 and
Vertex Pharmaceuticals IIS (RAH).
Table 1. Subject Characteristics
Figure 1: Forced vital capacity Figure 2: Forced expiratory volume
in one second (% predicted)
Figure 3: Forced expiratory
flow at 25-75%
Figure 4. Forced expiratory volume
in one second (L/s)
Introduction
Purpose
Methods
Results
Conclusion
Variable Baseline
N 26
Age (yrs) 19.6 ± 1.6
Sex (M,F) 10,16
Median FEV1 % predicted 81
BMI (kg/m2) 21.1 ± 0.7
Body Fat (%) 25.9 ± 1.6
Systolic Blood Pressure (mm Hg) 108 ± 2
Diastolic Blood Pressure (mm Hg) 63 ± 1
O2 Saturation (%) 97.6 ± 0.3
Fat Free Mass (kg) 39.0 ± 2.3
Exercise Intensity Predicts Change in Post-Exercise
Lung Function
Figure 5. Diffusing capacity for carbon
monoxide
Acknowledgements
Table 2. Exercise Data
Values are mean ± SEM. Values are mean ± SEM.
Subjects: Twenty-six patients with CF (16 females and 10 males, ages 9-43
years old) participated in this study. Patients performed lung function testing
at baseline and again 10 minutes following maximal cardio-pulmonary
exercise testing (CPET) using the Godfrey protocol, on a cycle ergometer.
The purpose of this study was to determine if one session of maximal exercise
can improve lung function in patients with CF.
Pulmonary Function Test: Spirometric variables
measured were forced vital capacity (FVC), forced
expiratory volume in one second (FEV1), and
forced expiratory flow 25-75% (FEF 25-75%), using the
EasyOne Pro® Spirometry System. Additional lung
function parameters included assessment of lung
clearance index (LCI), single breath carbon
monoxide diffusion capacity (DLCOSB), exhaled
Maximal Exercise Capacity Test: Following an
overnight fast, patients performed a maximal exercise test
on a cycle ergometer using the Godfrey protocol. After 2
minutes of rest and 2 minutes of an unloaded warm-up,
exercise intensity was increased either 15 or 20 watts
every minute depending on the patient’s height. Expired
gases were collected breath by breath, and maximal
exercise capacity data was calculated using 30-second
averages.
nitric oxide (eNO), and impulse oscillimetry (IOS). Pulmonary function test
was performed on all subjects according to standards set by the American
Thoracic Society.
Data Analysis: Data are presented as mean ± SD. Paired t-tests were
performed to identify differences between pre and post exercise. Pearson
correlations were determined to identify associations between change in lung
function and exercise variables. Significance was set at p-value < 0.05.
Figure 6. Lung clearance index
Figure 8. Exhaled nitric oxideFigure 7. Vital capacity
Variable Max CPET
VO2 peak (L/min) 1.7 ± 0.1
VO2 peak (ml/kg/min) 30.1 ± 1.1
VO2 (% predicted) 75.9 ± 3.1
Peak Work (W) 139 ± 8
% VO2 peak @ AT 61.3 ± 2.0
VE (L/min) 70.7 ± 5.3
Resting Heart Rate (bpm) 72 ± 3
Max Heart Rate (bpm) 173 ± 3
Resting RER 0.88 ± 0.04
Max RER 1.24 ± 0.03
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