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Enabling Genomic Medicine Roundtable A Grand Challenge of Genome Sequencing: Complete Genomics of Human and Microbiome DNA: Comparing Healthy with IBD Presented by: Larry Smarr, UCSD (Calit2) Wednesday June 15, 2011 | San Francisco California

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11.06.15Enabling Genomic Medicine Roundtable: A Grand Challenge of Genome Sequencing: Complete Genomics of Human and Microbiome DNA: Comparing Healthy with IBDPresented by: Larry Smarr, UCSD (Calit2)San Francisco California

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Page 1: A Grand Challenge of Genome Sequencing: Complete Genomics of Human and Microbiome DNA: Comparing Healthy with IBD

Enabling Genomic Medicine Roundtable

A Grand Challenge of Genome Sequencing:Complete Genomics of Human and Microbiome DNA:

Comparing Healthy with IBDPresented by: Larry Smarr, UCSD (Calit2)

Wednesday June 15, 2011 | San Francisco California

Page 2: A Grand Challenge of Genome Sequencing: Complete Genomics of Human and Microbiome DNA: Comparing Healthy with IBD

Enabling Genomic Medicine Roundtable

IBD is an Autoimmune Disease—Correlated with SNPs and Microbiome Metagenomics

2Wednesday June 15, 2011 – San Francisco, California

Mutation in Interleukin-23 Receptor Gene—80% Higher

Risk of Pro-inflammatoryImmune Response

2009

Page 3: A Grand Challenge of Genome Sequencing: Complete Genomics of Human and Microbiome DNA: Comparing Healthy with IBD

Enabling Genomic Medicine Roundtable

IBD Couples Human & Microbiome DNA and Their Products

3Wednesday June 15, 2011 – San Francisco, California

~80% of Our Immune System is Based in our Gut

Follow Molecular Interactions with

Proteomics, Metabolomics,

&Transcriptomics of Joint Genomic

Production of Human DNA & Microbiome DNA