Gecko Biomedical Confidential

Maria Pereira April 2015

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Gecko Biomedical Confidential

Since 30.000 BC.

Tissue damage

Technically challenging

Leaks

Ineffective in friable tissues

Time consuming

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Wound closure:a large and growing market

$11.9 Billion in 2014

(7% CAGR)

160+ million of wounds closed

per year

60+% are surgical wound

related

Adhesives and sealants

represent 20% ($2.4B in 2014)

45% growth over 2010-2015

Gecko Biomedical Confidential3

Current sealants and adhesives suffer from poor design

Non-synthetic or with high toxicity

Lack of mechanical compatibility or good adhesion with tissue

Reactive to body fluids

Usage limited to open-surgery

an ideal surgical glue should meet three basic criteria. It should bond tissues strongly, it should be nontoxic and it

should work in wet environments like those found inside the body. Unfortunately, there isnt really anything out there

that can do all three of those, You can pick two, and thats easy, but getting all three is really pretty tricky.

Jonathan Wilker, Purdue University in West Lafayette, Indiana

Gecko Biomedical Confidential4

A Bioinspired Approach

Exclusive WW license form MIT on a portfolio of

6 patents

3 new patents filed by Gecko in

2015

A light activated adhesive to simplify surgical procedures

Gen

eral

surg

ery

MIS

Gecko Biomedical Confidential

Cardiovascular: challenging unmet need

Customizable mechanical profile

Customizable biodegradation profile

Cell ingrowth compatible

Biocompatible

Adhesion to different surgical materials

Adhesion after body fluid exposure(viscous and hydrophobic)

Fast on demand adhesion

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Gecko Biomedical Confidential

A light activated adhesive to simplify surgical procedures

Sealant for tissue leaks

A Adhesive patch for

defect closure

B

Reduce the number of sutures:- Safer procedures- Faster procedures - Minimally invasive procedures- Less tissue damage

Avoid the use of sutures:- Faster procedures - Minimally invasive procedures- Less tissue damage

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Lang, N. et al (2014) A Blood-Resistant Surgical Glue for Minimally InvasiveRepair of Vessels and Heart Defects, Sci. Transl. Med. 6, 218ra6 (2014)

April 17th 2014 -N Engl J Med 2014;

370:1556-1559

Gecko Biomedical receivedRadTechs Emerging Technology Award at RadTech 2014

A tool to transform how surgery is done: from open to minimally invasive procedures

Gecko Biomedical Confidential8

Sealing vessel with reduced number of sutures

Gecko Biomedical Confidential

Adjunct to sutures: first clinical indication ( targeted for 2016)

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Patching holes in infants hearts

Gecko Biomedical Confidential

Porcine animal model

Multidisciplinary team

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Gecko Biomedical Confidential

World Class team

Paradigm shift in Sealants, Adhesives and Minimally Invasive Surgery

Strong IP

Established ecosystem

Sustainable options for growth

Strong financial position with an 8M Series A and 4M non dilutive cash (2014-2016)

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