52 - · pdf fileof medical oncology, and leading pharmaceutical industries, ... bevilacqua...

52nd Annual Meeting of the Italian Cancer Society

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bridging the gap between cancer researchand effective therapies


Lost in translation:Lost in translation:Rome, 4 - 7 October 2010Rome, 4 - 7 October 2010

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Angelicum Congress CentreAngelicum Congress Centre

Contents

Speakers ................................................................................................ pag. 7

Scientific Programme ................................................................................ pag. 11

Posters ...................................................................................................... pag. 27

Information

Scientific Information ................................................................... pag. 74

General Information ................................................................... pag. 77

Social Programme ........................................................................ pag. 79

Registration Information ............................................................ pag. 80

Practical Information ................................................................... pag. 81

Civic Museum of Rome ................................................................ pag. 84

Acknowledgements .................................................................................... pag. 86

Under the Auspices of

Sotto l’Alto Patronato del Presidente della Repubblica

I.S.O.Istituto Superiore di Oncologia

Presidenza del Consigliodei Ministri

Ministero della Salute

LILTUniversità Tor Vergata


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SIC Scientific BoardPresident

Alfredo Fusco (Università degli Studi Federico II, Napoli)

President Elect

Riccardo Dolcetti (Centro di Riferimento Oncologico, Aviano - Pordenone)

Board

Anna Bagnato (Istituto Nazionale Tumori Regina Elena, Roma)

Vincenzo Bronte (Università degli Studi, Padova)

Alfredo Budillon (Istituto Nazionale Tumori Fondazione G. Pascale, Napoli)

Maurizio D’Incalci (Istituto di Ricerche Farmacologiche Mario Negri, Milano)

Silvia Giordano (Università degli Studi, Torino)

Salvatore Pece (Istituto Europeo di Oncologia, Milano)

Katia Scotlandi (Istituti Ortopedici Rizzoli, Bologna)

Gabriella Sozzi (Fondazione IRCCS Istituto Nazionale Tumori, Milano)

Stefania Tommasi (Istituto Tumori Giovanni Paolo II, Bari)

Past President

Adriana Albini (IRCCS Multimedica, Sesto San Giovanni - Milano)

Scientific CoordinatorsDonatella Del Bufalo (Istituto Nazionale Tumori Regina Elena, Roma)

Michele Milella (Istituto Nazionale Tumori Regina Elena, Roma)

Local Scientific CommitteeAnna Bagnato (Istituto Nazionale Tumori Regina Elena, Roma)

Annamaria Biroccio (Istituto Nazionale Tumori Regina Elena, Roma)

Stefania D’Atri (Istituto Dermopatico dell’Immacolata, Roma)

Ruggero De Maria (Istituto Superiore di Sanità, Roma)

Rita Falcioni (Istituto Nazionale Tumori Regina Elena, Roma)

Marcella Mottolese (Istituto Nazionale Tumori Regina Elena, Roma)

Giovanbattista Pani (Università Cattolica del Sacro Cuore, Roma)

Angela Santoni (Università degli Studi Sapienza, Roma)

Agostino Tafuri (Università degli Studi Sapienza, Roma)

Giuseppe Tonini (Università Campus Bio-Medico, Roma)

Organizing Secretariat AIM GroupAntonella FerraroRome Office: via Flaminia, 1068 - 00189 Romeph. +39 06 330531 - fax +39 06 [email protected]/2010/cancerologia

SIC Secretariat Società Italiana di CancerologiaMariaenrica ZunicaVia G. Venezian, 1 - 20133 Milanph. +39 02 2666895 - fax +39 02 [email protected] - www.cancerologia.it


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Welcome Letter

Dear colleagues and friends,We are delighted to invite you to Rome, October 4-7, 2010 for the 52nd Annual Meeting of the Italian Cancer Society (SIC). The Meeting will be organized in symposia, lectures, oral presentation sessions and poster discussions, covering the most exciting breakthroughs in laboratory, translational, and clinical research.Outstanding experts have agreed to share their latest results from cutting-edge basic and discovery-driven translational cancer research. We will also have an important join session with the Italian Association of Medical Oncology, and leading pharmaceutical industries, highlighting successes and pitfalls in the translation of exciting preclinical findings into novel new therapeutic approaches at the patient’s bedside. Traditionally, the lecture in memory of Prof. Giorgio Prodi will be given by an internationally recognized Italian investigator. We especially want to invite young investigators to participate in this Meeting, which offers an excellent opportunity to share one’s own research and to network with other investigators and young SIC members. Young investigators’ participation will be encouraged by the “Piero Trivella”, “Graziella Persico” and “European Association for Cancer Research” (EACR) Awards for the best poster presentations, by “Istituto Regina Elena” Prize for the best oral selected presentation, by the “Elena Cappannini” Award for the best 2009 publication, and by Pezcoller Foundation scholarship.

The Conference venue will be the Angelicum Congress Centre. Dating back to 1569, such historical location is situated in the heart of the Eternal City, a few meters from Piazza Venezia, Coliseum, Imperial Fora and the Quirinal Palace. Some of the greatest masters of the 17th century, such as Gian Lorenzo Bernini and Giacomo della Porta, have left their imprinting on the architecture and decor of the building.

We would like to express our sincere appreciation to members of the SIC board and of the Local Scientific Committee for their hard work and dedication in formulating the excellent Scientific Programme.We hope you will take advantage all of the outstanding science that the Annual Meeting has to offer by registering early and submitting an abstract within June 15, 2010.

We look forward to welcoming you all in Rome.

Donatella Del Bufalo Michele Milella Alfredo Fusco Scientific Coordinator Scientific Coordinator SIC President

Albini AdrianaMultimedica Castellanza (VA), Oncology Rese-arch Science and Technology Pole, Casa di Cura MultiMedica Spa - IRCCS, Milan, Italy

Agami ReuvenDivision of Gene Regulation, the Netherlands Cancer Institute, Amsterdam, The Netherlands

Aglietta MassimoDepartment of Clinical Oncology, Institute for Cancer Research and Treatment, University of Turin, Candiolo, Italy

Andreeff MichaelSection of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Anichini Andrea Experimental Oncology and Molecular Medicine, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy

Bagnato AnnaExperimental Research Center Regina Elena National Cancer Institute, Rome, Italy

Bevilacqua GenerosoDepartement Oncology, University of Pisa, Italy

Biroccio AnnamariaExperimental Research Center Regina Elena National Cancer Institute, Rome, Italy

Bronte VincenzoVeneto Oncology Institute (IOV) and Venetian Institute for Molecular Medicine (VIMM), Padua, Italy

Budillon Alfredo Experimental Pharmacology Unit, Dept. Experimental Oncology, National Cancer Institute, G. Pascale, Naples, Italy

Bussolino FedericoDepartment of Oncological Sciences, Institute for Cancer Research and Treatment, University of Turin, Candiolo, Italy

Ciardiello FortunatoDivision of Medical Oncology, Department of Experimental and Clinical Medicine and Surgery, Second University of Naples, Italy

Clarke Robert B.School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester, UK

Colombo Mario P.Molecular Immunology Unit, Department ofExperimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Croce Carlo M.Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, Ohio, USA

Speakers


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D’Atri StefaniaLaboratory of Molecular Oncology, Istituto Dermopatico dell’Immacolata-IRCCS, Rome, Italy

D’Incalci MaurizioDepartment of Oncology Mario Negri Institute for Pharmacological Research, Milan Italy

De Maria RuggeroIstituto Superiore di Sanità, Rome, Italy

Del Bufalo DonatellaExperimental Research Center Regina Elena National Cancer Institute, Rome, Italy

Dolcetti RiccardoCancer Bio-Immunotherapy Unit CRO - IRCCS, National Cancer Institute, Aviano, Italy

Dejana ElisabettaIFOM Foundation, IFOM-IEO Campus, University of Milan, Milan, Italy

De Maria RuggeroDepartment of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

Di Fiore Pier PaoloIFOM Foundation, Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, University of Milan, Milan, Italy

Di Nicolantonio FedericaLaboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Turin, Candiolo, Italy

Falcioni RitaExperimental Research Center Regina Elena National Cancer Institute, Rome, Italy

Foti Margaret American Association for Cancer Research, Philadelphia, USA

Frese KristopherCambridge Research Institute, Cancer Research UK, Cambridge, UK

Fusco AlfredoInstitute of Experimental Endocrinology and Oncology, National Research Council, Naples, Italy

Gallo Jorge D.Early Development Group, Oncology Business Unit, Pfizer Italia, Milan, Italy

Giavazzi RaffaellaDepartement of Oncology, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy

Giordano SilviaUniversità degli Studi, Turin, Italy

Gulino AlbertoLaboratory of Molecular Oncology, Department of Experimental Medicine, Sapienza University of Rome, Italy

Kroemer GuidoINSERM, Institut Gustave Roussy, Villejuif, France

Lillie TomAmgen Dompè, Uxbridge, UK

Marchetti PaoloOrdinario di Oncologia Medica e Direttore Unità Operativa Complessa di Oncologia, Azienda ospedaliera Sant’Andrea II facoltà di Medicina e chirurgia Università La Sapienza di Roma.

Melino GerryBiochemistry Laboratory, IDI-IRCCS, Department of Experimental Medicine and Biochemical Sciences, Tor Vergata University of Rome, Italy

Milella MicheleMedical Oncology Department Regina Elena National Cancer Institute, Rome, Italy

Mottolese Marcella Pathology Department Regina Elena National Cancer Institute, Rome, Italy

Natali Pier GiorgioExperimental Research Center Regina Elena National Cancer Institute, Rome, Italy

Pani Giovanbattista Università Cattolica del Sacro Cuore, Institute of General Pathology, Rome, Italy

Poeta Maria LuanaUniversità Campus Bio Medico, Rome, Italy

Pece Salvatore Department of Experimental Oncology IFOM - IEO Campus, Milan, Italy

Pelicci Pier GiuseppeDepartment of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Milan, Italy

Peters MoserNovartis Pharma, Basel, Switzerland

Piaggio GiuliaMolecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena National Cancer Institute, Rome, Italy

Piccolo StefanoDepartment of Medical Biotechnologies, University of Padua, Italy

Pierotti Marco A.Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Yuri Rukazenkov AstraZeneca Global R&D, Macclesfield, UK

Santoni AngelaDepartment of Molecular Medecine “Sapienza” University, Rome, Italy

Sacchi AdaExperimental Research Center Regina Elena National Cancer Institute, Rome, Italy

S. Scherer ?Global BioMarker, Roche/Genentech Inc, San Francisco, California, USA



Lost in translation:Lost in translation:Rome, 4 - 7 October 2010Rome, 4 - 7 October 2010Angelicum Congress CentreAngelicum Congress Centre


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Sozzi GabriellaDep. of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy

Scotlandi KatiaIstituti Ortopedici Rizzoli, Bologna, Italy

Stunnenberg Hendrik G.Radboud University Nijmegen, Nijmegen Center for Molecular Life Sciences, Department of Molecular Biology, Nijmegen, The Netherlands

Tafuri AgostinoDepartment of “Biotecnologie Cellulari ed Ematologia”, “Sapienza” University of Rome, Italy

Tommasi StefaniaNational Cancer Centre “Giovanni Paolo II”, Bari, Italy

Tonini GiuseppeMedical Oncology University Campus Bio-Medico, Rome, Italy

Vacca AngeloDepartment of Internal Medicine and Clinical Oncology, University of Bari, Italy

Vecchio GiancarloDipartimento Di Biologia E Patologia Cellulare E Molecolare “L.Califano”, University of Naples, Italy

Vousden Karen H.The Beatson Institute for Cancer Research, Glasgow, Scotland, UK

Zupi GabriellaExperimental Research Center Regina Elena National Cancer Institute, Rome, Italy

Scientific Programme


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Scientific ProgrammeMonday, October 4

14.00-19.00 REGISTRATION AND POSTER HANGING

15.00-16.15 OPENING CEREMONY Greetings from the Authorities

16.15-17.00 OPENING LECTURE Functions of wild type and mutant p53 K. Vousden (Glasgow, UK) - Sponsored by Fondazione Federico Calabresi

17.00 - 19.00 CANCER STEM CELLS Chairs: S. Pece (Naples, Italy), P.G. Natali (Rome, Italy)

Cancer stem cells from solid tumors: towards clinical application R. De Maria (Rome - Italy)

CANCER INITIATING CELLS IN K-RASG12V INDUCED LUNG ADENOCARCINOMA S. Mainardi (Molecular Oncology Programme, Fundación Centro Nacional de Investigaciones Oncológicas - Madrid, Spain), M. Barbacid

Endocytosis, stem cells and cancer P.P. Di Fiore (Milan - Italy)

EPITHELIAL-MESENCHYMAL TRANSITION CONFERS STEM-LIKE PROPERTIES TO LUNG TUMOR CELLS G. Bertolini (Fondazione IRCCS Istituto Nazionale Tumori Milano - Department of Experimental Oncology and Molecular Medicine - Milan, Italy), L. Roz, M. Boeri, G. Sozzi

Stem cells and breast cancer: treatment resistance, markers and novel therapeutic targets R.B. Clarke (Manchester - UK) - Sponsored by EACR

19.00 Welcome Cocktail

Tuesday, October 5

8.00 - 18.30 REGISTRATION

08.30 - 12.30 EPIGENETIC ALTERATIONS IN CANCER Chairs: S. Tommasi (Bari, Italy), G. Vecchio (Naples, Italy)

p73/p63 in cancer progression G. Melino (Rome, Italy)

ENDOGENOUS C-JUN ACTS AS A NEGATIVE MODULATOR IN MOUSE HEPATOCYTE PROLIFERATION INDUCED BY LIGANDS OF NUCLEAR RECEPTORS A. Columbano (Department of Toxicology - Cagliari, Italy) , V. Leoni, G.M. Ledda-Columbano, M. Pibiri, C. Saliba, A. Perra, M.A. Kowalik, O.M.V. Grobe, M. Ravo, A. Weisz, E. Ghiso, S. Giordano

A systems biology approach to decipher Acute Myeloid Leukemia H.G. Stunnenberg (Nijmegen - The Netherlands)

ONCOSUPPRESSOR METHYLATION: A POSSIBLE KEY ROLE IN COLON METASTATIC PROGRESSION R. Pinto (Istituto Tumori Giovanni Paolo II - Bari, Italy), D. Petriella, R. Lacalamita, G. Iannelli, N. Silvestris, G. Colucci, A. Paradiso, S. Tommasi

The epigenetic regulator NF-Y as a track of cell proliferation in vivo G. Piaggio (Rome - Italy)

10.30-11.00 Coffee break

Cancerous microRNAs and regulatory RNA binding proteins R. Agami (Amsterdam - The Netherlands)

P195 MIR-1 DOWNREGULATION PLAYS A CRITICAL ROLE IN THYROID CELL PROLIFERATION V. Leone (IEOS del CNR c/o Dipartimento di Biol. e Pat. Cell. e Mol., Facoltà di Medicina e Chirurgia, Università Federico II - Naples, Italy), D. D’Angelo, P.L. Pallante, A. Ferraro, E. Borbone, A. Fusco


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Scientific ProgrammeP282 TRANSCRIPTIONAL MODULES PREDICTING RESPONSE TO EGFR-TARGETED THERAPY OF KRAS- AND BRAF-WILD TYPE COLORECTAL CANCERS E. Medico (Institute for Cancer Research and Treatment, University of Torino, Candiolo - Turin, Italy), C. Petti, G. Picco, A. Bertotti, L. Trusolino, C. Isella

P269 PATHWAY PROFILING OF LASER CAPTURE MICRODISSECTED COLORECTAL CANCER REVEALS THE PRESENCE OF EARLY MARKERS OF AGGRESSIVENESS A. Silvestri (CRO IRCCS, National Cancer Institute, Department of Experimental Oncology 2, Aviano, Italy), C. Belluco, M. Pierobon, E. Mammano, V. Calvert, J. Deng, F. De Marchi, A. Colombatti, D. Nitti, L. Liotta, E. Petricoin

P291 MICRORNAS INVOLVEMENT IN FLUDARABINE REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA M. Ferracin (University of Ferrara - Dipartimento di Medicina Sperimentale e Diagnostica, Ferrara, Italy), B. Zagatti, L. Rizzotto, F. Cavazzini, M. Ciccone, E. Saccenti, L. Lupini, M. Negrini, A. Cuneo

P268 STATHMIN EXPRESSION AND P53 STATUS: A NEW RATIONALE FOR THE MANAGMENT OF OVARIAN CANCER M. Sonego (Centro di Riferimento Oncologico, Dep. of Experimental Oncology 2 - Aviano, Italy), M. Schiappacassi, M. Bagnoli, A. Dall’acqua, S. Lovisa, S. Canevari, G. Baldassarre

P298 A MOUSE TO HUMAN AUTOANTIBODY SIGNATURE IN PANCREATIC DUCTAL ADENOCARCINOMA M. Capello (Center for Experimental Research and Medical Studies (CeRMS), University of Turin - Turin, Italy), P. Cappello, F.C. Linty, A. Scarpa, P. Pederzoli, P. Nisticò, M. Milella, F. Novelli

P308 MASPIN EXPRESSION IS A FAVORABLE PROGNOSTIC FACTOR IN NON-SMALL CELL LUNG CANCER R. Berardi (Clinica Di Oncologia Medica. Università Politecnica Delle Marche - Ancona, Italy), A. Santinelli, A. Onofri, M. Scartozzi, E. Pisa, A. Brunelli, D. Stramazzotti, A. Sabbatini, S. Gasparini, A. Fianchini, S. Cascinu

P290 BLOCKING ERBB-3/P85 INTERACTION BY A PHSPHOTYROSYL PEPTIDE INDUCES APOPTOSIS IN BREAST CANCER. A NEW STRATEGY TO ESCAPE HERCEPTIN RESISTANCE V. Folgiero (Regina Elena Cancer Institue, Department of Experimental Oncology - Rome, Italy), S.E. Di Carlo, G. Bon, E. Spugnini, A. Di Benedetto, M. Milella, A. Fabi, M. Mottolese, G. Bossi, R. Falcioni

HIPK2-MEDIATED PHOSPHORYLATION OF H2B AT MIDBODY IS REQUIRED FOR CYTOKINESIS C. Rinaldo (Regina Elena National Cancer Institute-Dip Oncologia Sperimentale - Rome, Italy), A. Moncada, F. Siepi, A. Gradi, L. Ciuffini, D. D’Eliseo, G. Pierantoni, F. Esposito, F. Trapasso, A. Giorgi, E. Cundari, A. Fusco, E. Schininà, S. Soddu

Causes and consequences of microRNA dysregulation in cancer C.M. Croce (Columbus - USA)

12.30-12.45 Greetings from Italian Ministry of Welfare, Sen. Maurizio Sacconi

12.45-13.00 The social burden of cancer and the strategic importance of research F. Cognetti (Rome, Italy)

13.00-14.00 Lunch and poster viewing

14.00-17.00 PARALLEL POSTER DISCUSSION

14.00 - 15.30 POSTER DISCUSSION (ROOM MAjOR):

MOLECULARMARKERSOFDIAGNOSIS,PROGNOSIS,ANDRESPONSETOTHERAPYChairs: G. Bevilacqua (Pisa, Italy), G. Sozzi (Milan, Italy)

P306 MICRORNA EXPRESSION PROFILES OF TUMORS, NORMAL LUNG TISSUES AND PLASMA SAMPLES FROM SPIRAL-COMPUTED TOMOGRAPHY (CT) TRIAL FOR EARLY LUNG CANCER DETECTION M. Boeri (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy), C. Verri, L. Roz, D. Conte, P.G. Modena, F. Facchinetti, C.M. Croce, U. Pastorino, G. Sozzi

P59 HMENA/HMENA11A COOPERATE WITH EGFR FAMILY SIGNALLING PATHWAYS IN BREAST CANCER P. Trono (Regina Elena National Cancer Institute - Rome, Italy), F. Di Modugno, M. Mottolese, I. Terrenato, L. DeMonte, A. Di Benedetto, F. Belleudi, A. Santoni, P. Nisticò


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Scientific ProgrammeP63 THE EXPRESSION AND SUB-CELLULAR LOCALIZATION OF BCRP ARE AFFECTED BY EGFR PATHWAY IN NSCLC L. Porcelli (National Cancer Institute Giovanni Paolo II - Bari, Italy), G. Jansen, E. Giovannetti, G.L. Scheffer, G.J.P. Peters, A. Paradiso, A. Azzariti

P57 TARGETING IGF SIGNALING IN HERCEPTIN-RESISTANT BREAST CANCER S. Napoletano (Angiogenesis and Metastasis Research, RCSI - Dublin, Ireland), K. Ilm, J.H. Harmey

P194 ABL ACTIVITY IS REQUIRED FOR MET-TRIGGERED CELL SURVIVAL AND TUMORIGENESIS A. Furlan, A. Hussain, V. Stagni, S. Richelme, F. Conti, A. Moumen, A. Prodosmo, A. Destro, I. del Barco Barrantes, J.S.C. Arthur, A. Nebreda, M. Roncalli, D. Barilà (Lab. Cell Signaling, IRCCS Fondazione Santa Lucia and Department of Biology University of Tor Vergata - Rome, Italy), F. Maina

P71 IDENTIFICATION OF NEW KINASES INVOLVED IN THYROID CARCINOGENESIS THROUGH AN RNA INTERFERENCE SCREEN M. Castellone (IEOS/ CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare - Naples, Italy), M.C. Cantisani, M. Muthu, R. Bellelli, O. Kallioniemi, M. Santoro

P60 ERK5 IS OVEREXPRESSED IN EXPERIMENTAL LIVER INJURY AND IN HEPATOCELLULAR CARCINOMA (HCC) AND IS MODULATED BY SOLUBLE FACTORS IN HCC CELLS E. Rovida, N. Navari, S. Cannito, S. Giuntoli, G. Di Maira (University of Florence, Italy), P. Dello Sbarba, M. Parola, F. Marra

P273 ROLE OF DELTA16HER2 SPLICE VARIANT IN HER2-DRIVEN TUMOR GROWTH S. Pupa (Molecular Targeting Unit, Dept. Exp. Oncol. and Molecular Medicine, National Cancer Institute, Foundation IRCCS - Milan, Italy), A. Rossini, F. Gabrielli, C. Marchini, V. Ciravolo, P.A. Aiello, M. Montani, L. Pietrella, M. Iezzi, P. Musiani, E. Tagliabue, S. Ménard, A. Amici

14.00 - 15.30 POSTER DISCUSSION (ROOM MINOR):

CANCERGENETIC,DNADAMAGE,SIGNALTRANSDUCTIONChairs: A. Sacchi (Rome, Italy), L. Poeta (Rome, Italy)

P214 EPIGENETIC MECHANISMS UNDERLYING THE TRANSCRIPTIONAL REGULATION OF THE MICRORNA LET-7C IN ACUTE PROMYELOCYTIC LEUKEMIA S. Careccia, A. Pelosi (Regina Elena National Cancer Institute - Rome, Italy), V. Azzimato, N.G. Sukubo, A. Gurtner, J. Martens, M. Levrero, H.G. Stunnenberg, G. Piaggio, M.G. Rizzo

P178 TRANSCRIPTIONAL REPROGRAMMING BY E1A-ONCOGENE F. Nicassio (Milan, Italy), M. Marzi, E. Puggioni, V. Dall’olio, L. Bernard, M. Crescenzi, F. Bianchi, P.P. Di Fiore

P218 DECIPHERING THE TRANSCRIPTIONAL COMPLEX CRITICAL FOR EPIGENETIC REGULATION OF ENDOTHELIN-1 GENE EXPRESSION IN OVARIAN CANCER L. Rosanò (Regina Elena National Cancer Research, Molecular Pathology Laboratory - Rome, Italy), R. Cianfrocca, V. Di Castro, F. Spinella, P.G. Natali, A. Bagnato

P322 CHE-1 PROMOTES TUMOR CELL SURVIVAL BY SUSTAINING MUTANT P53 TRANSCRIPTION AND INHIBITING DNA DAMAGE RESPONSE ACTIVATION A. Desantis, T. Bruno, G. Bossi, S. Di Agostino, C. Sorino, F. De Nicola, S. Iezzi, A. Franchitto, B. Benassi, S. Galanti, F. La Rosa, A. Floridi, C. Passananti, G. Blandino, M. Fanciulli (Regina Elena National Cancer Institute - Rome, Italy)

P324 INDUCTION OF OCT-6/TST-1 POU DOMAIN TRANSCRIPTION FACTOR BY DOXORUBICIN: ROLE IN THE CONTROL OF REACTIVE OXYGEN SPECIES M. Cippitelli (Dipartimento di Medicina Molecolare, University of Rome -Sapienza- and Regina Elena Cancer Institute, CRS -Rome, Italy), D. Di Bona, C. Fionda, G. Malgarini, A. Santoni


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Scientific ProgrammeP38 METABOLIC ALTERATIONS AND PROTEOMIC PROFILE OF HUMAN CANCER CELLS RESISTANT TO HER INHIBITORS R. Rosa (Dept. Endocrinologia e Oncologia Molecolare e Clinica, Università Federico II - Naples, Italy), M. Vitale, F. Monteleone, L. Cardone, T. Gelardi, R. Bianco, V. Damiano, M. Succoio, C. D’ambrosio, A. Scaloni, N. Zambrano, G. Tortora

P79 COMBINATIONS OF RETINOIDS AND LAPATINIB IN THE TREATMENT OF BREAST CARCINOMAS WITH CO-AMPLIFICATION OF THE ERBB2 AND RARA GENES G. Paroni (Istituto di Ricerche Farmacologiche Mario Negri - Milan, Italy), V. Guarnaccia, A. Zanetti, C. Bassano, G. Gardini, E. Garattini

P16 SYNERGISTIC ANTITUMOR EFFECTS OF ‘VERTICAL’ COMBINATION STRATEGIES INHIBITING MULTIPLE STEPS ALONG THE RAF/MEK/ERK CASCADE M. Milella (Regina Elena National Cancer Institute - Rome, Italy), M.R. Ricciardi, L. Ciuffreda, P. Bergamo, S. Iacovelli, C. Di Sanza, U. Cesta Incani, F. Cognetti, D. Del Bufalo, A. Tafuri

P14 COMBINATIONS OF CHEMOTHERAPY AND BEVACIZUMAB IN A XENOGRAFT MODEL OF HUMAN OVARIAN CARCINOMA P. Oliva (Laboratory of Biology and Treatment of Metastases, Dept. Oncology, Mario Negri Institute for Pharmacological Research - Milan, Italy), A. Decio, V. Castiglioni, D. Belotti, M.R. Bani, R. Giavazzi

15.30 - 17.00 POSTER DISCUSSION (ROOM MINOR):

TUMORIMMUNOLOGYANDMICROENVIRONMENTChairs: A. Anichini (Milan, Italy), R. Falcioni (Rome, Italy)

P163 ECO-GUIDED INTRATUMORAL INJECTION OF CCL16 AND CPG COUPLED WITH SYSTEMIC IL-10 INHIBITION CURES ORTHOTOPICALLY IMPLANTED TRAMP TUMORS G. Mauri (IRCCS Istituto Nazionale dei Tumori, Department of Experimental Oncology, Molecular Immunology Unit - Milan, Italy), C. Tripodo, L. Babini, M. Parenza, C. Chiodoni, M.P. Colombo

P167 A NOVEL BIOLOGICAL SYSTEM TO STUDY THE IMMUNE THERAPEUTIC ROLE OF LEPTIN IN CANCER M. Galgani (Istituto di Endocrinologia ed Oncologia Sperimentale G. Salvatore CNR - Naples, Italy), G. Matarese

15.30 - 17.00 POSTER DISCUSSION (ROOM MAjOR):

INNOVATIVETHERAPIESANDMECHANISMSOFDRUGRESISTANCEChairs: K. Scotlandi (Bologna, Italy), G. Zupi (Rome, Italy)

P27 FREG PEPTIDE INHIBITS MELANOMA GROWTH IN VITRO AND IN VIVO A. Facchiano (Laboratorio Patologia Vascolare, Istituto Dermopatico della Immacolata, IDI-IRCSS - Rome, Italy), M.S. Aguzzi, D. Faraone, G. Toietta, D. Ribatti, A. Parazzoli, P. Colombo, M.C. Capogrossi

P09 CPTH6 INHIBITS HISTONE ACETYLTRANSFERASE ACTIVITY IN HUMAN LEUKAEMIA CELL LINES Y. Ragazzoni, C. Gabellini (Experimental Chemotherapy Laboratory,Regina Elena National Cancer Institute - Rome, Italy), A. Pelosi, M. Desideri, P. Filetici, D. Secci, M.G. Rizzo, D. Del Bufalo, D. Trisciuoglio

P49 CHARACTERIZATION OF A NEW MYXOID LIPOSARCOMA RESISTANT CELL LINE: INVOLVEMENT OF TRANSCRIPTION REGULATION I. Fuso Nerini, S. Uboldi, S. Bernasconi, M. Romano, F. Sala, S. Di Giandomenico (Istituto di Ricerche Farmacologiche Mario Negri, Dipartimento di Oncologia - Milan, Italy), G. Damia, M. Ganzinelli, E. Erba, M. D’Incalci

P48 PRECLINICAL RESULTS OF HUMAN MONOCLONAL ANTIBODY ANTI-IGF1R AVE1642 (SANOFI-AVENTIS) IN EWING’S SARCOMA AND POSSIBLE MECHANISM OF RESISTANCE C. Garofalo (Istituto Ortopedico Rizzoli - Experimental Oncology Lab - Bologna, Italy), M.C. Manara, M.T. Marino, P. Picci, K. Scotlandi

P29- ACTIVITY OF ZOLEDRONIC ACID ON THE INTERACTION BETWEEN MESENCHYMAL STEM CELLS AND BREAST CANCER CELLS N. Normanno (INT-Fondazione Pascale- Cell Biology and Biotherapy Unit, Naples, Italy), M. Gallo, L. Lamura, A. De Luca

P42 THE P38 KINASE PATHWAY IS INVOLVED IN THE RESISTANCE OF PROSTATE CANCER CELLS TO ZOLEDRONIC ACID B. Pucci (Mercogliano Oncology Research Center (Crom) - Mercogliano, Italy), M.R. Milone, M. Rocco, G. Piro, F. Bruzzese, A. Budillon


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Scientific ProgrammeP121 VITAMIN D3 REGULATES PDLIM2 EXPRESSION IN MCF7 BREAST CANCER CELLS E. Vanoirbeek (Katholieke Universiteit Leuven Laboratorium voor Experimentele Geneeskunde en Endocrinologie - Leuven, Belgium), G. Eelen, I. Buellens, M. Van Camp, L. Verlinden, S. Marcelis, K. Marchal, R. Bouillon, A. Verstuyf

P226 THE EFFECTS OF CARBON NANOTUBES ON ANGIOGENESIS AND METABOLIC FUNCTIONS E. Cesana (Oncological Research Area, Casa di cura Multimedica-IRCCS -Milan, Italy), R. Cammarota, E. Principi, I. Sogno, A. Parodi, D. Noonan, A. Albini


17.20 - 18.50 CANCER MODELING Chairs: S. Giordano (Turin, Italy), R. Giavazzi (Milan, Italy)

Pancreatic cancer models and medicine K. Frese (Cambridge - UK)

GENERATING A PANCREATIC CANCER MOUSE MODEL: FROM CANCER STEM CELLS TO IN VIVO IMAGING STRATEGIES R. Ritelli (ARC-NET Research Centre, University of Verona, Policlinico G.B. Rossi - Verona, Italy), M. Dandrea, L. Calderan, F. Boschi, P. Marzola, A. Scarpa

P328CELL DELIVERY OF PEPTIDES MIMICKING THE DOCKING SITE OF MET INHIBITS ANGIOGENESIS AND VASCULAR TUMOR GROWTH R. Cammarota (Casa di Cura MultiMedica - IRCCS - Milan, Italy), A.R. Cantelmo, D.M. Noonan, C. Focaccetti, M. Prat, A. Albini

Molecular basis of vascular stabilization in tumors E. Dejana (Milan - Italy)

18.50-19.50 Meeting of SIC Young Investigators

P160 HER2/NEU OVEREXPRESSING BREAST CANCER PATIENTS RETAIN AN IMMUNOLOGICAL PROFICIENCY COMPROMISED IN HER2/NEU-NEGATIVE CASES E. Muraro (Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Cancer Bio-Immunotherapy Unit - Aviano, Italy), D. Martorelli, E. Turchet, G. Miolo, S. Scalone, E. Comaro, R. Talamini, A. Veronesi, D. Crivellari, R. Dolcetti

P102 CHEMOKINE NITRATION PREVENTS INTRATUMORAL INFILTRATION OF ANTIGEN-SPECIFIC T CELLS B. Molon (Istituto Oncologico Veneto-IOV-IRCCS - Padua, Italy), S. Ugel, F. Del Pozzo, C. Soldani, D. Avella, A. De Palma, A. Monegal, B. Savino, A. Gasco, A. Viola, V. Bronte

P91 NOTCH SIGNALING PROMOTES OXIDATIVE STRESS DEFENSE: IMPLICATION IN NOTCH CANCER BIOLOGY S. Manca, S. Cialfi, L. Barbieri, G. Biolcati, D. Uccelletti, C. Palleschi, A. Magrelli, M. Salvatore, D. Taruscio, I. Screpanti, C. Talora (Sapienza Università di Roma, Dip. Medicina Sperimentale - Rome, Italy)

P241 MET-ONCOGENE TRANSFORMS HUMAN PRIMARY BONE-DERIVED CELLS BY TARGETING OSTEO PROGENITORS N. Dani, M. Olivero, S. Patanè, M. VanDuist, K. Mareschi, F. Fagioli, M.F. Di Renzo (Laboratory of Cancer Genetics, University School of Medicine, Institute for Cancer Research and treatment - Candiolo, Turin, Italy)

P128 MIRNAS IMPAIR MET-MEDIATED INVASIVE GROWTH C. Migliore (IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine - Candiolo, Italy), A. Petrelli, E. Ghiso, S. Corso, L. Capparuccia, A. Eramo, V. Leoni, L. Atzori, L. Zorcolo, G. Casula, A. Columbano, S. Giordano

P100 HIF-1 UPREGULATION BY IL-1 CONTRIBUTES TO THE MIGRATORY POTENTIAL OF BREAST CANCER CELLS I. Filippi, D. Miglietta, M. Moschetta, R. Giavazzi, F. Carraro, A. Naldini (Department of Physiology, University of Siena - Siena, Italy)


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Scientific Programme11.00-12.00 “GIORGIO PRODI” LECTURE

Introduction A. Fusco (Naples - Italy)

“Men, Mice and Molecules: Present-shaping Past” M.A. Pierotti (Milan - Italy)

12.00 - 12.45 AWARD CEREMONY

“Piero Trivella”, “Graziella Persico” and “EACR” Awards for the best posters

“Elena Cappannini” Award for the best 2009 publication

“Pezcoller Foundation” scholarship Award, Gios Bernardi, President

12.45 - 14.40 Lunch and Poster viewing

14.00 - 16.40 HIGHLIGHTS FROM PHARMA INDUSTRY Chairs: M. D’Incalci (Milan, Italy), G. Tonini (Rome, Italy)

Epidermal growth factor receptor and its first tyrosine kinase inhibitor Gefitinib - a journey of discoveryY. Rukazenkov (Macclesfield - UK)

Development of the PI3K inhibitor at Novartis Oncology M. Peters (Basel - Switzerland)

Focusing on new targets for the treatment of cancer: PF-3758309, a small-molecule, potent inhibitor of p21.activated kinase (PAK)j.D. Gallo (Milan - Italy)

Biomarkers and personalized healthcare in angiogenesis: unravel the tangle S. Scherer (S. Francisco - USA)

Pursuing answers on multiple fronts - Amgen Oncology DevelopmentT. Lillie (Uxbridge - UK)

title to be announced F. Russo ()

Wednesday, October 6

08.45 - 10.30 MOLECULAR MECHANISMS OF SENESCENCE AND CELL DEATH Chairs: R. Dolcetti (Aviano, Italy), A. Santoni (Rome, Italy)

The desirable death... of the cancer cell G. Kroemer (Villejuif - France)

CHARACTERIZATION OF A NEW CANCER-ASSOCIATED MUTANT OF P53 WITH A MISSENSE MUTATION (K351N) IN THE TETRAMERIZATION DOMAIN L. Tuosto (Istituto Pasteur - Fondazione Cenci Bolognetti, Department of Cellular Biology and Development, Sapienza University - Rome, Italy) M. Muscolini, E. Montagni, S. Caristi, M. Corazzari, M. Piacentini, G. Blandino, A. Costanzo, K. Sakaguchi

DELTA-NP63-ALPHA IS AN ONCOGENE THAT INHIBITS SENESCENCE AND PROMOTES TUMOR-INITIATING STEM-LIKE PROLIFERATION M. Pecoraro, V. Aranda, H. Vogel, S. Muthuswamy, A. Mills, W.M. Keyes (Centre for Genomic Regulation, Differentiation and Cancer Program - Barcelona, Spain)

Induction of senescence and cell death through interference with telomere maintenance mechanisms in human tumors N. Zaffaroni (Milan - Italy)

Pezcoller Foundation scholarship 2008 Winner Award TARGETING AUTOPHAGY IN CANCER THERAPY M.Pennati( Milan, Italy)

10.30 - 11.00 Coffee Break


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Scientific ProgrammeThursday, October 7

09.00-12.30 MICROENVIRONMENT AND TUMOR PROGRESSION Chairs: A. Albini (Milan, Italy) V. Bronte (Padua, Italy) Cell and matricellular accomplices for tumor development M.P. Colombo (Milan - Italy)

MET UPREGULATION BY IONIZING RADIATION FOSTERS CANCER INVASIVE GROWTH AND RADIORESISTANCE F. De Bacco (Institute for Cancer Research and Treatment - Candiolo, Italy), E. Casanova, P. Luraghi, G. Reato, B. Viola, T. Perera, P.M. Comoglio, C. Boccaccia

L-ARGININE DEPLETION IN THE TUMOR MICROENVIRONMENT PROMOTES MAMMARY TUMORIGENESIS S. Astigiano, M. Morini, A. De Lerma Barbaro, P. Damonte, D. Noonan, V. Bronte, O. Barbieri (Istituto Nazionale per la Ricerca sul Cancro -Genoa, Italy)

Synaptic proteins tackle angiogenesis F. Bussolino (Turin - Italy)


Epithelial plasticity and metastasis S. Piccolo (Padua - Italy)

HUMAN MYELOID-DERIVED SUPPRESSOR CELLS: INDUCTION IN VITRO WITH GROWTH FACTORS AND ANALYSIS OF MOLECULAR MECHANISMS OF IMMUNOSUPPRESSION S. Solito (Department of Oncology and Surgical Sciences, Oncology Section, University of Padua - Padua, Italy), E. Falisi, L. Pinton, S. Francescato, G. Basso, P. Zanovello, V. Bronte, S. Mandruzzato

16.40 - 17.00 Coffee break

17.00 - 19.00 DEVELOPMENT OF INNOVATIVE THERAPEUTICS (joint Meeting SIC - AIOM)

Towards personalized target therapies in colorectal cancer: - The genetic basis of response and resistance F. Di Nicolantonio (Turin - Italy)

- Challenges for patient selection F. Ciardiello (Naples - Italy) IMIDs and bisphosphonates affecting angiogenesis microenvironment and synergizing with chemo in patients with multiple myeloma A. Vacca (Bari - Italy)

The search for new therapeutic targets in sarcomas M. Aglietta (Turin - Italy)

Tumor and leukemia microenvironment: from biology to clinical target M. Andreeff (Houston - USA)

19.00 SIC General Assembly

20.30 Social Dinner at Open Colonna - Palazzo delle Esposizioni


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Scientific Programme MOLECULAR MECHANISMS CONTROLLING THE EXPRESSION OF NKG2D AND DNAM-1 LIGANDS ON DRUG-INDUCED SENESCENT MM CELLS: ROLE OF ROS AND DNA DAMAGE RESPONSE M. Iannitto (Sapienza University - Department of Experimental Medicine and Pathology - Istituto Pasteur-Fondazione Cenci Bolognetti - Rome, Italy), A. Soriani, M. Cippitelli, C. Fionda, G. Malgarini, M.R. Ricciardi, M.T. Petrucci, R. Guarini, R. Foà, A. Santoni

Regulation of Hedgehog/Gli function in neural stem/progenitor and medulloblastoma cells A. Gulino (Rome - Italy)

12.30-13.00 CLOSING LECTURE

Regulation of self-renewal in cancer stem cells P.G. Pelicci (Milan - Italy)

13.00 - 13.15 “ISTITUTO REGINA ELENA” AWARD FOR THE BEST ORAL SELECTED PRESENTATION

13.15 - 13.30 CLOSING REMARKS

Posters


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PostersINNOVATIVE THERAPEUTIC APPROACHES

P01 - HIGH ANTI-TUMOR EFFICACY OF COMBINED PROTEASOME INHIBITORS AND ASO TRADD ON CHEMORESISTANT HEPATOCARCINOMA CELLSE. Witort (University of Florence, Florence, Italy), A. Lupia, M. Lulli, S. Capaccioli

P02 - PROGRESS ON HPV VACCINE-BASED THERAPY FOR HEAD AND NECK CANCERA. Venuti (Regina Elena National Cancer Institute, Rome, Italy), R. Franconi

P03 - EGFP-HEC1 FUSION PROTEIN: A VALUABLE ALTERNATIVE TO HEC1-SIRNA FOR THE INDUCTION OF APOPTOSIS IN HUMAN CANCER CELLSP. Totta (CNR, Rome, Italy), G. Vargiu, F. Degrassi

P04 - LITHOCHOLIC ACID COMPETITIVELY INHIBITS EPHA2-EPHRINA1 BINDING: PHARMACOLOGICAL AND STRUCTURAL CONSIDERATIONSM. Tognolini (University of Parma, Parma, Italy), C. Giorgio, I.H. Mohamed, L. Flammini, M. Incerti, A. Lodola, E. Barocelli

P05 - A NOVEL GLUTATHIONE S-TRANSFERASE INHIBITOR ENHANCES TEMOZOLOMIDE EFFICACY AGAINST MALIGNANT MELANOMAL. Tentori (University of Tor Vergata, Rome, Italy), A.S. Dorio, E. Mazzon, A. Muzi, A. Sau, S. Cuzzocrea, G. Federici, A. M. Caccuri, G. Graziani P06 - DNA VACCINATION STRATEGIES FOR ANTI-TUMOUR EFFECTIVE GENE THERAPY PROTOCOLSE. Signori (CNR, Rome, Italy), P. Chiarella, E. Massi, M. De Robertis, V.M. Fazio

P07 - GENE EXPRESSION PROFILE OF MALIGNANT MELANOMA CELLS TREATED WITH A STRUCTURAL ANALOGUE OF CURCUMIN (D6)C. Rozzo (CNR, Sassari, Italy), A. Corrias, M. Pescatori, S. Cossu, I. Sassu, G. Palmieri, G. Delogu, M.A. Dettori, D. Fabbri, M. Pisano

P08 - PARP1 IS ACTIVATED AT TELOMERES UPON G4 STABILIZATION: POSSIBLE TARGET FOR TELOMERE-BASED THERAPYA. Rizzo (Regina Elena National Cancer Institute, Rome, Italy), E. Salvati, M. Scarsella, M. Porru, S. Iachettini, L. Tentori, G. Graziani, M. D’incalci, M. Stevence, A. Orlandi, D. Passeri, E. Gilson, G. Zupi, C. Leonetti, A. Biroccio P10 - A PHASE II CLINICAL TRIAL ON HEPATIC INTRA-ARTERIAL INjECTION OF YTTRIUM-90 MICROSPHERES IN UNRESECTABLE COLORECTAL LIVER METASTASES REFRACTORY TO STANDARD I.V. CHEMOTHERAPY. EXPERIENCE AND RESULTSG. Pizzi (Regina Elena National Cancer Institute, Rome, Italy), L. Carpanese, G. Vallati, R. Sciuto, S. Rea, L. Romano, A. Annovazzi, C. Di Russo, C.L. Maini, M. Crecco

P11 - ROLE OF YTTRIUM 90 RADIO EMBOLIZATION IN THE TREATMENT OF ADVANCED HEPATOCELLULAR CARCINOMA: A SINGLE INSTITUTE EXPERIENCEG. Pizzi (Regina Elena National Cancer Institute, Rome, Italy), L. Carpanese, G. Vallati, R. Sciuto, S. Rea, L. Romano, A. Annovazzi, C. Di Russo, C.L. Maini, M. Crecco

P12 - ACETYL-L-CARNITINE: A METABOLIC ENHANCER OF CANCER CHEMOTHERAPYC. Pisano (Sigma-Tau SpA Industrie Farmaceutiche Riunite, Pomezia, Italy), L. Vesci, F.M. Milazzo, M.B. Guglielmi, R. Foderà, M. Barbarino, G. Petrangolini, M. Tortoreto, P. Perego, V. Zuco, A. Orlandi, D. Passeri, G. Pollastrone, I. La Porta, F. Zunino

P13 - MTOR PATHWAY IS A DRUGGABLE CANDIDATE IN MALIGNANT PLEURAL MESOTHELIOMA TARGETED THERAPEUTIC APPROACHC. Dell’Aglio (Institute For Cancer Research And Treatment, Candiolo - Torino, Italy), Y. Pignochino, M. Basiricò, S. Inghilleri, M. Zorzetto, M. Luisetti, P. Morbini, M. Aglietta, E. Pozzi, G. Stella

P15 - TARGETING MYC VIA OMOMYC AS A MODEL THERAPEUTIC STRATEGYS. Nasi (CNR, Rome, Italy), M. Savino, E. Favuzzi, L. Soucek, D. Annibali


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PostersP17 - POLYPHENOLIC EXTRACTS FROM CYNARA SCOLYMUS L. HAVE ANTITUMORAL ACTIVITY ON BREAST CANCER CELLSA. Mileo, D. Di Venere, A. Cardinali, V. Linsalata, R. Fraioli, S. Miccadei (Regina Elena National Cancer Institute, Rome, Italy)

P18 - LONG-TERM PEMETREXED (PEM) EXPOSURE WITH OR WITHOUT ANTINEOPLASTIC AGENTS IN DIFFERENT HUMAN CANCER CELL LINES. A PRECLINICAL EXPERIENCE AND DEVELOPMENT OF NEW POTENTIAL THARAPEUTIC APPROACHESM. Marangolo (Istituto Oncologico Romagnolo, Ravenna, Italy), F. Fanini, L. Turci, W. Zoli

P19 - EXPLORATORY STUDY ON THE EFFECTS OF CHLORAMBUCIL/HYDROXYCHLOROQUINE-LOADED ANTI-CD20 NANOPARTICLES ON MALIGNANT B CELLS AND ON A HUMAN/MOUSE MODEL OF BURKITT LYMPHOMAN. Mezzaroba (University of Trieste, Trieste, Italy), E. Mansilla, S. Zorzet, G. Larsen, C. Tripodo, L. Nunez, G. Marin, F. Tedesco, P. Macor

P20 - N-CYCLIC BAY-SUBSTITUTED PERYLENE G-QUADRUPLEX LIGANDS CAN INDUCE TELOMERE DAMAGE AND HAVE SELECTIVE ANTIPROLIFERATIVE EFFECTS ON CANCER CELLSS. Iachettini (Regina Elena National Cancer Institute, Rome, Italy), V. Casagrande, E. Salvati, A. Alvino, A.D. Bianco, A. Ciammaichella, C. D’ Angelo, L. Ginnari-Satriani, C. Leonetti, S. Neidle, G. Ortaggi, M. Porru, A. Rizzo, M. Franceschin, A. Biroccio

P21 - DISCOVERY OF NATURAL EXTRACT INTERFERRING WITH EPHA2-EPHRINA1 SYSTEMC. Giorgio (University of Parma, Parma, Italy), I. Hassan Mohamed, R. Bruni, G. Domenichini, E. Barocelli, M. Tognolini

P22 - ANTI-PROLIFERATIVE AND PRO-APOPTOTIC EFFECTS OF SORAFENIB IN BREAST CANCER CELLS IN VITROC. Fumarola (University of Parma, Parma, Italy), M. Bonelli, K. Airoud, R. Alfieri, A. Cavazzoni, M. Galetti, S. La Monica, D. Generali, P.G. Petronini

P23 - CROCUS SATIVUS EXTRACT COMPONENTS INHIBIT CELL PROLIFERATION AND INDUCE CELL DEATH AND APOPTOSIS IN BREAST AND PROSTATE CANCER CELL LINESC. Festuccia (Experimental Medicine, Laboratory of Radiobiology, L’aquila, Italy), A.M. D’Alessandro, A. Mancini, A. De Simone, C. Marroccella, G.L. Gravina, F. Marampon, M. Di Cola, V. Tombolini, C. Tatone

P24 - THE TORC1/TORC2 INHIBITOR, PALOMID 529 (P529), REDUCES TUMOR GROWTH AND SENSITIZES TO CHEMOTHERAPY AND RADIOTHERAPY AGGRESSIVE HORMONE REFRACTORY PROSTATE CANCER CELLS BOTH IN VITRO AND IN VIVOC. Festuccia (Experimental Medicine, Laboratory of Radiobiology, L’aquila, Italy), G.L. Gravina, F. Marampon, L. Biordi, D. Sherris, V. Tombolini

P25 - THE INHIBITION OF CHEMOKINE RECEPTOR CXCR7 MEDIATES TUMOR CELL GROWTH AND INVASIVENESS IN PRECLINICAL MODELS OF PROSTATE CANCERC. Festuccia (Experimental Medicine, Laboratory of Radiobiology, L’aquila, Italy), G.L. Gravina, M. Angelici, R. Montironi, L. Ventura, F. Marampon, G. Pratesi, M. Tortoreto, M. Penfold, V. Tombolini

P26 - HISTONE DEACETYLASE INHIBITOR BELINOSTAT (PXD-101) REPRESSES ANDROGEN RECEPTOR AND ACTS SYNERGISTICALLY WITH CASTRATION AND BICALUTAMIDE IN HORMONE REFRACTORY PROSTATE CANCER MODELSC. Festuccia (Experimental Medicine, Laboratory of Radiobiology, L’aquila, Italy), G.L. Gravina, F. Marampon, F. Petini, L. Biordi, E. Ricevuto, C. Ficorella, V. Tombolini

P28 - TRANSLATIONAL STUDY OF NON PEGYLATED LIPOSOMAL DOXORUBICIN ACTIVITY IN HORMONE-REFRACTORY PROSTATE CANCERF. Fabbri (IRST, The Cancer Institute of Romagna, Meldola, Italy), M. Montanari, G.L. Frassineti, E. Rondini, R. Mattioli, S. Luzi Fedeli, S. Carloni, W. Zoli, D. Amadori, G. Cruciani

P30 - REACTIVATION OF MUTANT P53 BY ZINC INCREASES THE RESPONSE OF TUMOR CELLS TO ANTICANCER DRUGSR. Puca (Regina Elena National Cancer Institute, Rome, Italy), L. Nardinocchi, G. D’Orazi


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PostersP31 - DOWN-REGULATION OF PTTG1 CONTRIBUTES TO PHA-848125-INDUCED CELL GROWTH INHIBITION IN MELANOMAS. Caporali (IRCCS, Rome, Italy), E. Alvino, U. Pfeffer, A. Esposito, M. Ciomei, M.G. Brasca, E. Bonmassar, S. D’Atri

P32 - ANTITUMOR MECHANISM OF THE HDAC INHIBITOR VORINOSTAT AND THE EGF-R INHIBITOR GEFITINIB AS SINGLE AGENTS OR IN COMBINATION: A PROTEOMIC STUDYF. Bruzzese (Fondazione G. Pascale National Cancer Institute, Naples, Italy), L. Bianchi, A. Gagliardi, M. Rocco, M. Puglia, A. Gimigliano, E. Di Gennaro, L. Bini, A. Budillon

P33 - EFFECTS OF ALOE ARBORESCENS WHOLE-LEAF jUICE ON PROLIFERATION RATE AND OXIDATIVE STATUS IN HUMAN CARCINOMA AND ENDOTHELIAL CELLSA. Bassi (University of Genoa, Genoa, Italy), C. Scanarotti, G. Vito, M.F. Catalano, S. Penco, P. Romano, M.A. Pronzato

P34 - LIPOPEROXIDES AS POTENTIAL ANTITUMOUR DRUGS: EVALUATION OF THEIR APOPTOTIC AND ANTI-ANGIOGENETIC PROPERTIESA. Bassi, C. Scanarotti (University of Genoa, Genoa, Italy), G. Vito, S. Penco, R. Sanguineti, P. Romano, E.L. Iorio, M. Carratelli, M.A. Pronzato

P35 - EVALUATION OF THE EFFECTS OF IONIZING RADIATION IN COMBINATION WITH ONCOLYTIC VIRUS DL922-947A. Abagnale (University of Naples Federico II, Naples, Italy), S. Libertini, G. Botta, C. Passaro, S. Barbato, G. Portella

P36 - STATINS POTENTIATES THE ACTIVITY OF MEK INHIBITOR PD0325901 IN MULTIPLE MYELOMA CELLSM.R. Ricciardi (“Sapienza” University, Rome, Italy), M. Milella, P. Bergamo, E. Calabrese, A. Levi, F. Gentilini, R. Foà, A. Tafuri, M.T. Petrucci

P37 – PRECLINICAL STUDY OF COMBINED BCL-2 AND mTOR INHIBITION: TARGET MOLECOLAR THERAPY IN ACUTE LYMPHOBLASTIC LEUKEMIA CELLSS. Iacovelli (“Sapienza” University, Rome, Italy), M.R. Ricciardi, A. Miele, P. Bergamo, S. Decandia, A. Vitale, A. Testi, M.T. Petrucci, M. Milella, R. Foà, A. Tafuri

DRUG RESISTANCE

P39 - MIR-221/222 REGULATE TEMOZOLOMIDE SENSITIVITY IN GLIOMA CELL LINES TARGETING THE DNA METHYLTRANSFERASE MGMTC. Quintavalle (University of Naples, Naples, Italy), M. Iaboni, M. Brenca, D. Fiore, E. Donnarumma, S. Di Costanzo, G. Romano, G. Condorelli

P40 - MC70, A POTENT INHIBITOR OF ABC TRANSPORTERS INVOLVED IN MULTIDRUG RESISTANCE: IN VITRO CHARACTERIZATIONA. Quatrale (National Cancer Institute Giovanni Paolo II, Bari, Italy), L. Porcelli, N.A. Colabufo, F. Berardi, R. Perrone, A. Paradiso, A. Azzariti

P41 - MECHANISMS OF RESISTANCE TO THE NOVEL BRAF INHIBITOR PLX4032S. Purgante (University of Milano-Bicocca, Milan, Italy) L. Mologni, M. Viltadi, C. Gambacorti Passerini

P43 - ADDRESSING THE EFFECTS OF PI3K INHIBITION BY A GENE EXPRESSION ANALYSIS ON EPITHELIAL OVARIAN CANCER CELL LINESP. Pinciroli (IRCCS, Milan, Italy), C. Alberti, S. Canevari, A. Tomassetti

P44 - TGF-BETA-ACTIVATED KINASE 1 (TAK1) IS A THERAPEUTIC TARGET MODULATING PANCREATIC CANCER CHEMORESISTANCED. Melisi (Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale, Naples, Italy), Q. Xia, T. Moccia, G. Paradiso, C. Carbone, J. Ling, J.L. Abbruzzese, A. Budillon, P.J. Chiao

P45 - PLGF INDUCES MELANOMA RESISTANCE TO TEMOZOLOMIDE THROUGHT A MECHANISM THAT INVOLVES NF-KB ACTIVATIONL. Levati, F. Ruffini, A. Muzi, G. Graziani, S. D’Atri, P.M. Lacal (University of Rome Tor Vergata, Rome, Italy)


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PostersP46 - GENE EXPRESSION ANALYSIS OF CHEMORESISTANT CARCINOID CELLSU. Olszewski (Ludwig Boltzmann Cluster of Translational Oncology, Vienna, Austria), R. Zeillinger, E. Ulsperger, K. Geissler, G. Hamilton

P47 - ACTIVATION OF HER FAMILY MEMBERS IN GASTRIC CARCINOMA CELLS MEDIATES RESISTANCE TO MET INHIBITIONE. Ghiso (University of Torino, Candiolo – Torino, Italy), S. Corso, V. Cepero, J.R. Sierra, C. Migliore, A. Bertotti, L. Trusolino, P.M. Comoglio, S. Giordano

P50 - HEME OXYGENASE-1 AS A POSSIBLE NEW THERAPEUTIC TARGET IN NEUROBLASTOMAA.L. Furfaro (University of Genoa, Genoa, Italy), J.R. Zumba Macay, B. Marengo, C. Domenicotti, M. Nitti, C. De Ciucis, M.A. Pronzato, U.M. Marinari, N. Traverso

P51 - OVERCOMING TRASTUZUMAB RESISTANCE IN HER2-OVEREXPRESSING BREAST CANCER CELLS BY THE MULTIKINASE INHIBITOR, SORAFENIBS. Capellero (University of Turin, Turin, Italy), G. Cavalloni, A. Milani, C. Peraldo Neia, A. Sapino, C. Pecchioni, M. Aglietta, F. Montemurro, G. Valabrega

P52 - EIF4E PHOSPHORYLATION BY THE MNK KINASES IN PANCREATIC CANCER CELLS SUPPORTS PROLIFERATION AND SURVIVAL TO GENOTOXIC STRESSL. Adesso, S. Calabretta (University of Rome La Sapienza, Rome,Italy), R. Geremia, G. Capurso, G. Delle Fave, C. Sette

P53 - 6-(7-NITRO-2,1,3-BENZOXADIAZOL 4-YLTHIO)HEXANOL (NBDHEX): A POSSIBLE TREATMENT STRATEGY FOR MESOTHELIOMAF. Pellizzari Tregno (University of Tor Vergata, Rome, Italy), A. Sau, A. Pastore, A.S. Dorio, C. Lo Sterzo, L. Federici, A.M. Caccuri

P54 - DASATINIB REDUCES FAK PHOSPHORYLATION INCREASING THE EFFECTS OF RPI-1 INHIBITION IN A RET/PTC1-EXPRESSING CELL LINED. Caccia (Istituto Nazionale Tumori, Milan, Italy), F. Miccichè, G. Cassinelli, P. Mondellini, P. Casalini, I. Bongarzone

P55 - ACQUISITION OF CHEMORESISTANCE AND EMT PHENOTYPE IS LINKED WITH ACTIVATION OF THE ENDOTHELIN A RECEPTOR PATHWAY IN OVARIAN CARCINOMA CELLSR. Cianfrocca (Regina Elena National Cancer Institute, Rome, Italy), L. Rosanò, V. Di Castro, F. Spinella, M.R. Nicotra, A. Lucidi, G. Ferrandina, P.G. Natali, A. Bagnato

P56 - RESISTANCE TO CURCUMIN IS MEDIATED BY THE OVEREXPRESSION OF THE ATP BINDING CASSETTE GENE ABCA1B. Bachmeier (Ludwig-Maximilians-University, Munich, Germany), P. Killian, E. Kronski, V. Mirisola, G. Angelini, A. Nerlich, U. Pfeffer

SIGNAL TRANSDUCTION AND INTRACELLULAR TRAFFICKING

P58 - MYC TARGETING IN EMBRYONAL RHABDOMYOSARCOMA BY MEK/ERK INHIBITORA. Di Rocco, F. Marampon, C. Ciccarelli, B.M. Zani (University of L’Aquila, L’Aquila, Italy)

P61 - CSF1R ELICITS PROLIFERATIVE SIGNALS AND UNDERGOES CYTOPLASMIC-NUCLEAR SHUTTLING IN RESPONSE TO CSF1 IN BREAST CANCER CELLSE. Rovida (University of Florence, Florence, Italy), A. Morandi, V. Barbetti, M. Riverso, P. Dello Sbarba

P62 - NEUROPILINS ROLE IN TUMOR CELL PROLIFERATIONS. Rizzolio (IRCC, Turin, Italy), L. Capparuccia, A. Casazza, L. Tamagnone

P64 - THE INDUCIBLE CYCLIC ADENOSINE 3’-5’-MONOPHOSPHATE EARLY REPRESSOR (ICER) ENHANCES CHEMOTHERAPY SENSITIVITY IN MYELOID LEUKEMIA CELLSE. Manara (University of Padua, Padua, Italy), A. Beghin, C. Tregnago, E. Baron, M. Pigazzi, G. Basso

P65 - PROTEOMIC MOLECULAR PROFILING IN BONE METASTASISC. Novello (Istituto Ortopedico Rizzoli, Bologna, Italy), A. Chiechi, V. Espina, G. Magagnoli, P. Picci, E.F. Petricoin III, M.S. Benassi, L.A. Liotta


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PostersP66 - THE RAN GTPASE NETWORK REGULATES THE MITOTIC APPARATUS AND THE OUTCOME OF MICROTUBULE-TARGETING DRUGS IN CANCER CELLSP. Lavia (CNR, Rome, Italy), E. Roscioli, A. Bolognesi, M. Giubettini, W.M. Rensen

P67 - CTLA-4 EXPRESSED BY HUMAN DENDRITIC CELLS MODULATES THEIR CYTOKINE SECRETION AND INDUCTION OF T CELL PROLIFERATIONS. Laurent (University of Genoa, Genoa, Italy), P. Carrega, D. Saverino, P. Piccioli, M. Camoriano, A. Morabito, B. Dozin, V. Fontana, R. Simone, L. Mortara, M.C. Mingari, G. Ferlazzo, M.P. Pistillo

P68 - DGKA, BY REGULATING ATYPICAL PKC, IS A KEY TRANSDUCER OF SDF1A-INDUCED INVASIVE BEHAVIOUR IN BREAST CANCER CELLSA. Graziani (University of Piemonte Orientale, Novara, Italy), C. Cianflone, F. Chianale, M. Gaggianesi, A. Pighini, I. Gregnanin, N. Filigheddu, N. Surico, G. Baldanzi

P69 - THE AURORA-A/TPX2 COMPLEX: REGULATION AND ROLES IN TUMORIGENESISM. Giubettini (CNR, Rome, Italy), I.A. Asteriti, J. Scrofani, W.M. Rensen, M. De Luca, P. Lavia, G. Guarguaglini

P70 - RILP REGULATES THE G1 SUBUNIT OF THE V-ATPASEM. De Luca (University of Salento, Lecce, Italy), L. Cogli, R. Bramato, V. Nisi, C. Bucci

P72 - THE DELETION OF NF-KB/P50 MODIFIES THE OUTCOMES OF NOTCH3-DEPENDENT T CELL LEUKEMIAA. Campese (“Sapienza” University, Rome, Italy), P. Grazioli, S. Colantoni, A. Barbarulo, S. Checquolo, M.P. Felli, G. Scafetta, A. Gulino, I. Screpanti

P73 - NBDHEX INDUCES TRAF2-MEDIATED CELL CYCLE ARREST AND APOPTOSIS IN U-2OS OSTEOSARCOMA CELL LINEA. Sau, G. Filomeni, S. D’aguanno, F. Pellizzari Tregno, A. Urbani, M. Serra, M. Pasello, C. Lo Sterzo, L. Federici, A.M. Caccuri (University of Tor Vergata, Rome, Italy)

AUTOPHAGY, APOPTOSIS, NECROSIS AND SENESCENCE

P74 - DIFFERENTIAL EFFECTS OF IMATINIB IN PRIMARY AND METASTATIC MELANOMA CELLSB. Ascione, L. Gambardella, S. Basciani, L. Gnessi, E. Straface, W. Malorni, R. Vona (Istituto Superiore di Sanità, Rome, Italy)

P75 - ROLE OF ONCOGENE-INDUCED SENESCENCE IN THYROID CARCINOGENESISM.G. Vizioli (Istituto Nazionale Tumori, Rome, Italy), M.C. Anania, E. Tarantino, C. Miranda, S. Pagliardini, S. Pilotti, M. Pierotti, A. Greco

P76 - GALECTIN-3 PROTECTS MYCN SINGLE COPY NEUROBLASTOMA CELLS FROM APOPTOSIS: A MECHANISM IMPARED BY MYCNV. Veschi (University of Rome, Rome, Italy), M.L. Petroni, I. Massimi, C. Dominici, H. P.Mcdowell, I . Screpanti, L. Frati, A. Bartolazzi, A. Gulino, G. Giannini

P77 - HIGH MOBILITY GROUP A1 (HMGA1) PROTEINS LOCALIZE AT THE MITOCHONDRIA AND INHIBIT THE P53-MEDIATED INTRINSIC-APOPTOTIC PATHWAYM. Tornincasa (Università degli Studi di Napoli Federico II, Naples, Italy), F. Esposito, A. Cappa, G.M. Pierantoni, A. Fusco

P78 - HUMAN GLIOBLASTOMA CELL SURVIVAL AND MIGRATION ARE COUNTERACTED BY MUSCARINIC RECEPTOR ACTIVATIONA. Tata (University La Sapienza, Rome, Italy), R. Ricordy, P. Ruggero, G. Centofante, C. Conte, M. Ferretti, M. Sciaccaluga, L. Catacuzzeno, P. Mancini, E. Castgli, A. Calogero

P80 - INDUCTION OF AUTOPHAGY AS A SURVIVAL MECHANISM FOLLOWING OXIDATIVE STRESS IN ESOMEPRAZOLE-TREATED HUMAN MELANOMA CELLSM. Marino (National Institute of Health, Rome, Italy), A. De Milito, M. Djavaheri-Mergny, A. Villa, S. Meschini, F. Lozupone, G. Venturi, P. Della Mina, L. Rivoltini, P. Codogno, S. Fais


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PostersP81 - NOVEL SMAC MIMETICS INDUCE MELANOMA CELL DEATH IN COMBINATION WITH TRAIL AND BORTEZOMIBD. Lecis (Irccs, Milan, Italy), C. Drago, P.F. Seneci, A. Anichini, D. Delia

P82 - MICRORNA INVOLVED IN TRAIL RESISTANCE IN HUMAN GLIOBLASTOMA CELLSM. Iaboni (Federico II University of Naples, Naples, Italy), C. Quintavalle, M. Garofalo, G.A Romano, C.M. Croce, G. Condorelli

P83 - DIFFERENT ATG PROTEINS REGULATE CELL SURVIVAL OR AUTOPHAGIC CELL DEATH IN CANCER DISEASEM. Condello (Istituto Superiore di Sanità, Rome, Italy), P. Lista, E. Federici, G. Arancia, S. Meschini

P84 - PRO-APOPTOTIC ACTIVITY OF 15-DEOXY-DELTA 12,14-PGj2 IN CHEMORESISTANT MELANOMA CELLS: ROLE OF THE IKK/ NF-KB PATHWAYL. Ciuffini (University of Rome Tor Vergata, Rome, Italy), G. Belardo, M.G. Santoro

P85 - INTERFERON-BETA AFFECTS P53 TRANSACTIVATING ACTIVITY IN CUTANEOUS HUMAN PAPILLOMAVIRUS 38 (HPV38)-TRANSFORMED KERATINOCYTESM. Chiantore (Istituto Superiore Di Sanità, Rome, Italy), S. Vannucchi, R. Accardi, M. Tommasino, E. Affabris, G. Fiorucci, G. Romeo

P86 - AUTOPHAGY PROTECTS GLIOMA CELLS FROM THE CYTOTOXIC EFFECTS OF THE ONCOLYTIC ADENOVIRUS DL922-947G. Botta (University of Federico Ii, Naples, Italy), S. Libertini, C. Passaro, A. Abagnale, S. Barbato, G. Perruolo, P. Formisano, G. Portella

P87 - INVESTIGATING 5-FLUOROURACIL-INDUCED CARDIAC TOXICITYC. Focaccetti (Irccs, Milan, Italy), A. Parodi, R. Cammarota, E. Principi, G. Pennesi, F. Sessa, A. Albini

TUMOR MICROENVIRONMENT: INFLAMMATION, HYPOXIA ANDANGIOGENESIS

P88 - BCL-2 REGULATES HIF-1ALPHA PROTEIN STABILIZATION IN HYPOXIC MELANOMA CELLS VIA THE MOLECULAR CHAPERONE HSP90D. Trisciuoglio (Regina Elena National Cancer Institute, Rome, Italy), C. Gabellini, M. Desideri, E. Ziparo, G. Zupi, D. Del Bufalo

P89 - INDOMETHACIN ALTERS TUMOR ASSOCIATED MACROPHAGES POLARIZATIONV. Toto (Ce.S.I. Age Research Center ,G. D’annunzio Foundation, Chieti, Italy), A. Hysi, L. Stramucci, P. Felicetti, V. Farfariello, T. Pannellini, C. Curcio, F. Sabatini, M. Mariotti, P. Ascione, M. Liberatore, P. Musiani M. Iezzi

P90 - INTERPLAY BETWEEN HIF-1<ALPHA>/VEGF AND MPGES-1/PGE-2 SIGNALING IN TUMOR ANGIOGENESIS: ROLE OF DIHYDROXYPHENYLETHANOL, A NATURAL PRODUCT FROM OLIVE OILE. Terzuoli (University of Siena, Istituto Toscano Tumori (ITT), Rome, Italy), S. Donnini, F. Finetti, L. Morbidelli, M. Ziche

P92 - ENDOTHELIN AXIS INDUCES VEGF-C EXPRESSION AND STIMULATES LYMPHANGIOGENESISF. Spinella (Regina Elena National Cancer Institute, Rome, Italy), V. Caprara, E. Garrafa, V. Di Castro, L. Rosano, M.R. Nicotra, P.G. Natali, A. Bagnato

P93 - ENDOTHELIN AXIS AUTOCRINE LOOP IS POSITIVELY REGULATED BY THE INTERPLAY BETWEEN ET-1 AND HYPOXIA-INDUCIBLE FACTOR-1 IN MELANOMA CELLS: IMPLICATION IN TUMOR PROGRESSIONF. Spinella (Regina Elena National Cancer Institute, Rome, Italy), V. Caprara, R. Cianfrocca, L. Rosano, V. Di Castro, P.G. Natali, A. Bagnato


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PostersP94 - MAST CELLS POSITIVE TO TRYPTASE IN BREAST CANCER TISSUE: A NEW POSSIBLE ANTIANGIOGENETIC TARGETG. Ranieri (National Cancer Institute Giovanni Paolo Ii, Bari Italy), R. Patruno, A. Mangia, V. Goffredo, V. Di Lecce, P. Valerio, M. Ammendola, G. De Sarro, C.D. Gadaleta

P95 - DLL4-BLOCKADE IMPAIRS T-ALL CELL VIABILITY AND ENGRAFTMENT IN NOD/SCID MICEI. Pusceddu (IRCCS, Padua, Italy), S. Minuzzo, V. Agnusdei, L. Moserle, M. Masiero, M. Crescenzi, T. Hoey, E. Seganfreddo, G. Basso, A. Ferrando, A. Amadori, S. Indraccolo

P96 - LACK OF EPITHELIAL- OR LEUCOCYTE-PRODUCED SPARC RESPECTIVELY PROMOTE INFLAMMATION AND HAMPER ITS RESOLUTION IN DSS-INDUCED COLITISA. Passafaro (IRCCS, Milan, Italy), E. Di Carlo, M.P. Colombo

P97 - CANCER-ASSOCIATED FIBROBLASTS PROMOTE EPITHELIAL MESENCHYMAL TRANSITION ASSOCIATED WITH STEMNESS IN PROSTATE CARCINOMA CELLSP. Chiarugi (Department of Biochemical Sciences, Florence, Italy), E. Giannoni, F. Bianchini, L. Calorini, M.L. Taddei

P98 - A CROHN’S DISEASE- ASSOCIATED VARIANT OF THE OCTN1 INTESTINAL CATION TRANSPORTER INCREASES THE RISK OF COLORECTAL CANCER IN YOUNG INDIVIDUALS AND IN ULCERATIVE COLITIS PATIENTSG. Pani (Università Cattolica, Institute of General Pathology Rome), M. Martini, A. Ferrara, M. Giachelia, E. Panieri, T. Galeotti, L.M. Larocca

P99 -THE MONOCLONAL ANTIBODY OC-20 SPECIFIC FOR A CELL BINDING SITE OF PERIOSTIN: EVIDENCES FOR ITS PREFERENTIAL LOCALIZATION INSIDE MELANOMA CELLSP. Orecchia, R. Conte, P. Castellani, E. Balza, M.C. Mingari, B. Carnemolla (National Cancer Institute Department of Translational Oncology, Genoa, Italy)

P101 - NEW ROLE FOR ATM IN CELLULAR RESPONSE TO HYPOXIAM. Mongiardi (Cnr, Rome, Italy), V. Stagni, D. Giaccari, M. Natoli, M.L. Falchetti, D. Barilà, A. Levi

P103 - ROLE OF IRF-8 IN THE INTERFACE OF MELANOMA TUMOR CELL-IMMUNE SYSTEM INTERACTIONF. Mattei (Istituto Superiore di Sanità, Rome, Italy), G. Schiavoni, F. Spadaro, M. Spada, A. Fragale, M. Sanchez, A. Sistigu, A. Battistini, L. Gabriele

P104 - TISSUE REMODELLING IN BREAST CANCER: HUMAN MAST CELL TRYPTASE AS AN INITIATOR OF MYOFIBROBLAST DIFFERENTIATIONA. Malfettone (National Cancer Centre ‘Giovanni Paolo Ii’, Bari, Italy), L. Resta, R. Rossi, A. Paradiso, G. Simone, A. Mangia

P105 - ANTIANGIOGENIC AND ANTITUMOR EFFECTS OF HIV- PROTEASE INHIBITORS (HIV-PIS) IN A TRANSGENIC MOUSE MODEL OF SPONTANEOUS CERVICAL CANCERF. Maione (Laboratory of Transgenic Mouse Models, Ircc And Department of Oncological Sciences, University of Turin, School of Medicine, Turin, Italy), C. Meda, S. Capano, P. Monini, B. Ensoli, F. Bussolino, E. Giraudo

P106 - HIF-1ALPHA STABILIZATION BY MITOCHONDRIAL ROS PROMOTES MET-DEPENDENT INVASIVE GROWTH AND VASCULOGENIC MIMICRY IN MELANOMA CELLSG. Comito (Department of Biochemical Sciences, Florence, Italy), M. Calvani, E. Giannoni, F. Bianchini, L. Calorini, E. Torre, C. Migliore, S. Giordano, P.Chiarugi

P107 - TARGETING CANCER-RELATED INFLAMMATION: SELECTIVE IMPAIREMENT OF MONOCYTES/ MACROPHAGES AFTER IN VIVO ADMINISTRATION OF THE ANTI-TUMOR AGENT TRABECTEDING. Germano (Irccs Istituto Clinico Humanitas, Rozzano, Italy), A. Anselmo, S. Pesce, R. Frapolli, E. Bello, L. Basso, L. Ricci, P.G. Casali, R. Sanfilippo, R. Mortarini, A. Anichini, A. Mantovani, M. D’incalci, P. Allavena

P109 - ANTIANGIOGENIC ACTIVITY OF A VEGFR-1-DERIVED PEPTIDE THAT INHIBITS VEGFR-1 BINDING TO NEUROPILIN-1G. Colotti, A. Orecchia, M. Ungarelli, F. Ruffini, P.M. Lacal, G. Zambruno, V. Morea, C.M. Failla (IDI-IRCCS, Rome, Italy)


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PostersP110 - ANALYSIS OF MELANOMA CELL PROTEOME REVEALS SPECIFIC PROTEIN PATHWAYS LIKELY INVOLVED IN TUMOR AGGRESSIVENESSS. Rossi, M. Cordella, P. Pagnotto, C. Senatore, D. D’Arcangelo, A. Facchiano, F. Facchiano (Istituto Superiore di Sanità, Rome, Italy)

P111 - INHIBITION OF BETA 1 INTEGRIN AND IL-3R BETA COMMON SUBUNIT INTERACTION HINDERS TUMOR ANGIOGENESISP. Dentelli (University of Turin, Turin, Italy), B. Uberti, A. Rosso, A. Castelli, A. Trombetta, C. Olgasi, G. Togliatto, C. Barale, P. Defilippi, M.F. Brizzi

P112 - THE BIFLAVONOID AMENTOFLAVONE INHIBITS NEOANGIOGENESIS AND TUMOR GROWTH PREVENTING THE ACTIVITY OF PRO-ANGIOGENIC VEGFSS. De Falco (Cnr, Rome, Italy), V. Tarallo, L. Lepore, M. Mercellini, L. Tudisco, F. Del Piaz, C. Pisano, N. De Tommasi

P113 - ZINC ANTAGONIZES HIF-1/VEGF SIGNALING IN VITRO AND IN VIVOL. Nardinocchi (Regina Elena National Cancer Institute, Rome, Italy), R. Puca, V. Pantisano, A. Aiello, M. Porru, C. Leonetti, A. Farsetti, G. D’Orazi

P114 - CXCR4 BUT NOT CD133 EXPRESSION PREDICTS RECURRENCE-FREE SURVIVAL IN RENAL CELL CARCINOMAC. D’Alterio (Cancer Institute G. Pascale, Naples, Italy), L. Cindolo, M. Polimero, L. Portella, C. Consales, A. Riccio, M. Cioffi, R. Franco, P. Chiodini, G. Cartenì, V. Mirone, N. Longo, L. Marra, S . Perdonà, L. Claudio, S. Scala

P115 - INVADOPODIA ECM PROTEOLYSIS IS REGULATED BY THE METABOLIC MICROENVIRONMENTE. Antelmi (University of Bari, Bari, Italy), M.T. Mancini, R.A. Cardone, M.R. Greco, G. Busco, V. Casavola, S.J. Reshkin

P116 - CIRCULATING PERIVASCULAR PROGENITORS, A TARGET OF PDGFR INHIBITIONA. Calleri (European Institute of Oncology, Milan, Italy), P. Mancuso, P. Marighetti, J. Quarna, I. Martin Padura, P. Braidotti, F. Bertolini

P117 - NK CELLS MODULATION OF TUMOR ANGIOGENESISA. Bruno (Università Degli Studi Dell’Insubria, Varese, Italy), A. Ventura, C. Focaccetti, A. Pagani, L. Mortara, S. Tenconi, V. Conti, M. Cilli, L. Chiossone, E. Vivier, L. Boni, A. Imperaori, A. Albini, D. Noonan

P118 - TRAIL IS INVOLVED IN HYPOXIA-INDUCED APOPTOSIS OF ACUTE MYELOID LEUKEMIA T(8;21)-POSITIVE CELLSV. Barbetti (University of Florence, Florence, Italy), S. Giuntoli, M. Tanturli, E. Rovida, P. Dello Sbarba

P119 - CONTRIBUTION OF FIBROBLASTS ISOLATED FROM PRIMARY LUNG CANCERS AND NORMAL LUNG TISSUE TO TUMOR GROWTHF. Andriani (IRCCS, Milan, Italy), G. Bertolini, R. Caserini, S. Bursomanno, P. Gasparini, U. Pastorino, G. Sozzi, L. Roz

P120 - CONNECTING EGFR ACTIVATION TO INFLAMMATORY SIGNALING IN EPITHELIAL OVARIAN CANCERC. Alberti (IRCCS, Milan, Italy), B. Valeri, S. Canevari, A. Tomassetti

CELL ADHESION, MIGRATION, INVASION AND METASTASIS

P122 - CD38 IS PART OF A NETWORK OF MOLECULES REGULATING THE HOMING OF CLL CELLST. Vaisitti (University of Turin, Turin, Italy), A. Zucchetto, D. Rossi, G. D’Arena, G. Gaidano, V. Gattei, F. Malavasi, S. Deaglio

P123 - MULTIPLE EFFECT OF ELECTROPORATION ON ADHESIVE BEHAVIOR OF FIBROBLASTS AND BREAST CANCER CELLSR. Tzoneva Dimitrova (Institute of Biophysics,Electroinduced Effects in Biomembranes,Sofia,Bulgaria), V. Pechlivanova, V. Krysteva, I. Tsoneva, R. Tzoneva


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PostersP124 - SLUG (SNAI2) IS TRANSCRIPTIONALLY REGULATED BY C-MYB AND IS REQUIRED FOR INVASION AND BONE MARROW HOMING OF CANCER CELLS OF DIFFERENT ORIGINB. Tanno, F. Sesti, V. Cesi, G. Bossi, G. Ferrari-Amorotti, R. Bussolari, D. Tirindelli, B. Calabretta, G. Raschellà (ENEA, Laboratory of Radiation Biology and Biomedicine, Rome, Italy)

P125 - AN EMERGING ROLE OF MATRIX METALLOPROTEINASE (MMP)-13 IN OSTEOLYTIC BREAST CANCER METASTASISE. Pivetta (CRO-IRCCS, Aviano (Pn), Italy), M. Pecolo, M. Scapolan, B. Wassermann, A. Colombatti, P. Spessotto

P126 - ROLE OF CXCR4/SDF-1 AXIS IN SOFT TISSUE SARCOMA PROGRESSIONC. Peraldo Neia (Turin University Medical School; Department of Oncological Sciences, Institute for Cancer Research and Treatment (IRCC) Candiolo, Italy), G. Grignani, G. Migliardi, G. Cavalloni, A. Pisacane, S. Aliberti, Y. Pignochino, M. Risio, M. Aglietta

P127 - CD157 IS A POTENTIAL TARGET FOR INHIBITION OF PERITONEAL DISSEMINATION AND INVASION AND A PROGNOSTIC FACTOR IN OVARIAN CANCER PATIENTSE. Ortolan (University of Turin, Turin, Italy), S. Morone, P. Bovino, N. Lo Buono, G. Nacci, R. Parrotta, R. Arisio, D. Katsaros, I. Rapa, E. Ferrero, G. Migliaretti, M. Volante, A. Funaro

P129 - MOLECULAR PLAYERS OF EMT-MET TRANSITIONS IN HEPATOCYTES: MECHANISMS AND PERSPECTIVES FOR TUMOR GENE THERAPYA. Marchetti (Istituto Pasteur - Fondazione Cenci Bolognetti, Dpt of Cellular Biotechnologies And Haematology, Sapienza University, Rome, Italy), L. Santangelo, A.M. Cozzolino, C. Cicchini, T. Alonzi, L. Amicone, M. Tripodi

P130 - EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) EXPRESSION ON CIRCULATING ENDOTHELIAL CELLS FROM EGFR-POSITIVE METASTATIC COLORECTAL CANCER (MCRC) PATIENTSM. Manzoni (Irccs, Pavia, Italy), S. Delfanti, S. Mariucci, B. Rovati, G. Mazzini, M. Danova

P131 - CD157 EXPRESSION AND PROGNOSTIC SIGNIFICANCE IN MALIGNANT PLEURAL MESOTHELIOMAP. Bovino (University of Turin, Turin, Italy), S. Morone, E. Ortolan, A. Giacomini, N. Lo Buono, I. Rapa, M. Volante, M. Papotti, F. Malavasi, A. Funaro

P132 - HMENA SPLICING AND PANCREATIC CANCER: HMENA11A HAS AN ANTI-INVASIV FUNCTION AND IS DOWNREGULATED IN HUMAN PANCREATIC TUMOR TISSUESP. Iapicca (Regina Elena National Cancer Institute Rome, Italy), F. Di Modugno, M. Mottolese, M. Alessio, D. Del Bello, P. Visca, A. Santoni, M. Milella, P. Nisticò

P133 - ZIBOTENTAN (ZD4054): A SPECIFIC ENDOTHELIN-A RECEPTOR ANTAGONIST - PRECLINICAL AND CLINICAL PROFILE IN CANCERJ. Growcott (Astrazeneca, Alderley Park, Macclesfield, United Kingdom), J. Curwen, N. Curtis, T. Morris

P134 - ROLE OF ESTROGEN RECEPTOR BETA IN THE CONTROL OF HUMAN PROSTATE CANCER PROGRESSIONP. Negri Cesi, C. Festuccia (University of L’Aquila, L’Aquila), M. Piccolella, D. Ruscica, M. Motta

P135 - MIR-126 TUMOR SUPPRESSOR ROLE IN MELANOMAA.M. Lustri (Istituto Superiore di Sanità, Rome, Italy), A. Cannistraci, F. Felicetti, N. Felli, M.C. Errico, L. Bottero, P. Segnalini, G. Mattia, A. Carè

P136 - METABOLIC SYNDROME PROMOTES PRE-NEOPASTIC CHANGES OF THE COLONIC MUCOSAE. De Masi, F. Franceschi (Catholic University of Rome, Rome, Italy), M.G. Mancino, G. Cammarota, A.I. Cazzato, D. Roccarina, G. Gigante, B. Giupponi, G. De Marco, A. Gasbarrini, N. Gentiloni Silveri, G. Gasbarrini

P137 - MICRO-RNA-146A NEGATIVELY MODULATES MELANOMA CELL INVASIVENESSL. Levati (Istituto Dermopatico dell’Immacolata - IRCCS - Laboratory of Molecular Oncology, Rome, Italy), E. Pagani, P.M. Lacal, F. Ruffini, E. Bonmassar, E. Alvino, S. D’Atri


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PostersP138 - OPN DEFICENCY ACCELLERATES THE ONSET OF PRIMARY PROSTATE TUMOR GROWTH IN TRAMP MICEG. Mauri, E. Di Carlo, I. Arioli, M.P. Colombo, B. Comuzzi (Fondazione IRCCS Istituto Nazionale dei Tumori Amadeo Lab, Molecular Immunology Unit, Dept. Experimental Oncology, Milan, Italy)

P139 - IN AMPULLA OF VATER CARCINOMA THE EXPRESSION PATTERN OF CLAUDINS 3 AND 5 CORRELATES WITH AGGRESSIVENESS DETERMINANT AND SURVIVALF. Comper (Arc-Net Research Centre, University of Verona, Policlinico G.B. Rossi, Verona, Italy), N. Sperandio, S. Beghelli, M. Falconi, A. Scarpa

P140 - EMILIN2: AN EXTRACELLULAR MATRIX PROTEIN AFFECTING TUMOR PROGRESSION AND METASTASISR. Colladel (CRO IRCSS, Aviano, Italy), S. Marastoni, E. Lorenzon, E. Andreuzzi, F. Todaro, A. Colombatti, M. Mongiat

P141 - CATHEPSIN B INHIBITION INTERFERES WITH METASTATIC POTENTIAL OF HUMAN MELANOMA: AN IN VITRO AND IN VIVO STUDYL. Ciarlo (University of Tor Vergata, Rome, Italy), P. Matarrese, B. Ascione, R. Vona, M. Marconi, C. Leonetti, M. Scarsella, A.M. Mileo, C. Catricalà, M. Piacentini, M. Paggi, W. Malorni

P142 - NHERF1, A NOVEL MOLECULAR SWITCH, PROGRAMS BREAST TUMOR PHENOTYPES AND METASTATIC ORGANOTROPISMM.R. Greco, N. Rucci, M. Capulli, A. Teti, G. Busco, V. Casavola, E. Antelmi, A. Bellizzi, A. Paradiso, S.J. Reshkin, R.A. Cardone (University of Bari, Bari, Italy)

P143 - SERUM-ACTIVATED K- AND CL-CURRENTS UNDERLAY U87-MG GLIOBLASTOMA CELL MIGRATION

L. Catacuzzeno, P. Ruggieri, F. Aiello, B. Fioretti, L. Sforna, E. Castigli, A.M. Tata, F. Franciololini, A. Calogero (“Sapienza” University, Latina, Italy)

P144 - MIGRATION AND INVASION BEHAVIOURS OF TUMOR CELLSM. Colone (Istituto Superiore di Sanità, Rome, Italy), G. Bozzuto, M. Condello, P. Ruggieri, L. Toccacieli, A. Molinari

P145 - ROLE OF P70S6K IN BREAST CANCER RECURRENCEB. Belletti (Centro di Riferimento Oncologico, Aviano, Italy), M. Sonego, S. Massarut, T. Perin, I. Pellizzari, S. D’Andrea, G. Baldassarre

P146 - OBESITY IN ELDERLY: EVIDENCE ABOUT THE ROLE OF ADIPOKINES IN PROSTATE TUMOR PROGRESSIONA. Angelucci (University of L’Aquila, L’Aquila, Italy), G. Pace, L. Di Martino, G. Bologna, C. Vicentini, M. Bologna

TUMOR IMMUNOLOGY AND IMMUNOTHERAPY

P147 - INDUCTION OF HUMAN PAPILLOMA VIRUS-SPECIFIC CD4+ T LYMPHOCYTES BY E7 PULSED AUTOLOGOUS DENDRITIC CELLS IN HLA-A2 POSITIVE HEALTHY DONORSL. Canotti (University of Brescia, Brescia, Italy), C. Romani, E. Bandiera, E. Bignotti, R. Tassi, P. Todeschini, F.E. Odicino, G. Tognon, C. Donzelli, M. Falchetti, A.D. Santin, S. Pecorelli, A. Ravaggi

P148 - ANTHRAX TOXIN RECEPTOR 1- DERIVED DNA SEQUENCE AS ADjUVANT FOR ANTI-CANCER IMMUNO-CHEMOTHERAPYF. Venanzi (University of Camerino, Camerino, Italy), A. Concetti, K. Havas

P149 - EFFECTIVE IMMUNOPREVENTIVE STRATEGIES AGAINST TUMOR ONSET IN A HUMAN HER-2 TRANSGENIC MOUSE MODELV. Stivani (University of Bologna, Bologna, Italy), A. Antognoli, L. Landuzzi, A. Murgo, A. Palladini,V. Grosso, S. Croci, M. Ianzano, G. Nicoletti, E. Quaglino, A. Amici, P.L. Lollini, C. De Giovanni, P. Nanni

P150 - COMBINATION OF CPG-ODN, MONOCLONAL ANTIBODY AND CHEMOTHERAPY IN VERY ADVANCED OVARIAN XENOGRAFT TUMORSM. Sommariva (University of Milan, Milan, Italy), M. De Cesare, L. Sfondrini, S. Ménard, C. Melani, N. Zaffaroni, G. Pratesi, E. Tagliabue, A. Balsari


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PostersP151 - AN ADENOSINERGIC LOOP CONTRIBUTES TO THE GENERATION OF A MICROENVIRONMENT FAVORING GROWTH AND EXPANSION OF CLL CELLSS. Serra (University of Turin, Turin, Italy), A.L. Horenstein, C. Tripodo, T. Vaisitti, V. Audrito, D. Rossi, D. Gottardi, G. Gaidano, F. Malavasi, S. Deaglio

P152 - COMBINING HUMAN AND RODENT SEQUENCES IN ERBB2 DNA VACCINES BLUNTS IMMUNE TOLERANCE AND DRIVES ANTI-TUMOR IMMUNITYE. Quaglino (University of Turin, Turin, Italy), C. Mastini, F. Riccardo, E. Ercole, M. Montani, A. Amici, G. Forni, F. Cavallo

P153 - IMPACT OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) GENE CHARACTERIZATION ON ANTICANCER DRUG CYTOTOXICITY IN THYMIC EPITHELIAL TUMORS (TET): PRELIMINARY DATAG. Palmieri (Federico II University, Naples, Italy), S. Conti, S. Sioletic, R. Martucci, L. Petillo, G. Merola, M. Imbimbo, C. Buonerba, A. Evoli, G. Di Lorenzo, M. Marino

P154 - GOOD SYNDROME IN A SERIES OF 30 THYMOMA PATIENTS: ALTERATIONS IN NK, T AND B CELL COMPARTMENTS AND BY PROGRESSIVE INCREASE IN NAÏVE CD8 T CELLSG. Palmieri (Federico II University, Naples, Italy), G. Merola, M. Imbimbo, L. Montella, M. Marino, P. Federico, L. Petillo, C. Buonerba, M. Merola, G. Di Lorenzo, A. Masci, L. Racioppi, L. Vitiello

P155 - NOTCH3-IC STABILITY IN T CELL LEUKEMIA IS REGULATED BY ACETYLATIONR. Palermo (Sapienza University, Rome, Italy), S. Checquolo, A. Giovenco, G. Ferrara, V. Kumar, P. Grazioli, A.F. Campese, M. Napolitano, A. Gulino, A. Vacca, I. Screpanti

P156 - EVALUATION OF PERIPHERAL BLOOD DENDRITIC CELLS IN PATIENTS WITH COLORECTAL CARCINOMAG. Orsini (University of Pisa, Pisa, Italy), A. Legitimo, A. Failli, P. Ferrari, A. Nicolini, R. Spisni, P. Miccoli, R. Consolini

P157 - DISTINCT PATHWAYS OF ANTIGEN PROCESSING OF MUC1 TUMOR-ASSOCIATED GLYCOPROTEIN IN DENDRITIC CELLS (DCS)S. Pauselli, H. Rahimi, F. Belleudi, C. Napoletano, M.R. Torrisi, M. Nuti (Sapienza University of Rome, Rome, Italy), A. Rughetti

P158 - SURGICAL CYTOREDUCTION AND CHEMOTHERAPY ARE ABLE TO REVERT IMMUNOSUPPRESSIVE STATUS IN OVARIAN CANCER PATIENTSM. Nuti (Sapienza University of Rome, Rome, Italy), C. Napoletano, F. Bellati, V. Visconti, I. Zizzari, C. Marchetti, M. Antonilli, A. Rughetti, P. Benedetti Panici

P159 - COMBINATION OF DACARBAZINE AND PEPTIDE-VACCINATION ENHANCES THE ANTI-TUMOR ACTIVITY AND SHAPES THE ANTI-MELAN-A AND THE ANTI-GP100 T-CELL CLONES REPERTOIRE IN MELANOMA PATIENTSB. Palermo (Regina Elena National Cancer Institute Rome), D. Del Bello, N. Gualtieri, G. Ruocco, C. Di Donna, C. Nuzzo, L. Imberti, P.G. Natali, F. Belardelli, E. Proietti, C. Catricalà, V. Ferraresi, P. Nisticò

P161 - TUMOR-REACTIVE CD8+ EARLY EFFECTOR T CELLS IDENTIFIED AT TUMOR SITE IN PRIMARY AND METASTATIC MELANOMAR. Mortarini (IRCCS, Milan, Italy), A. Molla, C. Vegetti, I. Bersani, R. Zappasodi, F. Arienti, F. Ravagnani, A. Maurichi, R. Patuzzo, M. Santinami, M. Di Nicola, A. Anichini

P162 - ANTITUMOR VACCINES AND IMMUNOTHERAPEUTIC STRATEGIES BASED ON CIITA-DRIVEN MHC CLASS II EXPRESSION IN CANCER CELLSL. Mortara (University of Insubria, Varese, Italy), V. Frangione, G. Capone, P. Castellani, A. De Lerma Barbaro, R.S. Accolla

P164 - RECRUITMENT OF HUMAN ENDOTHELIAL CELLS EXPRESSING ALPHA-GAL EPITOPES INTO TUMOR VESSELS AS A NOVEL STRATEGY TO PROMOTE COMPLEMENT DEPENDENT TUMOR REGRESSIONP. Macor (University of Trieste, Trieste, Italy), N. Mezzaroba, F. Bossi, S. Biffi, C. Garrovo, S. Zorzet, F. Tedesco


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PostersP165 - HUMAN LEUKOCYTE ANTIGEN E (HLA-E) IS WIDELY ESPRESSED AND FUNCTIONAL IN TUMOR CELLS, AND ASSOCIATES WITH A FAVORABLE PROGNOSISE. Lo Monaco (Regina Elena National Cancer Institute, Rome, Italy), M. Benevolo, E. Tremante, P.G. Natali, E. Melucci, C. Cerboni, A. Zingoni, F. Rollo, M.G. Diodoro, I. Sperduti, M. Cosimelli, M. Mottolese, P. Giacomini

P166 - MANIPULATING DENDRITIC CELLS BY STAT3 SILENCING TO IMPLEMENT THEIR USE IN CANCER IMMUNOTHERAPYS. Gessani (Istituto Superiore di Sanità, Rome, Italy), I. Sanseverino, M.C. Gauzzi, C. Purificato, L. Beltrame, D. Cavalieri

P168 - THE PROLYL-ISOMERASE PIN1 REPRESENT A REGULATOR OF NOTCH3-IC PROTEIN FUNCTIONAL ACTIVITYS. Checquolo (Sapienza University, Rome, Italy), G. Ferrara, R. Palermo, D. Bellavia, M. Pelullo, A. Gulino, I. Screpanti

P169 - COTREATMENT WITH APICIDIN AND DOCETAXEL INDUCES IMMUNOGENIC APOPTOSIS AND ENHANCES EXPRESSION OF CTCFL IN METASTATIC BREAST CELLSM. Buoncervello (Istituto Superiore di Sanità, Rome, Italy), P. Borghi, G. Romagnoli, F. Spadaro, E. Toschi, F. Mattei, M. Ferrantini, F. Belardelli, L. Gabriele

P170 - ADOPTIVE IMMUNOTHERAPY STRATEGIES FOR RELAPSED OR METASTATIC BONE SARCOMAS: PRECLINICAL MODELS AND CLINICAL APPLICATIONS.M. Muraro (Regina Margherita Children’s Hospital, Turin, Italy), E. Signorino, S. Pastiglia, F. Saglio, F. Fagioli

CANCER GENETIC

P171 - GENETIC SUSCEPTIBILITY IN MALE BREAST CANCERV. Silvestri (“Sapienza” University, Rome, Italy), P. Rizzolo, M. Falchetti, I. Zanna, G. Giannini, A. Gulino, D. Palli, L. Ottini

P172 - TRANSCRIPTIONAL REGULATION OF PROSTATE CANCER PROGNOSTIC GENES BY THE ENOS/ERB COMBINATORIAL COMPLEX: SILENCING OF GLUTATHIONE TRANSFERASE P1A. Re (Regina Elena National Cancer Institute, Rome, Italy), A. Aiello, S. Nanni, A. Grasselli, V. Benvenuti,V. Pantisano, C. Priolo, S. Sentinelli, L. Strigari, M. Loda, S. Ciccone, A. Sacchi, P.F. Bassi, F. Pierconti, F. Pinto, M. Gallucci, A. Pontecorvi, S. Bacchetti, M. Lo Bello, A. Farsetti

P173 - ATM HETEROZYGOSITY AS A MAjOR TUMOR-SUSCEPTIBILITY FACTOR IN THE GENERAL POPULATIONA. Prodosmo (Istituto Regina Elena, Rome, Italy), A. De Amicis, C. Nisticò, E. Cundari, L. Chessa, S . Soddu

P174 - COULD BRCA POLYMORPHISMS INCREASE BREAST CANCER RISK?B. Pilato (Istituto Tumori Giovanni Paolo II, Bari, Italy), S. De Summa, K. Danza, R. Pinto, M. Digennaro, R. Lambo, G. Iannelli, A. Paradiso, S. Tommasi

P175 - KCTD21 IS A NOVEL MEMBER OF THE HEDGEHOG ANTAGONIST RENKCTD11 UBIQUITIN LIGASE ADAPTOR FAMILYM. Pelloni (“Sapienza” University, Rome, Italy), E. De Smaele, M. Moretti, L. Di Marcotullio, A. Greco, M.A. Occhione, D. Cucchi, L. Pietrosanti, P. Infante, L. Canettieri, E. Ferretti, M. Maroder, I. Screpanti, A. Gulino

P176 - CBX7 REPRESSES THE APPEARANCE OF THE MALIGNANT PHENOTYPE, MODULATING THE EXPRESSION OF SPECIFIC EFFECTOR GENESP.L. Pallante, R. Sepe (CNR, Rome, Italy), A. Federico, F. Forzati, A. Fusco

P179 - DIFFERENCES IN CELL CYCLE PROGRESSION BETWEEN HUMAN MELANOMA CELL LINESA. Nasar (College of Medicine-Thi-Qar University, Alnasiryha, Iraq)

P180 - DEREGULATION OF MIR-221/222 CLUSTER AFFECTS P27 EXPRESSION IN MULTIPLE MYELOMAM. Lionetti (University of Milan, Milan, Italy), D. Verdelli, D. Ronchetti, L. Nobili, L. Agnelli, L. Mosca, L. Lombradi, G. Lambertenghi Deliliers, A. Neri


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PostersP181 - EFFECTS OF THE EXPRESSION OF M1775R AND A1789T BRCA1 MISSENSE VARIANTS ON THE TRANSCRIPTOME OF HELA CELLSC. Guglielmi (University of Pisa Pisa Italy), C. Iofrida, E. Melissari, V. Mariotti, M. Di Russo, L. Guidugli, G. Lombardi, M.A. Caligo, S. Pellegrini

P182 - PATZ INHIBITS BCL6 AND IS CRITICAL FOR THE DEVELOPMENT OF LYMPHOMAS IN MICE AND HUMANSM. Fedele (CNR, Naples, Italy), R. Pero, D. Palmieri, T. Valentino, T. Angrisano, G. Troncone, R. Franco, L. Del Vecchio, L. Chiariotti, A. Fusco

P183 - BIOLOGICAL AND CLINICAL RELEVANCE OF QUANTITATIVE GLOBAL METHYLATION OF REPETITIVE DNA SEQUENCES IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITH 17P DELETIONS. Fabris (University of Milan, Hematology 1/CTMO, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan Italy), V. Bollati, L. Agnelli, F. Morabito, V. Motta, G. Cutrona, S. Matis, V. Gigliotti, M. Gentile, M. Zappa, G. Lambertenghi Deliliers, P.A. Bertazzi, M. Ferrarini, A. Baccarelli, A. Neri

P184 - ROLE OF ETV4 EXPRESSION IN PROSTATE CANCERN. Passaro (Istituto Toscano Tumori, Florence, Italy) C. Pescucci, A. Pellecchia, M. Sica, B. Peruzzi, T. Rondelli, M. Berardi, R. Notaro, M. De Angioletti

P185 - NOTCH 3 LEVELS CONTROL PROLIFERATION AND TUMORIGENICITY OF COLON CANCER CELLSM. Curtarello (IRCCS, Padua, Italy), V. Serafin, M. Ghisi, L. Persano, L. Moserle, M. Masiero, L. Bonanno, E. Rossi, G. Esposito, S. Minuzzo, I. Pusceddu, P. Dalerba, C. Castelli, A.L. Harris, A.M. Jubb, M. Sturzl, A. Amadori, S. Indraccolo

P186 - POTENTIAL PATHWAYS INVOLVED IN EMBRYONAL RHABDOMYOSARCOMA DEVELOPMENTS. Croci (University of Bologna, Bologna, Italy) M. Ianzano, G. Nicoletti, M. Urbini, A. Palladini, A. Antognoli, A. Murgo, V. Grosso, V. Stivani, L. Landuzzi, C. De Giovanni, P-L. Lollini, P. Nanni

P187 - GENETIC AND IMMUNOHISTOCHEMICAL SURVEY OF PROTEIN KINASES IN PANCREATIC ENDOCRINE TUMORSV. Corbo (Arc-Net Research Centre, University of Verona, Policlinico G.B. Rossi, Verona, Italy), S. Beghelli, S. Bersani, E. Amato, F. Amedeo, G. Malpeli, D. Antonello, A. Scarpa

P188 - CANCER CANDIDATE (CAN) KINASE GENES IN EXOCRINE NEOPLASMS OF THE PANCREASV. Corbo, R. Ritelli, S. Prejanò (University of Verona, Policlinico G.B. Rossi, Verona, Italy), S. Barbi, N. Funel, D. Campani, A. Bardelli, A. Scarpa

P189 - MEN1 IN PANCREATIC ENDOCRINE TUMORS: ANALYSIS OF GENE AND PROTEIN STATUS IN 169 SPORADIC NEOPLASMS REVEALS ALTERATIONS IN THE VAST MAjORITY OF CASESV. Corbo (ARC-NET Research Centre, University of Verona, Policlinico G.B. Rossi, Verona, Italy), I. Dalai, M. Scardoni, S. Barbi, S. Beghelli, S. Bersani, L. Albarello, C. Doglioni, C. Schott, P. Capelli, M. Chilosi, L. Boninsegna, K-F. Backer, M. Falconi, A. Scarpa

P190 - ANTI-APOPTOTIC ROLE OF CHE-1/HAX1 INTERACTION IN SEVERE CONGENITAL NEUTROPENIA (SCN), A PRELEUKEMIC CONDITIONN. Corbi (Regina Elena National Cancer Institute, Rome, Italy), A. Onori, C. Pisani, M.G. Di Certo, C. Passananti

P191 - MFSD2A IS A NOVEL LUNG TUMOUR SUPPRESSOR GENE WHOSE EXPRESSION IS MODULATED BY A 5’-REGION POLYMORPHISMF. Colombo (IRCCS, Milan, Italy), M. Spinola, F.S. Falvella, J.P. Sullivan, D.S. Shames, L. Girard, P. Spessotto, J.D. Minna, T.A. Dragani

P192 - MICRORNAS IN PAPILLARY THYROID CARCINOMAV. Catalano (IRCCS, Milan, Italy), D. Degl’Innocenti, L. De Cecco, M.G. Rizzetti, A. Greco, M.G. Borrello

P193 - UPREGULATION OF MYTOGEN ACTIVATED PROTEIN KINASE KINASE 3 BY MUTANT P53 IS REQUIRED FOR GAIN OF FUNCTION MUTATIONSG. Bossi (Regina Elena National Cancer Institute, Rome, Italy), A. Gurtner, G. Starace, G. Norelli, G. Piaggio, A. Sacchi


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PostersCONTROL OF GENE EXPRESSION AND EPIGENETICS

P195 - MIR-143 AND MIR-145 INHIBIT THE GROWTH OF COLON CANCER CELLS BY TARGETING MULTIPLE ONCOGENIC ACTIVITIESC. Valvo (Istituto Superiore Sanità, Rome, Italy), A. Pagliuca, E. Fabrizi, S. di Martino, L. Ricci-Vitiani, R. De Maria

P196 - EPIGENETIC CONTROL OF HYPOXIA-INDUCED PLGF EXPRESSIONL. Tudisco (Institute of Genetics and Biophysics Adriano Buzzati-Traverso ,CNR, Naples, Italy), M.R. Matarazzo, F. Della Ragione, M. D’Esposito, S. De Falco

P197 - WNT ANTAGONIST GENES ARE DOWN-REGULATED IN MEDULLOBLASTOMAF. Valdora, P. Scaruffi, B. Banelli, S. Stigliani (Istituto Nazionale per la Ricerca sul Cancro IST, Genoa, Italy), S. Moretti, S. Bonassi, I. Adolfo, M. Zollo, M. Oberthuer, J. Theissen, M. Romani, G. Cinalli, A. Iolascon, G.P. Tonini, S. Coco

P198 -GENE AND MIRNA EXPRESSION PROFILING INDUCED BY CISPLATIN ON MB CELLSS. Stigliani (Istituto Nazionale per la Ricerca sul Cancro IST, Genoa, Italy), S. Coco, F. Valdora, P. Scaruffi, S. Moretti, G. Cesari, G. Pietra, M.C. Mingari, G. Basso, A. Iolascon, G.P. Tonini

P199 - IDENTIFICATION AND CHARACTERIZATION OF MATRIX ATTACHMENT REGION-BINDING PROTEINS IN HUMAN PROSTATIC CANCER CELL LINESE. Repaci (Istituto Nazionale Per La Ricerca Sul Cancro, Genoa, Italy), C. Balbi, P. Barboro P200 - MYCN TRANSCRIPTIONALLY CONTROLS THE EXPRESSION OF THE NIjMEGEN BREAKAGE SYNDROME GENE PRODUCT P95 NIBRIN/NBS1M. Petroni (Sapienza University, Rome, Italy), M. Mellone, S. Albini, V. Veschi, I. Massimi, I. Screpanti, L. Frati, D. Fruci, A. Gulino, B. Cardinali, G. Giannini

P201 - REDUCTION OF jHDM1B LEVELS CONFERS A GROWTH ADVANTAGE TO CANCER CELLS LACKING P53 FUNCTIONM. Penzo (Università Di Bologna, Bologna, Italy), M. Calienni, D. Trere’, M. Derenzini, L. Montanaro

P202 - FUNCTIONAL ROLE OF A RESTRICTED SIGNATURE OF MICRORNAS IN ACUTE PROMYELOCYTIC LEUKAEMIAA. Pelosi (Regina Elena National Cancer Institute Rome Italy), S. Careccia, N.G. Sukubo, V. Azzimato, P. Romania, G. Marziali, U. Testa, F. Lo-Coco, M.G. Rizzo

P203 - NOVEL DYSKERIN-MEDIATED MECHANISM OF P53 INACTIVATION THROUGH DEFECTIVE MRNA TRANSLATIONL. Montanaro (Università Di Bologna, Bologna, Italy), M. Calienni, S. Bertoni, L. Rocchi, D. Treré, M. Derenzini

P204 - NOVEL ANTIPROLIFERATIVE ROLES FOR THE POLYCOMB GROUP PROTEINS IN LUNG CANCERD. Malanga, M. Scrima (Biogem S.C. A R.L., Ariano Irpino (Av), Italy), F. Colelli, G. Viglietto

P205 - P3H COLLAGEN PROLYL HYDROXYLASES ARE TISSUE SELECTIVE TUMOUR SUPPRESSORSC. Lo Nigro (S. Croce General Hospital, Cuneo, Italy), L. Lattanzio, N. Syed, M. Monteverde, A. Dasoula, E. Hatzimichael, A. Papoudou-Bai, P. Schmid, M. Merlano, T. Crook

P206 - CULLIN3/RENKCTD11 COMPLEX, A NOVEL SCF-LIKE E3 UBIQUITIN LIGASE, REGULATES HEDGEHOG SIGNALING THROUGH DEGRADATION OF HDAC1P. Infante (“Sapienza” University, Rome, Italy), L. Di Marcotullio, A. Greco, L. Pietrosanti, S. Coni, L. Canettieri, E. De Smaele, E. Ferretti, I. Screpanti, A. Gulino

P207 - THE DEACETYLASE INHIBITOR PANOBINOSTAT IS A CYTOTOXIC DRUG AND INDUCER OF IODINE UPTAKE IN ANAPLASTIC THYROID CANCER PRIMARY CULTURESM.G. Catalano (University of Turin, Turinx, Italy), M. Pugliese, A. Germano, R. Poli, S. Asioli, N. Palestini, F. Mainini, N. Fortunati, G. Boccuzzi

P208 - THE PAN-DAC INHIBITOR LBH589 INDUCES NIS (SODIUM-IODIDE SYMPORTER) EXPRESSION IN BREAST CANCERN. Fortunati (University of Turin, Turin, Italy), M.G. Catalano, F. Marano, M. Pugliese, F. Mainini, G. Boccuzzi


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PostersP209 - THE CBX7 PROTEIN, WHOSE EXPRESSION IS DECREASED IN HUMAN CARCINOMAS, POSITIVELY REGULATES E-CADHERIN EXPRESSION BY INTERACTING WITH THE HDAC2 PROTEINA. Federico (CNR, Naples, Italy), P.L. Pallante, M. Bianco, M. Monti, M. Cozzolino, V. Leone, P. Pucci, A. Fusco

P210 - GENE EXPRESSION PROFILING WITH RNA FROM FORMALIN-FIXED PARAFFIN-EMBEDDED TISSUES. A PRELIMINARY STUDY IN HUMAN BREAST CANCER SAMPLESM. Digito (University of Padua, Padua, Italy), K. Tavella, G. Zavagno, G. Esposito, E. Orvieto, B. Celegato, C. Casella, M. Briarava, P. Segato, R. Grancara, D. Nitti

P211 - EPIGENETIC CONTROL OF MEDULLOBLASTOMA CELL GROWTH: IDENTIFICATION OF GLI ACETYLATION AS A KEY TRANSCRIPTIONAL CHECKPOINT OF HEDGEHOG SIGNALINGS. Coni (“Sapienza” University, Rome, Italy), G. Canettieri, L. Antonucci, A. Greco, A. Giorgi, E. Miele, L. Di Marcotullio, E. De Smaele, E. Ferretti, P. Gallinari, C. Steinkuhler, M.E. Schininà, I. Screpanti, A. Gulino

P212 - MIR-191 DOWNREGULATION PLAYS A ROLE IN THYROID CARCINOGENESISM. Colamaio (CNR, Naples, Italy), E. Borbone, S. Battista, A. Fusco

P213 - EPIGENETIC DETERMINANTS OF RET GENE TRANSCRIPTIONAL ACTIVATION IN NEUROBLASTOMA CELLST. Angrisano (Università degli Studi di Napoli Federico II, Naples, Italy), S. Sacchetti, F. Natale, S. Keller, S. Peluso, F. Lembo, R. Pero, L. Chiariotti

P215 - ENHANCER OF ZESTE HOMOLOG 2 OVEREXPRESSION HAS A CRITICAL ROLE IN THE DEVELOPMENT OF ANAPLASTIC THYROID CARCINOMASE. Borbone (CNR, NOGEC,CEINGE, Biotecnologie Avanzate-Napoli, & SEMM - European School of Molecular Medicine, Naples, Italy), G. Troncone, A. Ferraro, Z. Jasencakova, N. Hornig, F. Esposito, A. Fusco, V. Orlando

P216 - UHRF1 IS UPREGULATED IN PROSTATE CANCER AND INDUCES EPIGENETIC GENE SILENCING OF TUMOR SUPPRESSOR GENESI. Bonapace (University of Insubria, Busto Arsizio, Italy), F. Babbio, C. Pistore, I. Castiglioni, L. Curti, M. Kunderfranco, G. Carbone, C. Catapano

P217 - EPIGENETIC MODIFICATIONS IN A T(8;21) ACUTE MYELOID LEUKAEMIA CELL LINE CAUSED BY ADMINISTRATION OF TWO HDAC INHIBITORS, VPA AND SAHAV. Barbetti (University of Florence, Florence, Italy), A. Gozzini, S. Giuntoli, M. Tanturli, V. Santini, P. Dello Sbarba, E. Rovida

P219 - MUTP53 DEPENDENT REGULATION OF MICRORNA IN CANCERV. Ambrosino (Istituto Tumori Regina Elena, Rome, Italy), A. Gurtner, G. Piaggio, A. Sacchi, G. Piaggio

P220 - ENDOTHELIAL CELLS SENESCENCE: ACTIVATION OF A PRO- OR ANTI- ANTIANGIOGENIC PROGRAM?A. Cantelmo (Oncology Research Laboratory, Casa di Cura MultiMedica - IRCCS, Milan, Italy), G. Di Giacomo, U. Pfeffer, L. Ruggiero, D. Noonan, A. Albini

INFECTIOUS AGENTS AND CANCER

P221 - HPV INFECTIONS ASSOCIATED TO SKIN CANCER: ONGOING REPORTS A. Carbone (Regina Elena National Cancer Institute, Rome, Italy), F. Paolini, V. Silipo, P. Piemonte, P. Frascione, R. Covello, M. Benevolo, A. Venuti

P222 - BOVINE PAPILLOMAVIRUS E7 ONCOPROTEIN BINDS TO P600 IN AN “EQUINE MODEL” OF PAPILLOMAVIRUS INDUCED NEOPLASIAA. Corteggio, O. Di Geronimo, S. Roperto, F. Roperto, G. Borzacchiello (University of Naples Federico II, Naples, Italy)


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PostersNANOTECHNOLOGY

P223 - IN VITRO AND IN VIVO HIGH ANTITUMOR ACTIVITY OF ZOLEDRONIC ACID-LOADED LIPOSOMES S. Zappavigna (Second University, Naples, Italy), M. Marra, G. Salzano, C. Leonetti, P.F. Tassone, M. Scarsella, T. Calimeri, M.I. La Rotonda, A. Abbruzzese, P.S. Tagliaferri, G. De Rosa, M. Caraglia

P224 - IN VITRO AND IN VIVO ASSESSMENT OF LIPOSOMAL NANOVECTORS FOR PDT OF GLIOBLASTOMA G. Bozzuto (Istituto Superiore di Sanità, Rome, Italy), S. Mannino, C. Bombelli, A. Stringaro, L. Toccacieli, A. Mangiola, G. Maira, G. Mancini, A. Molinari

P225 - RECONSTRUCTION OF TRANSCRIPTIONAL REGULATORY NETWORKS IN MULTIPLE MYELOMAL. Agnelli (University of Milan, Hematology 1/CTMO, Fondazione IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy), M. Forcato, K. Todoerti, D. Ronchetti, S. Fabris, M. Lionetti, G. Tuana, F. Ferrari, L. Lombardi, G. Lambertenghi Deliliers, S. Bicciato, A. Neri

SYSTEM BIOLOGY AND EMERGING TECHNOLOGIES

P227 - IMPACT OF BIOSPECIMEN HANDLING ON METABOLOMIC RESEARCH IN BREAST AND OVARIAN CANCERA. Ricci (Istituto Superiore Di Sanità, Rome, Italy), E. Iorio, M.E. Pisanu, R. Canese, M. Giannini, V. Cappelletti, D. Mezzanzanica, S. Canevari, F. Podo

P228 - CD157 EXPRESSION ENHANCES INVASIVENESS OF OVARIAN CANCER CELLS AND INDUCES A MESENCHYMAL PHENOTYPEN. Lo Buono (University of Turin Medical School, Turin, Italy), P. Bovino, S. Morone, R. Parrotta, E. Ferrero, M. Scianna, C. Giverso, L. Preziosi, F. Malavasi, A. Funaro, E. Ortolan

P229 - ROLE OF IGF SYSTEM IN DIFFERENTIATION OF OSTEOSARCOMA CELLSC. Contaldo (Ior, Bologna, Italy), M. Sciandra, M.C. Manara, G. Nicoletti, C. Zucchini, L. Valvassori, P. Picci, K. Scotlandi

P230 - CORRELATION BETWEEN CK19 MRNA COPY NUMBER DETECTED BY ONE STEP NUCLEIC ACID AMPLIFICATION (OSNA) IN POSITIVE SENTINEL NODE AND RISK OF METASTASES IN AXILLARY LYMPH NODES OF BREAST CANCER PATIENTSS. Buglioni (Regina Elena National Cancer Institute, Rome, Italy ), B. Casini, E. Gallo, I. Terrenato, C.A. Amoreo, P. Canalini, M. Mottolese, P. Perri, F. Di Filippo, F. Marandino

CANCER STEM CELLS

P231 - CHARACTERIZATION OF OVARIAN CANCER INITIATING CELLSF. Ricci (Istituto Di Ricerche Farmacologiche Mario Negri, Milan, Italy), S. Bernasconi, M. Ganzinelli, G. Russo, E. Erba, C. Mangioni, R. Fruscio, M. Broggini, G. Damia

P232 - CD133 AND NEW POTENTIAL MARKERS OF TUMOR-INIZIATING CELLS IN COLON CANCERM. Puglisi (Gemelli Hospital, Rome, Italy), A. Sgambato, M. Barba, E. Giorda, M.F. Errico, A. Boninsegna, N. Saulnier, A.C. Piscaglia, R. Carsetti, A. Cittadini, A. Gasbarrini

P233 - NANOG IS ESSENTIAL IN NEURONAL AND MEDULLOBLASTOMA STEM CELLS ACTING IN A CROSS-FUNCTIONAL NETWORK WITH HEDGEHOG/GLI1A. Po (Sapienza University, Rome, Italy), E. Ferretti, E. Miele, E. De Smaele, A. Paganelli, G. Canettieri, S. Coni, L. Di Marcotullio, M. Biffoni, L. Massimi, C. Di Rocco, I. Screpanti, A. Gulino

P234 - SYNERGISM OF EVEROLIMUS AND SORAFENIB IN OSTEOSARCOMA (OS) PRECLINICAL MODELS: EVEROLIMUS AFFECTS CANCER STEM CELLS AND SORAFENIB ACTS ON BULK POPULATIONY. Pignochino (Università Cattolica, Institute of General Pathology, Rome, Italy), G. Grignani, C. Dell’Aglio, M. Basiricò, L. Gammaitoni, M. Motta, S. Bruno, M. Alberghini, P. Picci, M. Aglietta


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PostersP235 - METABOLIC RESISTANCE OF LIVER CANCER STEM CELLS TO THE MULTIKINASE INHIBITOR SORAFENIBV. Tesori, A.C. Piscaglia, A. Pontoglio, M. Barba, R. Scatena, A. Gasbarrini, G.B. Pani (Università Cattolica, Rome, Italy)

P236 - PHARMACOLOGICAL TARGETING OF CRIPTO SIGNALING DIRECTS EMBRYONIC STEM CELL FATE AND IMPAIRS THEIR TUMORIGENIC POTENTIAL IN VIVOG. Minchiotti (CNR, Naples, Italy), E. Lonardo, C. Parish, C. D’Aniello, O. Guardiola, M. Ruvo, S. De Falco, E. Arenas

P237 - SEMAPHORINS AND THEIR RECEPTORS IN LUNG STEM/PROGENITOR CELLS AND LUNG TUMORSC. Micucci (Polytechnic University of Marche, Ancona, Italy), S. Orciari, S. Di Nuzzo, A. Catalano

P238 - A REGOLATORY CIRCUIT INVOLVING AKT1-IL6-STAT3 IS CRUCIAL FOR LUNG CANCER STEM/TUMOR INITIATING CELL MAINTENANCED. Malanga (BioGem s.c. a r.l, Ariano Irpino, AV, Italy), I. Guerriero, C. De Marco, N. Rinaldo, M. Ravo, G. Ciliberto, A. Weisz, G. Viglietto

P239 - DETECTING NEW ONCOANTIGENS IN BREAST CANCER INITIATING CELLS THROUGH MOUSE AND HUMAN DATA INTEGRATIONS. Lanzardo (University of Turin, Turin, Italy), L. Conti, G. Forni, H. Pinto, D. Cantarella, F. Cavallo, R.A. Calogero

P240 - RPPMA AND KINASE INHIBITORS SCREENING: A COMPLEMENTARY APPROACH FOR THE IDENTIFICATION OF NOVEL POTENTIAL THERAPEUTIC TARGETS OF COLON ADENOCARCINOMAE. Fabrizi (Università Di Catania Catania, Italy), M. Signore, L. Ricci-Vitiani, S. Di Martino, S. Navarra, R. De Maria

P242 - THYMOSIN BETA 4 TARGETING IMPAIRS TUMORIGENIC ACTIVITY OF COLON CANCER STEM CELLSS. Di Martino (Scuola Superiore Di Catania, Catania, Italy), L. Ricci Vitiani, C. Collinari, M. Biffoni, D. Merlo, R. De Maria, E. Garaci

P243 - AROMATASE INHIBITORS AND HERCEPTIN ON CD44+/CD24LOW BREAST CANCER CELLSS. Corvigno (Facoltà Di Medicina E Chirurgia, Naples, Italy), A. Nardone, A. Brescia, M.V. Russo, D. D’Andrea, C. Manta, B.M. Veneziani

P244 - THE TLR2 PATHWAY IS REQUIRED FOR SELF-RENEWAL OF MAMMARY CANCER STEM CELLSL. Conti (University of Turin, Turin, Italy), S. Lanzardo, G. Forni, H. Pinto, D. Cantarella, R.A. Calogero, F. Cavallo

P245 - TARGETING OF BCR/ABL AND GSK-3BETA TO ERADICATE CHRONIC MYELOID LEUKEMIA-INITIATING CELLSA. Coluccia (Vito Fazzi Hospital (Asl-Le), University of Salento, Lecce, Italy), S. De Leo, G. Reddiconto, M. Greco, I.E. Palamà, S. De Matteis, C. Gambacorti-Passerini, L. Dini, N. Di Renzo, M. Maffia

P246 - THE TUMOR SUPPRESSOR P53 REGULATES POLARITY OF SELF-RENEWING DIVISIONS IN MAMMARY STEM CELLSA. Cicalese (IEO, IFOM, Milan, Italy), G. Bonizzi, C.E. Pasi, M. Faretta, S. Ronzoni, B. Giulini, C. Brisken, S. Minucci, P.P. Di Fiore, P.G. Pelicci, These authors contributed equally to this work

P248 - ISOLATION OF CELLS WITH CHARACTERISTIC OF STEM/PROGENITOR CELLS FROM EPITHELIAL OVARIAN CANCERI. Bortolomai (Fondazione IRCCS, Milan, Italy), S. Miotti, A. Zacchetti, I. Facetti, F. Raspagliesi, B. Valeri, P. Perego, G. Cossa, S. Canevari

P249 - TUMOR INITIATING COLON CANCER CELLS IN HUMAN COLON CANCER AND LIVER METASTASISA. Bellizzi (National Cancer Institute Giovanni Paolo II, Bari, Italy), A. Azzariti, S. Montemurro, G. Simone, A. Paradiso

P250 - DRUG-INDUCED ACTIVATION OF CHK1 MEDIATES LUNG CANCER STEM CELL CHEMO-RESISTANCE REPRESENTING A POTENT THERAPEUTIC TARGET TO TREAT LUNG TUMORSM. Bartucci (Istituto Superiore di Sanità, Rome, Italy), S. Svensson, P. Romania, R. Dattilo, F. Lotti, M. Biffoni, M. Pilozzi, M. Patrizii, C. Rinaldo, M. Signore, A. Zeuner, A. Eramo, R. De Maria


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PostersP251 - THE MOLECULAR PROFILE OF MAMMARY STEM CELLS PROVIDES A NEW OUTLOOK ON THE CELLULAR, MOLECULAR AND CLINICAL HETEROGENEITY OF BREAST CANCERSD. Tosoni, S. Confalonieri, M. Vecchi, G. Mazzarol, G. Viale, P.G. Pelicci, S. Pece (IFOM, FIRC, University of Milan, Istituto Europeo di Oncologia, Milan Italy), P.P. Di Fiore

CELL METABOLISM AND CELL CYCLE REGULATION

P252 - CD99 AS A KEY MOLECULE IN THE REGULATION OF OSTEOBLASTIC DIFFERENTIATIONM. Sciandra (Istituto Ortopedico Rizzoli - Laboratory of Experimental Oncology, Bologna, Italy), M.T. Marino, M.C. Manara, P. Picci, K. Scotlandi

P253 - ARGONAUTE ROLES IN NEUROBLASTOMAC. Parisi (Sapienza University, Rome, Italy), C. Catalanotto, F. Pietrolati, C. Cogoni

P254 - STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF THE LEUKAEMIA-ASSOCIATED NUCLEOPHOSMIN C-TERMINAL DOMAINC. Lo Sterzo (Cnr, Università Sapienza, Rome, Italy), G.L. Scaglione, L. Federici, A. Arcovito, F. Scaloni, A. Di Matteo, B. Falini, B. Giardina, M. Brunori

P255 - RELEVANCE OF ALTERED CHOLINE KINASE ACTIVITY AND EXPRESSION IN THE BIOLOGY OF EPITHELIAL OVARIAN CANCERA. Granata (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy), M.T. Comito, L. De Cecco, E. Iorio, A. Ricci, M.E. Pisanu, Z. Bhujwalla, F. Podo, S. Canevari, D. Mezzanzanica, M. Bagnoli

P256 - P57KIP2 EXPRESSION IS UP-REGULATED BY INHIBITORS OF BCR-ABL TYROSINE KINASE IN CHRONIC MYELOGENOUS LEUKEMIA CELLSA. Borriello, I. Caldarelli, D. Bencivenga, V. Cucciolla, A. Oliva, L. Ronzoni, S. Perrotta, F. Della Ragione (Second University, Naples, Italy)

P257 - PKC-DEPENDENT PHOSPHORYLATION OF P27 AT T198 CONTRIBUTES TO P27 STABILIZATION AND CELL CYCLE ARRESTF. De Vita (BioGem scarl, Ariano Irpino (AV), Italy), C. De Marco, V. Iovane, N. Rinaldo, O. Paciello, S. Papparella, G. Biglietto

P258 - CYTOKINESIS FAILURE DUE TO LOSS OF SUBSTRATE ADHERENCE ESTABLISHES GENOME INSTABILITYM. De Santis Puzzonia (Istitute of Molecular Biology and Pathology, National Research Council, Rome, Italy), E. Cundari, F. Degrassi

MOLECULAR EPIDEMIOLOGY AND CHEMOPREVENTION

P259 - MULTIPLEX ANALYSIS OF PLASMA CYTOKINES IN SUBjECTS AT HIGH RISK OF LUNG CANCERE. Vaghi (Fondazione Irccs Istituto Nazionale Tumori, University of Milan, Milan Italy), F. Ambrogi, M. De Bortoli, M. Cremona, E. Calabrò, E. Biganzoli, U. Pastorino, I. Bongarzone

P260 - FGFR4 GLY388ARG POLYMORPHISM MODULATES CANCER PATIENTS’ SURVIVAL IN POOLED ANALYSISE. Frullanti (Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy), C. Berking, N. Harbeck, P. Jézéquel, A. Haugen, C. Mawrin, O. Parise Jr., H. Sasaki

P261 - ARE THE ITALIANS LIVING IN LONDON ABANDONING THE PROTECTIVE MEDITERRANEAN DIET?M. Del Duca (London Metropolitan University, London, United Kingdom), T. Sellacci, K.Y. Manon, D. Bhakta


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PostersP262 - EFFECT OF BACILLUS CLAUSII ADMINISTRATION IN THE RECTAL MUCOSA OF MICE TREATED WITH INTRARECTAL INSTILLATION OF THE CARCINOGEN N-METHYLNITROSUREAF. Franceschi (Catholic University of Rome, Rome, Italy), M. Marini, A.C. Piscaglia, N. Saulnier, A. Pugliesi, R. Ricci, B. Giupponi, G. De Marco, D. Roccarina, G. Gigante, F. Barbaro, F. Mancini, N. Gentiloni Silveri, G. Gasbarrini, A. Gasbarrini

MOLECULAR MARKERS OF DIAGNOSIS, PROGNOSIS AND RESPONSE TO THERAPY

P263 - SECRETOME ANALYSIS OF jVM-13 CELL LINE FOR THE IDENTIFICATION OF NEW CHRONIC LYMPHOCYTIC LEUKEMIA BIOMARKERSL. Zanetti Domingues, C. Carniti, D. Caccia, M. De Bortoli (Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy), P. Corradini, I. Bongarzone

P264 - PROGNOSTIC VALUE OF MICRORNA EXPRESSION IN EWING’S FAMILY TUMOURSS. Ventura (Istituto Ortopedico Rizzoli, Bologna, Italy), F. Nakatani, M. Ferracin, M. Negrini, P. Picci, K. Scotlandi

P265 - ANALYSIS OF EGFR AND K-RAS MUTATIONS BY TRANSESOPHAGEAL ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION (EUS-FNA) IN NON-SMALL CELL LUNG CANCER (NSCLC)P. Ulivi (I.R.S.T., Meldola, Italy), M. Romagnoli, A. Tesei, E. Chiadini, C. Gurioli, C. Arienti, G. Casoni, A. Dubini, D. Calistri, V. Poletti, W. Zoli

P266 - MOLECULAR MARKER COMBINATIONS USEFUL TO PREOPERATIVELY DISTINGUISH BENIGN FROM MALIGNANT THYROID LESIONSS. Tomei (University Hospital, Pisa, Italy), I. Marchetti, F. Lessi, G. Bevilacqua, C.M. Mazzanti

P267 - TRACKING INFRARED SIGNATURES OF DRUGS IN CANCER CELLS BY FOURIER TRANSFORM MICROSPECTROSCOPY (MICROFTIR)G. Bellisola (University of Padua,Padua, Italy), M. Della Peruta, M. Vezzalini, E. Moratti, A. Lonetti, G. Martinelli, L. Vaccari, G. Birarda, M. Piccinini, G. Cinque, C. Sorio

P270 - DIFFERENT KRAS MUTATIONS CONFER DIFFERENT DRUG SENSITIVITY IN NON SMALL CELL LUNG CANCER (NSCLC)P. Rusconi (Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy), M. Marabese, M.C. Garassino, M. Broggini, E. Rulli, O. Martelli, G. Farina, A. Scanni

P271 - FKBP51 IS A PROMISING BIOMARKER FOR EARLY CANCER DETECTIONS. Romano (Federico Ii University, Naples, Italy), A. D’angelillo, E. De Luna, G. Ilardi, R. Bisogni, A.L. Di Pace, A. Sorrentino, S. Staibano, M.F. Romano

P272 - EGFR, HER2 AND PIK3CA AS NOVEL BIOMARKERS IN MALE BREAST CANCERP. Rizzolo (University of Rome Sapienza, Rome, Italy), V. Silvestri, M. Falchetti, I. Zanna, D. Palli, A. Gulino, L. Ottini

P274 - NOVEL APPROACH FOR DETECTION OF MINIMAL RESIDUAL DISEASE IN HEAD AND NECK SQUAMOUS CELL CARCINOMA SURGICAL MARGINSM. Poeta (Johns Hopkins University, Baltimore, Usa), V.M. Fazio, J. Manola, D. Goldenberg, A. Forastiere, J. Califano, J. Ridge, J. Goodwin, D. Kenady, J. Saunders, W. Westra, D. Sidransky, W. Koch

P275 - ALTERATION OF PHOSPHATIDYLCHOLINE METABOLISM IN HER2-OVER EXPRESSING OVARIAN CANCERM. Pisanu (Istituto Superiore Di Sanità, Rome, Italy), L. Paris, A. Ricci, R. Canese, E. Surrentino, M. Bagnoli, L. De Cecco, D. Mezzanzanica, E. Iorio, S. Canevari, F. Podo

P276 - BREAST CANCER AND CORRESPONDING ABDOMINAL AND/OR PELVIC METASTASISS. Petroni (N.C.I Giovanni Paolo II, Bari, Italy), T. Addati, G. Falco, M.A. Caponio, R. Altieri, V. Rubini, S. Tommasi, G. Simone, F. Giotta


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PostersP277 - DETECTION OF EGFR MUTATIONS IN CYTOLOGICAL AND SURGICAL SPECIMENS OF NONSMALL CELL LUNG CANCERD. Petriella (Istituto Tumori Giovanni Paolo II, Bari, Italy), M.C. Asselti, E. Mattioli, R. Daprile, V. Rubini, B. Pilato, K. Danza, S. De Summa, D. Galetta, G. Simone, S. Tommasi

P278 - HPV16 E2 GENE MODULATES THE EXPRESSION OF ERBB3 RECEPTOR DURING CARCINOGENESISF. Paolini (Regina Elena National Cancer Institute, Rome, Italy), S. Flamini, E. Muccioli, M. Mottole, A. Venuti

P279 - ROLE OF IFN METAGENE IN BREAST CANCERV. Musella (Fondazione Irccs Istituto Nazionale Dei Tumori, Milan, Italy), M. Callari, L. De Cecco, P. Miodini, R. Orlandi, V. Cappelletti, M.G. Daidone

P280 - IDENTIFICATION OF THE ZINC FINGER 216 (ZNF216) IN PROSTATE CANCER: A POTENTIAL REGULATOR OF EGFR ACTIVITYG. Mincione (University G. D’annunzio Chieti-Pescara, Chieti, Italy), G. Vianale, M.C. Di Marcantonio, D. Angelucci, M. Marchisio, C. Tarantelli, R. Muraro

P281 - LOSS OF HETEROZYGOSITY OF AN INTRON1 POLYMORPHIC SEQUENCE OF EPIDERMAL GROWTH FACTOR RECEPTOR IN BASAL-LIKE BREAST CANCER AND AUTOLOGOUS PERITUMORAL TISSUES: RELATIONSHIP WITH EGFR PROTEIN EXPRESSIONE. Melucci (Regina Elena National Cancer Institute, Rome, Italy), V. Dimartino, S. Conti, V. D’Alicandro, A. Di Benedetto, A. Fabi, C. Nisticò, C. Ercolani, B. Antoniani, L. Perracchio, C. Botti, M. Mottolese

P283 - PROGNOSTIC ROLE OF SERUM P53 ANTIBODIES IN LUNG CANCERM. Mattioni (Regina Elena National Cancer Institute, Rome, Italy), S. Soddu, P. Visca, G. Alessandrini, F. Facciolo

P284 - INTRINSIC RESISTANCE TO THE ANTIPROLIFERATIVE AND PROAPOPTOTIC EFFECTS OF AZD6244, A SELECTIVE MEK1/2 INHIBITOR, IS ASSOCIATED WITH K-RAS AND PI3KCA GENE MUTATIONS IN COLORECTAL CANCER CELLSM. Marra (Second University of Naples, Naples, Italy), T. Troiani, L. Vecchione, A. Capasso, E. Martinelli, W. De Roock, S. Tejpar, E. Van Cutsem, A. Abbruzzese, M. Caraglia, F. Ciardiello

P285 - ROLE OF A-TYPE LAMINS IN NEUROBLASTOMA DIFFERENTIATIONG. Maresca (CNR, Rome, Italy), I. Arisi, R. Brandi, M. D’Onofrio, A. Felsani, I. D’Agnano

P286 - GENETIC AND EPIGENETIC DETERMINANTS OF OUTCOME IN LOCALLY ADVANCED HEAD-AND-NECK CANCERC. Lo Nigro (S. Croce General Hospital, Cuneo, Italy), T. Crook, D. Vivenza, L. Lattanzio, M. Monteverde, A. Comino, H.M. Coley, N. Syed, M. Gasco, M. Merlano

PP287 - BCL-2 REARRANGEMENT IS A PROGNOSTIC MARKER IN HCV-ASSOCIATED DIFFUSE LARGE B CELL LYMPHOMAS DERIVED FROM MALT LYMPHOMAS

M. Libra (University of Catania, Catania, Italy), L. Militello, F. Nicoletti, A. Carbone, F. Stivala

P288 - INVOLVEMENT OF ALK IN RHABDOMYOSARCOMAP. Gasparini (Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy), L. Passoni, F. Facchinetti, R. Caserini, P. Collini, C. Meazza, A. Ferrari, M. Massimino, G. Sozzi

P289 - SYNTENIN-1 EXPRESSION CORRELATES WITH METASTATIC PROGRESSION IN UVEAL MELANOMAR. Gangemi (Istituto Nazionale Per La Ricerca Sul Cancro, Genoa, Italy), G. Barisione, A. Brizzolara, V. Mirisola, F. Lanza, C. Mosci, S. Salvi, M. Truini, S. Boccardo, M. Cilli, I. Airoldi, P. Queirolo, M. Jager, A. Daga, U. Pfeffer, S. Ferrini

P292 - DEVELOPMENT OF A TECHNICAL STRATEGY FOR OBTAINING RELIABLE GENE EXPRESSION PROFILES FROM FFPE BREAST CANCER SAMPLESE. Di Buduo (Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy), V. Musella, P. Miodini, M.L. Carcangiu, B. Paolini, M. Scuro, M. Callari, G. Bianchini, V. Cappelletti, M.G. Daidone

P293 - CHANGES IN HER2 OVEREXPRESSION BETWEEN PRIMARY TUMOR AND AUTOLOGOUS METASTASES: CORRELATIONS WITH CLINICAL AND BIOLOGICAL FEATURESA. Di Benedetto (Regina Elena National Cancer Institute, Rome, Italy), C. Ercolani, E. Melucci, B. Antoniani, V. Dimartino, V. D’alicandro, S. Buglioni, L. Perracchio, G. Metro, A. Fabi, M. Mottolese


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PostersP294 - TELOMERE/TELOMERASE INTERPLAY IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIAE. Ramazzo (University of Padua, Padua, Italy), L. Bonaldi, S. Keppel, P. Del Bianco, L. Trentin, G. Semenzato, F. Frezzato, V. Martini, C. Visco, E. Novella, E. Peotta, A. De Rossi

P295 - ASSOCIATION AMONG RISK FACTORS AND TUMOR MARKERS IN BREAST CANCERM. Croce (CINIBA, Faculty of Medical Sciences, UNLP, La Plata ARGENTINA), S. Demichelis, L. Cermignani, M. Isla Larrain, A. Segal-Eiras,C. Alberdi

P296 - PROTOARRAY DATA CONFIRMATION BY ELISA: STATISTICAL ISSUES.F. Comper (Arc-Net Research Centre, University of Verona, Policlinico G.B. Rossi, Verona, Italy), S. Barbi, A. Scarpa

P297 -STUDY ON THE APPLICATION OF MONOCLONAL ANTIBODIES SPECIFIC FOR BCR/ABL OUT OF FRAME (OOF) PEPTIDE IN THE DETECTION OF BCR/ABL+ CELLS BY IMMUNO-BASED ASSAYSP. Chiarella (Laboratory of Molecular Medicine And Biotechnology, Cir, Campus Bio-Medico University of Rome, Rome, Italy), V. Summa, E. Signori, D. Bilbao-Cortes, A.M. Sawyer, F. Lococo, V.M. Fazio

P299 - EGFR ANALYSIS ON PROGNOSTIC TISSUE MICRO ARRAY OF ORAL CAVITY SQUAMOUS CELL CARCINOMASG. Aquino (INT Fondazione Pascale, Naples, Italy), G. Liguori, F. Collina, V. Gigantino, F. Zito, G. Scognamiglio, F. Longo, F. Ionna, M.P. Curcio, G. Pannone, R. Franco,G. Botti

P300 - UROTENSIN RECEPTOR (UTR) AS PROGNOSTIC MARKER IN TRANSITIONAL BLADDER CANCERV. Gigantino (INT Fondazione Pascale, Naples, Italy), F. Collina, L. Marra, M. Cerrone, G. Aquino, C. Santonastaso, S. Pignata, G. Facchini, L. Marra, P. Grieco, M. Caraglia, R. Franco, G. Botti

P301 - HYPEREXPRESSION OF HOX C13 IN MELANOMA PROGRESSIONM. Cantile (Int Fondazione Pascale, Naples, Italy), G. Gentilcore, E. Simeone, M. Cerrone, G. Scognamiglio, M. Farina, M. Svelto, R. Franco, C. Cillo, A. Anniciello, P. Ascierto, F. Fulciniti, G. Botti

P302 - MULTIPLE K-RAS MUTATIONS AT CODONS 13, 15 AND 19 IN AN AGGRESSIVE

COLON CANCER CASE REPORTL. Pacini, D. Ponti, C. Fabbiano, B. Sardella, G. Battisti, V. Petrozza, G. Giannini, A. Calogero (“Sapienza” University, Latina, Italy)

P303 - THE ROLE OF OXIDATIVE STRESS AS A POSSIBLE CO-FACTOR IN HPV CARCINOGENESISE. Bucaj (Sapienza University, Regina Elena Institute for Cancer Research, Rome, Italy), A. Fiorini, K. Filipi, C. Blarzino, C. Foppoli, S. Celiku, C. Cini, C. Minosse, F. De Marco

P304 - HIGH PREVALENCE OF RETINOBLASTOMA PROTEIN LOSS IN TRIPLE-NEGATIVE BREAST CANCERS AND ITS ASSOCIATION WITH A GOOD PROGNOSIS IN PATIENTS TREATED WITH ADjUVANT CHEMOTHERAPYE. Brighenti (University of Bologna, Bologna, Italy), L. Montanaro, D. Trerè, M. Derenzini

P305 - ALTERNATIVE SPLICING OF THE ANGIOGENESIS ASSOCIATED EXTRA-DOMAIN B OF FIBRONECTIN REGULATES THE ACCESSIBILITY OF THE B-C LOOP OF THE TYPE III REPEAT 8E. Ventura, E. Balza, F. Sassi, A. Parodi, P. Castellani, B. Carnemolla, L. Zardi, L. Borsi (Istituto Nazionale per la Ricerca sul Cancro Dpt Translational Oncology, Genoa, Italy)

P307 - COMPARISON OF HER2 OVEREXPRESSION, GENE AMPLIFICATION AND CHROMOSOME 17 CENTROMERE COPY NUMBER IN PRIMARY PANCREATIC ADENOCARCINOMA, METASTATIC LYMPH NODE AND METASTASISS. Boccardo (National Institute For Cancer Research, Genoa, Italy), S. Salvi, P. Ferro, N. Gorji, P. Dessanti, D. Gianquinto, A. Vigani, M.C. Franceschini, M. Truini, M.P. Pistillo, F. Fedeli, S. Roncella

P309 - INCIDENCE OF O6-METHYLGUANINE DNA METHYLTRANSFERASE EXPRESSION IN PITUITARY ADENOMAS: OUR EXPERIENCE AT THE “REGINA ELENA” NATIONAL CANCER INSTITUTER. Baldelli (Regina Elena National Cancer Institute, Endocrinology, Rome, Italy), M.A. Carosi, D. Panichi, A. Barnabei, S. Telera, A. Pompili, M.L. Appetecchia, E. Pescarmona


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PostersP310 - PROSPECTIVE VALIDATION OF A PROGNOSTIC GENE EXPRESSION SIGNATURE AND IDENTIFICATION OF EGFR AS A DRUG TARGETG. Angelini, V. Mirisola, A. Amaro, S. Boccardo, S. Salvi, S. Coupland, B. D’amato, F. Lanza, C. Mosci, M. Truini, U. Pfeffer (National Cancer Research Institute, Genoa, Italy)

P311 - FUCOSYLATED NUCLEOLIN AND CANCER CELLSS. Aldi (University of Siena, Siena, Italy), A. Capone, L. Ermini, F. Rosati

P312 - PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C IN THE PROGRESSION OF BREAST CANCER: A NEW TARGET TO CONTROL DIFFERENTIATION AND EPITHELIAL-MESENCHYMAL TRANSITIONL. Abalsamo (Istituto Superiore di Sanità, Rome, Italy), F. Spadaro, S. Cecchetti, L. Paris, E. Iorio, L. Lugini, G. Bozzuto, A. Molinari, C. Ramoni, F. Podo

P313 - A NEW METABOLOMIC APPROACH FOR PROSTATE CANCER DETECTIONI. Sogno (IRCCS, Milan, Italy), V.F. Dibari, G. Pennesi, S. Cristoni, A. Albini

P314 - HMENA SPLICING IN LUNG CANCER: HMENA11A IDENTIFIES A NON INVASIVE PHENOTYPE IN LUNG CANCER CELL LINES AND HAS A POWERFUL PROGNOSTIC IMPACT IN RESECTED NODE-NEGATIVE NON-SMALL-CELL LUNG CANCER (NSCLC)F. Di Modugno (Regina Elena National Cancer Institute, Rome, Italy), E. Bria, P.L. Iapicca, M. Mottolese, I. Sperduti, P. Visca, B. Antoniani, F. Facciolo, F. Cognetti, M. Milella, P.Nisticò

P315 - RETINOL AND RETINOID RECEPTORS EXPRESSION INFLUENCES ADAPTIVE CHANGES OF CUTANEOUS CELLS DURING SKIN CANCER PROGRESSIONA. Orlandi (Tor Vergata University of Rome, Rome, Italy), G. Costanza, E. Doldo, M.G. Scioli, L.G. Spagnoli

DNA DAMAGE AND MOLECULAR RESPONSES TO DAMAGE

P316 - POLYMORPHISMS AND DOSIMETRIC DATA EXPLAIN FIBROSIS AFTER SINGLE SHOT PARTIAL BREAST IRRADIATION IN PRONE POSITION: PRELIMINARY RESULTSP. Pinnarò, E. Falvo, C. Giordano, S. Arcangeli, G. Arcangeli, G. Citro, G. Iaccarino, V. Bandoni, A. Soriani, P. Muti, L. Strigari (Regina Elena National Cancer, Rome, Italy)

P317 - INHIBITION OF THE ACTIVATION-LOOP AUTOPHOSPHORYLATION OF HIPK2 YIELDS TO AN INSOLUBLE MISFOLDED PROTEINF. Siepi (Regina Elena National Cancer Institute, Rome, Italy), V. Gatti, S. Camerini, A. Prodosmo, C. Rinaldo, M. Crescenzi, S. Soddu

P318 - DNA DAMAGE INDUCED BY CAMPTOTHECINS IS STABILIZED BY G-QUADRUPLEX LIGANDSM. Porru (Regina Elena National Cancer Institute, Rome, Italy), E. Salvati C. D’Angelo, A. Orlandi, D. Passeri, M. Franceschin, F. Zunino, M. Stevens, A.M. Biroccio, C. Leonetti

P319 - THE P53-REGULATOR, MDM4 (MDMX) ACTS IN VIVO AS TUMOR SUPPRESSORF. Mancini (CNR, Catholic University, Rome, Italy), G. Di Conza, M. Pellegrino, A. Apollo, L. Fici, A. Pontecorvi, S. Xiong, G. Lozano, F. Moretti

P320 - REINVIGORATING QUIESCENT ATM DYNAMICS IN LNCAP CELL LINE VIA EPIGALLOCATECHIN-3-GALLATE (EGCG)A. Farooqi (The University of Lahore, Lahore, Pakistan), S. Bhatti

P321 - PKC ISOFORM BALANCE FAVOURS DNA DAMAGE DECIDING THE NEUROBLASTOMA CELL FATEB. Marengo (G. Gaslini Institute, Genoa, Italy), C. De Ciucis, R. Ricciarelli, A.L. Furfaro, U.M. Marinari, M.A. Pronzato, C. Domenicotti


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Posters




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PostersP323 - STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF P53/CHE-1 INTERACTIONF. De Nicola (Istituto Regina Elena, Rome, Italy), A. Desantis, T. Bruno, S. Di Agostino, S. Iezzi, C. Sorino, F. Goeman, G. Blandino, M. Fanciulli

P325 - CELL CYCLE DEPENDENT REGULATION OF CCDC6 GENE PRODUCT: FUNCTIONAL INTERACTION WITH MITOTIC KINASES AND THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASE 4A. Celetti (CNR, Naples, Italy), F. Merolla, C. Luise

P326 - ATM, DNA DAMAGE RESPONSE AND SURVIVAL IN HUMAN NEURAL STEM CELLSL. Carlessi (IRCCS, Milan, Italy), F. Morelli, D. Delia

P327 - THE SHELTERIN PROTEIN TRF2 INHIBITS CHK2 ACTIVITY AT TELOMERES IN THE ABSENCE OF DNA DAMAGEG. Buscemi (IRCCS, Milan, Italy), L. Zannini, D. Delia

CANCER MODELLING AND IMAGING

P329 - A TRANSGENIC MOUSE MODEL TO IMAGE NF-Y TRANSCRIPTIONAL ACTIVITY IN PHISIOLOGICAL PROCESSES OF LIVING ORGANISMSS. Artuso (Regina Elena National Cancer Institute, Rome, Italy), I. Manni, F. Goeman, B. Ramachandran, G. Bossi, C. Cencioni, F. Spallotta, G. Toietta, A. Maggi, M. Capogrossi, C. Gaetano, A. Sacchi, P. Ciana, G. Piaggio

Information


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Scientific Information

Italian CME CreditsThe Meeting has been awarded with n.13 total creditsCredits have been requested for the following categories:

• Medical Doctor (Oncology, Medical Genetics, Hemathology, Pharmacology e tossicologia, patologia clinica)

• Biologists

To obtain credits, Italian participants must return the evaluation form and the learning to the Registration Desk.

Audiovisual InstructionsA Slide Centre is located in the Meeting Venue.ONLY PC DATA PROJECTION IS AVAILABLE DURING THE MEETINGEach room is provided with a laptop. Therefore the use of your personal laptop is not allowed.Should speakers have their personal laptop or CD Rom or USB key, they are kindly requested to go to the Slide Centre to have their presentation copied. The presentation will be then forwarded through a LAN network from the Multimedia Slide Centre directly to the computer in the presentation room.We kindly recommend speakers to contact the Slide Centre the day before their presentation. If this is not possible, please deliver your Power Point presentation 1 hour before for Power Point presentations on CD-ROM or USB key and the day before for presentations of early morning session.

Slide Centre• October 4, 2010 14.00-19.00 hrs.• October 5, 2010 08.00-18.00 hrs.• October 6, 2010 08.00-19.00 hrs.• October 7, 2010 08.00-13.00 hrs.

Speakers• follow the instructions indicated at the paragraph “Audiovisual Instruction”• find yourself in the Meeting Room at least 10 minutes before the beginning of the Session• respect the timing assigned to the Session and to each presentation• all presentations, discussions and questions must be in English.• please note that, for the oral selected presentations, the presenting author must be registered

to the Meeting to give his/her presentation.

Poster Presentations• Posters are displayed for the entire duration of the Meeting. Remain at your poster during

the assigned session.• all presentations, discussions and questions must be in English.• please note that the presenting author must be registered to the Meeting to give his/her

presentation.

Guidelines for Poster Display• Poster boards are labelled with the number of the abstract, as listed in the abstract book• Accepted posters will be displayed in a dedicated area. Please, check the number assigned

to your poster upon your arrival.• Poster size must be cm. 70 (width) x cm. 100 (height) and the format must be VERTICAL.• Posters must be hanged on from October 4 at 14.00 and should be removed on October 7

from 12.00 to 15.00• Pins and tape will be at your disposal at the Congress Venue, in case you need them• The Organizing Secretariat is not responsible for posters that have not been collected at the

end of the Congress. Posters not collected will be discarded by the Organizing Secretariat.

AWARDS CEREMONY

WednesdayOctober6,2010(12.00-12.45)Those who wish to apply for the prize must present their poster at the Meeting even in case their abstract has been selected as oral presentation. Should the winner not be present at the Award Ceremony, the prize will be awarded following a merit ranking order.

“Piero Trivella”, “Graziella Persico” and “EACR” Prizes to the best posters

“Elena Cappannini” Prize to the best 2009 publication as first author in innovative approaches for cancer treatments

Scholarship “Pezcoller Foundation - Ferruccio and Elena Bernardi”

ThursdayOctober7,2010(13.00-13.15)“Istituto Regina Elena” Award to the best oral selected presentation


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General Information


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Meeting VenueAngelicumCongressCentreLargo Angelicum, 1 - 00184 Romeph. +39 06 67021 - fax +39 06 6790407www.angelicum.org

Organizing SecretariatAIMGroupAntonella FerraroRome Office: via Flaminia, 1068 - 00189 Romeph. +39 06 330531 - fax +39 06 [email protected] - www.aimgroup.eu/2010/cancerologia

SIC SecretariatSocietàItalianadiCancerologiaMariaenrica ZunicaVia G. Venezian, 1 - 20133 Milanph. +39 02 2666895 - fax +39 02 [email protected] - www.cancerologia.it

LanguageThe official language of the Meeting is English. Simultaneous translation will not be provided.

BadgesParticipants are kindly requested to wear their badge throughout the Meeting.

Badge colours:• Transparent Participants• Red Speakers• Yellow Exhibitors• Green Guests

Certificates of AttendanceCertificate of attendance is issued on request to all registered participants at the end of the Meeting.

Exhibition and SponsorshipA technical, pharmaceutical and publication exhibition will take place in the Meeting Venue throughout the scientific works.

Exhibition opening hours• October 4, 2010 14.00-19.00 hrs.• October 5, 2010 08.30-18.30 hrs. • October 6, 2010 08.30-19.00 hrs.• October 7, 2010 08.30-13.00 hrs.

Hotel ReservationThe Organizing Secretariat will be at the participants’ disposal for any information regarding hotel reservations

Social Programme

Monday,October4thAngelicum Congress Center

hrs. 19.00 Opening Ceremony 20.00 Welcome Cocktail

WednesdayOctober6thRestaurant “Open Colonna”, Palazzo delle Esposizioni

hrs. 20:30 Social Dinner with music entertainment. The “Open Colonna” is located at walking distance from the Congress Venue.

PLEASENOTETHATYOUSHOULDBRINGYOURCONFERENCEBADGETOBEEXHIBITATTHEENTRANCE

FromTuesday5toOctobertoThursday7October2010Civic Museums of Rome

1 free access for 1 person to one of the (information in the Conference bags)

PLEASENOTETHATYOUSHOULDBRINGTHECOUPONTOBEEXHIBITATTHEENTRANCE


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Registration InformationRegistration Fees

on-site registration

SIC MEMBER (*) e 430,00

NON SIC MEMBER (**) e 534,00

SIC MEMBER UNDER 35 (*) e 280,00

NON SIC MEMBER UNDER 35 (**) e 351,00

(*) VAT non applicable as for the law ex Art. 4 DPR 633/72; (**) VAT 20% included

All registered delegates will receive the following:• Badge for entering to all Scientific Sessions and Exhibition Area • Admission to the Opening Ceremony and Welcome Cocktail, coffee breaks, buffet lunches

throughout the Meeting • Conference Bag containing the Meeting Programme, Abstract book and scientific material • Certificate of attendance • CME credits• 1 free access to the Civic Museums of Rome• Admission to the Social Dinner at Open Colonna - Palazzo delle Esposizione, October 5th 2010

from 20.30

Payment MethodsCashCreditcards (American Express, VISA, Eurocard/Master Card).Check only for Italian Participants

Opening Hours of the Registration Desk• October 4, 2010 14.00-19.00 hrs.• October 5, 2010 08.30-18.30 hrs.• October 6, 2010 08.30-19.00 hrs.• October 7, 2010 08.30-13.00 hrs.

Practical Information

How to reach the Meeting VenueFrom Leonardo da Vinci Fiumicino Airportby train: from railway station, inside Fiumicino Airport, trains depart for Termini station every 30 minutes. From Termini station to the Meeting Venue see below.by taxi: fixed charge for rides between Leonardo da Vinci Airport and Termini railway station: Euro 40,00, including baggage, for a maximum of four passengers (authorized taxi-cabs are white).

From Ciampino Airportby bus: at Ciampino Airport there are different bus companies, that will bring you to the Termini station in about 45 minutes. From Termini station to the Meeting Venue site see below.by taxi: fixed charge for rides between Ciampino Airport and Termini railway station: Euro 30,00 including baggage, for a maximum of four passengers (authorized taxi-cabs are white).

From Termini railway stationby bus: departure from Piazza dei Cinquecento,1, just outside Termini station. Take bus number 40 to 2 stops and get off at stop Nazionale/Quirinale. Walk 100 meters on your left to Largo Angelicum, 1.by walking: 1,5 Km from the Meeting Venue, about 15 minutes walking along Via Nazionale (full of shops) to Largo Angelicum, 1.by car: follow the indication for Stazione Termini. As soon you are at the Termini railway station, park the car and follows the indication above (access to Largo Angelicum by car is denied in day hours).by subway: take subway line A, stop at Piazza della Repubblica; at this point you can either walk down Via Nazionale (full of shops) till Largo Angelicum 1 (about 10/15 minutes) or take the bus number 64 and get off after 4 stops at the stop Nazionale/Quirinale or take number 40 to 2 stops and get off at stop Nazionale/Quirinale. Walk 100 meters on your left to Largo Angelicum, 1.

Another possibility is to take subway line B, get off at Colosseo, and reach the Meeting Venue by walking (about 8 minutes): facing the Colosseum turn right to start walking on Via dei Fori Imperiali towards Piazza Venezia, at the first street light, cross the street and turn right, after few meters turn left on via di Tor dei Conti (a nice walk on a narrow street of Rome with archaeological ruins) straight ahead for 400 meters continuing on Salita del Grillo till largo Angelicum, 1.

For further detail on route please refer to http://infopoint.atac.roma.it/bw.asp?lingua=eng


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How to get around RomeRome is a city rich in monuments, artistic places and other beauties. Most of these are located in the historical centre.The best way to visit Rome is on foot: churches, squares and monuments are easily reachable.There are 3000 restaurants, including pizzerias, taverns, exotic places, picture-galleries, ice-cream shops. Rome is the capital of the religious art and in the historical centre there are more than 400 churches rich in paintings and frescoes. As regards to the culture, there are 50 museums and picture-galleries, 200 contemporary art galleries, 42 public and private libraries, 80 theatres or theatrical clubs and more than 140 cinemas.

Public transportationThe cost of the surface and underground transportation is the same (1 Euro, valid for 75 minutes, 1 metro/train trip only).Tickets of different time limit and itinerary are available at ATAC counters, news-stands, tobacconistsand automatic ticket dispensers, but not in buses. All tickets must be validated at the beginning of the first trip either at underground station or on buses.Please note that tickets must be bought before boarding on the bus.

TaxiLicensed taxis are white, have a name, an identification number, and are equipped with a taximeter.Do not trust people who approach you offering private taxi service. In the city centre there are a number of taxi-ranks, like for example in Piazza della Repubblica, Piazza Venezia and Largo Argentina. A taxi can be called at the following telephone numbers: +39 063570, +39 064994, +39 065551.Please remember that in this case the taxi-meter is turned on when the taxi picks up the call.Because of the frequent changes made to the rates, you should read carefully the information shown inside the taxi.

SubwayThe 2 line system has an X shape, with both lines meeting at the Central Railway Station Termini.The first line, line B south, goes from Laurentina to Rebibbia.Line A links Anagnina, in the south, with Battistini, in the northwest.The metro operates from 5.30 until 23.30 (1.30 on Fridays and Saturdays) every 3-4 minutes during rush hours, every 5-6 minutes during the day and every 8-10 minutes early morning and late evening.

CurrencyAccording to the Monetary Union, the official currency is the Euro.

Bank and exchangeBanks are open from Monday to Friday, from 8.30 to 13.30 and some of them again in the afternoon from 14.45 to 15.45 (afternoon opening may vary depending on the bank).Banks are closed on Saturday and Sunday. Many banks have automatic currency exchange machines that also take credit cards. Most hotels, restaurants and shops accept foreign currencyand major credit cards.

WeatherOctober weather in Rome is generally warm. Rain is also possible.The temperature doesn’t rise over 15°C / 59°F.

ElectricityVoltage in Italy is mostly 220 volts - 50 Hz.Foreign appliances could require an adapter.

Useful links

www.romaturismo.it

www.metroroma.it

www.adr.it

www.rome.info

www.liveinrome.com


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Civic Museums of Rome

MuseiCapitoliniPiazza del Campidoglio 1 - 00186 RomaOpening hours Tuesday-Sunday 9.00am-8.00pm; (the ticket office closes an hour in advance) CentraleMontemartiniVia Ostiense 106 - 00154 RomaOpening hours Tuesday-Sunday 9.00am-7.00pm; (the ticket office closes half an hour in advance) MercatieForodiTraianoVia IV Novembre 94 - 00187 RomaOpening hours tuesday-sunday 9.00am-7.00pm (the ticket office closes one hour before closing time)

Museodell’AraPacisLungotevere in Augusta - 00100 RomaOpening hours Tuesday-Sunday 9.00am-7.00pm; (the ticket office closes an hour in advance)

MuseodiSculturaAnticaGiovanniBarraccoCorso Vittorio Emanuele 166/A - 00186 RomaOpening hours Tuesday-sunday 9.00am-7.00pm; (the ticket office closes an hour in advance)

MuseodellaCiviltàRomanaPiazza G. Agnelli, 10 - 00144 RomaOpening hours Tuesday-Saturday 9.00am-2.00pm; Sunday 9.00am-1.30pm (the ticket office closes one hour in advance). MuseodelleMuraVia di Porta San Sebastiano - 00100 RomaOpening hours Tuesday-Sunday 9.00am-2.00pm (the ticket office closes half an hour in advance)

VilladiMassenzioVia Appia Antica 153 - 00179 RomaOpening hours Tuesday-Sunday 9.00-13.30 (the ticket office closes an half hour in advance)

MuseoRomaPiazza San Pantaleo, 10 - 00186 RomaOpening hours Tuesday-Sunday 9.00am-7.00pm, (the ticket office closes half an hour in advance)

MuseoNapoleonicoPiazza di Ponte Umberto I, 1 - 00186 RomaOpening hours Tuesday-Sunday 9.00am-7.00pm; (the ticket office closes half an hour in advance)

MACROVia Reggio Emilia 54 - 00198 RomaOpening hours Tuesday-Sunday 9.00am-7.00pm; (the ticket office closes half an hour in advance)

MACROTestaccioandLaPelandaPiazza Orazio Giustiniani 4 - 00153 RomaOpening hours Tuesday-Sunday 4.00 pm - 12.00 pm (Last admission 1 hour before closing time) MuseoPietroCanonicaaVillaBorgheseViale Pietro Canonica (Piazza di Siena) 2 - 00197 RomaOpening hours Tuesday-Monday 9.00am-7.00pm; (the ticket office closes an hour in advance) MuseodiRomainTrasteverePiazza Sant’Egidio 1/b - 00153 RomaOpening hours Tuesday-Sunday 10.00am-8.00pm; (the ticket office closes an hour in advance) MuseidiVillaTorloniaVia Nomentana 70 - 00161 RomaOpening hours from the 1st October until the last Saturday of October: 9.00-17.30; (the ticket office closes fourty-five minutes prior to closing) PlanetarioeMuseoAstronomicoPiazza G. Agnelli 10 - 00144 RomaThe Planetario is situated into the same building that accommodates the Museo della Civiltà RomanaOpening hours From 1 September until 30th June: Tuesday-friday 9.00am-2.00pm Saturday and Sunday 9.00am-7.00pm; Opening hours may be subject to variation (the ticket office closes an hour in advance)


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Gold Sponsor

Silver Sponsor

Ephoran

Merck Serono

Roche diagnostic

SIC

Quiagen

Milipore

Perkins

Merck Chemicals




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Supporter

ABCAM

International PBI

AcknowledgementsThe Scientific and the Organizing Committees would like to express their gratitude

to all those who have generously contributed to the best success of the Meeting


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Save the date!

53nd Annual Meetingof the Italian Cancer Society

Turin, Autumn 2011

Scientific Coordinator

Silvia GiordanoUniversità degli Studi di Torino, Torino (Italy)

Organizing Secretariat

AIM GroupAntonella Ferraro

Rome Office: via Flaminia, 1068 - 00189 Romeph. +39 06 330531 - fax +39 06 33053229

[email protected]/2010/cancerologia

52 - · pdf fileof medical oncology, and leading pharmaceutical industries, ... bevilacqua...

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