a potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in...

2005 Receptor binding activity X 0280 A Potent and Selective Nonpeptide Antagonist of the Melanocortin-4 Receptor In- duces Food Intake in Satiated Mice. — Compound (I) is reported to show the stron- gest antagonistic activity and highest selectivity towards the targeted receptor of all tested compounds. — (CHEN*, C.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 10, 2541-2546; Dep. Med. Chem., Neurocrine Biosci., Inc., San Diego, CA 92121, USA; Eng.) — C. Oppel 39- 215

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Page 1: A Potent and Selective Nonpeptide Antagonist of the Melanocortin-4 Receptor Induces Food Intake in Satiated Mice

2005

Receptor binding activityX 0280 A Potent and Selective Nonpeptide Antagonist of the Melanocortin-4 Receptor In-

duces Food Intake in Satiated Mice. — Compound (I) is reported to show the stron-gest antagonistic activity and highest selectivity towards the targeted receptor of all tested compounds. — (CHEN*, C.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 10, 2541-2546; Dep. Med. Chem., Neurocrine Biosci., Inc., San Diego, CA 92121, USA; Eng.) — C. Oppel

39- 215

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