XLVI New Patents

cells to the the cytotoxic effect of oxidized lipoproteins. Oxidized lipoproteins are used to treat disease states such as cancer. malaria and viral infections such as acquired immunodefi- ciency syndrome (AIDS). Proton and carbon- 13 NMR spectroscopy is used to measure the degree and effect of treatment with oxidized lipoproteins.

5192909

SPECTROSCOPIC LOCALIZATION USING

PINWHEEL NMR EXCITATION PULSES

Christopher Hardy. Paul A Bottomley, Harvey Cline, assigned to General Electric Company

An NMR system performs in vivo localized NMR spectroscopy. A two-dimensional selec- tive RF excitation pulse is used to localize to a cylindrical region of interest, and either phase encoding or slice selective inversion is used to localize to a disk in the cylindrical region of interest. The two-dimensional selective RF ex- citation is performed in a series of pulse sequences rather than a single pulse sequence, and the resulting series of acquired NMR signals are summed together to substantially cancel signal conributions from outside the cylindrical region of interest.

5192910

TEMPERATURE-CONTROL DEVICE FOR SAMPLES

Phillip Hepp, Werner H Tschopp, Marti Rindlis- bather, Oska Schett, assigned to Spectrospin AG

In a temperature-control device for samples, in particular for NMR spectroscopy, comprising a vessel (20) provided with an opening (19) for receiving a measuring sample (l), an inlet opening (10) for introduction of the fluid, an outlet opening (15) for the outflow of the fluid and a flow channel (18) through which at least a partial flow of the fluid is guided past the sample (1) as direct fluid flow, from the bottom to the top, there is provided at least one by-pass chan- nel (17) which is arranged in such a way that an

additional partial fluid Bow can be guided past the upper area of the said sample (1) in the form of a by-pass fluid flow (7). This enables also the upper area of the sample (1) to be temperature- controlled in an efficient way so as to minimize the temperature gradient in the sample (1). The temperature-control device may comprise, in the upper area of the sample (I), a heat-exchanger system (14) which concentrates the direct fluid flow ( 8) after it has been combined with the by- pass fluid flow (8) around the sample (1). One achieves in this manner efficient temperature control of the upper section of the sample by the fluid flow, without any disturbing thermal ob- stacIes.

5192911

NMR PROBE INCORPORATING RF SHIELDING OF SAMPLE

Howard D W Hill, Michael D Cummings as- signed to Varian Associates Inc

Parasitic excitation of an NMR sample is mini- mized by providing shielding of the sample against RF pick-up from coil leads or like pro- ximate conductive structure in the interior re- gion of the RF coil.

5194809

NMR-SCOPE

Hyok S Lew

A diagnostic device comprises a magnet pro- viding a nonalternating magnetic field with a gradient in a direction perpendicular to the nonalternating magnetic field, and a scope in- cluding a transmitter coil and a receiver coil with the central axes disposed parallel to the direction of the gradient in the nonalternating magnetic field, wherein a pulse of alternating current of a specific frequency with a specific duty cycle period generates a nuclear magnetic resonance emission from a test mass located at a specified distance from the scope, and analysis of the in- tensity of the nuclear magnetic emission so gene- rated by certain procedures provides amounts of different molecular species making up the test mass, and the time rate of fluid change in the test mass.