a case of nash with hypothyroidism
TRANSCRIPT
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A INTERESTING CASE OF
HEPATOMEGALY
A. KARTHICK RAMALINGAM
PROF. P. VIJAYARAGHAVAN’S UNIT
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37 Year old Mrs. Lakshmi was admitted with
C/o Abdomen distension - 3 months
Abdomen Pain - 3 months
HOPI:
Patient was apparently normal till 3 months ago after which she developed abdomen distension insidious onset , increasing in size , uniform abdomen distension
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Abdomen distension not associated with Oliguria , pedal edema , facial puffiness, chest pain ,palpitation.
Dyspnoea – insidious onset , progressive , grade II was present.
Abdomen pain – right hypochondrium, dull aching type pain, continuous, aggravated by lying on right side & deep inspiration .
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H/O jaundice -3 months, yellow coloured urine , no clay coloured stools , no pruritis
No LOW LOA+ No fever, bleeding tendencies, altered sleep Past H/o
Hypothyroid – 8 months—on thyroxine -75 mcg
No other co morbid illness
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Personal H/O
No Habituations Menstrual and marital H/O
amennorhea-8 months
3 Children Treatment H/o
No H/o chronic drug intake other than thyroxine
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General Examination Conscoius Oriented obesity Afebrile
Icteric pale Facial puffiness Dry skin Hoarse voice
BP:110/70 mmHg PR:86/min JVP not Raised BMI 26.93kg/sq m
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P/A uniform distension Skin normal Hepatomegaly present
17 cm below right costal margin
tender , nodular surface, firm in consistency , no bruit
No splenomegaly. No Free fluid Other systems normal
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Differential Diagnosis
Infective cause HCC Haematological malignancy Amyloidosis
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InvestigationsCBC
Hb 6 gm%
TC 9600cells/dl
DC P68 L29 E3
ESR 28/60
MCV 79.5 fl
MCHC 28.3
RBS 101 mg/dl
UREA 22 mg/dl
Creatinine 0.7 mg /dl
Na 147
K 2.9
HCO3 21
Cl 100
LFT
T.Bilirubin 2.5
SGOT 48
SGPT 22
ALP 148
T.Protein 6.5
Globulin 3.2
albumin 3.3
PT 19 sec
INR 1.9
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Peripheral smear:
Normocytic Normochromic anemia
Free T4 0.3 ng/dl
TSH 72.5mic IU/ml
Urine
Alb Nil
Sug Nil
Dep 0-2 Pus cell/hpf
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USG Abdomen: Hepatomegaly with fatty infiltration. Portal Vein 15 mm. normal flow Splenomegaly 14 cm
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CECT Abdomen Liver enlarged – 24 cm. Diffusely
hypodense area of altered density seen in segment 5/8
GB contracted Spleen 15 cm enlarged IMP: Fatty liver with hepatomegaly.
Areas of altered density noted in segments 5/8 of right of liver
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P.V Doppler
Liver increased in echoes ,enlarged.
portal vein 1 cm at the hilum .(Flow +)
Portal vein 1.4 cm at the confluence of splenic and SM vein
Velocity 18.87 cm/s
Hepatopedal flow+
Hepatic veins flow + Spleen 14.4 cm enlarged .
Splenic Vein 17 cm at the hilum
IMPRESSION Hepatosplenomegaly with Fatty liver
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Blood for QBC – Negative HBsAg -- Negative Anti HCV – Negative HIV I & II – Negative AFP – not elevated
T. Cholesterol 174 mg/dl
HDL 32 mg/dl
LDL 120 mg/dl
VLDL 22 mg/dl
TGL 109 mg/dl
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OGD: Lax OGJ . Otherwise normal
ECHO- Normal
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NAFLD score Age, BMI, hyperglycemia, AST/ALT ratio,
platelet count, and serum albumin level Score =0.915
< -1.455: predictor of absence of significant fibrosis (F0-F2 fibrosis)(negative predictive value of 93%)≤ -1.455 to ≤ 0.675: indeterminate score> 0.675: predictor of presence of significant fibrosis (F3-F4 fibrosis)(positive predictive value of 90% )
Formula : -1.675 + 0.037 × age (years) + 0.094 × BMI (kg/m2) + 1.13 ×
IFG/diabetes (yes = 1, no = 0) + 0.99 × AST/ALT ratio – 0.013 × platelet (×109/l) – 0.66 × albumin (g/dl)
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ANA -- Negative S.Ceruloplasmin 20.5mg/dl(18-35mg/dl) S . Iron 23.8 mcg/dl(50-150 mcg/dl) TIBC 283 mcg/dl(300-360mcg/dl) Ferritin 21.04 ng/dl (50-200mcg/dl)
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Final diagnosis
Non alcoholic steatohepatitis Pre -Obesity Hypothyroidism Nutritional anemia
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Treatment given
Thyroxine dose increased to 125 mcg/day
T.vitamin E 400mg twice a day FST 100 mg twice a day
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At dischargeCBC
Hb 11.8 gm%
TC 8000
DC P80 L20
ESR 4/10
Platelet 2.5 lakh
TSH 39.98mIU/ml
Patient is now on thyroxine 150 mcg/day
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DISCUSSION
NAFLD
a) There is evidence of hepatic steatosis , either by imaging or by histology.
b)There is no causes for secondary hepatic fat accumulation such as alcohol consumption , use of steatogenic drugs or hereditary disorders.
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NAFL
The presence of hepatic steatosis with no evidence of hepatocellular injury in the form of ballooning of the hepatocytes
NASH
The presence of hepatic steatosis and inflammation with hepatocyte injury(ballooning) with or without fibrosis
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Prevalence : NAFLD 6.3 to 33%(median -20%) NASH 3 to 5 %
High risk groups Type 2 Diabetes Mellitus Obesity Dyslipedemia Metabolic syndrome
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Emerging Risk factors
PCOD Hypothyroidism Obstructive sleep apnea Hypopituitarism Hypogonadism Pancreatoduodenal resection
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What is significant alcohol consumption for eligibility for NASH in clinical practice
>21 drinks per week in men >14 drinks per week in women
over a period of 2 years before baseline histology
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When to evaluate incidentally discovered hepatic steatosis
Unsuspected hepatic steatosis detected on imaging have symptoms or signs attributable to liver disease or have abnormal liver biochemistries – should be evaluated as for NAFLD
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Screening for high risk groups ?
Not recommended
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Non invasive methods to assess steatohepatitis S.Aminotransferase, USG ,CT,MR donot
reliably assess steatohepatitis and fibrosis in patients with NAFLD.
Liver biopsy is the most reliable approach
Non invaisve approaches include
a) NAFLD fibrosis score
b)Enhanced fibrosis score
c)Transient elastography
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When to do biposy ?
Those who are increased risk to have steatohepaitis and advanced fibrosis.
( NAFLD score , metabolic syndrome can be used to predict risk)
Competing etiologies for hepatic steatosis and co existing chronic liver disease cannot be excluded without a liver biopsy
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Management
Loss of 3 to 5 % weight loss improves steatosis ,loss of 5 to 10 % improves necroinflammtion
Metformin is not recommended as a specific treatment for liver disease in adults with NASH
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Vitamin E 800IU/day improves liver histology in biopsy proven NASH. Considered as first line therapy in this population
Statins should not be used specifically to treat NASH. Can be used in dyslipedemia.
UDCA is not recommended
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Hypothyroidism and NASH Journal of Clinical Gastroenterology: October 2003 - Volume 37 - Issue 4 - pp 340-343 Liver, Pancreas, and Biliary Tract: Clinical Research
Is Hypothyroidism a Risk Factor for Non-Alcoholic Steatohepatitis?
Liangpunsakul, Suthat MD; Chalasani, Naga MD Abstract Purpose: Thyroid hormones play an important role in the regulation of lipid and
carbohydrate metabolism, both of which are affected in patients with non-alcoholic steatohepatitis (NASH). Anecdotally, we have observed that a number of patients with NASH carried a diagnosis of hypothyroidism. However, it is unknown if thyroid dysfunction plays any role in the pathogenesis of NASH. To further investigate this observation, we conducted a case-control study to determine the association between hypothyroidism and NASH
Conclusion: These data suggest that hypothyroidism is associated with human NASH. Further research is needed to confirm this finding and to understand its implications.
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Dig Dis Sci. 2012 Feb;57(2):528-34. doi: 10.1007/s10620-011-2006-2. Epub 2011 Dec 20.
Prevalence of hypothyroidism in nonalcoholic fatty liver disease.
Pagadala MR, Zein CO, Dasarathy S, Yerian LM, Lopez R, McCullough AJ. Source Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Abstract BACKGROUND: A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has
been suggested. The recognized link between hypothyroidism and elements of the metabolic syndrome may explain this association.
AIM: The purpose of this study was to determine the prevalence of hypothyroidism in a cohort of
patients with NAFLD and analyze the potential factors associated with hypothyroidism in this patient population.
CONCLUSIONS: A higher prevalence of hypothyroidism was demonstrated in patients with NAFLD
compared to controls. Among subjects with NALFD, female gender, increased BMI and history of abstinence from alcohol were associated with hypothyroidism. Patients with hypothyroidism were also more likely to have NASH
Hypothyroidism and NASH
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Hypothyroidism and anaemia Anaemia is seen in 1/3 to ½ patients with
hypothyroidism Usually mild to moderate , lower levels do occur Anaemia can be microcytic , normocytic ,
macrocytic. Aneamia of chronic disease is the most common(normocytc normochromic) .
Microcytosis occurs in the setting of mennorhagia
Macrocytosis can be seen even without anaemia . Overt macrocytosis suggest perinicious anaemia or folate deficiency
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Thank you