a practical approach to precision medicine · 1/13/2016 · ucsf coursera genomic and precision...
TRANSCRIPT
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A practical approach to precision medicine
education Jeanette McCarthy, MPH, PhD
Precision Medicine Advisors Duke University, Center for Applied and Precision Medicine
UCSF, Genomic Medicine Initiative
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Characteristics of health care providers hindering uptake of
precision medicine
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Supporting evidence, root
causes, solutions
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Health care providers are unaware
“It is very unclear to me that this should be even in the top 25 topics in primary care. I see the value in oncology and advancing knowledge but what else?”
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It’s not my problem
3500 genetic counselors 1/245 physicians
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Historically, genomic medicine has been confined to medical geneticists and
genetic counselors
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Is precision medicine a primary care issue?
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Precision medicine in primary care Diagnostic sequencing
Predisposition testing
Pharmacogenomics
Consumer genomics
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Health care providers are skeptical
“I don't (and shouldn't) adopt any new technology test or therapy until patient centered improvements in outcomes are demonstrated and until that RCT data is available, I am going to tune this out.”
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138 drugs with PGx in label
Adapted from: Community Pharmacist Pharmacogenetics Network Rxpgx.com
CPIC only (21)
Guidelines (9)
No guidelines (108)
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Health care providers lack confidence
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Surveys show lack of knowledge and skills
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Reasons for lack of self-confidence • Lack of appropriate training in genomic medicine
Medical school
Narrowly focused content Mostly taught in first year
Limited opportunities for practicing health
care providers to learn
CME
• Lack of clinical experience with genomic tools
Stanek et al. 2012
13% of 10,000 physicians had ordered a PGx test in the past 6 months
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UCSF Coursera Genomic and Precision Medicine, Spring 2014
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Coursera GPM overview
• Designed for health care providers • Seven 1-hour lectures + brief assessment • 14.00 AMA PRA Category 1 CME credits
(requires final grade of 70% or above) • Modular – allows one to skip over sections
based on competence
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Syllabus Week 1: Human genomics Week 2: Prenatal carrier testing and newborn screening Week 3: The use of NGS for solving diagnostic dilemmas Week 4: Methods of association Week 5: Predictive tests for common, complex diseases Week 6: Pharmacogenomic testing Week 7: Tumor profiling
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Students
From survey (n=470): 65 countries (37% from US), 118 involved in patient care
Spring 2014
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Students Spring 2015
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Pre-course survey
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Student forum - problem solving
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Assessments – built in research
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Drop off
0
1,000
2,000
3,000
4,000
5,000
6,000
1.1 1.3 1.5 2.2 2.4 3.2 3.4 4.2 4.4 5.1 5.3 6.1 6.3 7.1 7.3
Viewers by module
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Drivers ≠ mechanics
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Guiding principles • Structure around clinical applications of PM • Address awareness • Teach skills to build confidence • Both didactic and time behind the wheel
(hands-on learning) • Brief and focused • Convenient
Driving school
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Clinical applications of PM • Rare Mendelian diseases
• Carrier testing
• Newborn screening
• NGS for Idiopathic diseases
• Common Mendelian diseases • Hereditary cancer predisposition panels
• Hereditary heart disease predisposition panels
• Common disease/common variants (limitations)
• Pharmacogenomics
• Tumor molecular profiling in cancer
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• Order more tests? • Order fewer tests? • Maximize the potential value of existing
genomic information from patients
What are the behaviors we want to change?
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Driver’s school: didactic content • Current testing landscape • Indications for testing • Selecting a test • Interpreting results • Value of testing • Limitations of testing
Build a library for training across institutions
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Considerations: • Reach, convenience, interaction, cost Formats: • Online videos (on demand) • Online videos (set period) • Webinar • Live (grand rounds)
Driver’s school: didactic format
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Drivers school: behind the wheel
Evaluating clinical
validity/utility Where and how
to order test
Interpreting and using results to manage patient
Explaining benefits,
limitations and results to
patients
Give providers the experience of ordering, interpreting and communicating test results
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Workshops
Convenient CME
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Driver’s license • Certification?
Owner’s manual • Practical guide, websites, CDS Jiffy Lube • Genetic counselors or similar
Other pieces
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Educating and enabling providers
Empowering consumers
The push and pull of precision medicine
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Genome, from Big Science Media
www.genomemag.com