a new method for targeting enveloped viruses
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LJ-001. A new Method For Targeting enveloped viruses. Skeleton. Enveloped and Naked Viruses Modes of Infection LJ-001. Naked Viruses . Gary E. Kaiser . What are enveloped viruses?. Skeleton. Enveloped and Naked Viruses Modes of Infection LJ-001. Russell Kightley Media. - PowerPoint PPT PresentationTRANSCRIPT
A NEW METHOD FOR TARGETING ENVELOPED VIRUSES
LJ-001
Skeleton Enveloped and Naked Viruses
Modes of Infection
LJ-001
Naked Viruses
Gary E. Kaiser
What are enveloped viruses?
Skeleton Enveloped and Naked Viruses
Modes of Infection
LJ-001
Russell Kightley Media
Excretory Pathways Naked
Lytic cycle Exocytosis
Enveloped
Dan StowellBotany Online Visual Resource Library
Skeleton Enveloped and Naked Viruses
Modes of Infection
LJ-001
LJ001 an aryl methyldiene rhodanine derivative
A small anti-viral molecule effective against enveloped (but not naked) viruses.
Wolf et. al.
LJ001 acts on virus membranes in an irreversible manner
Wolf et. al.
Broad Spectrum Influenza A Filoviruses Poxviruses Arenaviruses Bunyaviruses Paramyxoviruses Flaviviruses HIV-1 Hepatitis C Ebola And others
Viruses lack a ‘biogenic’ membrane
Viruses can’t make their own proteins or repair their membrane like a cell can
How?
Russell Kightley Media
Wolf et. al.
How we would use this Still very early in development, further testing
needed
Shorten Viral Infection Course Preventative Measure?
Could be put in condoms
New treatment for multiple viruses Eliminate temporary infections Fight Chronic ones
LJ001 is effective at very low doses Potentially Excellent Therapeutic Index
Sources (pictures not from papers)
Russell Kightley Media Virco Online Humanitarian Futures Programme Gary E. Kaiser HOPES (The Huntinton’s Disease
Outreach Project for Education) at Stanford
Molecular Station
Sources(papers)
Wolf et. al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62. Epub 2010 Jan 28.
Balzarini J. Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nat Rev Microbiol. 2007 Aug;5(8):583-97.
Kudchodkar S., Levine, B. Viruses and Autophagy. Reviews in Medical Virology. 2009; 19: 359-378
Melikyan GB. Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm. Retrovirology. 2008 Dec 10;5:111.
Xkcd.com