9.3 CELL CYCLE REGULATION

WHAT YOU WILL LEARN-How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells

READING Q’s

NAME-When are some of the important combinations active?

-mitosis and interphase (G1, S, G2)

READING Q’s

DEFINE-What is cancer?

-the uncontrolled growth and division of cells

READING Q’s

IDENTIFY-What is an example of a carcinogen that occurs in nature?

-ultraviolet radiation from the SUN

READING Q’s

IDENTIFY-Which statement about apoptosis is correct?

A- Apoptosis can lead to cancer.

B- Apoptosis can prevent cancer.

READING Q’s

DESCRIBE-What are stem cells?

-unspecialized cells that can develop into a variety of specialized cells

http://www.youtube.com/watch?v=cs2cNLNMjN0

Bill Nye Greatest Discoveries—CELL DIVISION

GROUP WORK: APPLICATION NOTES

-As a group complete the application notes using your knowledge from the reading.

9.3 MAIN IDEA

Normal cell cycle is regulated by cyclin proteins

9.3 CELL CYCLE REGULATION

WHAT YOU WILL LEARN-How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells

READING Q’s

DEFINE-What is cancer?

-the uncontrolled growth and division of cells

NORMAL CELL CYCLE

NORMAL CELL CYCLE

SUMMARIZE: How cells regulate the cell cycle.-Cells use _______________ and _______________ to control the cell cycle.

-Different combinations of _______________ start the cell cycle at different _______________.

-The cell also uses _______________ to monitor the cycle for quality control.

-In _______________, the cell checks the DNA for damage. If there is any damage, the cycle won’t proceed to _______________.

-In _______________, the spindle fibers are malfunctioning, the cycle won’t proceed to ___________.

CDK-Cyclin dependent kinases

mitosis

G1 stageS stage

cytokinesis

cyclins

cyclin/CDKcheckpoin

ts cyclin/CDK

CANCER CELL CYCLE

SEQUENCE:The cause/effects of cancer

A failure in regulation of cell cycle

uncontrolled growth/division of cells

cancer cells go unchecked

crowding out normal cells--leading to tissue/organ failure

SUMMARIZE

ABNORMAL CELL CYCLE

IDENTIFY:Four environmental factors that cause cancer.

1-__________________________

2-__________________________

3-__________________________

4-__________________________http://www.youtube.com/watch?v=IeUANxFVXKcUnregulated cancer cell growth

CIGARETTE SMOKE/TOBACCO

ASBESTOS

X RAYS

ULTRAVIOLET RADIATION

APOPTOSIS

SUMMARIZE: Information about apoptosis-APOPTOSIS IS--process of programmed cell deathOrganisms use apoptosis to--destroy cells that are no longer needed -destroy cells damaged beyond repairProcesses that use apoptosis (examples)-

1-trees losing their leaves in autumn2-development of hands and feet in

embryo

READING Q’s

IDENTIFY-Which statement about apoptosis is correct?

A- Apoptosis can lead to cancer.

B- Apoptosis can prevent cancer.

APOPTOSIS

READING Q’sAPOPTOSIS

READING Q’s

1-”triggers” in body send signals for cell death[viruses/free radicals/stress/radiation]

2-capsases [proteins]:-break down cell components-produce DNases—destroys DNA in nucleus

3-cell shrinks and sends “distress” signals4-macrophages ingest/clean away shrunken cells

APOPTOSIS

http://www.youtube.com/watch?v=7WRkY8q_F3k

http://www.youtube.com/watch?v=xkASer3gEnc

STEM CELLS

LIST: Write three facts you discovered about stem cells

1-unspecialized cells that can develop into a variety of specialized cells

2- 2 types: adult & embryonic

3- can be directed to a specific type of cellhttp://www.youtube.com/watch?v=cs2cNLNMjN0

Bill Nye Greatest Discoveries—CELL DIVISION

STEM CELLS

COMPARE/CONTRAST: Adult and embryonic stem cells

-comes from various tissues in body-present from infancy thru adulthood

-unspecialized cells that have potential to become specialized

-100-150 cells formed after fertilization-become specialized as embryo grows

SUMMARIZE

COMPLETE: A=apoptosis S=stem cells___ 1-After a sperm fertilizes an egg, the resulting mass of cells divides until there are about 100-150 cells.

___ 2-Some cells go through a programmed death.

___ 3-Embryonic cells shrivel and die, resulting in the formation of fingers and toes.

___ 4-Unspecialized cells are either embryonic or adult.

___ 5. This event occurs in cells that are damaged beyond repair.

S

A

A

S

A

SUMMARIZE

EXPLAIN: How cancerous cell growth differs from normal cell growth-The cancer cell cycle is much faster than the normal cycle.

-interphase is dramatically shorter in cancer cells

NORM stomach cellsCANCER stomach cellsInterphase 120 min 16 minProphase 60 min 15 minMetaphase 10 min 2 minAnanphase 3 min 1 minTelophase 12 min 3 min

CANCER DRUGS

OVERVIEW:-damage DNA

work in all phases of cell cycle-interfere w/DNA & RNA growth by replacing building blocks

destroy cell in S phase-interfere w/enzymes involved in DNA replication

work in all phases of cell cycle-inhibit enzymes needed to make proteins in cell cycle

work during MITOSIS, can damage cells at all stages

ILLUSTRATE