A 5-Year Experience of Benign Pancreatic Hyperenzymemia. - ResearchGate

http://www.researchgate.net/publication/261757263_A_5-Year_Experience_of_Benign_Pancreatic_Hyperenzymemia[09-Jan-15 1:19:41 PM]

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ArticleA 5-Year Experience of Benign PancreaticHyperenzymemia.

Pancreas (Impact Factor: 3.01). 04/2014; DOI: 10.1097/MPA.0000000000000138Source: PubMed

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Eleonora Galassi Chiara Birtolo Marina Migliori

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ABSTRACT Benign pancreatic hyperenzymemia is characterized by a long-term increaseof serum pancreatic enzymes in otherwise healthy subjects. This study was designed todetermine (a) whether all pancreatic enzymes are elevated, (b) the extent of each enzymeincrease, (c) the relative frequency of the familial form, and (d) the relative frequencies ofpancreatic and salivary hyperamylasemia and macroamylasemia.Two hundred seven asymptomatic subjects with benign pancreatic hyperenzymemia werestudied during the 5-year period. Serum amylase, isoamylase, and lipase levels wereassessed by immunoenzymatic assays.Most (n = 183; 88.4%) patients had benign pancreatic hyperenzymemia; 155 (74.9%)patients had an abnormal increase of all 3 enzymes, 15 (7.2%) patients of only lipase, and13 (6.3%) patients of only amylase and pancreatic isoamylase. Lipase levels were thehighest (1.1-21 times above upper limit). Of the 183 subjects, 72 were members of 35different families, 15 (7.2%) had increased salivary amylase, and 9 (4.3%) hadmacroamylasemia. Wide day-to-day fluctuations of pancreatic enzymes, including fallswithin the reference ranges, were recorded.All enzymes were increased in benign pancreatic hyperenzymemia, with lipase showing thehighest elevation. Doctors should reassure patients about the benign nature of thiscondition and limit repeating useless examinations. [less]

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Article: Benign pancreatic hyperenzymemia: apediatric experience.Antonella Diamanti, Maria S Basso, Lidia Monti, AntonellaDaniele, Cristian Noto, M Castro

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Vincenzo StanghelliniUniversity of Bologna

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A 5-Year Experience of Benign Pancreatic Hyperenzymemia. - ResearchGate

http://www.researchgate.net/publication/261757263_A_5-Year_Experience_of_Benign_Pancreatic_Hyperenzymemia[09-Jan-15 1:19:41 PM]

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Article: "Non-parallel transport" of enzyme proteinby the pancreas.S S Rothman

Nature 03/1967; 213(5075):460-2. · 42.35 Impact Factor