6 october 2007illumina, inc. - igsp talk deirdre b. parsons 1 illumina, inc..::. a decade of...
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6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Illumina, Inc.
.::. a decade of beads .::.
.::. a handful of lessons .::.
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Illumina, Inc. – The Big Picture
• So where did the technology and the company come from? And why is it unique?
– Technology derived from an academic chemistry laboratory
• What lessons can we as scientists learn from the Illumina story?
– Development of Illumina’s technology teaches scientists commercialization lessons of their inventions
• What lessons can those in policy-making positions learn from this story?
– Case study illustrates the intentions of the Bayh-Dole Act of 1980
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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What is Illumina today?
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Technological Applications
• SNP Genotyping
• Gene Expression
• Proteomics
• Drug/pharmaceutical screening
• Chemical/odor sensing
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Illumina Partnerships• GlaxoSmithKline, PLC• ChevronTexaco Energy/Research• Genome Quebec Innovation Centre• The Wellcome Trust Sanger Institute• National Center Biochip Technology• Johns Hopkins University• Whitehead Institute• University of Tokyo• Centre National de Genotypage• University of Southern California• University of California, Los Angeles• Genomas, Inc.• The Wellcome Trust Sanger Institute• Galileo Genomics, Inc. / Genzion Biosciences, Inc.• North American Rheumatoid Arthritis Consortium• Invitrogen, Inc.• National Cancer Institute• Max-Planck Institute of Psychiatry• PARC Team• PharmacoDesign• Cancer Research UK: Edinburgh University Colon Cancer
Genetics Group; Institute of Cancer Research; Cancer Research UK London Research Institute
• Aviagen, Inc.• North Shore-Long Island Jewish Health System• University of Pennsylvania, the Broad Institute, the CARe
Consortium
• SAIC-Frederick, Inc.• Center for Inherited Disease Research (CIDR) • Shafallah Center• deCODE• The Children's Hospital of Philadelphia• Johnson & Johnson Pharmaceutical R&D, LLC• ReaMetrix• Massachusetts General Hospital; Harvard Medical School• The United States Department of Agriculture (USDA)
Agricultural Research Service (ARS), the University of Missouri-Columbia (MU) and the University of Alberta (UA)
• MicroArray Quality Control (MAQC) project: FDA, NIH, EPA and USDA
• Duke University• Top 5 Pharmaceutical companies• Amgen / Brigham & Women's Hospital• Erasmus MC• The Genome Institute of Singapore• Children's Hospital of Eastern Ontario• Mayo Clinic• Asuragen• deCODE• National Genome Research Network• Golden Helix• IntegraGen• National Institute of Genomic Medicine (INMEGEN)• SNP Genetics
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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So where did it all begin?
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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David Walt, Ph.D.Department of Chemistry
Tufts University
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Technological Origins
Covalentattachment
Sensor
Single opticalfiber
to camerafor detection
Target
Major limitation: ONE sensor per fiber optic cable
to camerafor detection
to camerafor detection
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Bundled optical fiber
Technological Development
Single optical fiber Pointed optical fiber
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Optical fiber with wells…
… and BEADS!Images courtesy of David R. Walt, PhD
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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BeadArray Technology
Generation of random arrays
Binding changes dye color of bead
Pools of beads
Fluorescent light signals to detector
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Chronology of Key Events
96 97 98 99 00 01 02 03 04 05 06 07
Beads in wells
Pittsburgh Conference
Series A financing
Series B financing
Series C financingIPO raises $103 Million
Illumina founded
nGenetics acquired
FastTrack Genotyping
HapMap Project
Spyder acquired
CyVera acquired
Solexa merger
1M SNP BeadChip
Tec
hn
olo
gy
Fin
ance
Bu
s in
e ss
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Things to consider1. This is a story about a company with unique technology
2. That technology was developed by a researcher• Hero story• Balance of Open Science Norms and Commercialization
3. Many factors impacted the success of the researcher, the technology and the company:
• Knowledge of IP
• Timing• Industrial partnerships• Due diligence on many fronts• Technology transfer
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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What does this mean for YOU?
• Performing open academic science and commercializing your inventions is possible
• Knowledge of intellectual property is the vehicle
• Realistic expectations is a requirement
6 October 2007 Illumina, Inc. - IGSP TalkDeirdre B. Parsons
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Acknowledgements
Center for Genome Ethics, Law & Policy
• Bob Cook-Deegan, MD• Subhashini Chandrasekharan, PhD
Master’s Committee• Hunt Willard, PhD• Fred Dietrich, PhD
Fuqua School of Business• Ronnie Chatterji, PhD
Columbia University – School of Public Policy
• Bhaven Sampat, PhD
Tufts University• David Walt, PhD• Peggy Newell, Vice Provost• Martin Son, OTLIC• Nina Green, Director, OTLIC
Illumina, Inc.• John Stuelpnagel, DVM• Todd Dickinson, PhD• Maurissa Bornstein
BioVenture Investors• Marc Goldberg
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C
GA