NEW FROM GARLAND SCIENCE

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A FIRST COURSE IN

SYSTEMS BIOLOGY

EBERHARD O. VOIT

A First Course in Systems Biology is a textbook designed for advanced undergraduate and graduate students. Its main focus is the development of computational models and their applications to diverse biological systems.

Because the biological sciences have become so complex that no individual can acquire complete knowledge in any given area of specialization, the education of future systems biologists must instead develop a student’s ability to retrieve, reformat, merge, and interpret complex biological information.

This book provides the reader with the background and mastery of methods to execute standard systems biology tasks, understand the modern literature, and launch into specialized courses or projects that address biological questions using theoretical and computational means. The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and larger-scale, often open-ended questions for further reflection.

ONLINE RESOURCESOnline resources for students and instructors can be found atwww.garlandscience.com/systems-biology.

For instructors who recommend or adopt

the book for their course:

• Artwork in JPEG & PPT formats.• Solutions to end-of-chapter exercises.

For students:

• Online flashcards.• Data tables for end-of-chapter exercises.• Hints to end-of-chapter exercises.

KEY FEATURES• Learning Objectives at the beginning of each chapter• Boxes describing specific computational techniques• End-of-chapter exercises, with solutions available to instructors• End-of-chapter references and suggestions for further reading

6. Gene Systems7. Protein Systems8. Metabolic Systems9. Signaling Systems10. Population Systems11. Integrative Analysis of Genome, Protein, and Metabolite Data

12. Physiological Modeling: the Heart as Example13. Systems Biology in Medicine and Drug Development14. Design of Biological Systems15. Emerging Topics in Systems Biology

1. Biological Systems2. Introduction to Mathematical Modeling3. Static Network Models4. The Mathematics of Biological Systems5. Parameter Estimation

CONTENTS

A sample chapter and detailed table of contents are available at www.garlandscience.com/systems-biology

disease

disease predictorslate biomarkersearly biomarkers

Figure 13.3

Figure 13.3 Hierarchial biomarker networks.

X 1, X

2, X

3, X

40

1.0

0.5

0 300150time

X1 X2

X3 X4

Figure 10.12Figure 10.12 Even small dynamic systems

may exhibit deterministic chaos.

April 2012978-0-8153-4467-4 • £44.00

464 pages • 330 illustrations • Paperback

To request an inspection copy or order on-line visit www.garlandscience.com/systems-biology

CUSTOM PUBLISHING: Garland Science Custom Publishing enables the creation of materials from multiple sources, including A First Course in Systems Biology, in just a few clicks. Visit http://garland.sharedbook.com to learn more.

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PRAISE FOR A FIRST COURSE IN SYSTEMS BIOLOGY“The exercises combined with the explanatory notes in [Chapter 11] make a complete student project.

This is ideal material for a standalone practical course, or for the final

student assignment in a longer course as it is very open-ended and will

reflect the current literature.”

ANDREW DALBY,

INSTITUTE OF ANIMAL HEALTH, UK

“Chapter 5 was great. It gives a good overview of what is available and

works for biological model parameter estimation, and points out the

common pitfalls that are encountered. If all the chapters [are] like this one I[will] adopt the book in a heartbeat.”

WILLIAM T. BAUMANN,

VIRGINIA TECH, USA

THE AUTHOREberhard O. Voit is Professor and Georgia Research Alliance Eminent Scholar at the Georgia Institute of Technology. He is also the founding director of Georgia Tech’s new Integrative BioSystems Institute. He has written extensively on the analysis of biological systems, including two textbooks, an edited research text and about 180 scientific papers and book chapters.

GSVOIT1201 ISBN: 978-0-418-26368-6

3 Park Square, Milton Park,Abingdon, OXONOX14 4RNwww.garlandscience.com

To place an order contact your local bookseller or Taylor and Francis sales representative.

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