6. slide persentasi.ppt

8/18/2019 6. Slide Persentasi.ppt

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Di Susun Oleh :

LYDIA M 10310216 ADICONOTAREZA 101001002

M INDIRA F 10310218 WIJA DARMAN101001261

SRI MAULANA PUTRI 10310373 DELFIANDRY Y.SRG 101001117

IDA AYU 09310216 LIZASARTIA 101001038

JENDRI !ENDRA P. 09310078

#$. A#%&S'.A


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Defnisi Malaria merupakan penyakit infeksi akut hingga

kronik yang disebabkan oleh satu atau lebih spesies

Plasmodium, ditandai dengan panas tinggi bersifat

intermiten, anemia dan hepato-splenomegali.


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EtiologiM()($*( #*+%,(,-( /)% '$///( #($(

(4 %$5(+- -% #()(5 4%+PlasmodiumP(#( 5(+*( %$#('( +'%+*%+

')(+5/#*5:*( 5()($*( %$*((.F();*'($5 5()($*( $/'*-(.M()($*(%.O()%.

P%)($( '(#( 5(+*( #*)(--( /)%(5- ,%*( Anopheles (('#*)($-( )(4+4 5%)()* $(+


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Siklus hidup malaria


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Patogenesis & patologiP(/4%%+*+ 5()($*( (-*,( #($* *%$(-+*

-/5')%-+ (($( '($(+*& *(4 #( )*4-4(.P(/4%%+*+( )%,* #*%-(-( '(#(

%$=(#*( '%*4-(( '%$5%(,*)*(+'%5,) #($( #($*'(#( -/(4)(+**$((+-)%$. O%)% -($%( +-*/4/*5%%,(,-( -%$+(-( %$*$/+* 5(-( (-(%$=(#* (%5*(.#*#4( (-*,( (#(( /-+* 5()($*( (4

5%%,(,-( 4(44(


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Faktor parasit:•Resistensi obat.•Kecepatan multiplikasi.•Cara invasi.•Sitoadherens.•Rosetting.•Polimorfisme antogenik.•Variasi antigenic.•oksin malaria.

Faktor pen!amu "host#:

•$munitas.•Sitokin proinflamasi.•%enetik.•&sia.•Kehamilan.

Faktor sosial ' geografi:

• (kses mendapat pengobatan.•)uda*a dan ekonomi.•Stabilitas politik.•$ntensitas transmisi n*amuk.

(simtomatik demam malaria berat kematian

Manifestasi klinik


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Maniestasi klinik

G%=()( +%$(4( 5()($*( '(#( '%#%$*( %$#*$* #($*,%,%$('( =%*+& (*:

1. G%=()( -)(+*- / %#%5*+ 5()($*( (( (4,%)5 5%5'(* -%-%,()( >*55*(+?@ (((4 '%$(5( -()* 5%#%$*( 5()($*(. G%=()( **

5%$'(-( +( '($/-*+5%& (4 %$#*$* #($* *4(+(#*5 ,%$$(: M%44*4*) >+%)(5( 1"60 5%*?& %$=(#* +%%)(

'%;(( +*/ #()(5 %$*$/+* #( -%)($ (((*4%*- (4 5%*5,)-( 5%4*4*)#*4*.

D%5(5 >+%)(5( 26 =(5?& *5,) +%%)('%#%$*( 5%4*4*)& #%5(5 #%4( + ,(#(+%-*($ 37&"0/C& '(#( '%#%$*( *'%$'($(+*%5*( >)%,* #($* " '%$+%? B0/C.


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%$-%$*4( >+%)(5( 2 =(5?& *5,) +%%)( #%5(5& %$=(#*(-*,( 4(44( 5%(,/)*+5% , +%*44( '$/#-+*-%$*4( ,%$(5,(. (#(4-(#(4 #()(5 -%(#(( ,%$(&

-%$*4( +(5'(* 5%5,(+(* , +%'%$* /$(4 5(#*.*(+(( +%%)( ,%$-%$*4(& '%#%$*( 5%$(+( +%( -%5,()*.

D* #(%$( %#%5*+ 5()($*( #*5(( '%#%$*( %)(5%5'(* *5*(+ %$(#(' 5()($*(& 4%=()( -)(+*- #* ((+*5,) *#(- ,%$$( ,(-( ,*+( =(#* *#(- #*%5-( 4%=()(%$+%,& -(#(4 5;) 4%=()( )(*.

2.G%=()( 5()($*( #()(5 '$/4$(5 '%5,%$((+( 5()($*(:D%5(5M%44*4*)%$-%$*4(D('( #*+%$(* #%4( 4%=()( )(*: S(-* -%'()(& 5() #(

5(. G%=()( -(+ #(%$( +%%5'(: #*($% '(#( ,()*( >#* T*5*5?&%$* // (( '%4()'%4() '(#( /$(4 #%(+( >#* P('(?&';( #( 5%44*4*)#*4* '(#( /$(4 #%(+( >#* Y/4(-($(?.


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A%5*( +%$*4 #*=5'(*& (-*,(:!%5/)*+*+ /)% '($(+*.!(5,(( #' %$*$/'/%+*+.!(5,(( #' '%)%'(+( $%*-)/+*.P%4($ +*/-*.

E$*$/


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Klinis Malaria alciparum (cari klinis tentangvivaxI-,(+* 91 ($*.P$/#$/5() +(-* -%'()(& %$* ,%)(-(4

4-(*& )%+& '%$(+(( #*4*& 5()& 5(&#*($%.P((+ *$%4)%$ #( *#(- '%$*/#*-& +%$*4 B0/C.

A%5*( )%,* 5%/=/) #4 )%-/'%* 5//+*/+*+.S')%/5%4()* %$* $(,(.!%'(/5%4()* I-%$+.

%)(*( $* (),5*$*(& *()*& -$*+()4$()%$.L(*: -/)+*& '%5/* (+'*$(+*& -%$*4( ,-

'# + /$5().


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!emuan "a#oratorium (cari ttg vivaxA%5*( /$5/-$/5*- /$5/+**- ($+ %$#('(. J5)( )%-/+*( #('( $%#( *44( /$5()& +%-()*'

'(#( **44( +%-*($ 100000L?.

P(#( *


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Diagnosis P%5%$*-+(( %%+ #($( - 5()($*(. T%%+( '$%'($( #($( %,() #( *'*+.

T%+ (*4%: PF %+ 9"H +%+**


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;($*4(5,($5()$*( *(


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A#( $ cara diagnostik (4 #*'%$)-(- 5%4((-( +%+%/$(4 * '/+**<

5()($*( (( *#(- (* '%5%$*-+(( #($(%'* >*'*+%,()? #( #%%-+* (*4%.

D($( %'* 5%=(#* '%5%$*-+(( %$'%*4

gold standard.I%$'$%(+* (4 #*#('( #($* #($( %'*(#()( =%*+ #( -%'(#(( '($(+*.

D%%-+* (*4% #*4(-( ('(,*)( *#(-

%$+%#*( 5*-$/+-/' - 5%5%$*-+('$%'($( #($( %'* #( '(#( -%(#((%5%$4%+* (4 '%$) #*(4/+*+ +%4%$( #%4( -%$(+ dip stick .


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Diagnosis #andingD%5(5 5%$'(-( +()( +( 4%=()( 5()($*( (4

5%/=/)& (4 =4( #*=5'(* '(#( (5'*$ +%5('%(-* *


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A#( #( '%$,(( '(/)/4* (4 5%#(+($%$=(#* '(#( 5()($*(:

Perubahan vaskuler & ,%$'( (;$( +%)+%) #($( 5%$( #( '%5,(('%5,) #($( -('*)%$ #* /$4(/$4(#()(5 $%+'/ 5/$() #( $%+'/ +%))%$ 5%$(4+(4 '$/+%+


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Anoksia / hipoksia jaringan. A/-+*( -($%( =5)( %$*$/+* 5%$& $/5,/+*+ '(#( -('*)%$

'%5,) #($(& #( /)5% #($( (4 ,%$-$(4 -($%('%$5%(,*)*(+ '%5,) #($( 5%*4-( %$(#(' ;(*$( #(

'$/%*& #*+%,(,-( /)% -%$+(-( %#/%). P%$)%-(( +%+(5( %$*$/+* (4 #**


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M()($*( %$(

M()($*( ,%$( #*(#(* #%4( +()( +( 4(44( '(/)/4*-)**- (( )%,* ,%$*- **: >3? M()($*( #%4( 4(44( -%+(#($( >('(*& #%)*$*5&+'/$& #( -/5(? (( GCS >G)(+4/ C/5( S;()%? 1- /$(4 #%(+( #( " - ((-((-. G(44(-%+(#($( 5%%(' B 30 5%* (( 5%%(' +%%)('((+ $. M()($*( #%4( *-%$+ >,*))*$,* +%$5 B 3 54H?. M()($*( #%4( 4(44( /)*4/$*( 005)2 =(5 (( -$%(** +%$5 B 3 54H?. M()($*( #%4( (%5*( ,%$( >!, " 4$H ((%5(/-$* 1"H?.

M()($*( #%4( %#%5( '($ >+%+(- ('(+& 4%)*+(?. M()($*( #%4( *'/4)*-%5*( >4)( #($( 0 54H?. M()($*( #%4( 4(44( +*$-)(+* (( +/- >%-((+*+/)*- 70 55!4 '(#( /$(4 #%(+( (( "0 55!4'(#( ((- 1" (. M()($*( #%4( *'%$'($(+*%5*( >P)(+5/#*5 B "H?.


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M()($*( #%4( 5(*+ ,(#( B 0/C?. M()($*( #%4( -%)%5(( (4 %-+$%5 >'$/+$(*/?@'%#%$*( *#(- 5(5' ##- (( ,%$=()(& ('( (#((-%)(*( %$/)/4* %$%.

M()($*( ,%$( ,*(+(( %$=(#* '(#( +%-%)/5'/- *#**# (45%5*)*-* 5*+()( '$%#*+/& /,(+*/+(*+*-(? #()(5 =(4-( (- (4 )(5(.


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M()($*( ;%$%,$()M()($*( /(- +%$*4 5%%,(,-( -%5(*(.G%=()( (4 *5,) #('( (5'(- +%,(4(* '%$(

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*)( -(#($ )(-( B6 55/)) '$/4/+( =%)%-.


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M()($*( ()4*# T%$=(#*( +/- (+-)($.

T(#(: T%-(( +*+/)*- 70 55!4.P%$,(( ((( '%$*


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T$/5,/+*/'%*( A-*,( '%4($

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P$/4/+*+

P$/4/+*+ 5()($*( ,%$( %$4(4 -%;%'(( #*(4/+*+ &-%%'(( #( -%;%'(( '%4/,((.

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P$/4/+*+ 5()($*( ,%$( #%4( -%4(4()( +(


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SP -*(.

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P%4/,(( 5()($*( ,%$(.

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R%+*+%+* /,(

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RPT : R*(( P%(-* A+5(

RP : >?


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!E)M% K%S)1

6. slide persentasi.ppt

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