2003 Isoquinoline derivatives

Isoquinoline derivativesR 0420 6,7-Dihydroxyisoquinoline-3-carboxylic Acids Are Potent Inhibitors on the Bind-

ing of Insulin-Like Growth Factor (IGF) to IGF-Binding Proteins: Optimization of the 1-Position Benzoyl Side Chain. — A series of 1-benzoylisoquinolines (VI) are synthesized (no yields given) and evaluated as IGF-binding protein inhibitors. SAR studies indicate that isoquinoline (VIb) is a potent inhibitor. — (CHEN*, C.; et al.; Bioorg. Med. Chem. Lett. 13 (2003) 11, 1927-1930; Dep. Med. Chem., Neurocrine Biosci., Inc., San Diego, CA 92121, USA; Eng.) — M. Schroeter

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