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A. D. Katsambas· T. M. Lotti (Eds.) European Handbook of Dermatological Treatments

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Page 1: A. D. Katsambas· T. M. Lotti (Eds.) European Handbook of …978-3-662-03835-2/1.pdf · This is simply a corrected edition of the European Handbook of Dermatological Treatments, which

A. D. Katsambas· T. M. Lotti (Eds.)

European Handbook of Dermatological Treatments

Page 2: A. D. Katsambas· T. M. Lotti (Eds.) European Handbook of …978-3-662-03835-2/1.pdf · This is simply a corrected edition of the European Handbook of Dermatological Treatments, which

Springer-Verlag Berlin Heidelberg GmbH

Page 3: A. D. Katsambas· T. M. Lotti (Eds.) European Handbook of …978-3-662-03835-2/1.pdf · This is simply a corrected edition of the European Handbook of Dermatological Treatments, which

A. D. Katsambas T. M. Lotti (Eds.)

European Handbook of Dermatological Treatments

2nd, revised reprint

, Springer

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Professor Andreas D. Katsambas University of Athens - Greece of Dermatology and Venerology 35, Skoufa Str. GR-106 73 Athens Greece

Professor Torello M. Lotti University of Florence, Florence, Italy 23, Via Dante Alghierie I-51015 Montecatini Terme (PT) Italy

2"d revised reprint 2000

The Library of Concress has cataloged the original printing as follows:. European handbook of dermatological treatments/ A.D. Katsamaba, T.M. Lotti, eds.

p. cm. Includes bibliographical references. ISBN 978-3-662-03837-6 ISBN 978-3-662-03835-2 (eBook) DOI 10.1007/978-3-662-03835-2 1. Skin--Deseases--Handbooks, manuals, etc. 2. Dermatology­

·Handbooks, manuals, etc.!. Katsambas, A.D. (Andreas D.), 1944· 1!. Lotti, T. M. (Torello M.), 1953- . [DNLM: 1. Skin Diseases--therapy. 2. Skin Diseases--diagnosis.

3. Diagnosis, Differential. 4· Dermatologie Agents--administration & dosage. WR 650 E89 1999) RL74.E94 1999 616.5--dc21 DNLM/DLC for Library of Congress

This work is subject to copyright. Ali rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in ohter way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright. Law of September 9,1965, in its current version, and permis­sion for use must always be obtained from Springer-Verlag Berlin Heidelberg GmbH. Violations are liable prosecution under the German copyright law.

© Springer-Verlag Berlin Heidelberg 2000

Originally published by Springer-Verlag Berlin Heidelberg New York in 2000 Softcover reprint of the hardcover 2nd edition 2000

The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regula­tions and therefore free for general use.

Produci Liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature.

Cover design: E. Kirchner, Heidelberg

Typesetting: cicero Lasersatz, Dinkelscherben

Printed on acid-free paper- SPIN: 10773671- 22/3130 - 5 4 3 2

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Preface

This handbook presents the combined work of many prominent dermatologists from throughout Europe, based on their profound knowledge and clinical experience in various fields of dermatology.

The purpose of this manual is to provide an easy to use guide that describes not only the many dermatological diseases diagnosed today, but also the analogous drugs and methods of treatment available. Hence, as indicated in the title, dermatologists and non-dermatologists will find its contents to be most useful and concise.

The manual is divided into three main sections, diseases, methods, and drugs. The first part of the Handbook defines each disease with brief information on its etiology and pathophysiology. This is followed by a short account of diagnostic procedures and an extensive discussion of treatment and therapy. The authors try not only to present the classic and modern approaches to treatment, but also to provide their personal recommendations on the base of their expertise. The middle section describes up-to­date methods and the possible use of therapeutic equipment, for diagnosis and treat­ment. The final part provides an alternative approach, indicating where medication and drugs could be an appropriate choice in the treatment of dermatological diseases.

This is simply a corrected edition of the European Handbook of Dermatological Treatments, which has been minimally revised and retains the exact form of the pre­vious publication.

The response received from the initial publication of the Handbook, was enthusias­tic and the book was widely accepted. It has been a great pleasure to provide this Handbook to fellow colleagues and new dermatologists in the continuing endeavour to treat dermatological and cutaneous diseases.

We wish to express our gratitude to all the distinguished colleagues who contributed towards this venture.

Andreas Katsambas Torello Lotti

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Contents

Diseases

Acne .............. . W.J. Cunliffe, and D.C. Seukeran

Acne Inversa ................ . R. Chatelain, C. Hary, B. Konz, and G. Plewig

Actinic Keratosis ... F. Camacho-Martinez

Adamantiades-Beh~et's Disease C.C. Zouboulis

Alopecia Areata Management R.Happle

Androgenic Alopecia . . . . . . . . . . . . C. Pierard-Franchimont, and G.E. Pierard

Antiphospholipid Syndrome ...... . P.G. Vlachoyiannopoulos, and H.M. Moutsopoulos

Aphthous Stomatitis G.Laskaris

Apocrine Miliaria . . . . . . . . H.R. Bruckbauer, and H.J. Vogt

Atopic Dermatitis . . . . . . . E.J.M. Van Leent, and J.D. Bos

Balanitis .. D.Freedman

Basal Cell Carcinoma D. Roseeuw, and A.D. Katsambas

3

11

15

21

31

38

44

51

56

58

69

75

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VIII

Bowen's Disease G. Avgerinou

Bullous Pemphigoid A. Varelzidis

Candidiasis (Candidosis-Moniliasis-Trush) D. Rigopoulos

Contents

89

92

99

Chronic Actinic Dermatitis .............................. 106 G.M.Murphy

Cicatricial Alopecia . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 111 A. Tosti, and B.M. Piraccini

Contact Dermatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 117 L.Kanerva

Cutaneous Vasculitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 127 T.Ryan

Darier's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 131 C. Varotti, and F. Bardazzi

Dermatitis Herpetiformis . . . . . . . . . . . . . . . . . . . . . . . . . . .. 134 C. Gooptu, and F. Wojnarowska

Dermatomyositis S. Jablonska

............................ 138

Dermatophyte Infections .............................. 144 A. Tosti, and B.M. Piraccini

Diaper Dermatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 149 S. Reimann, and T.A. Luger

Drug-Induced Pemphigus. ............................. 153 K.E. Harman, and M.M. Black

Drug Eruption J.Revuz

............................. 155

Drug Photosensitivity ................................. 159 P. Santoianni, and E.M. Procaccini

Eccrine Miliaria . . . . . . . . . .... . . . . . . . . . . . . . . . . . . . . .. 164 H.R. Bruckbauer, and H.J. Vogt

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Contents IX

Epidermolysis Bullosa ........ . 167 G. Menchini, B. Bianchi, and T. M. Lotti

Erysipelas .. . M. Balabanova

. ....................... 177

Erythema Multiforme ................................. 181 F. M. Brandao

Erythema Nodosum .................................. 185 A.Claudy

Erythrasma ....................................... 189 E. Koumantaki-Mathioudaki

Erythroplasia of Queyrat ............................... 192 B.-R.Balda

Factitial Dermatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 195 N. Tsankov, and 1. Stranski

Folliculitis . . G.R. Rousselet

.............................. 198

Furuncles and Carbuncles ..................... 202 R. Stadler, and M. Westenberger-Treumann

Gonorrhoea M.A. Waugh

Granuloma Annulare N. Raison-Peyron, and J. Meynadier

Hand Dermatitis ... K. Thestrup-Pedersen

..................... 209

......................... 212

. ........................ 218

Herpes Simplex Genitalis . . . . . . . . . . . . . . . . . . . . . . . . . . 224 P. Teofoli, P. Puddu, and T. M. Lotti

Herpes Simplex Virus Infection (Oro-facial) . . . . . . . . . . . . . . . . . . . . . 229 S.Kroon

Herpes Zoster . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 234 S. Georgala

Hirsutism ....................................... 241 S. Rogers

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x Contents

HIV Infection and AIDS: Present Status of Antiretroviral Therapy R. Husak, L. U. WOlfer, and C.C.E. Orfanos

.. 246

Hyperhidrosis . . . . . . . . . . . . . . .. ..................... 256 G. Campanile, G. Hautmann, and T.M. Lotti

Ichthyoses . . . . . . . . . . . M. Paradisi, and A. Giannetti

. .................... 261

Impetigo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 267 S. Veraldi, and R. Caputo

Kaposi's Sarcoma J.D. Stratigos

................................ 272

Keloids and Hypertrophic Scars . . . . . . . . . . . . . . . . . . . . . . . . . 281 G. Hautmann, and A. Mastrolorenzo

Keratoacanthoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287 P. Campolmi, M. Benci, C. Vallecchi, and T. M. Lotti

Leg Ulcers .. A.A. Ramelet

. ................ 292

Leishmaniasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301 M. Onder, and M.A. Gurer

Lentigo Maligna .................................... 308 R.P.R. Dawber, and Z.S. Gaspar

Leprosy or Hansen's Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313 B. Flageul, and L. Dubertret

Lichen Planus A.Rebora

.............................. 324

Lichen Simplex Chronicus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 328 M. Gantcheva

Lupus Erythematosus ................................ 333 B. Crickx, and S. Belaich

Lymphomas Primary Cutaneous ........................... 340 W.A. van Vloten

Malignant Melanoma ................................. 355 B.R.Balda

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Contents

Mastocytosis (Urticaria Pigmentosa) A.P. Oranje, and D. Van Gysel

XI

363

Melasma . . . . . . . . . . .. ............................ 368 A.D. Katsambas, and T.M. Lotti

Mite Bites G.Leigheb

............................ 374

Molluscum Contagiosum ............................... 376 M. V. Milinkovic, and L. M. Medenica

Morphea: Circumscribed Scleroderma . . . . . . . . . . . . . . . . . . . . . . . . 384 U. F. Haustein

Necrobiosis Lipoidica ................................. 387 E. Grosshans

Nevi (Benign Melanocytic) .............................. 392 N. G. Stavrianeas

Nummular Eczema ................................... 407 H.R. Bruckbauer, S. Karl, and J. Ring

Pediculosis G. Campanile, and G. Hautmann

Pemphigus Erythematosus K.E. Harman, and M.M. Black

......................... 414

........................... 419

Pemphigus Foliaceus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 421 K.E. Harman, and M.M. Black

Pemphigus Vegetans .................................. 425 K.E. Harman, and M.M. Black

Pemphigus Vulgaris ............................. 428 V. Ruocco, and S. Brenner

Photo ageing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 437 N.M. Craven, and C.E.M. Griffiths

Pityriasis Lichenoides Acuta . . . . . . . . . . . . . . . . . . . . . . . . . . . 441 L. Andreassi

Pityriasis Lichenoides Chronica . . . . . . . . . . . . . . . . . . . . . . . . . . . . 445 G. Lange Vejlsgaard

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XII

Pityriasis Rosea H.Degreef

Contents

.. 449

Pityriasis Rubra Pilaris . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 453 W.A.D. Griffiths

Polymorphic Light Eruption (PLE) . . . . . . . . . . . . . . . . . . . . . . . . . . 459 J. Ferguson, and A.D. Katsambas

Porphyrias ...... . . .......................... 463 M. Lecha, and C. Herrero

Pruritus .. D. Ioannides

. ............................... 470

Psoriasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 477 U. Mrowietz, and E. Christophers

Purpuras ............. . . . . . . . . . . . . . . . . . . . . . . 488 T.M. Lotti, C. Comacchi, and 1. Ghersetich

Pyoderma Gangrenosum M. Camilleri, and J.1. Pace

...................... 494

Raynaud's Phenomenon ............................... 504 C.G.M. Kallenberg

Rosacea . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 508 F.C.Powell

Sarcoidosis ....................................... 515 A.Rebora

Scabies .. . ................................ 518 A. G6rkiewicz-Petkow

Seborrheic Dermatitis ................................. 523 J. Faergemann

Seborrheic Keratosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 527 A. Picoto

Sjogren's Syndrome .................................. 531 A.G. Tzioufas, and H.M. Moutsopoulos

Skin Diseases from the Marine Environment .................... 536 G. Monfrecola

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Contents

Solar Urticaria M. Jeanmougin

XIII

541

Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . 545 D. Roseeuw, and A. D. Katsambas

Subacute Cutaneous Lupus Erythematosus ..................... 549 M.N. Manoussakis, and H.M. Moutsopoulos

Syphilis .. M.A. Waugh

. .................... 556

Systemic Sclerosis - Scleroderma . . . . . . . . . . . . . . . . . . . . . . . . . . . 564 U. F. Haustein

Tick Dermatoses .................................... 570 G.Leigheb

Tinea Versicolor. Pityriasis Versicolor . . . . . . . . . . . . . . . . . . . . . . . . . 572 M. Le Maitre, and A. Dompmartin

Toxic Epidermal Necrolysis A.Minas

.......................... 577

Urethritis: Gonococcal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 583 D. Freedman

Urethritis: Nongonococcal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 589 D. Freedman

Urticaria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 595 F. Lawlor, and M.W. Greaves

Varicella .. S. Georgala

. ............................. 602

Vascular Birthmarks: Vascular Malformations and Haemangiomas . . . . . . . . 608 H. Yang, and G. W. Cherry

Vitiligo ......................................... 617 A.D. Katsambas, T.M. Lotti, and J. P. Ortonne

Warts and Condylomas ..... . .................... 624 J.M. Mascaro, and J.M. Mascaro Jr.

Xanthomas .......... . . ......................... 631 A.D. Tosca, and J.C. Katsantonis

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XIV Contents

Methods

Biopsy .......................................... 639 E.Haneke

Chemical Peelings ................................... 645 1. Ghersetich, P. Teofoli, M. Ribuffo, and T.M. Lotti

Cryosurgery . . . . . . . . . M.C. Boullie, and Ph. Lauret

Curettage E.Haneke

. ................. 657

.............................. 662

Electrosurgery ..................................... 664 E.Haneke

Epiluminescence Microscopy of Pigmented Skin Lesions . . . . . . . . . . . . . . 668 V. De Giorgi, and P. Carli

Extracorporeal Photo chemotherapy ......................... 675 B.R.Balda

Hair Restoration Surgery ............................... 678 S. Letessier

Lasers in Dermatology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 687 1. Leite

Moh's Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 693 A. Picoto, J.M. Labareda, R. Themido, and F. Coelho

Patch Testing A.Katsarou

................. 696

Photo chemotherapy .................................. 702 Ch. Antoniou

Sclerotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 707 E. Del Bianco, G. Muscarella, and P. Cappugi

Skin Augmentation (Fillings) 1. Rusciani, and S. Petraglia

..................... 712

Skin Resurfacing with the CO2 Laser ......................... 720 S. Letessier, and C. Veres

UVB Phototherapy Ch. Antoniou

................................ 727

Vaccine Strategies via Dendritic Cells in the Treatment of Malignant Melanoma 730 S. Moretti, and T.M. Lotti

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Contents xv

Drugs

Antibacterial Agents in Dermatology . . . . . . . . . . . . . . . . . . . . . . . . . 737 H. Giamarellou

Antifungals .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 748 V. Bettoli, and A. Tosti

Antihistamines ..................................... 756 A.D. Katsambas,A. Stratigos, and T.M. Lotti

Antiviral Drugs ..................................... 762 G. Hautmann, G. Campanile, E. Puma, and A.D. Katsambas

Bleaching Agents . . . . . . . W. Westerhof, and M.D. Njoo

. ........... 766

Corticosteroids Topical . . . . . . . . . . . . . . . . . . . . . . . . 778 J.G. Camarasa, and A. Gimenez-Arnau

Glucocorticoids Systemic ............................... 787 J.G. Camarasa, and A. Gimenez-Arnau

Insect Repellents ... S. Motta, and M. Monti

. ....................... 797

Psychoactive Agents in Dermatology . . . . . . . . . . . . . . . . . . . . . . . . . 803 G. Hautmann, and E. Panconesi

Retinoids J.H. Saurat

............................ 812

Scabicides and Pediculicides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 819 A. G6rkiewicz-Petkow

Sunscreens ....................................... 825 D. Rigopoulos, Ch. Antoniou, and A.D. Katsambas

Topical Anaesthetics in Dermatology . . . . . . . . . . . . . . . . . . . . . . 829 F. B. de Waard-van der Spek, and A.P. Oranje

Topical Preparation and Vehicles M. Monti, and S. Motta

..................... 834

Subject Index .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 847

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List of contributors

Andreassi, L. Dept. of Dermatology, Policlinico "Le Scotte", University of Siena, Siena-Italy

Antoniou, Ch. "A Sygros Hospital", 5 Dragoumi St., Athens 16121-Greece

Avgerinou, G. Dept. of Dermatology, University of Athens, "A Sygros Hospital", 5 Dragoumi St., Athens 16121-Greece

Balabanova, M. Dept. of Dermatology, Medical University, Sofia-Bulgaria

Balda,B.R. Dept. of Dermatology & Allergology, Zentralklinikum Augsburg, Stenglin StraBe 2, D-86156 Augsburg-Germany

Bardazzi, F. Dept. of Dermatology, Faculty of Medicine, University of Bologna, V. Massarenti 1, 1-40138 Bologna-Italy

Belaich,S. 101, Rue de Rennes, F-75006 Paris-France

Bettoli, V. Universita degli Studi di Bologna, Dept. di Medicina Clinica Specialistica e Sperimen­tale, Clinica Dermatologica, Ospedale Policlinico S. Orsola-Malpighi, Via Massarenti, 1-40138 Bologna-Italy

Bianchi,B. Via Crispi 38, Pisa 56100-Italy

Black,M.M. st. John's Institute of Dermatology, st. Thomas's Hospital, Lambeth Palace Road, London SE17EH-England

Bos,J.D. Dept. of Dermatology AO 252, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE-Amsterdam-The Netherlands

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XVIII List of contributors

Boullie, M. C. Hopital Charles Nicolle, 1, Rue de Germont, Rouen-France

Brandao,F. R. S. Domingos, A Lapa 89-5, P-1200 Lisboa-Portugal

Brenner, S. Dept. of Dermatology, Sourasky Medical Center, Tel Aviv-Israel

Bruckbauer, H. R. Dept. of Dermatology & Allergy, am Biederstein, Technical University Munich, BiedersteinerstraBe 29, D-80802 Munich-Germany

Camacho-Martinez, F. Universitdad de Sevilla, Dept. de Dermatologia, Avda. Republica, Argentina 22,5 D, Sevilla-Spain

Camarasa, J. Dermatology Department, Hospital del Mar. 1M 1M, Univ. Autonoma de Barcelona, Passceig Maritim 25-29,08003 Barcelona-Spain

Camillier, M. Mayo-Clinic, Minnesota -USA

Campanile, G. L. Dept. of Dermatology, University of Florence, 37 via Alfani, 1-50121 Florence-Italy

Campolmi, P. Dept. of Dermatology, University of Florence, Florence-Italy

Caputo,R. Institute of Dermatologic Science, University of Milan, Milan -Italy

Cappugi,P. Dept. of Dermatology, University of Florence, Florence-Italy

Carli, P. Dept. of Dermatology, University of Florence, 37 via Alfani, 1-50121 Florence-Italy

Chatelain, R. Dermatologische Klinik & Poliklinik, Ludwig-Maximilians, Univ. Mtinchen, FrauenlobstraBe 9-11, D-80337 Munich-Germany

Cherry,G. Churchill Hospital, Headington, Oxford OX3 7LJ-UK

Christophers, E. Dept. of Dermatology, University of Kiel, SchittenhelmstraBe 7, D-24105 Kiel-Germany

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List of contributors

Claudy,A. Clinique Dermatologique, Hopital Edouard Herrior, Place d' Arsanval, F-69437 Lyon Cedex 03-France

Coelho,F. Superior Technician Farmacy, Centro de Dermatologia Medic-Cirurgica, ARS de Lisboa e Vale do Tejo, Rua Jose Estevao 135,1150 Lisboa-Portugal

Comacchi, C. Dept. of Dermatology, University of Florence, 37 via Alfani, U -50121 Florence-Italy

Craven, N. M. Section of Dermatology, University of Manchester, Manchester-UK

Crickx,B. Paris-France

Cunliffe, W. J. Skin Research Centre, The General Infirmary at Leeds-Leeds LSI3EX-UK

Dawber, R. P. R. Dept. of Dermatology, The Churchill Hospital, OX3 7LJ Oxford-UK

Del Bianco, E. Dept. of Dermatology, Univ. of Florence, Florence-Italy

De Giorgi Dept. of Dermatology, University of Florence, 37 via Alfani, I -50121 Florence-Italy

Degreef,H. Universitaire Ziekenhuizen Leuven Derm., UZ Sint-Rafael, Kapucijnenvoer 35, B-3000 Leuven-Belgium

De Waard-Van der Spek, F. B.

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Dept. of Dermato-Venereology, Univ. Hospital Rotterdam, Rotterdam-The Netherlands

Dompmartin, A. Caen-France

Dubertret, L. Dept. of Dermatology, Hospital Henri Mondor, 51 Av. Du Marechal Lattre de Tassigny, F-94010 Creteil-France

Faergemann, J. Dept. of Dermatology, Sahlgrenska University Hospital, S-41345 Gothenburg-Sweden

Ferguson, J. Photobiology Unit, Ninewells Hospital and Medical School, Dundee, DDI 9SY-Scotland

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Flageul, B. Paris-France

Figueiredo, A. Rua Infanta D. Maria Lt 38-B 3 Esq, P-303 Coimbra-Portugal

Freedman, D. 88 Ranelagh Village, Dublin 6-Ireland

Gantcheva, M.

List of contributors

Dept. of Dermatology, Medical University, 1 Georgi Sifiiski Str., 1431 Sofia-Bulgaria

Gaspar, Z. S. Princess Alexandra Hospital, Woollongabba, Queensland-Australia

Georgala, S. Dept. of Dermatology, University of Athens, "A Sygros Hospital", Athens-Greece

Ghersetich, I. Dept. of Dermatology, University of Florence, via degli Alfani 37, 1-50121 Florence-Italy

Giamarellou, H. Athens University School of Medicine, Infectious Diseases Department, "Laiko General Hospital", Athens 11527-Greece

Gimenez-Arnau, A. Dept. of Dermatology, Hospital del Mar. 1M 1M, Univ. Autonoma de Barcelona, Passeig Maritim 25-29, 08003 Barcelona-Spain

Giannetti, A. Dept. of Dermatology, University of Modena, via del Pozzo 71,1-41100 Modena-Italy

Gooptu,c. Dept. of Dermatology, The Churchill Hospital, Headington OS3 7LJ Oxford-UK

Gorkiewicz-Petkow, A. Dept. of Dermatology, Warsaw School of Medicine, Koszykowa 82A, 02-008 Warsaw-Poland

Greaves,M. St. John's Institute of Dermatology, St. Thomas's Hospital, Lambeth Palace Road, London SE17EH-UK

Griffiths, C. E. M. Section of Dermatology, Univ. Manchester School of Medicine, Hope Hospital, Manchester M6 8HD-UK

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List of contributors

Griffiths, W. A. D. st. John's Institute of Dermatology, st. Thomas's Hospital, Lambeth Palace Road, London SE17EH-UK

Grosshans, E. Clinique Dermatologique, Faculte de Medicine, I-Place de l'Hopital, F-67091 Strasbourg-France

Gurer Ali, M. GAZI University, Ankara -Turkey

Haneke,E. Hautklinik, Arrenbergerstra6e 20-56, D-42117 Wuppertal-Germany

Happle,R. Dept. of Dermatology, Philipp Univ. of Marburg, Deutschhausstra6e 9, D-35033 Marburg-Germany

Harman, K. E. st. John's Institute of Dermatology, St. Thomas's Hospital, Lambeth Palace Road, London SE17EH-UK

Hary,C. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Univ. Munich, Frauenlobstra6e 9-11, D-80337 Munich-Germany

Haustein, u.F. Dept. of Dermatology, Univ. of Leipzig, Liebigstra6e 21, D-04103 Leipzig-Germany

Hautmann, G. Dept. of Dermatology, Univ. of Florence, 37 via Alfani, 1-50121 Florence-Italy

Herrero,C. Servei de Dermatologia, Hospital Clinic, Facultat de Medicina, Univ. de Barcelona, Barcelona-Spain

Husak,R. Dept. of Dermatology, Univ. Medical Ctr BF, The Free University of Berlin, Hindenburgdamm 30, D-12200 Berlin-Germany

loannides, D. Dept. of Dermatology, Aristotle Univ., Medical School, 3 PP Germanou Street, 54622 Salonika-Greece

Jablonska, S. Dept. of Dermatology, Warsaw School of Medicine, Koszykowa 82a, 02-008 Warsaw-Poland

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XXII

Jeanmougin, M. 155 Boulevard Magenta, F-75009 Paris-France

Kallenberg, C. G. M. Cronningen-The Netherlands

Kanerva,L. Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN -00250 Helsinki -Finnland

Karl, S.

List of contributors

Dept. of Dermatology & Allergy, am Biederstein, Technical University Munich, BiedersteinerstraBe 29, D-80802 Munich-Germany

Katsambas, A. D. Dept. of Dermatology, University of Athens, "A Sygros Hospital", 5 Dragoumi St., Athe­ns 16121-Greece

Katsantonis, J. c. Dept. of Dermatology, Faculty of Medicine, University of Crete, Heraklion 71110 Crete-Greece

Katsarou, A. Dept. of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi Street, Athens 16121-Greece

Konz,B. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Univ. Munich, FrauenlobstraBe 9-11, D-80337 Munich-Germany

Koumantaki-Mathioudaki, E. Dept. of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi Street, Athens 16121-Greece

Kroon,S. Pederstupvej 40, DK-5210 Odens NV-Denmark

Labareda, J. M. Centro de Dermatologia Medico-Cirurgica, ARS de Lisboa e Vale do Tejo, Rua Jose Estevao 135,1150 Lisboa-Portugal

Vejlsgaard-Lange, G. Rigshospitalet Copenhagen Univ. Hospital, The Rhima Center, Tagensvej 20, DK-22o Copenhagen N-Denmark

Larregue, M. 350, Avenue Jacques-Coeur, 86021 Poitiers, France

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List of contributors XXIII

Laskaris, G. Dept. of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi Street, Athens 16121-Greece

Lauret, Ph. Hopital Charles Nicolle, 1, rue de Germont, Rouen-France

Lawlor, F. Dermatology Unit, St. Andrew's Hospital, Devas Street, Bow London E3 3NT -UK

Lecha,M. Servei de Dermatologia, Hospital Clinic, Facultat de Medicina, Univ. de Barcelona, c/VillarroeI170, E-08036 Barcelona-Spain

Ledo,A. Pasei de la Castellana 167, E-28046 Madrid-Spain

Leigheb,G. Dept. di Science Mediche, Universita degli studi di Torino, via Solaroloi 17, 1-28100 Novara-Italy

Leite, L. Calcada da Ajuda 82-1, P-1300 Lisboa -Portugal

Le Maitre, M. 1 Avenue de 6 Juin, F-14000 Caen-France

Letessier, S. 28 Place Saint-Ferdinand, F-75017 Paris-France

Lotti, T.M. Dept. of Dermatology, University of Florence, 37 via Alfani, 1-50121 Florence-Italy

Luger, T.A. Universitats-Hautklinik Munster, Von-EsmarchstraBe 56, D-48149 Munster-Germany

Manoussakis, M. N. Dept. of Pathophysiology, School of Medicine, University of Athens, Greece

Mascaro, J. M. Hospitale Clinic, Dept. of Dermatology, Casanova 143, E-08036 Barcelona-Spain

Mascaro, J. M. Jr. Hospitale Clinic, Dept. of Dermatology, Casanova 143, E-08036 Barcelona-Spain

Mastrolorenzo, A. Dept. of Dermatology, University of Florence-Italy

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XXIV

Medenica, 1. J. M. Belgrade-Yugoslavia

Menchini, G. Dept. of Dermatology, University of Siena, Siena-Italy

Meynadier, J.

List of contributors

Service de Dermatologie, Hopital st. Eloi, 2 Avenue Bertin Sans, F-34295 Montpellier Cedex 5-France

Millinkovic, M. M. Dept. of Dermatology, University of Belgrade, Belgrade-Yugoslavia

Minas,A. Dept. of Dermatology, Aristotle University Medical School,3 PP Germanou St, 54622 Salonica-Greece

Monfrecola, G. Dept. of Dermatology, University Frederico II of Naples, Via Pansini 5, 1-80131 Napoli-Italy

Monti,M. University of Milan, Istituto Clinico Humanitas, Unit of Dermatology, Via Manzani 56, 1-20089 Rozzana Milano-Italy

Moretti, S. Dept. of Dermatology, University of Florence, Florence-Italy

Motta,S. University of Milan, Istituto Clinico Humanitas, Unit of Dermatology, Via Manzani 56, 1-20089 Rozzana Milano-Italy

Muscarella, G. Dept. of Dermatology, Univ. of Florence, Florence-Italy

Moutsopoulos, H. M. Dept. of Pathophysiology, School of Medicine, National University of Athens, Greece

Mrowietz, U. Dept. of Dermatology, University of Kiel, SchittenhelmstraBe 7, D-24105 Kiel-Germany

Murphy, G. M. National Photobiology Unit, Beaumont Hospital, Dublin-Ireland

Njoo,M.D. Netherlands Institute for Pigmentary, Disorders, AMC IWO Gebouw, Meibergdreef 35, 1105 AZ Amsterdam-The Netherlands

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List of contributors

Onder,M. Dept. of Dermatology, GAZI University, Ankara-Turkey

Oranje, A. P. Dept. of Dermato-Venereology, University Hospital & Erasmus Univ., Rotterdam-The Netherlands

Orfanos, C.E. Dept. of Dermatology, Univ. Medical Center BF, The Free Univ. of Berlin, Berlin-Germany

Ortonne, J.-P. Service de Dermatologie, Hopital de l' Archet II, Nice-France

Pace, J. L. University of Malta School, Msida & st. Philip's Hospital, Venera-Malta

Panconesi, E. Dept. of Dermatology, University of Florence, Florence-Italy

Paradisi, M. lstituto San Gallicano, Rome-Itlay

Petraglia, S. Catholic University, Dept. of Dermatology, Lgo A. Gemelli 8, 00168 Rome-Italy

Picoto,A. Centro de Dermatologia, Medico-Cirurgica de Lisboa, Lisboa-Portugal

Pierard, G. E.

xxv

Dept. of Dermatopathology, Univ. Of Liege, CHU Sart Tilma, B-4000 Liege-Belgium

Pierard-Franchimont, C. Dept. of Dermatopathology, Univ. Of Liege, CHU Sart Tilma, B-4000 Liege-Belgium

Piraccini, B. M. Dept. of Dermatology, University of Bologna, Bologna-Italy

Plewig,G. Dept. of Dermatology, Ludwig-Maximilians University, Munich-Germany

Powell, F. Regional Centre of Dermatology, Mater Hospital, Dublin-7-lreland

Procaccini, E. M. Dept. of Dermatology, University of Naples, Naples-Italy

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Raison-Peyron, N. Montpellier-France

Ramelet, A. A. 2 Place Benjamin Constant, CH-lO03 Lausanne-Switzerland

Rebora,A. Dept. of Dermatology, University of Genoa, Genoa-Italy

Reimann,S. Dept. of Dermatology, University of Munster, Munster-Germany

Revuz,J.

List of contributors

Service de Dermatologie, Hopital Henri-Mondor, F-94010 Creteil Cedex-France

Ribuffo,M. Dept. of Immundermatology, IDI IRCCS, Rome-Italy

Rigopoulos, D. Univ. Dermatological Clinic, "A Sygros Hospital", 5, I Dragoumi Street, Athens 16121-Greece

Ring,J.O. Dept. of Dermatology & Allergy Biederstein, Technical University Munich, Munich -Germany

Rogers, S. St. Vincent's Hospital, Elm Park, Dublin 4-Ireland

Roseeuw,D. Academic Hospital, Free Univ. of Brussels, Belgium -Brussels

Rousselet, G. R. Choisy Ie Roi -France

Ruocco,V. Dept. of Dermatology, Second Univ. of Naples, Naples-Italy

Rusciani, L. Catholic University, Rome-Italy

Ryan, T. Hill House, Abberbury Avenue, Iffley, OX44EU Oxford-UK

Santoianni, P. Dept. of Dermatology, University of Naples, Naples-Italy

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List of contributors XXVII

Saurat, J.-H. Dept. of Dermatology, Geneva-Switzerland

Stadler, R. Hautklinik, Klinikum Minden, PortastraBe 7-9, D-32423 Minden-Germany

Stavrianeas, N. G. Dept. of Dermatology, Univ. of Athens, "A Sygros Hospital", Athens-Greece

Stratigos, A. J. Dept. of Dermatology, Univ. of Athens-Greece

Stratigos, J. D. Dept. of Dermatology, Univ. of Athens-Greece

Teofoli,P. Dept. of Immunodermatology, Instituto Dermopatico, del'Immacolata, Rome-Italy

Themido,R. Centro de Dermatologia Medico-Cirurgica,ARS de Lisboa e Vale do Tejo, Rua Jose Estevao 135,1150 Lisboa-Portugal

Thestrup-Pedersen, K. Dept. of Dermatology, Marselisborg Hospital, Univ. of Aarhus, Aarhus C-Denmark

Tosca,A.D. Dept. of Dermatology, Faculty of Medicine, Univ. of Crete, Heraklion 71110 Crete-Grasse

Tosti,A. Univ. degli Studi di Bologna, Clinica Dermatologica, Osepdale Polic1inico S. Orsola-Malpighi, Via Massarenti 1,1-40138 Bolognia-Italy

Tsankov,N. Medical University, Dept. of Dermatology, 1 Georgi Sofiski Str, 1431 Sofia-Bulgaria

Tzioufas,A. G. Dept. of Pathophysiology, School of Medicine, Univ. of Athens, Athens-Greece

Van Gysel, D. Dept. of Pediatrics, Ons Lieve Vrouw Hospital, Aalst -Belgium

Van Leent, E. J. M. Dept. of Dermatology, Academic Medical Center, Univ. of Amsterdam, PO Box 22700, 1100 DE Amsterdam

Van Vloten, W. Dept. of Dermatology, Univ. Hospital, Utrecht-The Netherlands

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XXVIII List of contributors

Varelzidis, A. Dept. of Dermatology, University of Athens, Athens-Greece

Varotti, C. Dept. of Dermatology, University of Bologna, Bologna-Italy

Veraldi, S. Inst. of Dermatological Sciences, University of Milan, Via Pace 9, 20122 Milan-Italy

Veres, C. 5 rue Villebois-Mareuil, 75017 Paris-France

Vlachoyiannopoulos, P. G. Dept. of Pathophysiology, National University of Athens, Athens-Greece

Vogt,H.J. Dept. of Dermatology & Allergy, am Biederstein, Technical University of Munich, BiedersteinerstraBe 29, D-80802 Munich-Germany

Waugh,M.A. University of Leeds, General Infirmary at Leeds-Leeds-KU

Westenberger-Treumann, M. Hautklinik, Klinikum-Minden, PortastraBe 7-9

Westerhof, W. Netherlands Institute for Pigmentory Disorders,Amsterdam-Netheriands

Wolfer, L. U. Dept. of Dermatology, Univ. Medical Center, Free Univ. of Berlin, Hindenburgdamm 30, 12200 Berlin-Germany

Yang,H. Dept. of Dermatology, Oxford-UK

Zouboulis, C. C. Dept. of Dermatology, Univ. Medical Center BF, The Free Univ. of Berlin, Berlin-Germany