a patient with chest pain and st-elevation in avr and st ... · mr lp, 55-years-old • history:...

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A patient with chest pain and ST-elevation in aVR and ST depression in all other leads ACCA Masterclass 2017 Sofie Gevaert

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Page 1: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

A patient with chest pain and ST-elevation in aVR and ST depression in all other leads

ACCA Masterclass 2017

Sofie Gevaert

Page 2: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Mr LP, 55-years-old

• History:

• Hypertension, treated with Perindopril 5mg and Nebivolol 5mg

• Current:

• 01.00 am: progressive severe thoracic pain radiating to left arm

• Orthopnoea

• 112Medical emergency team

• Other CV risk factors:

• Hyperlipidaemia

• Obesity

• Sudden death of father at 50 y

ACCA Masterclass 2017

Page 3: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

MET 08.00 am: parameters, clinical exam

• BP 142/72 mmHg, HR 160 bpm, regular, SaO2 88%, Resp R 27/min

• Clammy, cold extremities

• No jugular distension

• No cardiac murmur

• Bilateral crepitations

• No peripheral edema

ACCA Masterclass 2017

Page 4: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ACCA Masterclass 2017

FMC in patient with chest pain

ACCA toolkit 2015

Page 5: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ECG 08.05 am

ACCA Masterclass 2017

Page 6: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ACCA Masterclass 2017

1. ER: Patient with chest pain, 08.28 am

ACCA toolkit 2015

Page 7: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Further strategy?

• Further stabilisation, diagnostics in ER?

• Direct transfer to cathlab?

ACCA Masterclass 2017

Page 8: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

2. ER: dyspnoea, orthopnoea

ACCA Masterclass 2017ACCA toolkit 2015

Page 9: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Chest X-ray 08.32 am

ACCA Masterclass 2017

Furosemide 40mg IV (MET)

Page 10: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Quick look echo

ACCA Masterclass 2017

Page 11: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

?

ACCA toolkit 2015

Page 12: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ACCA Masterclass 2017

CONGESTION - +

HYPO _PERFU S +IOn

ESC guidelines AHF 2015

Page 13: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ACCA Masterclass 2017ACCA toolkit 2015

Page 14: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

08.45 am

• Ongoing chest pain despite high dose opioids

• SaO2 90 despite FiO2 90%

• Persisting respiratory failure despite initial measures

• Troponin T 435 ng/L, creatinine 2.1 mg/dL (CKD-EPI 30 mL/min), Hct 42%

• PH 7.24, PCO2 47mmHg, lactate 34.1 mg/dL (<11.3 mg/dL, =3.8mmol/L)

ACCA Masterclass 2017Sedation, Intubation

Page 15: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Invasive strategy: Timing, antithrombotic R/ andaccess

• Timing?• Antiplatelet?

• None

• ASA mono

• DAPT

• Anticoagulation?• None

• UFH

• LMWH

• Fondaparinux

• Bivalirudin

• Access?

ACCA Masterclass 2017

Page 16: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ACCA Masterclass 2017ACCA toolkit-ESC guidelines NSTE-ACS2015

Timing

Page 17: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ACCA Masterclass 2017ACCA toolkit 2015

Page 18: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Ischemic risk

ACCA Masterclass 2017

Page 19: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Bleeding risk

ACCA Masterclass 2017

Page 20: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

High ischemic and high bleeding riskKD and shock state

UFH 5000 IU bolus

ASA 200mg IV

ACCA Masterclass 2017ESC guidelines NSTE-ACS 2015

Page 21: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Coronary angiography 09.20 am

ACCA Masterclass 2017

Shock, peripheral VC:Femoral access

Page 22: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

ACCA Masterclass 2017

CT angiography 09.50 am

ESC guidelines Aortic dis. 2014

Page 23: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

Type A dissection with dissection left main

• Urgent surgery

• Tear ascending aorta

• Urgent surgery:Hemiarch

Sinotubular junction proximal arch

• Postoperative: stroke, AKI

• Rehab program

ACCA Masterclass 2017

Page 24: A patient with chest pain and ST-elevation in aVR and ST ... · Mr LP, 55-years-old • History: • Hypertension, treated with Perindopril 5mg and Nebivolol 5mg • Current: •

THANK YOU

ACCA Masterclass 2017

Sofie Gevaert