7: arranz am, delbroek l, van kolen k, guimarães mr ......and memory deficits in appps1-21...

1: Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper

B, de Wit

J, Verstreken P, Moechars D. Synaptic Contacts Enhance Cell-to-Cell Tau

Pathology

Propagation. Cell Rep. 2015 May 26;11(8):1176-83. doi:

10.1016/j.celrep.2015.04.043. Epub 2015 May 14. PubMed PMID: 25981034.

2: Frigerio CS, Lau P, Troakes C, Deramecourt V, Gele P, Van Loo P, Voet

T, De

Strooper B. On the identification of low allele frequency mosaic

mutations in the

brains of Alzheimer disease patients. Alzheimers Dement. 2015 Apr 28.

pii:

S1552-5260(15)00120-X. doi: 10.1016/j.jalz.2015.02.007. [Epub ahead of

print]

PubMed PMID: 25937274.

3: Aerts L, De Strooper B, Morais VA. PINK1 activation-turning on a

promiscuous

kinase. Biochem Soc Trans. 2015 Apr 1;43(2):280-6. doi:

10.1042/BST20150002.


4: Hu W, Dooley J, Chung SS, Chandramohan D, Cimmino L, Mukherjee S,

Mason CE, de

Strooper B, Liston A, Park CY. miR-29a maintains mouse hematopoietic stem

cell

self-renewal by regulating Dnmt3a. Blood. 2015 Apr 2;125(14):2206-16.

doi:

10.1182/blood-2014-06-585273. Epub 2015 Jan 29. PubMed PMID: 25634742;

PubMed

Central PMCID: PMC4383797.

5: Aerts L, Craessaerts K, De Strooper B, Morais VA. PINK1 kinase

catalytic

activity is regulated by phosphorylation on serines 228 and 402. J Biol

Chem.

2015 Jan 30;290(5):2798-811. doi: 10.1074/jbc.M114.620906. Epub 2014 Dec

19.

PubMed PMID: 25527497; PubMed Central PMCID: PMC4317039.

6: Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré

K,

Berezovska O, Sachse C, Chávez-Gutiérrez L. The dynamic conformational

landscape

of γ-secretase. J Cell Sci. 2014 Dec 12. pii: jcs.164384. [Epub ahead of

print]


7: Arranz AM, Delbroek L, Van Kolen K, Guimarães MR, Mandemakers W,

Daneels G,

Matta S, Calafate S, Shaban H, Baatsen P, De Bock PJ, Gevaert K, Vanden

Berghe P,

Verstreken P, De Strooper B, Moechars D. LRRK2 functions in synaptic

vesicle

endocytosis through a kinase-dependent mechanism. J Cell Sci. 2014 Dec

12. pii:

jcs.158196. [Epub ahead of print] PubMed PMID: 25501810.

8: De Strooper B. Lessons from a failed γ-secretase Alzheimer trial.

Cell. 2014

Nov 6;159(4):721-6. doi: 10.1016/j.cell.2014.10.016. PubMed PMID:

25417150.

9: Papadopoulou AS, Serneels L, Achsel T, Mandemakers W, Callaerts-Vegh

Z, Dooley

J, Lau P, Ayoubi T, Radaelli E, Spinazzi M, Neumann M, Hébert SS,

Silahtaroglu A,

Liston A, D'Hooge R, Glatzel M, De Strooper B. Deficiency of the miR-

29a/b-1

cluster leads to ataxic features and cerebellar alterations in mice.

Neurobiol

Dis. 2014 Oct 12;73C:275-288. doi: 10.1016/j.nbd.2014.10.006. [Epub ahead

of

print] PubMed PMID: 25315682.

10: De Strooper B, Chávez Gutiérrez L. Learning by failing: ideas and

concepts to

tackle γ-secretases in Alzheimer's disease and beyond. Annu Rev Pharmacol

Toxicol. 2015;55:419-37. doi: 10.1146/annurev-pharmtox-010814-124309.

Epub 2014

Oct 1. PubMed PMID: 25292430.

11: Benilova I, Gallardo R, Ungureanu AA, Castillo Cano V, Snellinx A,

Ramakers

M, Bartic C, Rousseau F, Schymkowitz J, De Strooper B. The Alzheimer

disease

protective mutation A2T modulates kinetic and thermodynamic properties of

amyloid-β (Aβ) aggregation. J Biol Chem. 2014 Nov 7;289(45):30977-89.

doi:

10.1074/jbc.M114.599027. Epub 2014 Sep 24. PubMed PMID: 25253695; PubMed

Central

PMCID: PMC4223304.

12: Salta E, Lau P, Sala Frigerio C, Coolen M, Bally-Cuif L, De Strooper

B. A

self-organizing miR-132/Ctbp2 circuit regulates bimodal notch signals and

glial

progenitor fate choice during spinal cord maturation. Dev Cell. 2014 Aug

25;30(4):423-36. doi: 10.1016/j.devcel.2014.07.006. Epub 2014 Aug 14.

PubMed

PMID: 25132384.

13: De Kloe GE, De Strooper B. Small molecules that inhibit Notch

signaling.

Methods Mol Biol. 2014;1187:311-22. doi: 10.1007/978-1-4939-1139-4_23.

Review.


14: Serneels L, Tesseur I, De Strooper B. Assay to probe proteolytic

processing

of Notch by γ-secretase. Methods Mol Biol. 2014;1187:223-9. doi:

10.1007/978-1-4939-1139-4_17. PubMed PMID: 25053493.

15: Fazzari P, Snellinx A, Sabanov V, Ahmed T, Serneels L, Gartner A,

Shariati

SA, Balschun D, De Strooper B. Cell autonomous regulation of hippocampal

circuitry via Aph1b-γ-secretase/neuregulin 1 signalling. Elife. 2014 Jun

2;3.

doi: 10.7554/eLife.02196. PubMed PMID: 24891237; PubMed Central PMCID:

PMC4073283.

16: Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W,

Koentjoro

B, Sue C, Gevaert K, De Strooper B, Verstreken P, Vandenberghe W. The

deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial

ubiquitination and

mitophagy. Hum Mol Genet. 2014 Oct 1;23(19):5227-42. doi:

10.1093/hmg/ddu244.

Epub 2014 May 22. PubMed PMID: 24852371.

17: O'Flanagan CH, Morais VA, Wurst W, De Strooper B, O'Neill C. The

Parkinson's

gene PINK1 regulates cell cycle progression and promotes cancer-

associated

phenotypes. Oncogene. 2015 Mar 12;34(11):1363-74. doi:

10.1038/onc.2014.81. Epub

2014 Mar 31. PubMed PMID: 24681957.

18: Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S,

Aerts L,

Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De

Strooper B. PINK1 loss-of-function mutations affect mitochondrial complex

I

activity via NdufA10 ubiquinone uncoupling. Science. 2014 Apr

11;344(6180):203-7.

doi: 10.1126/science.1249161. Epub 2014 Mar 20. PubMed PMID: 24652937.

19: Lau P, Frigerio CS, De Strooper B. Variance in the identification of

microRNAs deregulated in Alzheimer's disease and possible role of

lincRNAs in the

pathology: the need of larger datasets. Ageing Res Rev. 2014 Sep;17:43-

53. doi:

10.1016/j.arr.2014.02.006. Epub 2014 Mar 4. Review. PubMed PMID:

24607832.

20: Pimenova AA, Thathiah A, De Strooper B, Tesseur I. Regulation of

amyloid

precursor protein processing by serotonin signaling. PLoS One. 2014 Jan

21;9(1):e87014. doi: 10.1371/journal.pone.0087014. eCollection 2014.

PubMed PMID:

24466315; PubMed Central PMCID: PMC3897773.

21: Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De

Strooper B,

Hébert SS. Gene and MicroRNA transcriptome analysis of Parkinson's

related LRRK2

mouse models. PLoS One. 2014 Jan 10;9(1):e85510. doi:

10.1371/journal.pone.0085510. eCollection 2014. PubMed PMID: 24427314;

PubMed


22: Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N,

De

Strooper B. Signature amyloid β profiles are produced by different γ-

secretase

complexes. J Biol Chem. 2014 Feb 14;289(7):4346-55. doi:

10.1074/jbc.M113.530907.

Epub 2013 Dec 13. PubMed PMID: 24338474; PubMed Central PMCID:

PMC3924297.

23: Vos M, Lovisa B, Geens A, Morais VA, Wagnières G, van den Bergh H,

Ginggen A,

De Strooper B, Tardy Y, Verstreken P. Near-infrared 808 nm light boosts

complex

IV-dependent respiration and rescues a Parkinson-related pink1 model.

PLoS One.

2013 Nov 11;8(11):e78562. doi: 10.1371/journal.pone.0078562. eCollection

2013.


24: Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J,

Steinbusch HW,

Lesch KP, Fitzsimons CP, De Strooper B, Rutten BP. Epigenetically

regulated

microRNAs in Alzheimer's disease. Neurobiol Aging. 2014 Apr;35(4):731-45.

doi:

10.1016/j.neurobiolaging.2013.10.082. Epub 2013 Oct 18. Review. PubMed

PMID:

24238656.

25: Tesseur I, De Strooper B. When the dust settles: what did we learn

from the

bexarotene discussion? Alzheimers Res Ther. 2013 Nov 7;5(6):54. doi:

10.1186/alzrt218. eCollection 2013. PubMed PMID: 24229456; PubMed Central

PMCID:

PMC3979032.

26: Sala Frigerio C, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe

R, Wallin

A, Bjerke M, Zetterberg H, Blennow K, De Strooper B. Reduced expression

of

hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology. 2013

Dec

10;81(24):2103-6. doi: 10.1212/01.wnl.0000437306.37850.22. Epub 2013 Nov

8.


27: Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno

F,

Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori

E,

Alston R, Kuchnio A, Farace MG, Fazio VM, Piacentini M, De Strooper B,

Achsel T,

Neri G, Neven P, Evans DG, Carmeliet P, Mazzone M, Bagni C. The fragile X

protein

binds mRNAs involved in cancer progression and modulates metastasis

formation.

EMBO Mol Med. 2013 Oct;5(10):1523-36. doi: 10.1002/emmm.201302847. Epub

2013 Sep

16. Erratum in: EMBO Mol Med. 2014 Apr;6(4):567. PubMed PMID: 24092663;

PubMed


28: Benilova I, De Strooper B. Neuroscience. Promiscuous Alzheimer's

amyloid: yet

another partner. Science. 2013 Sep 20;341(6152):1354-5. doi:

10.1126/science.1244166. PubMed PMID: 24052299.

29: Lo AC, Tesseur I, Scopes DI, Nerou E, Callaerts-Vegh Z, Vermaercke B,

Treherne JM, De Strooper B, D'Hooge R. Dose-dependent improvements in

learning

and memory deficits in APPPS1-21 transgenic mice treated with the orally

active

Aβ toxicity inhibitor SEN1500. Neuropharmacology. 2013 Dec;75:458-66.

doi:

10.1016/j.neuropharm.2013.08.030. Epub 2013 Sep 10. PubMed PMID:

24035915.

30: Lau P, Bossers K, Janky R, Salta E, Frigerio CS, Barbash S, Rothman

R,

Sierksma AS, Thathiah A, Greenberg D, Papadopoulou AS, Achsel T, Ayoubi

T, Soreq

H, Verhaagen J, Swaab DF, Aerts S, De Strooper B. Alteration of the

microRNA

network during the progression of Alzheimer's disease. EMBO Mol Med. 2013

Oct;5(10):1613-34. doi: 10.1002/emmm.201201974. Epub 2013 Sep 9. PubMed

PMID:


31: Reinhard C, Borgers M, David G, De Strooper B. Soluble amyloid-β

precursor

protein binds its cell surface receptor in a cooperative fashion with

glypican

and syndecan proteoglycans. J Cell Sci. 2013 Nov 1;126(Pt 21):4856-61.

doi:

10.1242/jcs.137919. Epub 2013 Aug 28. PubMed PMID: 23986479.

32: Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R,

Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D,

Schweizer M,

Horré K, De Strooper B, Saftig P. Postnatal disruption of the

disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures,

learning

deficits, altered spine morphology, and defective synaptic functions. J

Neurosci.

2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013.

PubMed

PMID: 23926248.

33: Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buée L, De

Strooper B,

Balschun D, D'Hooge R. Amyloid and tau neuropathology differentially

affect

prefrontal synaptic plasticity and cognitive performance in mouse models

of

Alzheimer's disease. J Alzheimers Dis. 2013;37(1):109-25. doi:

10.3233/JAD-122296. PubMed PMID: 23788007.

34: Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS,

De

Strooper B, Raposo G, van Niel G. BACE2 processes PMEL to form the

melanosome

amyloid matrix in pigment cells. Proc Natl Acad Sci U S A. 2013 Jun

25;110(26):10658-63. doi: 10.1073/pnas.1220748110. Epub 2013 Jun 10.

PubMed PMID:


35: Shariati SA, De Strooper B. Redundancy and divergence in the amyloid

precursor protein family. FEBS Lett. 2013 Jun 27;587(13):2036-45. doi:

10.1016/j.febslet.2013.05.026. Epub 2013 May 23. Review. PubMed PMID:

23707420.

36: Tesseur I, Lo AC, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M,

Gijsen

H, Moechars D, Mercken M, Kemp J, D'Hooge R, De Strooper B. Comment on

"ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits

in AD

mouse models". Science. 2013 May 24;340(6135):924-e. doi:


37: Soldano A, Okray Z, Janovska P, Tmejová K, Reynaud E, Claeys A, Yan

J, Atak

ZK, De Strooper B, Dura JM, Bryja V, Hassan BA. The Drosophila homologue

of the

amyloid precursor protein is a conserved modulator of Wnt PCP signaling.

PLoS

Biol. 2013;11(5):e1001562. doi: 10.1371/journal.pbio.1001562. Epub 2013

May 14.


38: Haddad DM, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM,

Craessaerts

K, Leyssen M, Nascimento RM, Vianna-Morgante AM, De Strooper B, Van Esch

H,

Morais VA, Verstreken P. Mutations in the intellectual disability gene

Ube2a

cause neuronal dysfunction and impair parkin-dependent mitophagy. Mol

Cell. 2013

Jun 27;50(6):831-43. doi: 10.1016/j.molcel.2013.04.012. Epub 2013 May 16.

PubMed

PMID: 23685073.

39: Mandemakers W, Abuhatzira L, Xu H, Caromile LA, Hébert SS, Snellinx

A, Morais

VA, Matta S, Cai T, Notkins AL, De Strooper B. Co-regulation of

intragenic

microRNA miR-153 and its host gene Ia-2 β: identification of miR-153

target genes

with functions related to IA-2β in pancreas and brain. Diabetologia. 2013

Jul;56(7):1547-56. doi: 10.1007/s00125-013-2901-5. Epub 2013 Apr 18.

PubMed PMID:


40: Barao S, Zhou L, Adamczuk K, Vanhoutvin T, van Leuven F, Demedts D,

Vijverman

AC, Bossuyt X, Vandenberghe R, De Strooper B. BACE1 levels correlate with

phospho-tau levels in human cerebrospinal fluid. Curr Alzheimer Res. 2013

Sep;10(7):671-8. PubMed PMID: 23566348.

41: Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De

Maeyer JH,

Schuurkes JA, D'Hooge R, De Strooper B. Chronic 5-HT4 receptor activation

decreases Aβ production and deposition in hAPP/PS1 mice. Neurobiol Aging.

2013

Jul;34(7):1779-89. doi: 10.1016/j.neurobiolaging.2013.01.020. Epub 2013

Mar 6.


42: Shariati SA, Lau P, Hassan BA, Müller U, Dotti CG, De Strooper B,

Gärtner A.

APLP2 regulates neuronal stem cell differentiation during cortical

development. J

Cell Sci. 2013 Mar 1;126(Pt 5):1268-77. doi: 10.1242/jcs.122440. Epub

2013 Jan

23. PubMed PMID: 23345401.

43: Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W,

Daneels G,

De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P,

Moechars

DW. Development of an enzyme-linked immunosorbent assay for detection of

cellular

and in vivo LRRK2 S935 phosphorylation. J Pharm Biomed Anal. 2013 Mar

25;76:49-58. doi: 10.1016/j.jpba.2012.12.002. Epub 2012 Dec 16. PubMed

PMID:


44: Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S,

Miller

MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF,

Freeman E,

De Strooper B, Vulsteke V, Scrocchi L, Zetterberg H, Portelius E, Hutter-

Paier B,

Havas D, Ahlijanian M, Flood D, Leventhal L, Shapiro G, Patzke H,

Chesworth R,

Koenig G. Modulation of γ-secretase by EVP-0015962 reduces amyloid

deposition and

behavioral deficits in Tg2576 mice. Mol Neurodegener. 2012 Dec 18;7:61.

doi:

10.1186/1750-1326-7-61. PubMed PMID: 23249765; PubMed Central PMCID:

PMC3573960.

45: Thathiah A, Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M,

De Kloe

G, Munck S, De Strooper B. β-arrestin 2 regulates Aβ generation and γ-

secretase

activity in Alzheimer's disease. Nat Med. 2013 Jan;19(1):43-9. doi:

10.1038/nm.3023. Epub 2012 Dec 2. PubMed PMID: 23202293.

46: Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg

AL,

Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J,

Jureus A,

Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A,

Lund J,

Arvidsson PI, De Strooper B, Lendahl U, Lundkvist J. Alzheimer's disease:

presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-

lowering

strategy. J Neurosci. 2012 Nov 28;32(48):17297-305. doi:

10.1523/JNEUROSCI.1451-12.2012. PubMed PMID: 23197721.

47: De Strooper B, Scorrano L. Close encounter: mitochondria, endoplasmic

reticulum and Alzheimer's disease. EMBO J. 2012 Nov 5;31(21):4095-7. doi:

10.1038/emboj.2012.279. Epub 2012 Oct 9. PubMed PMID: 23047154; PubMed

Central

PMCID: PMC3492737.

48: Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W,

Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L,

Swerts J,

Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K,

Moechars

DW, De Strooper B, Verstreken P. LRRK2 controls an EndoA phosphorylation

cycle in

synaptic endocytosis. Neuron. 2012 Sep 20;75(6):1008-21. doi:

10.1016/j.neuron.2012.08.022. PubMed PMID: 22998870.

49: Vandersteen A, Masman MF, De Baets G, Jonckheere W, van der Werf K,

Marrink

SJ, Rozenski J, Benilova I, De Strooper B, Subramaniam V, Schymkowitz J,

Rousseau

F, Broersen K. Molecular plasticity regulates oligomerization and

cytotoxicity of

the multipeptide-length amyloid-β peptide pool. J Biol Chem. 2012 Oct

26;287(44):36732-43. doi: 10.1074/jbc.M112.394635. Epub 2012 Sep 19.

PubMed PMID:


50: Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L,

Chen Z,

Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B,

Joussen

AM, Boulton ME. β-Secretase (BACE1) inhibition causes retinal pathology

by

vascular dysregulation and accumulation of age pigment. EMBO Mol Med.

2012

Sep;4(9):980-91. doi: 10.1002/emmm.201101084. Epub 2012 Aug 20. PubMed

PMID:


51: De Strooper B, Voet T. Alzheimer's disease: A protective mutation.

Nature.

2012 Aug 2;488(7409):38-9. doi: 10.1038/488038a. PubMed PMID: 22859199.

52: Mandemakers W, Snellinx A, O'Neill MJ, de Strooper B. LRRK2

expression is

enriched in the striosomal compartment of mouse striatum. Neurobiol Dis.

2012

Dec;48(3):582-93. doi: 10.1016/j.nbd.2012.07.017. Epub 2012 Jul 29.

PubMed PMID:

22850484.

53: Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W,

Moechars D, Mercken M, Gevaert K, De Strooper B. The neural cell adhesion

molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. J Biol Chem.

2012

Jul 27;287(31):25927-40. doi: 10.1074/jbc.M112.377465. Epub 2012 Jun 12.

Erratum

in: J Biol Chem. 2012 Sep 28;287(40):33719. Gevaer, Kris [corrected to

Gevaert,

Kris]. PubMed PMID: 22692213; PubMed Central PMCID: PMC3406677.

54: Bezprozvanny I, Supnet C, Sun S, Zhang H, De Strooper B. Response to

Shilling

et al. (10.1074/jbc.M111.300491). J Biol Chem. 2012 Jun 8;287(24):20469;

author

reply 20470. doi: 10.1074/jbc.L112.356790. PubMed PMID: 22685228; PubMed

Central

PMCID: PMC3370228.

55: Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I,

Blum D, De

Strooper B, Buée L. Neurotoxicity and memory deficits induced by soluble

low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by

using a

novel animal model. J Neurosci. 2012 Jun 6;32(23):7852-61. doi:

10.1523/JNEUROSCI.5901-11.2012. PubMed PMID: 22674261.

56: Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, De

Strooper

B, Rousseau F, Multhaup G, Schymkowitz J, Langedijk JP, Annaert W.

Peptides based

on the presenilin-APP binding domain inhibit APP processing and Aβ

production

through interfering with the APP transmembrane domain. FASEB J. 2012

Sep;26(9):3765-78. doi: 10.1096/fj.11-201368. Epub 2012 Jun 1. PubMed

PMID:

22661005.

57: Carmeliet P, De Strooper B. Alzheimer's disease: A breach in the

blood-brain

barrier. Nature. 2012 May 23;485(7399):451-2. doi: 10.1038/485451a.

PubMed PMID:

22622564.

58: Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR,

Van

Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken

P.

Vitamin K2 is a mitochondrial electron carrier that rescues pink1

deficiency.

Science. 2012 Jun 8;336(6086):1306-10. doi: 10.1126/science.1218632. Epub

2012

May 10. PubMed PMID: 22582012.

59: Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M,

Borgers

M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J,

Serneels L,

Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B.

The

mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO

J. 2012

May 16;31(10):2261-74. doi: 10.1038/emboj.2012.79. Epub 2012 Apr 13.

PubMed PMID:


60: Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-

Raga G,

Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O,

Muñoz FJ,

Dotti CG, De Strooper B. Modification of γ-secretase by nitrosative

stress links

neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med. 2012

Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2. PubMed

PMID:


61: De Strooper B, Iwatsubo T, Wolfe MS. Presenilins and γ-secretase:

structure,

function, and role in Alzheimer Disease. Cold Spring Harb Perspect Med.

2012

Jan;2(1):a006304. doi: 10.1101/cshperspect.a006304. Review. PubMed PMID:


62: Benilova I, Karran E, De Strooper B. The toxic Aβ oligomer and

Alzheimer's

disease: an emperor in need of clothes. Nat Neurosci. 2012 Jan

29;15(3):349-57.

doi: 10.1038/nn.3028. Review. PubMed PMID: 22286176.

63: Salta E, De Strooper B. Non-coding RNAs with essential roles in

neurodegenerative disorders. Lancet Neurol. 2012 Feb;11(2):189-200. doi:

10.1016/S1474-4422(11)70286-1. Review. PubMed PMID: 22265214.

64: Vilain S, Esposito G, Haddad D, Schaap O, Dobreva MP, Vos M, Van

Meensel S,

Morais VA, De Strooper B, Verstreken P. The yeast complex I equivalent

NADH

dehydrogenase rescues pink1 mutants. PLoS Genet. 2012 Jan;8(1):e1002456.

doi:

10.1371/journal.pgen.1002456. Epub 2012 Jan 5. PubMed PMID: 22242018;

PubMed


65: Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski

B, Zuklys

S, Hollander GA, Matthys P, Gray DH, De Strooper B, Liston A. The thymic

epithelial microRNA network elevates the threshold for infection-

associated

thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Nat

Immunol. 2011 Dec 18;13(2):181-7. doi: 10.1038/ni.2193. PubMed PMID:

22179202;

PubMed Central PMCID: PMC3647613.

66: Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB,

Townsend DM,

Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of

the

ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production

by

altering Nicastrin maturation and intracellular localization. J Biol

Chem. 2012

Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.

PubMed

PMID: 22086926; PubMed Central PMCID: PMC3256850.

67: Thimiri Govinda Raj DB, Ghesquière B, Tharkeshwar AK, Coen K, Derua

R,

Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens

E,

Borghs G, Callewaert N, Swinnen J, Gevaert K, Annaert W. A novel strategy

for the

comprehensive analysis of the biomolecular composition of isolated plasma

membranes. Mol Syst Biol. 2011 Oct 25;7:541. doi: 10.1038/msb.2011.74.

PubMed


68: Nesic I, Guix FX, Vennekens K, Michaki V, Van Veldhoven PP, Feiguin

F, De

Strooper B, Dotti CG, Wahle T. Alterations in phosphatidylethanolamine

levels

affect the generation of Aβ. Aging Cell. 2012 Feb;11(1):63-72. doi:

10.1111/j.1474-9726.2011.00760.x. Epub 2011 Nov 28. PubMed PMID:

22023223.

69: Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper

B,

Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T,

Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch

JW.

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-

secretase

processing of amyloid precursor protein. J Biol Chem. 2011 Nov

25;286(47):40443-51. doi: 10.1074/jbc.M111.280495. Epub 2011 Sep 28.

PubMed PMID:


70: Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis

for

Alzheimer's disease: an appraisal for the development of therapeutics.

Nat Rev

Drug Discov. 2011 Aug 19;10(9):698-712. doi: 10.1038/nrd3505. Review.

PubMed

PMID: 21852788.

71: Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L,

Veerle B,

Coen K, Munck S, De Strooper B, Schiavo G, Annaert W. ADP ribosylation

factor 6

(ARF6) controls amyloid precursor protein (APP) processing by mediating

the

endosomal sorting of BACE1. Proc Natl Acad Sci U S A. 2011 Aug

23;108(34):E559-68. doi: 10.1073/pnas.1100745108. Epub 2011 Aug 8. PubMed

PMID:


72: Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U,

Staufenbiel M. The Swedish APP mutation alters the effect of genetically

reduced

BACE1 expression on the APP processing. J Neurochem. 2011 Oct;119(1):231-

9. doi:

10.1111/j.1471-4159.2011.07412.x. Epub 2011 Sep 1. PubMed PMID: 21812781.

73: Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars

D, Eberle

W, Bartic C, Van Leuven F, Callewaert G. Synaptic dysfunction in

hippocampus of

transgenic mouse models of Alzheimer's disease: a multi-electrode array

study.

Neurobiol Dis. 2011 Dec;44(3):284-91. doi: 10.1016/j.nbd.2011.07.006.

Epub 2011

Jul 18. PubMed PMID: 21807097.

74: Benilova I, De Strooper B. An overlooked neurotoxic species in

Alzheimer's

disease. Nat Neurosci. 2011 Jul 26;14(8):949-50. doi: 10.1038/nn.2871.

PubMed

PMID: 21792191.

75: Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K,

De

Strooper B, Vandenberghe W. Parkin interacts with Ambra1 to induce

mitophagy. J

Neurosci. 2011 Jul 13;31(28):10249-61. doi: 10.1523/JNEUROSCI.1917-

11.2011.


76: Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP.

Deletion

of Adam10 in endothelial cells leads to defects in organ-specific

vascular

structures. Blood. 2011 Jul 28;118(4):1163-74. doi: 10.1182/blood-2011-

04-348557.

Epub 2011 Jun 7. PubMed PMID: 21652679; PubMed Central PMCID: PMC3148163.

77: Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D,

Jorissen E,

Petrowitz B, Bartsch U, De Strooper B, Saftig P, Glatzel M. Lack of

a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular

accumulation

and loss of shedding of the cellular prion protein in vivo. Mol

Neurodegener.

2011 May 27;6:36. doi: 10.1186/1750-1326-6-36. PubMed PMID: 21619641;

PubMed


78: Nelson O, Supnet C, Tolia A, Horré K, De Strooper B, Bezprozvanny I.

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. J

Biol

Chem. 2011 Jun 24;286(25):22339-47. doi: 10.1074/jbc.M111.243063. Epub

2011 Apr

29. PubMed PMID: 21531718; PubMed Central PMCID: PMC3121381.

79: Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere

K, Van

Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven

C,

Vandenberghe R, De Strooper B. Amyloid precursor protein mutation E682K

at the

alternative β-secretase cleavage β'-site increases Aβ generation. EMBO

Mol Med.

2011 May;3(5):291-302. doi: 10.1002/emmm.201100138. Epub 2011 Apr 15.

PubMed


80: Brodaty H, Breteler MM, Dekosky ST, Dorenlot P, Fratiglioni L, Hock

C,

Kenigsberg PA, Scheltens P, De Strooper B. The world of dementia beyond

2020. J

Am Geriatr Soc. 2011 May;59(5):923-7. doi: 10.1111/j.1532-

5415.2011.03365.x. Epub

2011 Apr 13. PubMed PMID: 21488846.

81: Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B.

Functional

and topological analysis of Pen-2, the fourth subunit of the gamma-

secretase

complex. J Biol Chem. 2011 Apr 8;286(14):12271-82. doi:

10.1074/jbc.M110.216978.

Epub 2011 Feb 4. PubMed PMID: 21296884; PubMed Central PMCID: PMC3069430.

82: Thathiah A, De Strooper B. The role of G protein-coupled receptors in

the

pathology of Alzheimer's disease. Nat Rev Neurosci. 2011 Feb;12(2):73-87.

doi:

10.1038/nrn2977. Review. PubMed PMID: 21248787.

83: Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM,

Salloway

S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's

disease: a

review and proposal for the prevention of Alzheimer's disease. Alzheimers

Res

Ther. 2011 Jan 6;3(1):1. doi: 10.1186/alzrt59. PubMed PMID: 21211070;

PubMed


84: Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May

PC,

Karran E, De Strooper B. Inhibition of beta-secretase in vivo via

antibody

binding to unique loops (D and F) of BACE1. J Biol Chem. 2011 Mar

11;286(10):8677-87. doi: 10.1074/jbc.M110.194860. Epub 2011 Jan 5. PubMed

PMID:


85: Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck

R,

Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P. The

disintegrin/metalloproteinase Adam10 is essential for epidermal integrity

and

Notch-mediated signaling. Development. 2011 Feb;138(3):495-505. doi:

10.1242/dev.055210. PubMed PMID: 21205794; PubMed Central PMCID:

PMC3014635.

86: Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W,

Debulpaep M,

Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D,

Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J,

De

Strooper B. Neurotoxicity of Alzheimer's disease Aβ peptides is induced

by small

changes in the Aβ42 to Aβ40 ratio. EMBO J. 2010 Oct 6;29(19):3408-20.

doi:

10.1038/emboj.2010.211. Epub 2010 Sep 3. PubMed PMID: 20818335; PubMed

Central

PMCID: PMC2957213.

87: Jorissen E, De Strooper B. Gamma-secretase and the intramembrane

proteolysis

of Notch. Curr Top Dev Biol. 2010;92:201-30. doi: 10.1016/S0070-

2153(10)92006-1.

Review. PubMed PMID: 20816396.

88: Benilova I, De Strooper B. Prion protein in Alzheimer's pathogenesis:

a hot

and controversial issue. EMBO Mol Med. 2010 Aug;2(8):289-90. doi:

10.1002/emmm.201000088. PubMed PMID: 20698011; PubMed Central PMCID:

PMC3377329.

89: Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu

AN,

Sergeant N, Buée L, De Strooper B. Genetic ablation of Dicer in adult

forebrain

neurons results in abnormal tau hyperphosphorylation and

neurodegeneration. Hum

Mol Genet. 2010 Oct 15;19(20):3959-69. doi: 10.1093/hmg/ddq311. Epub 2010

Jul 21.


90: De Strooper B, Annaert W. Novel research horizons for presenilins and

γ-secretases in cell biology and disease. Annu Rev Cell Dev Biol.

2010;26:235-60.

doi: 10.1146/annurev-cellbio-100109-104117. Review. PubMed PMID:

20604710.

91: Annaert W, De Strooper B. Alzheimer's disease neurons fail the acid

test.

Cell. 2010 Jun 25;141(7):1112-4. doi: 10.1016/j.cell.2010.06.009. PubMed

PMID:

20602994.

92: de Strooper B. Cancer and neurodegeneration meet. EMBO Mol Med. 2010

Jul;2(7):245-6. doi: 10.1002/emmm.201000078. PubMed PMID: 20583009;

PubMed


93: Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of

presenilins in neuronal calcium homeostasis. J Neurosci. 2010 Jun

23;30(25):8566-80. doi: 10.1523/JNEUROSCI.1554-10.2010. PubMed PMID:

20573903;


94: Morais VA, De Strooper B. Mitochondria dysfunction and

neurodegenerative

disorders: cause or consequence. J Alzheimers Dis. 2010;20 Suppl 2:S255-

63. doi:

10.3233/JAD-2010-100345. Review. PubMed PMID: 20463408.

95: Espuny-Camacho I, Dominguez D, Merchiers P, Van Rompaey L, Selkoe D,

De

Strooper B. Peroxisome proliferator-activated receptor gamma enhances the

activity of an insulin degrading enzyme-like metalloprotease for amyloid-

beta

clearance. J Alzheimers Dis. 2010;20(4):1119-32. doi: 10.3233/JAD-2010-

091633.


96: De Strooper B. Proteases and proteolysis in Alzheimer disease: a

multifactorial view on the disease process. Physiol Rev. 2010

Apr;90(2):465-94.

doi: 10.1152/physrev.00023.2009. Review. PubMed PMID: 20393191.

97: Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L,

Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G,

Blobel

CP, Glatzel M, De Strooper B, Saftig P. The disintegrin/metalloproteinase

ADAM10

is essential for the establishment of the brain cortex. J Neurosci. 2010

Apr

7;30(14):4833-44. doi: 10.1523/JNEUROSCI.5221-09.2010. PubMed PMID:

20371803;


98: De Strooper B, Vassar R, Golde T. The secretases: enzymes with

therapeutic

potential in Alzheimer disease. Nat Rev Neurol. 2010 Feb;6(2):99-107.

doi:

10.1038/nrneurol.2009.218. Review. PubMed PMID: 20139999; PubMed Central

PMCID:

PMC2879045.

99: Bergmans BA, De Strooper B. gamma-secretases: from cell biology to

therapeutic strategies. Lancet Neurol. 2010 Feb;9(2):215-26. doi:

10.1016/S1474-4422(09)70332-1. Review. PubMed PMID: 20129170.

100: Lau P, de Strooper B. Dysregulated microRNAs in neurodegenerative

disorders.

Semin Cell Dev Biol. 2010 Sep;21(7):768-73. doi:

10.1016/j.semcdb.2010.01.009.

Epub 2010 Jan 18. Review. PubMed PMID: 20080199.

101: Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L,

Müller U,

Dotti CG, De Strooper B. Neurons generated from APP/APLP1/APLP2 triple

knockout

embryonic stem cells behave normally in vitro and in vivo: lack of

evidence for a

cell autonomous role of the amyloid precursor protein in neuronal

differentiation. Stem Cells. 2010 Mar 31;28(3):399-406. doi:

10.1002/stem.296.


102: Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant

M, Haddad

D, Frezza C, Mandemakers W, Vogt-Weisenhorn D, Van Coster R, Wurst W,

Scorrano L,

De Strooper B. Parkinson's disease mutations in PINK1 result in decreased

Complex

I activity and deficient synaptic function. EMBO Mol Med. 2009

May;1(2):99-111.

doi: 10.1002/emmm.200900006. PubMed PMID: 20049710; PubMed Central PMCID:

PMC3378121.

103: Thathiah A, De Strooper B. G protein-coupled receptors, cholinergic

dysfunction, and Abeta toxicity in Alzheimer's disease. Sci Signal. 2009

Oct

20;2(93):re8. doi: 10.1126/scisignal.293re8. Review. PubMed PMID:

19843960.

104: Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F,

Herdewijn

P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C,

Gevaert K,

De Strooper B. Analysis of the gamma-secretase interactome and validation

of its

association with tetraspanin-enriched microdomains. Nat Cell Biol. 2009

Nov;11(11):1340-6. doi: 10.1038/ncb1978. Epub 2009 Oct 18. PubMed PMID:

19838174.

105: Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper

B, del

Monte G, de la Pompa JL, Maroto M. Notch is a critical component of the

mouse

somitogenesis oscillator and is essential for the formation of the

somites. PLoS

Genet. 2009 Sep;5(9):e1000662. doi: 10.1371/journal.pgen.1000662. Epub

2009 Sep

25. PubMed PMID: 19779553; PubMed Central PMCID: PMC2739441.

106: Huysseune S, Kienlen-Campard P, Hébert S, Tasiaux B, Leroy K,

Devuyst O,

Brion JP, De Strooper B, Octave JN. Epigenetic control of aquaporin 1

expression

by the amyloid precursor protein. FASEB J. 2009 Dec;23(12):4158-67. doi:

10.1096/fj.09-140012. Epub 2009 Aug 17. PubMed PMID: 19687153.

107: Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K,

Van

Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT,

Sprangers B,

Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge

R, De

Strooper B. gamma-Secretase heterogeneity in the Aph1 subunit: relevance

for

Alzheimer's disease. Science. 2009 May 1;324(5927):639-42. doi:

10.1126/science.1171176. Epub 2009 Mar 19. PubMed PMID: 19299585; PubMed

Central

PMCID: PMC2740474.

108: Hébert SS, De Strooper B. Alterations of the microRNA network cause

neurodegenerative disease. Trends Neurosci. 2009 Apr;32(4):199-206. doi:

10.1016/j.tins.2008.12.003. Epub 2009 Mar 4. Review. PubMed PMID:

19268374.

109: Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M,

Miscione GP,

Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper

B, Muñoz

FJ. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces

glycation and tau fibrillation. Brain. 2009 May;132(Pt 5):1335-45. doi:

10.1093/brain/awp023. Epub 2009 Feb 27. PubMed PMID: 19251756.

110: Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K,

Vanbrabant

M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper

B,

Merchiers P. The orphan G protein-coupled receptor 3 modulates amyloid-

beta

peptide generation in neurons. Science. 2009 Feb 13;323(5916):946-51.

doi:


111: Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss

K, Maes

E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De

Strooper

B. ADAM10, the rate-limiting protease of regulated intramembrane

proteolysis of

Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the

gamma-secretase. J Biol Chem. 2009 Apr 24;284(17):11738-47. doi:

10.1074/jbc.M805894200. Epub 2009 Feb 11. PubMed PMID: 19213735; PubMed

Central

PMCID: PMC2670177.

112: Dotti CG, De Strooper B. Alzheimer's dementia by circulation

disorders: when

trees hide the forest. Nat Cell Biol. 2009 Feb;11(2):114-6. doi:

10.1038/ncb0209-114. PubMed PMID: 19188916.

113: Hébert SS, Horré K, Nicolaï L, Bergmans B, Papadopoulou AS,

Delacourte A, De

Strooper B. MicroRNA regulation of Alzheimer's Amyloid precursor protein

expression. Neurobiol Dis. 2009 Mar;33(3):422-8. doi:

10.1016/j.nbd.2008.11.009.

Epub 2008 Dec 9. PubMed PMID: 19110058.

114: O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL,

Eimer WA,

Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De

Strooper B,

Haass C, Bennett DA, Vassar R. Phosphorylation of the translation

initiation

factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

Neuron.

2008 Dec 26;60(6):988-1009. doi: 10.1016/j.neuron.2008.10.047. PubMed

PMID:


115: Tolia A, De Strooper B. Structure and function of gamma-secretase.

Semin

Cell Dev Biol. 2009 Apr;20(2):211-8. doi: 10.1016/j.semcdb.2008.10.007.

Epub 2008

Nov 1. Review. PubMed PMID: 19007897.

116: Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU,

St

George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA,

Müller U, van

Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs

endocytosis of lipoprotein particles and membrane cholesterol

homeostasis. J

Neurosci. 2008 Nov 12;28(46):12097-106. doi: 10.1523/JNEUROSCI.2635-

08.2008.


117: Wakabayashi T, De Strooper B. Presenilins: members of the gamma-

secretase

quartets, but part-time soloists too. Physiology (Bethesda). 2008

Aug;23:194-204.

doi: 10.1152/physiol.00009.2008. Review. PubMed PMID: 18697993.

118: Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K,

Depboylu C,

Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge

R, De

Strooper B. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage

and

sensorimotor gating that can be reversed with antipsychotic treatment.

Proc Natl

Acad Sci U S A. 2008 Jul 15;105(28):9775-80. doi:

10.1073/pnas.0800507105. Epub

2008 Jul 14. PubMed PMID: 18626010; PubMed Central PMCID: PMC2474502.

119: Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C,

Weggen

S, De Strooper B, Pietrzik CU. Increased AICD generation does not result

in

increased nuclear translocation or activation of target gene

transcription. Exp

Cell Res. 2008 Aug 1;314(13):2419-33. doi: 10.1016/j.yexcr.2008.05.003.

Epub 2008


120: Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B.

Glu(332)

in the Nicastrin ectodomain is essential for gamma-secretase complex

maturation

but not for its activity. J Biol Chem. 2008 Jul 18;283(29):20096-105.

doi:

10.1074/jbc.M803040200. Epub 2008 May 23. PubMed PMID: 18502756.

121: Tolia A, Horré K, De Strooper B. Transmembrane domain 9 of

presenilin

determines the dynamic conformation of the catalytic site of gamma-

secretase. J

Biol Chem. 2008 Jul 11;283(28):19793-803. doi: 10.1074/jbc.M802461200.

Epub 2008


122: Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W,

Silahtaroglu

AN, Kauppinen S, Delacourte A, De Strooper B. Loss of microRNA cluster

miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased

BACE1/beta-secretase expression. Proc Natl Acad Sci U S A. 2008 Apr

29;105(17):6415-20. doi: 10.1073/pnas.0710263105. Epub 2008 Apr 23.

PubMed PMID:


123: Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M,

Jonckheere W,

Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J,

Rousseau F.

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that

affect

learning in mice. EMBO J. 2008 Jan 9;27(1):224-33. Epub 2007 Dec 6.

PubMed PMID:


124: Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B,

Steiner

H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one

of each

component. J Biol Chem. 2007 Nov 23;282(47):33985-93. Epub 2007 Oct 2.

PubMed

PMID: 17911105.

125: Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare

M,

Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De

Strooper

B, Leon A. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-

cyclopropanecarboxylic

acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-

amyloid

pathology in a transgenic mouse model of Alzheimer's disease without

causing

peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. Epub

2007 Sep

25. PubMed PMID: 17895400.

126: Hébert SS, De Strooper B. Molecular biology. miRNAs in

neurodegeneration.

Science. 2007 Aug 31;317(5842):1179-80. PubMed PMID: 17761871.

127: Mandemakers W, Morais VA, De Strooper B. A cell biological

perspective on

mitochondrial dysfunction in Parkinson disease and other

neurodegenerative

diseases. J Cell Sci. 2007 May 15;120(Pt 10):1707-16. Review. PubMed

PMID:

17502481.

128: Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.

Familial

Alzheimer disease-linked mutations specifically disrupt Ca2+ leak

function of

presenilin 1. J Clin Invest. 2007 May;117(5):1230-9. Epub 2007 Apr 12.

PubMed


129: Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler

SF.

Regulated intramembrane proteolysis of the interleukin-1 receptor II by

alpha-,

beta-, and gamma-secretase. J Biol Chem. 2007 Apr 20;282(16):11982-95.

Epub 2007

Feb 16. PubMed PMID: 17307738.

130: Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de

Strooper

B, Janssen O, Saftig P. ADAM10 regulates FasL cell surface expression and

modulates FasL-induced cytotoxicity and activation-induced cell death.

Cell Death

Differ. 2007 May;14(5):1040-9. Epub 2007 Feb 9. PubMed PMID: 17290285.

131: De Strooper B. Loss-of-function presenilin mutations in Alzheimer

disease.

Talking Point on the role of presenilin mutations in Alzheimer disease.

EMBO Rep.

2007 Feb;8(2):141-6. Review. PubMed PMID: 17268505; PubMed Central PMCID:

PMC1796779.

132: Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L,

De

Strooper B, Yu G, Bezprozvanny I. Presenilins form ER Ca2+ leak channels,

a

function disrupted by familial Alzheimer's disease-linked mutations.

Cell. 2006

Sep 8;126(5):981-93. PubMed PMID: 16959576; PubMed Central PMCID:

PMC3241869.

133: Theuns J, Marjaux E, Vandenbulcke M, Van Laere K, Kumar-Singh S,

Bormans G,

Brouwers N, Van den Broeck M, Vennekens K, Corsmit E, Cruts M, De

Strooper B, Van

Broeckhoven C, Vandenberghe R. Alzheimer dementia caused by a novel

mutation

located in the APP C-terminal intracytosolic fragment. Hum Mutat. 2006

Sep;27(9):888-96. PubMed PMID: 16917905.

134: Dominguez DI, Hartmann D, De Strooper B. BACE1 and presenilin: two

unusual

aspartyl proteases involved in Alzheimer's disease. Neurodegener Dis.

2004;1(4-5):168-74. Review. PubMed PMID: 16908986.

135: Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S,

Annaert W.

Presenilin-1 maintains a nine-transmembrane topology throughout the

secretory

pathway. J Biol Chem. 2006 Sep 8;281(36):26569-77. Epub 2006 Jul 14.

PubMed PMID:

16846981.

136: Tolia A, Chávez-Gutiérrez L, De Strooper B. Contribution of

presenilin

transmembrane domains 6 and 7 to a water-containing cavity in the gamma-

secretase

complex. J Biol Chem. 2006 Sep 15;281(37):27633-42. Epub 2006 Jul 14.

PubMed

PMID: 16844686.

137: Frezza C, Cipolat S, Martins de Brito O, Micaroni M, Beznoussenko

GV, Rudka

T, Bartoli D, Polishuck RS, Danial NN, De Strooper B, Scorrano L. OPA1

controls

apoptotic cristae remodeling independently from mitochondrial fusion.

Cell. 2006

Jul 14;126(1):177-89. PubMed PMID: 16839885.

138: Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K,

Metzger

K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L,

D'Hooge

R, Scorrano L, De Strooper B. Mitochondrial rhomboid PARL regulates

cytochrome c

release during apoptosis via OPA1-dependent cristae remodeling. Cell.

2006 Jul

14;126(1):163-75. PubMed PMID: 16839884.

139: Avila J, Nitsch RM, Haass C, De Strooper B. European Alzheimer

disease

funding. Nat Med. 2006 Jul;12(7):776-7. PubMed PMID: 16829945.

140: Hébert SS, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov MA,

Müller

U, De Strooper B. Regulated intramembrane proteolysis of amyloid

precursor

protein and regulation of expression of putative target genes. EMBO Rep.

2006

Jul;7(7):739-45. Epub 2006 May 19. PubMed PMID: 16729020; PubMed Central

PMCID:

PMC1500829.

141: Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J,

Esselmann H,

De Strooper B. Presenilin clinical mutations can affect gamma-secretase

activity

by different mechanisms. J Neurochem. 2006 Feb;96(3):732-42. Epub 2006

Jan 9.


142: Debrock S, De Strooper B, Vander Perre S, Hill JA, D'Hooghe TM.

Tumour

necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote

adhesion of

human endometrial epithelial cells to mesothelial cells in a quantitative

in

vitro model. Hum Reprod. 2006 Mar;21(3):605-9. Epub 2005 Oct 27. PubMed

PMID:

16253962.

143: Reinhard C, Hébert SS, De Strooper B. The amyloid-beta precursor

protein:

integrating structure with biological function. EMBO J. 2005 Dec

7;24(23):3996-4006. Epub 2005 Oct 27. Review. PubMed PMID: 16252002;

PubMed


144: Grimm MO, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, Duering M,

Tschäpe JA,

De Strooper B, Müller U, Shen J, Hartmann T. Regulation of cholesterol

and

sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol.

2005

Nov;7(11):1118-23. Erratum in: Nat Cell Biol. 2006 Apr;8(4):424. PubMed

PMID:

16227967.

145: De Strooper B. Nicastrin: gatekeeper of the gamma-secretase complex.

Cell.

2005 Aug 12;122(3):318-20. Review. PubMed PMID: 16096051.

146: Leyssen M, Ayaz D, Hébert SS, Reeve S, De Strooper B, Hassan BA.

Amyloid

precursor protein promotes post-developmental neurite arborization in the

Drosophila brain. EMBO J. 2005 Aug 17;24(16):2944-55. Epub 2005 Jul 28.

PubMed


147: Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S,

Serneels L,

Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R,

Bach P,

Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B.

Phenotypic

and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem.

2005

Sep 2;280(35):30797-806. Epub 2005 Jun 29. PubMed PMID: 15987683.

148: Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de

Strooper

B, Hartmann D, Saftig P. ADAM10 mediates E-cadherin shedding and

regulates

epithelial cell-cell adhesion, migration, and beta-catenin translocation.

Proc

Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7. Epub 2005 Jun 15. PubMed

PMID:


149: Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch

function in

presomitic mesoderm suggests a gamma-secretase-independent role for

presenilins

in somite differentiation. Dev Cell. 2005 May;8(5):677-88. PubMed PMID:

15866159.

150: Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa

M, De

Strooper B, Saftig P, Nukina N. beta Subunits of voltage-gated sodium

channels

are novel substrates of beta-site amyloid precursor protein-cleaving

enzyme

(BACE1) and gamma-secretase. J Biol Chem. 2005 Jun 17;280(24):23009-17.

Epub 2005

Apr 11. PubMed PMID: 15824102.

151: Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T,

Dolios G,

Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser

P, St

George-Hyslop P, Nishimura M. Random mutagenesis of presenilin-1

identifies novel

mutants exclusively generating long amyloid beta-peptides. J Biol Chem.

2005 May

13;280(19):19070-7. Epub 2005 Mar 10. PubMed PMID: 15764596.

152: Coolen MW, Van Loo KM, Van Bakel NN, Pulford DJ, Serneels L, De

Strooper B,

Ellenbroek BA, Cools AR, Martens GJ. Gene dosage effect on gamma-

secretase

component Aph-1b in a rat model for neurodevelopmental disorders. Neuron.

2005

Feb 17;45(4):497-503. PubMed PMID: 15721236.

153: Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann

D, Saftig

P. ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and

beta-catenin nuclear signalling. EMBO J. 2005 Feb 23;24(4):742-52. Epub

2005 Feb

3. Erratum in: EMBO J. 2005 May 4;24(9):1762. PubMed PMID: 15692570;

PubMed


154: Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E,

Tousseyn T,

Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De

Strooper B.

Differential contribution of the three Aph1 genes to gamma-secretase

activity in

vivo. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1719-24. Epub 2005 Jan

21.


155: Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M,

Delacourte

A, Dingwall C, De Strooper B, Dotti CG. Neuronal membrane cholesterol

loss

enhances amyloid peptide generation. J Cell Biol. 2004 Dec 6;167(5):953-

60.


156: Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, De

Strooper

B. Peroxisome-proliferator-activated receptor gamma induces a clearance

mechanism

for the amyloid-beta peptide. J Neurosci. 2004 Dec 1;24(48):10908-17.

PubMed

PMID: 15574741.

157: Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V,

Annaert

W, Hartmann D, De Strooper B. Coordinated and widespread expression of

gamma-secretase in vivo: evidence for size and molecular heterogeneity.

Neurobiol

Dis. 2004 Nov;17(2):260-72. PubMed PMID: 15474363.

158: Wilquet V, De Strooper B. Amyloid-beta precursor protein processing

in

neurodegeneration. Curr Opin Neurobiol. 2004 Oct;14(5):582-8. Review.

PubMed

PMID: 15464891.

159: Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels

L,

Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Presenilin 1

mediates

the turnover of telencephalin in hippocampal neurons via an autophagic

degradative pathway. J Cell Biol. 2004 Sep 27;166(7):1041-54. PubMed

PMID:


160: Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R,

Huppert

SS. Notch pathway is dispensable for adipocyte specification. Genesis.

2004

Sep;40(1):40-4. PubMed PMID: 15354292.

161: Wrigley JD, Nunn EJ, Nyabi O, Clarke EE, Hunt P, Nadin A, De

Strooper B,

Shearman MS, Beher D. Conserved residues within the putative active site

of

gamma-secretase differentially influence enzyme activity and inhibitor

binding. J

Neurochem. 2004 Sep;90(6):1312-20. PubMed PMID: 15341515.

162: Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo

T,

Nakajima M, Shinohara M, Saya H. Cell-matrix interaction via CD44 is

independently regulated by different metalloproteinases activated in

response to

extracellular Ca(2+) influx and PKC activation. J Cell Biol. 2004 Jun

21;165(6):893-902. Epub 2004 Jun 14. PubMed PMID: 15197174; PubMed

Central PMCID:

PMC2172408.

163: Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L,

Saftig P,

Craessaerts K, De Strooper B, Hartmann D. Partial loss of presenilins

causes

seborrheic keratosis and autoimmune disease in mice. Hum Mol Genet. 2004

Jul

1;13(13):1321-31. Epub 2004 May 5. PubMed PMID: 15128703.

164: Marjaux E, Hartmann D, De Strooper B. Presenilins in memory,

Alzheimer's

disease, and therapy. Neuron. 2004 Apr 22;42(2):189-92. Review. PubMed

PMID:

15091335.

165: Dejaegere T, de Strooper B. [Secretases as therapeutic targets for

the

treatment of Alzheimer's disease]. Verh K Acad Geneeskd Belg.

2004;66(1):29-58;

discussion 58-9. Review. German. PubMed PMID: 15074081.

166: Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H,

Yamamoto T, De Strooper B, Yamamoto K, Suzuki T. Coordinated metabolism

of

Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene

transactivation. J Biol Chem. 2004 Jun 4;279(23):24343-54. Epub 2004 Mar

22.


167: Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis

HD,

Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL,

Goate A,

Wolfe MS, Shearman M, Kopan R. A presenilin dimer at the core of the

gamma-secretase enzyme: insights from parallel analysis of Notch 1 and

APP

proteolysis. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13075-80. Epub

2003

Oct 17. PubMed PMID: 14566063; PubMed Central PMCID: PMC240747.

168: Moreau Y, Aerts S, De Moor B, De Strooper B, Dabrowski M. Comparison

and

meta-analysis of microarray data: from the bench to the computer desk.

Trends

Genet. 2003 Oct;19(10):570-7. Review. PubMed PMID: 14550631.

169: Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C,

Saftig P, De

Strooper B, Seed B. The cell adhesion protein P-selectin glycoprotein

ligand-1 is

a substrate for the aspartyl protease BACE1. J Biol Chem. 2003 Dec

5;278(49):48713-9. Epub 2003 Sep 24. PubMed PMID: 14507929.

170: Schulz JG, Annaert W, Vandekerckhove J, Zimmermann P, De Strooper B,

David

G. Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-

dependent

and modulates cytosolic signaling. J Biol Chem. 2003 Dec 5;278(49):48651-

7. Epub

2003 Sep 22. PubMed PMID: 14504279.

171: Lauwers E, Debyser Z, Van Dorpe J, De Strooper B, Nuttin B,

Baekelandt V.

Neuropathology and neurodegeneration in rodent brain induced by

lentiviral

vector-mediated overexpression of alpha-synuclein. Brain Pathol. 2003

Jul;13(3):364-72. PubMed PMID: 12946025.

172: Kahle PJ, De Strooper B. Attack on amyloid. EMBO Rep. 2003

Aug;4(8):747-51.

Epub 2003 Jul 25. PubMed PMID: 12897797; PubMed Central PMCID:

PMC1326345.

173: Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van

Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B.

Presenilins

mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin

glycosylation but remain catalytically inactive in the absence of wild

type

Presenilin. J Biol Chem. 2003 Oct 31;278(44):43430-6. Epub 2003 Jul 28.

PubMed

PMID: 12885769.

174: De Strooper B, Woodgett J. Alzheimer's disease: Mental plaque

removal.

Nature. 2003 May 22;423(6938):392-3. PubMed PMID: 12761533.

175: Dabrowski M, Aerts S, Van Hummelen P, Craessaerts K, De Moor B,

Annaert W,

Moreau Y, De Strooper B. Gene profiling of hippocampal neuronal culture.

J

Neurochem. 2003 Jun;85(5):1279-88. PubMed PMID: 12753086.

176: De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate

an

active gamma-Secretase complex. Neuron. 2003 Apr 10;38(1):9-12. Review.

PubMed

PMID: 12691659.

177: Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De

Strooper

B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity

mediates the

intramembranous cleavage of CD44. Oncogene. 2003 Mar 13;22(10):1511-6.

PubMed

PMID: 12629514.

178: Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K,

Mueller U,

Annaert W, De Strooper B. gamma-Secretase activity requires the

presenilin-dependent trafficking of nicastrin through the Golgi apparatus

but not

its complex glycosylation. J Cell Sci. 2003 Mar 15;116(Pt 6):1127-36.

PubMed

PMID: 12584255.

179: Kumar-Singh S, Julliams A, Nuydens R, Ceuterick C, Labeur C,

Serneels S,

Vennekens K, Van Osta P, Geerts H, De Strooper B, Van Broeckhoven C. In

vitro

studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence

for

two-staged neurotoxicity. Neurobiol Dis. 2002 Nov;11(2):330-40. PubMed

PMID:

12505425.

180: Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A,

Annaert W,

Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P. The

disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but

not for

alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002 Oct

1;11(21):2615-24. PubMed PMID: 12354787.

181: Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo

EH.

Presenilin couples the paired phosphorylation of beta-catenin independent

of

axin: implications for beta-catenin activation in tumorigenesis. Cell.

2002 Sep

20;110(6):751-62. PubMed PMID: 12297048.

182: Annaert W, De Strooper B. A cell biological perspective on

Alzheimer's

disease. Annu Rev Cell Dev Biol. 2002;18:25-51. Epub 2002 Apr 2. Review.

PubMed

PMID: 12142279.

183: Dominguez DI, De Strooper B. Novel therapeutic strategies provide

the real

test for the amyloid hypothesis of Alzheimer's disease. Trends Pharmacol

Sci.

2002 Jul;23(7):324-30. Review. PubMed PMID: 12119153.

184: Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K,

Serneels L,

Annaert W, De Strooper B. No endogenous A beta production in presenilin-

deficient

fibroblasts. Nat Cell Biol. 2002 Jul;4(7):E164; author reply E165-6.

PubMed PMID:

12105423.

185: Baekelandt V, Claeys A, Eggermont K, Lauwers E, De Strooper B,

Nuttin B,

Debyser Z. Characterization of lentiviral vector-mediated gene transfer

in adult

mouse brain. Hum Gene Ther. 2002 May 1;13(7):841-53. PubMed PMID:

11975850.

186: Flood DG, Reaume AG, Dorfman KS, Lin YG, Lang DM, Trusko SP, Savage

MJ,

Annaert WG, De Strooper B, Siman R, Scott RW. FAD mutant PS-1 gene-

targeted mice:

increased A beta 42 and A beta deposition without APP overproduction.

Neurobiol

Aging. 2002 May-Jun;23(3):335-48. PubMed PMID: 11959395.

187: Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour

M,

Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla

FM. A

physiologic signaling role for the gamma -secretase-derived intracellular

fragment of APP. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702.

Epub 2002

Mar 26. PubMed PMID: 11917117; PubMed Central PMCID: PMC123710.

188: Sisodia SS, Annaert W, Kim SH, De Strooper B. Gamma-secretase: never

more

enigmatic. Trends Neurosci. 2001 Nov;24(11 Suppl):S2-6. Review. PubMed

PMID:

11881741.

189: Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B.

Implication of

APP secretases in notch signaling. J Mol Neurosci. 2001 Oct;17(2):171-81.

Review.


190: Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R,

Suzuki T,

Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H.

Endoplasmic reticulum stress-inducible protein, Herp, enhances

presenilin-mediated generation of amyloid beta-protein. J Biol Chem. 2002

Apr

12;277(15):12915-20. Epub 2002 Jan 17. PubMed PMID: 11799129.

191: Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P,

Craessaerts

K, De Strooper B. Interaction with telencephalin and the amyloid

precursor

protein predicts a ring structure for presenilins. Neuron. 2001 Nov

20;32(4):579-89. PubMed PMID: 11719200.

192: De Strooper B, König G. An inflammatory drug prospect. Nature. 2001

Nov

8;414(6860):159-60. PubMed PMID: 11700538.

193: Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B. The

amyloid

precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase

is

rapidly degraded but distributes partially in a nuclear fraction of

neurones in

culture. J Neurochem. 2001 Sep;78(5):1168-78. PubMed PMID: 11553691.

194: Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H,

Beyermann M,

Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B,

Saftig P.

Elevation of beta-amyloid peptide 2-42 in sporadic and familial

Alzheimer's

disease and its generation in PS1 knockout cells. J Biol Chem. 2001 Nov

16;276(46):42645-57. Epub 2001 Aug 28. PubMed PMID: 11526104.

195: Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H,

Saftig P,

De Strooper B, Annaert W. The discrepancy between presenilin subcellular

localization and gamma-secretase processing of amyloid precursor protein.

J Cell

Biol. 2001 Aug 20;154(4):731-40. Epub 2001 Aug 13. PubMed PMID: 11502763;

PubMed


196: De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S,

Checler

F, Annaert W, Van Broeckhoven C, De Strooper B. Pathogenic APP mutations

near the

gamma-secretase cleavage site differentially affect Abeta secretion and

APP

C-terminal fragment stability. Hum Mol Genet. 2001 Aug 1;10(16):1665-71.

PubMed

PMID: 11487570.

197: Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B,

Grassi

J, Lopez-Perez E, Checler F. The disintegrins ADAM10 and TACE contribute

to the

constitutive and phorbol ester-regulated normal cleavage of the cellular

prion

protein. J Biol Chem. 2001 Oct 12;276(41):37743-6. Epub 2001 Jul 26.

PubMed PMID:

11477090.

198: Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R,

De

Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus

of

presenilins is obligatory for stabilization, complex formation, and

gamma-secretase activities of presenilins. J Biol Chem. 2001 Aug

31;276(35):33273-81. Epub 2001 Jun 29. PubMed PMID: 11432849.

199: Dominguez DI, De Strooper B, Annaert W. Secretases as therapeutic

targets

for the treatment of Alzheimer's disease. Amyloid. 2001 Jun;8(2):124-42.

Review.


200: De Strooper B, Annaert W. Where Notch and Wnt signaling meet. The

presenilin

hub. J Cell Biol. 2001 Feb 19;152(4):F17-20. PubMed PMID: 11266476;

PubMed


201: Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B,

Dotti

CG. Brain plasmin enhances APP alpha-cleavage and Abeta degradation and

is

reduced in Alzheimer's disease brains. EMBO Rep. 2000 Dec;1(6):530-5.

PubMed


202: Baekelandt V, De Strooper B, Nuttin B, Debyser Z. Gene therapeutic

strategies for neurodegenerative diseases. Curr Opin Mol Ther. 2000

Oct;2(5):540-54. Review. PubMed PMID: 11249757.

203: Annaert W, Cupers P, Saftig P, De Strooper B. Presenilin function in

APP

processing. Ann N Y Acad Sci. 2000;920:158-64. Review. PubMed PMID:

11193144.

204: Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA,

Multhaup G,

Craessaerts K, Annaert W, De Strooper B. Processing of beta-secretase by

furin

and other members of the proprotein convertase family. J Biol Chem. 2001

Feb

9;276(6):4211-7. Epub 2000 Nov 8. PubMed PMID: 11071887.

205: Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B,

Nuttin B,

Debyser Z. DNA-Dependent protein kinase is not required for efficient

lentivirus

integration. J Virol. 2000 Dec;74(23):11278-85. PubMed PMID: 11070027;

PubMed


206: Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M,

De

Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H,

Vanmechelen E, Kroisel PM, Van Broeckhoven C. Nonfibrillar diffuse

amyloid

deposition due to a gamma(42)-secretase site mutation points to an

essential role

for N-truncated A beta(42) in Alzheimer's disease. Hum Mol Genet. 2000

Nov

1;9(18):2589-98. PubMed PMID: 11063718.

207: Annaert W, De Strooper B. Neuronal models to study amyloid precursor

protein

expression and processing in vitro. Biochim Biophys Acta. 2000 Jul

26;1502(1):53-62. Review. PubMed PMID: 10899431.

208: Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De

Strooper B.

Total inactivation of gamma-secretase activity in presenilin-deficient

embryonic

stem cells. Nat Cell Biol. 2000 Jul;2(7):461-2. PubMed PMID: 10878813.

209: De Strooper B. Alzheimer's disease. Closing in on gamma-secretase.

Nature.

2000 Jun 8;405(6787):627, 629. PubMed PMID: 10864307.

210: De Strooper B, Annaert W. Proteolytic processing and cell biological

functions of the amyloid precursor protein. J Cell Sci. 2000 Jun;113 ( Pt

11):1857-70. Review. PubMed PMID: 10806097.

211: Saftig P, Hartmann D, De Strooper B. The function of presenilin-1 in

amyloid

beta-peptide generation and brain development. Eur Arch Psychiatry Clin

Neurosci.

1999;249(6):271-9. Review. PubMed PMID: 10653282.

212: De Strooper B, König G. Alzheimer's disease. A firm base for drug

development. Nature. 1999 Dec 2;402(6761):471-2. PubMed PMID: 10591201.

213: Haass C, De Strooper B. The presenilins in Alzheimer's disease--

proteolysis

holds the key. Science. 1999 Oct 29;286(5441):916-9. Review. PubMed PMID:

10542139.

214: Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G,

Westaway D,

George-Hyslop PS, Cordell B, Fraser P, De Strooper B. Presenilin 1

controls

gamma-secretase processing of amyloid precursor protein in pre-golgi

compartments

of hippocampal neurons. J Cell Biol. 1999 Oct 18;147(2):277-94. PubMed

PMID:


215: Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels

L,

Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel

R,

Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B.

Presenilin 2

deficiency causes a mild pulmonary phenotype and no changes in amyloid

precursor

protein processing but enhances the embryonic lethal phenotype of

presenilin 1

deficiency. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7. PubMed

PMID:


216: Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon

RA, Van

Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser

PE.

Developmental expression of wild-type and mutant presenilin-1 in

hippocampal

neurons from transgenic mice: evidence for novel species-specific

properties of

human presenilin-1. Mol Med. 1999 Aug;5(8):542-54. PubMed PMID: 10501657;

PubMed


217: Annaert W, De Strooper B. Presenilins: molecular switches between

proteolysis and signal transduction. Trends Neurosci. 1999

Oct;22(10):439-43.

Review. PubMed PMID: 10481190.

218: Hartmann D, De Strooper B, Saftig P. Presenilin-1 deficiency leads

to loss

of Cajal-Retzius neurons and cortical dysplasia similar to human type 2

lissencephaly. Curr Biol. 1999 Jul 15;9(14):719-27. PubMed PMID:

10421573.

219: De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm

JS,

Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A

presenilin-1-dependent gamma-secretase-like protease mediates release of

Notch

intracellular domain. Nature. 1999 Apr 8;398(6727):518-22. PubMed PMID:

10206645.

220: Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C,

Staufenbiel

M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X,

Yankner

BA. Destabilization of beta-catenin by mutations in presenilin-1

potentiates

neuronal apoptosis. Nature. 1998 Oct 15;395(6703):698-702. PubMed PMID:

9790190.

221: Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van

Leuven

F. Transgenic mice expressing an alpha-secretion mutant of the amyloid

precursor

protein in the brain develop a progressive CNS disorder. Behav Brain Res.

1998

Sep;95(1):55-64. PubMed PMID: 9754877.

222: Saftig P, de Strooper B. Downregulation of PS1 expression in neurons

decreases beta-amyloid production: a biochemical link between the two

major

familial Alzheimer's disease genes. Mol Psychiatry. 1998 Jul;3(4):287-9.

PubMed

PMID: 9702732.

223: Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K.

Cholesterol depletion inhibits the generation of beta-amyloid in

hippocampal

neurons. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6460-4. PubMed

PMID:


224: De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G,

Annaert

W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the

normal

cleavage of amyloid precursor protein. Nature. 1998 Jan 22;391(6665):387-

90.


225: De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K,

Cordell

B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F.

Phosphorylation, subcellular localization, and membrane orientation of

the

Alzheimer's disease-associated presenilins. J Biol Chem. 1997 Feb

7;272(6):3590-8. PubMed PMID: 9013610.

226: Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De

Strooper

B. Amyloidogenic processing of human amyloid precursor protein in

hippocampal

neurons devoid of cathepsin D. J Biol Chem. 1996 Nov 1;271(44):27241-4.

PubMed

PMID: 8910296.

227: Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C,

Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K,

Dotti CG.

The beta-amyloid domain is essential for axonal sorting of amyloid

precursor

protein. EMBO J. 1996 Oct 1;15(19):5218-29. PubMed PMID: 8895567; PubMed

Central

PMCID: PMC452266.

228: Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F.

Expression

in brain of amyloid precursor protein mutated in the alpha-secretase site

causes

disturbed behavior, neuronal degeneration and premature death in

transgenic mice.

EMBO J. 1996 Mar 15;15(6):1265-74. PubMed PMID: 8635459; PubMed Central

PMCID:

PMC450029.

229: Simons M, de Strooper B, Multhaup G, Tienari PJ, Dotti CG,

Beyreuther K.

Amyloidogenic processing of the human amyloid precursor protein in

primary

cultures of rat hippocampal neurons. J Neurosci. 1996 Feb 1;16(3):899-

908. PubMed

PMID: 8558258.

230: Tienari PJ, De Strooper B, Ikonen E, Ida N, Simons M, Masters CL,

Dotti CG,

Beyreuther K. Neuronal sorting and processing of amyloid precursor

protein:

implications for Alzheimer's disease. Cold Spring Harb Symp Quant Biol.

1996;61:575-85. Review. PubMed PMID: 9246484.

231: De Strooper B, Wu RR, Jaspers M, Van der Schueren B, Vekemans S,

Carmeliet

G, Van Leuven F, Van Den Oord J, Cassiman JJ. A 68-kD antigen, which is

probably

an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for

differentiating keratinocytes. Dermatology. 1996;193(3):212-20. PubMed

PMID:

8944343.

232: De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H.

Exchanging the

extracellular domain of amyloid precursor protein for horseradish

peroxidase does

not interfere with alpha-secretase cleavage of the beta-amyloid region,

but

randomizes secretion in Madin-Darby canine kidney cells. J Biol Chem.

1995 Dec

22;270(51):30310-4. PubMed PMID: 8530453.

233: De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K,

Dotti CG.

Production of intracellular amyloid-containing fragments in hippocampal

neurons

expressing human amyloid precursor protein and protection against

amyloidogenesis

by subtle amino acid substitutions in the rodent sequence. EMBO J. 1995

Oct

16;14(20):4932-8. PubMed PMID: 7588622; PubMed Central PMCID: PMC394596.

234: Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van

den

Berghe H. Expression in mouse embryos and in adult mouse brain of three

members

of the amyloid precursor protein family, of the alpha-2-macroglobulin

receptor/low density lipoprotein receptor-related protein and of its

ligands

apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the

40,000

molecular weight receptor-associated protein. Neuroscience. 1995

Apr;65(4):1009-25. PubMed PMID: 7542371.

235: Van Gool D, De Strooper B, Van Leuven F, Dom R. Amyloid precursor

protein

accumulation in Lewy body dementia and Alzheimer's disease. Dementia.

1995

Mar-Apr;6(2):63-8. PubMed PMID: 7606281.

236: De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B,

Van

Leuven F, Van den Berghe H. Basolateral secretion of amyloid precursor

protein in

Madin-Darby canine kidney cells is disturbed by alterations of

intracellular pH

and by introducing a mutation associated with familial Alzheimer's

disease. J

Biol Chem. 1995 Feb 24;270(8):4058-65. PubMed PMID: 7876155.

237: Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De

Strooper B,

Fryns JP, Van den Berghe H. Cloning, characterization, and chromosomal

localization to 4p16 of the human gene (LRPAP1) coding for the alpha

2-macroglobulin receptor-associated protein and structural comparison

with the

murine gene coding for the 44-kDa heparin-binding protein. Genomics. 1995

Jan

20;25(2):492-500. PubMed PMID: 7789983.

238: De Strooper B, Creemers JW, Moechars D, Huylebroeck D, Van De Ven

WJ, Van

Leuven F, Van den Berghe H. Amyloid precursor protein is not processed by

furin,

PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein

processing

enzymes. Biochim Biophys Acta. 1995 Jan 19;1246(2):185-8. PubMed PMID:

7819286.

239: Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L,

Overbergh

L, Torrekens S, Moechars D, De Strooper B, et al. Structure of the gene

(LRP1)

coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-

related

protein. Genomics. 1994 Nov 1;24(1):78-89. PubMed PMID: 7534747.

240: Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B,

Van

Leuven F, Van den Berghe H. Molecular cloning of the mouse gene coding

for alpha

2-macroglobulin and targeting of the gene in embryonic stem cells.

Genomics. 1994

Aug;22(3):519-29. PubMed PMID: 7528166.

241: Jaspers M, Vekemans S, Carmeliet G, van Leuven F, de Strooper B,

Deckmyn H,

Cassiman JJ. A monoclonal antibody to the alpha 2 integrin subunit cross-

reacts

with RGD-dependent epitopes in fibrinogen. Hybridoma. 1993 Aug;12(4):467-

74.


242: Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. alpha

2-Macroglobulin expression in neuritic-type plaques in patients with

Alzheimer's

disease. Neurobiol Aging. 1993 May-Jun;14(3):233-7. PubMed PMID: 7686641.

243: Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B,

Hilliker C,

Lorent K, Fias E, Umans L, Torrekens S, et al. Molecular cloning and

sequencing

of the murine alpha-2-macroglobulin receptor cDNA. Biochim Biophys Acta.

1993 Apr

29;1173(1):71-4. PubMed PMID: 8485155.

244: De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. Study of the

synthesis and secretion of normal and artificial mutants of murine

amyloid

precursor protein (APP): cleavage of APP occurs in a late compartment of

the

default secretion pathway. J Cell Biol. 1993 Apr;121(2):295-304. PubMed

PMID:


245: De Strooper B, Van Leuven F. Alpha 2-macroglobulin and subacute-

phase

responses in Alzheimer's disease. Immunol Today. 1993 Mar;14(3):143-4.

PubMed

PMID: 7682079.

246: Delabie J, Shipman R, Brüggen J, De Strooper B, van Leuven F,

Tarcsay L,

Cerletti N, Odink K, Diehl V, Bilbe G, et al. Expression of the novel

intermediate filament-associated protein restin in Hodgkin's disease and

anaplastic large-cell lymphoma. Blood. 1992 Dec 1;80(11):2891-6. PubMed

PMID:

1450414.

247: van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van

den

Berghe H. The primary sequence and the subunit structure of mouse

alpha-2-macroglobulin, deduced from protein sequencing of the isolated

subunits

and from molecular cloning of the cDNA. Eur J Biochem. 1992 Nov

15;210(1):319-27.


248: De Strooper B, Van Leuven F, Van den Berghe H. Alpha 2-macroglobulin

and

other proteinase inhibitors do not interfere with the secretion of

amyloid

precursor protein in mouse neuroblastoma cells. FEBS Lett. 1992 Aug

10;308(1):50-3. PubMed PMID: 1379551.

249: De Strooper B. [University education is more than higher education].

Verh K

Acad Geneeskd Belg. 1992;54(6):631-6. Dutch. PubMed PMID: 1296407.

250: De Strooper B, Van Leuven F, Van den Berghe H. The amyloid beta

protein

precursor or proteinase nexin II from mouse is closer related to its

human

homolog than previously reported. Biochim Biophys Acta. 1991 Dec

2;1129(1):141-3.


251: De Strooper B, Van Leuven F, Carmeliet G, Van Den Berghe H, Cassiman

JJ.

Cultured human fibroblasts contain a large pool of precursor beta 1-

integrin but

lack an intracellular pool of mature subunit. Eur J Biochem. 1991 Jul

1;199(1):25-33. PubMed PMID: 1906002.

252: De Strooper B, Van der Schueren B, Jaspers M, Saison M, Spaepen M,

Van

Leuven F, Van den Berghe H, Cassiman JJ. Distribution of the beta 1

subgroup of

the integrins in human cells and tissues. J Histochem Cytochem. 1989

Mar;37(3):299-307. PubMed PMID: 2645360.

253: Jaspers M, de Strooper B, Spaepen M, van Leuven F, David G, van den

Berghe

H, Cassiman JJ. Post-translational modification of the beta-subunit of

the human

fibronectin receptor. FEBS Lett. 1988 Apr 25;231(2):402-6. PubMed PMID:

2966078.

2

7: arranz am, delbroek l, van kolen k, guimarães mr ......and memory deficits in appps1-21...

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