thalesnano.com 5% rh/al 2o 3 – rhodium on alumina...

2

Table of contents Table of contents ______________________________________________________________ 2

About ThalesNano Inc. __________________________________________________________ 6

Instruments and system setups from ThalesNano ____________________________________ 7

H‐Cube® Pro ______________________________________________________________________ 8

H‐Cube® Mini Plus _________________________________________________________________ 10

H‐Cube® Midi ____________________________________________________________________ 12

Phoenix Flow Reactor™ ____________________________________________________________ 14

Gas Module™ ____________________________________________________________________ 16

IceCube™ ________________________________________________________________________ 18

Ozone Module™ __________________________________________________________________ 20

Flash Pyrolysis Platform™ ___________________________________________________________ 22

CatCart® Changer _________________________________________________________________ 24

CatCart® Packer ___________________________________________________________________ 26

Autosampler™ ____________________________________________________________________ 28

H‐Genie™ ________________________________________________________________________ 30

Distributor Network of ThalesNano _______________________________________________ 32

Service and Maintenance _______________________________________________________ 33

Care Platform™ Memberships ___________________________________________________ 34

CatCart® ____________________________________________________________________ 36

CatCart® Packages ____________________________________________________________ 40

CatCart® “call for papers” ______________________________________________________ 41

Choosing the right catalyst for tuning the reaction outcome ___________________________ 42

Commercially available CatCarts® From ThalesNano _________________________________ 44

Ti, Quartz sand – Inert materials _____________________________________________________ 45

10% Pd/C – Palladium on charcoal ____________________________________________________ 47

20% Pd(OH)2/C – Pearlman’s catalyst _________________________________________________ 48

5% Pd/Al2O3 – Palladium on alumina __________________________________________________ 49

10% Pd/CaCO3 – Palladium on calcium carbonate _______________________________________ 50

5% Pd/CaCO3 – Palladium on calcium carbonate _________________________________________ 51

3

5% Pd/BaCO3 – Palladium on barium carbonate _________________________________________ 52

5% Pd/C (S) – Palladium on charcoal (sulfided) _________________________________________ 53

5% Pd/C – Palladium on charcoal _____________________________________________________ 54

5% Pd/CaCO3‐Pb – Lindlar’s Catalyst __________________________________________________ 55

5% Pd/BaSO4 – Palladium on barium sulfate ____________________________________________ 56

1% Pd/Al2O3 – Palladium on alumina __________________________________________________ 57

10% Pd/Al2O3 – Palladium on alumina _________________________________________________ 58

Pd/C – ethylenediamine ____________________________________________________________ 59

5% Pd/SiO2 – Palladium on silica _____________________________________________________ 60

1% Pd/C – Palladium on charcoal _____________________________________________________ 61

2% Pd/SrCO3 – Palladium on strontium carbonate _______________________________________ 62

PdO – Palladium oxide _____________________________________________________________ 63

Pd Black – Palladium metal _________________________________________________________ 64

10% Pt/C – Platinum on charcoal _____________________________________________________ 65

1% Pt/SiO2 – Platinum on silica ______________________________________________________ 66

1% Pt/SiO2 polyethyleneimine – Platinum on modified silica ______________________________ 67

5% Pt/C (Bi) – Platinum on charcoal, doped with bismuth _________________________________ 68

1% Pt/C (V) – Platinum on charcoal, doped with vanadium ________________________________ 69

5% Pt/CaCO3 – Platinum on calcium carbonate __________________________________________ 70

1% Pt/SBA – Platinum on mesoporous silica ____________________________________________ 71

5% Pt/Al2O3 – Platinum on alumina ___________________________________________________ 72

5% Pt/C (S) – Platinum on charcoal, poisoned with Sulphur ________________________________ 73

1% Pt/Al2O3 – Platinum on alumina ___________________________________________________ 74

1% Pt/C – Platinum on charcoal ______________________________________________________ 75

5% Pt/C – Platinum on charcoal ______________________________________________________ 76

Raney Nickel – Al/Ni _______________________________________________________________ 77

Nickel Sponge ____________________________________________________________________ 78

Pricat™ Nickel 55/5P – Nickel catalyst on Diatomaceous earth _____________________________ 79

Nickel Sponge with 1% Mo __________________________________________________________ 80

Ni/SiO2‐Al2O3 – Nickel on Silica‐alumina support ________________________________________ 81

5% Rh/C – Rhodium on charcoal _____________________________________________________ 82

1% Rh/SiO2‐Polyethyleneimine – Rhodium on modified silica ______________________________ 83

4

5% Rh/Al2O3 – Rhodium on alumina __________________________________________________ 84

1% Au/Fe2O3 – Gold on Iron Oxide ____________________________________________________ 85

1% Au/C – Gold on charcoal _________________________________________________________ 86

1% Au/TiO2 – Gold on Titanium dioxide _______________________________________________ 87

Ru black – Ruthenium metal ________________________________________________________ 88

5% Ru/Al2O3 – Ruthenium on Alumina ________________________________________________ 89

5% Ru/C – Ruthenium on charcoal ____________________________________________________ 90

RuO2 – Ruthenium oxide ___________________________________________________________ 91

5% Re/C – Rhenium on charcoal _____________________________________________________ 92

Raney‐Cu – Raney type Copper ______________________________________________________ 93

CuO/Al2O3 – Copper(II)oxide on alumina _______________________________________________ 94

5% Cu in graphite – Copper metal powder mixed with graphite powder _____________________ 95

Raney Cobalt _____________________________________________________________________ 96

0.5% Ir/C – Iridium on charcoal ______________________________________________________ 97

1% Ir/C – Iridium on charcoal ________________________________________________________ 98

IrO2 – Iridium oxide ________________________________________________________________ 99

5% Ir/CaCO3 – Iridium on calcium carbonate ___________________________________________ 100

Zinc powder _____________________________________________________________________ 101

1% Pd – 0.3% Cu/Al2O3 – Palladium and copper on alumina _______________________________ 102

Pricat™ CZ 30/18T – Copper and Zinc on Diatomaceous earth _____________________________ 103

5% Pd – 1% Fe/C – Palladium and Iron on charcoal ______________________________________ 104

2.5% Pd – 2.5% Pt/C – Palladium and platinum on charcoal ______________________________ 105

4.5% Ru – 0.5% Pd/C – Ruthenium and palladium on charcoal ____________________________ 106

Pt(0) EnCat® – Platinum encapsulated catalyst _________________________________________ 107

Rh(COD)(dppf)/SiO2 – Rhodium complex catalyst on silica _______________________________ 108

Pd(0) EnCat® NP30 – Palladium encapsulated catalyst ___________________________________ 109

Pd(II) EnCat® 30 – Palladium encapsulated catalyst _____________________________________ 110

Pd(II) EnCat® TPP30 – Palladium encapsulated catalyst __________________________________ 111

Pd(II) EnCat® BINAP30 – Palladium encapsulated catalyst ________________________________ 112

Pd(PPh3)4 – Palladium Tetrakis – DVB resin bound ______________________________________ 113

Pd(II) EnCat® TOTP30 – Palladium encapsulated catalyst _________________________________ 114

RhCl(PPh3)3 – polymer bound – Wilkinson’s catalyst ____________________________________ 115

5

Pd(Cl)2(PPh3)2 ‐ DVB – Palladium complex on PS‐DVB resin _______________________________ 116

SiliaCat® DPP‐Pd – immobilized complex Pd ___________________________________________ 117

Triamine tetraacetate, silica‐supported (TAA) _________________________________________ 118

Quadrapure® TU – Immobilized Thiourea _____________________________________________ 119

Quadrapure®‐AEA, Immobilized Aminoethyl aminobut‐2‐enoate ester _____________________ 120

Quadrapure®‐AMPA, Aminomethylphosphonic acid ____________________________________ 121

Quadrapure®‐IDA, Immobilized Iminodiacetate ________________________________________ 122

Quadrapure®‐IMDAZ, Immobilized Imidazol‐1‐yl propylaminobut‐2‐enoate ester ____________ 123

Quadrapure®‐MPA, Immobilized Mercaptophenylaminobut‐2‐enoate ester _________________ 124

Quadrasil®‐AP, Aminopropyl _______________________________________________________ 125

Quadrasil®‐TA, Triamine ___________________________________________________________ 126

Quadrasil®‐MTU, Methylthiourea ___________________________________________________ 127

Quadrasil®‐MP, Mercaptopropyl ____________________________________________________ 128

Quadrasil®‐PHI, phenolic functionalized silica gel _______________________________________ 129

Quadrapure®‐PHE, phenolic functionalized polystyrene _________________________________ 130

Mercaptopropyl modified silica _____________________________________________________ 131

Amberlite® IR‐120 – Hydrogen form _________________________________________________ 132

QuadraPure™‐BZA – Immobilized benzylamine ________________________________________ 133

Amberlyst® 36 resin ______________________________________________________________ 134

Amberlite® IRA‐910, chloride form __________________________________________________ 135

Amberlyst® 35 Dry resin ___________________________________________________________ 136

NaIO4 – Sodium Periodate _________________________________________________________ 137

n‐Bu4NIO4 – Tetrabutylammonium (meta) periodate ____________________________________ 138

Full list of ThalesNano Inc’s CatCart® technology enabled literatures ___________________142

Safety and directives of ThalesNano Products _____________________________________166

6

About Us

ThalesNano Inc. is an innovation‐driven company focusing on the development of bench‐top flow chemistry instruments and solutions for synthetic chemical challenges.

The company was founded in 2002 in Budapest, Hungary. Since then, ThalesNano operates globally, with the help of our US office and worldwide distributor network. Currently, more than 1300 of our instruments are used worldwide. Our mission is to make flow chemistry the part of the daily laboratory routine and to make chemical processes safer, easier and more effective. We put a great emphasis to support research and development by aiding scientific collaborations and education.

Our first instrument on the market, the H‐Cube® continuous flow hydrogenation reactor was launched in 2004. The instrument was ground‐breaking with its innovative hydrogen generator coupled with the advantages of flow chemistry technology. It has received the R&D Top 100 Award and is used in hundreds of laboratories globally. During the recent years, the H‐Cube® has become the new industry standard for hydrogenation.

In response to market needs, ThalesNano has developed new continuous flow reactors to cover an extended chemical space in terms of both pressure and temperature. Nowadays, the company has the widest portfolio of laboratory‐scale instruments for pharmaceutical, biotechnology, fine chemical, flavor and fragrance, agrochemical and petrochemical markets, as well as for academic research groups and education.

Our family of products solves daily problems with difficult or dangerous reactions. We offer a convenient and safe alternative with easy reproducibility. In addition, with temperature range from ‐70 to 1000°C and pressure from vacuum to 200 bar a new chemical parameter window is achievable that is otherwise unreachable in batch processes.

7

Instruments and system setups from ThalesNano

8

H‐Cube® Pro General product information

The H‐Cube® Pro, the most popular instrument of ThalesNano, is the easily adjustable and more professional version of our award winner H‐Cube® reactor system. With the help of the fast parameter setting, the instrument allows fast reaction optimization of multiple variables (temperature, pressure, flow rate (residence time), hydrogen amount (equivalence), catalyst amount, concentration, solvent).

Technical specifications

Temperature range: 10 °C – 150 °C, 1 °C step setting option Pressure range: atmospheric – 100 bar, 1 bar step setting option Flow rate range: 0.3 mL/min – 3 mL/min, 0.1 mL/min step setting option CatCarts®: 30x4 mm, 70x4 mm and MicroCart™ H‐Cube type cartridges Hydrogen production: maximum 60 mL/min, 1% precision addition (volume) Productivity range: mg – g scale, depending on the chemical reaction

9

Instrument enabled technologies and reactions

Technical features

The H‐Cube® Pro has a built‐in reaction optimization algorithm (Simplex) which leads the reaction to a local maximum production in 10‐15 steps by changing three parameters automatically, according to the previous results. Also, based on our company’s experiences, a built‐in reaction parameter option is

available which gives an initial parameter set to the chemist to start with for numerous reaction types.

The system has a ’timer’ option as well. The calculated dead volumes, washing times and priming parameters can be adjusted by the user and the instrument carries out the reaction by automatically changing the valves.

The H‐Cube® Pro can be connected to other modules and reactors, like the Gas Module™, the Phoenix Flow Reactor™ or the Autosampler™. These instruments can be operated through the touch screen of the H‐Cube® Pro. By this, a wider chemical space and new opportunities for synthesis become available, like the addition of different gases to the reaction mixture, working on temperatures up to 450 °C and the complete automation of the system.

In H‐Cube® Pro’s software the user can set all the applied parameters and save the reaction conditions. Therefore, anytime when needed, they can be searched back and set again as a reproduction run, or checked for the conditions. The system automatically saves all reaction log files according to date and time when the reaction started. These saved files can be exported as .csv file to a PC through flash‐drive.

Chemical resistance and compatibility

The H‐Cube® Pro is typically built with SS316 tubing (stainless steel alloy), which contains nickel. Mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly advice to avoid using mineral acids as solvents and use base as quench material, if such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the tubing. Otherwise, the H‐Cube® Pro can operate with almost all the commercially available solvents. The limiting factors are the viscosity, the melting point and the pH of the used solvents.

For further information please contact us at [email protected].

10

H‐Cube® Mini Plus General product information

The H‐Cube® Mini Plus is an easy‐to‐use instrument designed primarily for routine hydrogenation reactions. This instrument is the modern, advanced and improved variant of the company’s award winner H‐Cube® reactor system. The design emphasizes the small footprint and versatility.


Temperature range: room temperature – 100 °C, 1 °C step setting option Pressure range: atmospheric – 100 bar, 1 bar step setting option Flow rate range: 0.3 mL/min – 3 mL/min, 0.1 mL/min step setting option CatCarts®: 30x4 mm, 70x4 mm and MicroCart™ H‐Cube type cartridges Hydrogen production: maximum 25 mL/min, maximum volume added at all time Productivity range: mg – g scale, depending on the chemical reaction

11


Technical features

The features of the H‐Cube® Mini Plus include a built‐in reaction parameter function which offers an initial parameter set, based on our research and experiences, to start with for numerous reaction types.

In the software of the H‐Cube® Mini Plus the user can set all the applied parameters and save the reaction conditions. Therefore, anytime when needed, they can be searched back and set again as a reproduction run, or checked for the conditions. The system automatically saves all reaction log files according to date and time when the reaction started. These saved files can be exported as .csv file to a PC through flash‐drive.


The H‐Cube® Mini Plus is typically built with SS316 tubing (stainless steel alloy), which contains nickel. Mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly advice to avoid using mineral acids as solvents and use base as quench material, if such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the tubing. Otherwise, the H‐Cube® Pro can operate with almost all the commercially available solvents. The limiting factors are the viscosity, the melting point and the pH of the used solvents.


12

H‐Cube® Midi General product information

The H‐Cube® Midi is designed for scaling up reactions optimized on the H‐Cube® series reactors. The reactor operates with MidiCart™ catalyst cartridges. The reactions parameters (temperature, pressure, flow rate (residence time), hydrogen amount (equivalence)) can be automatically controlled.

13


Temperature range: room temperature – 150 °C, 5 °C step setting option Pressure range: atmospheric – 100 bar, 5 bar step setting option Flow rate range: 3 mL/min – 25 mL/min, 0.5 mL/min step setting option CatCarts®: MidiCart™ type cartridges Hydrogen production: maximum 120 mL/min, 10% precision addition (volume) Productivity range: g – ½ kg scale, depending on the chemical reaction


Technical features

H‐Cube® Midi operates with MidiCarts™ which have 10 times bigger inner volume than the 70x4 mm CatCarts®. This allows the chemists to scale up the optimized reaction directly with minor changes just by multiplying the parameters from the smaller scale reactors.


The H‐Cube® Midi is typically built with SS316 tubing (stainless steel alloy), which contains nickel. Mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly advice to avoid using mineral acids as solvents and use base as quench material, if such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the tubing. Otherwise, the H‐Cube® Pro can operate with almost all the commercially available solvents. The limiting factors are the viscosity, the melting point and the pH of the used solvents.

For further information please contact us at [email protected] e‐mail address.

14

Phoenix Flow Reactor™ General product information

The Phoenix Flow Reactor™ is a versatile high capacity heater system. This reactor widens the commercial chemical space towards extreme high temperatures and high pressure. It can be used as a module for the H‐Cube® Pro or as part of an advanced continuous flow system for both homogeneous and heterogeneous reactions.


Temperature range: room temperature – 450 °C, 1 °C step setting option Pressure range: atmospheric – 200 bar, 1 bar step setting option Flow rate range: 0.1 mL/min – 10 mL/min, 0.1 mL/min step setting option CatCarts®: works with all cartridges from ThalesNano Productivity range: mg – kg scale depending on the chemical reaction Working modes: Standalone reactor or connected to H‐Cube® Pro

15


Technical features

The Phoenix Flow Reactor™ has a 250mm x 50mm heated zone. With different inner metal blocks, the size of the applied cartridge can vary from MicroCart™ volume to the 250 mm long cartridge with 1” width. This versatility makes the implementation of scale‐up processes possible, from mg to kg scale with one instrument. (For more information, please take a look into the maximum working temperatures listed at the cartridge types and the catalyst catalogue.)

The reactor can be used connected to the H‐Cube® Pro and controlled by its touch screen. In this case, the liquid transportation and the pressure regulation (100 bar) is provided and controlled by H‐Cube® Pro. The second option is to use the reactor as part of more complex continuous flow system, in which a backpressure regulator (up to 200 bar) and a high pressure HPLC pump (from 0.1 to 50 mL/min flow rate depending on the type of the pump, always with built‐in pressure sensor) provide the reactant transport and the pressure regulation.

The Phoenix Flow Reactor™ is designed for rapid heating and precise temperature control: the system heats up within 10 minutes from ambient temperature to 450 °C.


The tubing used for the Phoenix Flow Reactor™ is made of SS316 (stainless steel alloy). Since this alloy contains nickel, mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly advice to avoid using mineral acids as solvent, and use base as quench material, if such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the tubing. Otherwise, the Phoenix Flow Reactor™ can operate with almost all the commercially available solvents. The limiting factors are the viscosity, the melting point and the pH of the used solvents.


16

Gas Module™ General product information

The Gas Module™ is an automatic gas flow controller unit designed by ThalesNano. The system can work standalone as a precise gas dosing instrument, or connected to other ThalesNano instruments as an outer gas source reducer. 14 different gases can be used with the system: the basic software contains predefined data about the applicable gases and a custom mode for gas‐mixture regulation.


Temperature range: can work with slightly heated or cooled gases from 10‐50 °C Pressure range: atmospheric – 100 bar, 1 bar step setting option Gas flow rate range: 1 mL/min – 100 mL/min, 1 mL/min step setting option Gas types: H2, CO, N2, NO, N2O, O2, Air, SynGas, Ar, He, CH4, C2H6, C2H4, CO2, Custom

17


Technical features

Gas Module™ technology is based on mass flow controllers (MFC) which introduce gases to the batch or flow reaction precisely. By calculating the gas factor, the chemist can regulate the gas flow for custom gas mixtures also.

The Gas Module™ can be connected to the H‐Cube® Pro, the Phoenix Flow Reactor™ and the Autosampler™ systems. In case of using it with the H‐Cube® Pro, the Gas Module™ can be operated through its touch screen. By these, a wider chemical space is achievable with the use of different gases and temperatures up to 450 °C, or with complete automation.


The Gas Module™ is generally built SS316 tubing (stainless steel alloy). Since this alloy contains nickel, mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly advice to avoid using HCl as gas. Also, due to its low supercritical parameters, CO2 has special precautions as gas source.


18

IceCube™ General product information

IceCube™ is an instrument designed for high energy exothermic reactions. The wetted parts of the system are made of PTFE, from the addition point to the product collection. This feature enables the use of highly flammable or volatile materials without risking the reaction between the reagent and the system’s tubing. The IceCube™ reactor can cool its reaction zone down to ‐50 or ‐70 °C, and also heating it up to 80 °C, covering the commercial reaction temperatures of a normal batch chemistries. The IceCube™ reactor has two separable cooling zones, one for completing the reaction and the second one for quenching the reaction.

19


Temperature range: ‐70 (‐50) °C – 80 °C in the reaction zone, 1 °C step setting option ‐30 °C – 80 °C in the quench zone, 1 °C step setting option Pressure range: atmospheric – 7 bar, 1 bar step setting option Flow rate range: 0.2 mL/min – 4 mL/min, 0.1 mL/min step setting option, two pumps Loop system Variable volume, depending on the needs of the customer Productivity range: mg – kg scale, chemistry dependent


Technical features

IceCube™ has two reactor zones with separate temperature control. The cooled/heated area is made of aluminium plates in which the chemist can place PTFE tubing as the reaction zone. Typical volumes vary from µL to mL scale.

The reactor can be connected to ThalesNano’s Ozone Module™, which allows to perform ozonolysis reactions in safe manner. It has a built‐in quenching calculation option; setting the quenching concentration the system sets the quenching flow rate automatically, and vice versa, helping the chemist cease the excess ozone which remains unreacted during the reaction.

The different parts of the system can be operated individually with their touchscreens or connected to the Control Module™, and by this, the whole reactor setup can be controlled through one screen automatically.

The IceCube™ has a stackable reaction zone which can handle three individual aluminium panels. Through CAN communication, multiple pumps can be integrated into the system with PTFE mixers, and multistep reactions can be performed in one sequence.


The IceCube™ is generally built with PTFE tubing (poly‐tetrafluoro ethylene) with 1/8” or 1/16” outer diameter. Therefore, the system can operate with any solvents and reactants without restrictions. This polymer also enables the transportation of materials like Grignard reagents or organolithium solutions. Since it is a closed tube‐system, the reaction space is protected from air or moisture contaminations.


20

Ozone Module™ General product information

The Ozone Module™ is a gas generator which produces ozone from oxygen. Due to the small internal volumes, the instrument minimizes the risks of ozonolysis reactions. The instrument can be used as a standalone gas generator and also as part of ThalesNano’s IceCube™ Reactor system.


Temperature range: room temperature Pressure range: atmospheric – 6 bar O2 flow rate range: 1 mL/min – 100 mL/min, 1 mL/min step setting option Productivity range: mg – kg scale, depending on the chemical reaction Working modes: Standalone reactor or connected to the IceCube™ Reactor O3 mode or just carrying O2 gas O3 concentration: 10‐16% (volume), depending on O2 flow rate and cell temperature

21


Technical features

The built‐in ozone generator cell of the Ozone Module™ produces O3 from oxygen. As a gas source, any size of oxygen cylinders can be used with minimum 2.5 gas purity (99.5%). Higher gas purity can help to prolong the ozone cell’s lifetime. For introducing the oxygen gas, the cylinder should be applied with a low‐pressure reducer. The Ozone Module™ can handle 3‐5 bar gas addition. Higher gas pressure can damage the ozone cell and low pressure setting on a high‐pressure reducer causes alteration in the gas pressure and the system cannot change into stable state.

The IceCube™ Reactor is designed as an effective cooling system (down to ‐50 °C or ‐70 °C) for high energy reactions. The Ozone Module™ can be easily connected to it and by this, chemists can run their ozonolysis reaction in small volumes, continuously quenching the excess ozone gas from the line.


All wetted parts of the Ozone Module™ are made of PTFE. This plastic is completely inert and can hold several bar pressures. The instrument’s exit lines (waste or product) are equipped with check valves to prevent reaction solution to flow back into the instrument. Any liquid that enters the ozone cell can permanently damage the instrument.


22

Flash Pyrolysis Platform™ General product information

ThalesNano’s Flash Pyrolysis Platform™ is a high temperature and low‐pressure reactor for fast reactions which require high energy input to form the reactive intermediates. The reactor works in two modes: sublimation method for solid materials or spray method for dissolved starting materials.


Temperature range: r.t – 1000 °C, 1 °C step setting option in the furnace r.t – 400 °C in the preheater unit (sublimation mode) Pressure range: atmospheric – 10‐3 mbar Flow rate range: in spray mode: pump dependent parameter Productivity range: mg – g scale, depending on the chemical reaction Carrier gas: in spray mode: N2 or Ar

23


Technical features

The Flash Pyrolysis Platform™ is a powerful flash vacuum pyrolysis instrument which is capable to work at 1000 °C. The vacuum is maintained by a high‐performance pump, down to 1x10‐3 mbar pressure.

The applied cooled trap system is capable to collect the products at the end of the reactor system, and the chemist can gather the liquid or solid material by washing the trap with a suitable solvent.

The system can be applied for unimolecular reactions, such as ring closure, ring opening and rearrangement reactions.


When used in sublimation mode (or liquid evaporation mode), the Flash Pyrolysis Platform™ is built from quartz glass and therefore, it is applicable to the implementation of reactions up to 1000 °C.

When going in spray mode, the tubing used for carrying the solution is made of SS316 alloy. Since this alloy contains nickel, mineral acids (i.e. hydrochloric acid) can dissolve the metal as salt from the tube wall. Therefore, we strongly advice to avoid using mineral acids as solvent, and use base as quench material, if such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the tubing.


24

CatCart® Changer General product information

The CatCart® Changer is a modular unit which can be combined with the H‐Cube® series instruments (PEEK, SS, Pro, Mini Plus) and it controls the temperature of six individual chambers parallel. The system is controlled by a PC or by the software of the H‐Cube® Pro and helps fasten the catalyst screening and reaction optimization.

25


Temperature range: r.t. – 100 °C, 1 °C step setting option Pressure range: atmospheric – 100 bar, 1 bar step setting option Flow rate range: attached instrument depending flow rates CatCarts®: 30x4 mm, 70x4 mm and MicroCart™ H‐Cube® type cartridges Productivity range: mg – g scale, used for sublimation mode (or liquid evaporation).


Technical features

The CatCart® Changer is made for fasten optimization processes. The automatic injector changes the reaction lines when the heating block is ready and stable.

With the CatCart® Changer, multiple catalysts and different cartridge sizes can be used after each other without stopping the flow or the reaction.


The CatCart Changer™ is built with SS316 (stainless steel alloy) or PEEK tubing. The alloy contains nickel. Mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly advice to avoid using mineral acids as solvent, and use base as quench material, if such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the tubing. Otherwise, the CatCart® Changer can operate with almost all the commercially available solvents. The limiting factors are the viscosity, the melting point and the pH of the used solvents.


26

CatCart® Packer General product information

The CatCart® Packer system is made of two major parts. The first is the vacuum pump assisted CatCart® filling unit, which enables customers to fill their own CatCarts® with heterogeneous catalysts. The second unit is the CatCart® Closer: a mechanical press for closing the filled cartridges – this part can be purchased separately as well. With the help of this system, chemists can fill their own manufactured catalyst for research purposes.

Packing the CatCarts®

CatCart® closing system has 5 elements:

1) thin carbon filled PTFE ring, 2) 8 micron pore size stainless steel filter 3) 1.2 micron pore size PTFE membrane, 4) 8 micron pore size stainless steel filter, 5) thick carbon filled PTFE membrane for sealing the above parts

27

The parts have to be placed in the listed order at both ends of the cartridge and with the help of the Closer unit, sealed in carefully. After pressing the sealing ring, the overextended PTFE has to be cut off and the CatCart® is ready to use.


Technical features

The CatCart® Packer is designed primarily for customers who would like to use their own catalysts with ThalesNano’s instruments. The system creates an opportunity for the chemists to fill and test the catalysts promptly after manufacturing.

With the CatCart® Packer, the customer can fill 30x4 mm, 70x4 mm and MicroCart™ type catalysts also, varying the catalyst amount through packed bed length.


The CatCart® Packer works with ThalesNano provided one‐end‐sealed cartridges, the chemical compatibilities and restrictions are matching to the ones listed at the CatCart® information page.


28

Autosampler™ General product information

ThalesNano’s Autosampler™ is an automated system combining a Gilson liquid handler to other modular ThalesNano instruments, such as the H‐Cube®, the H‐Cube® Pro, the Gas Module™, the CatCart® Changer and the Phoenix Flow Reactor™. The setup helps the chemist optimize reaction conditions automatically.


Temperature range: 10 – 450 °C, 1 °C step setting option, depending on the connected instruments

Pressure range: atmospheric – 100 bar Flow rate range: 0.3 – 3 mL/min H2 production: no H2 – 60 mL/min, depending on the connected instruments Productivity range: mg – g scale, depending on the chemistry Vial number: Vial rack dependent, up to 56 vials

29


Technical features

Autosampler™ is capable of performing reactions automatically. The liquid handler injects the starting solution through a high‐pressure valve (up to 10 mL sample volume at a time) and collecting the product mixtures after the reactions.

Sampling and collecting with the Autosampler™ can happen from 4 mL to 35 mL vials, depending on the applied rack. Changing the racks in the liquid handler also varies the reaction number the system can perform during one complete series from 1 to more than 100.

The whole system can be operated through a PC on a graphical interface, where all the parameters, graphs and system performance can be followed and logged.

Connecting the CatCart® Changer to the system makes possible to run reactions on 6 different catalysts in one series. This makes catalyst research and optimization faster.


The wetted parts of the Autosampler™ are made of SS316 alloy. Since this alloy contains nickel, mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly advice to avoid using mineral acids as solvent, and use base as quench material, if such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the tubing.

For more information about the chemical resistance of the connected modular reactors, please read the instrument’s introducing page in this catalogue.


30

H‐Genie™ by General product information

The H‐Genie is a compact standalone high‐pressure hydrogen generator that produces hydrogen by the electrolysis of deionized water, with the available gas flow rate range between 100‐1000 NmL/min and pressure range between 1‐100 bar. The hydrogen purity is 99.99% at 100 bar.

The H‐Genie is designed to supply hydrogen to both batch and flow reactors at maximum safety. Even balloons can be filled safely and quickly. The total internal H2 volume is only 150 mL and is generated on‐demand. In the case of any power shortage or malfunction, the production halts and mechanical valves ensure the safe release of the remaining hydrogen from the generator to the fume hood. A built‐in H2 detector along with a full pressure test conducted at start‐up guarantee safe and secure usage. Hydrogen flow is measured using a mass flow controller. All data is displayed in a graph, which can be exported as a .csv file. An RS232 port allows remote access.

Working parameters

Pressure range: atmospheric – 100 bar (± 1 bar) Up to 90 bar in flow mode (depending on the pressure drop of the cartridge)

Hydrogen production: 100 mL/min – 1000 mL/min (± 1 mL/min) Productivity range: g – kg scale, depends on the reaction

31


Technical features

Due to H‐Genie’s™ high volume hydrogen production, it enables the user to fill up several autoclaves at the same time or run multiple flow reactions.

H‐Genie™ is equipped with a gas check valve which maintains the pressure difference between the gas and the liquid line. Therefore, no liquid can go backwards into the instrument.

High Pressure Hydrogen Safety

H‐Genie™ parameters:

Max. internal pressure (p): 110 bar

Internal gas volume (V): 0,15 L

p*V: 16,5 (bar*L)

For further information please contact us at [email protected] and [email protected] e‐mail addresses.

32

Distributor Network of ThalesNano ThalesNano Inc. is dedicated to deliver a good and quick service to our customers. For this purpose, a worldwide distributor network is working in the favor of both sides.

Europe Distributor Country Webpage Anamed & Analitik Grup

TR http://www.anamed.com.tr/thalesnano

Beun de Ronde BV. NL, LUX https://www.beunderonde.nl/flowsynthese.html Beun de Ronde Serlabo BE https://www.brs.be/flow_chemistry.html TECHNOPROCUR CZ, Spol. s r.o.

CZ http://www.technoprocur.cz/sortiment/farmaceuticky‐prumysl/

Serlabo Technologies FR http://www.serlabo.fr/fr/305‐chimie‐de‐flux Stepbio Srl IT http://www.stepbio.it/skproduttore.asp?IDProduttore=

33 LaboChema LT EE, LT, LV https://www.labochema.lt/ Selwa Sp. z o.o. PL http://selwa‐lab.pl/main Paralab P http://www.paralab.pt/partner/thalesnano ANALITIC LABORATORY RO http://www.analiticlaboratory.ro/ Galachem Ltd. RU Net Interlab, S.A. E https://net‐interlab.es/categoria‐producto/thalesnano/ Labotal Scientific Equipment LTD

IL http://labotal.co.il/firms_posts/thalesnano/

Asia Distibutor Country Webpage PyNN Corporation CN http://www.pynnco.com/ INKARP Instruments Private Limited

IN

ITS Science Inc. ID, MY, PH, TH, VN

http://its‐sciencemedical.com/its_cat/flow‐chemistry‐reactors/

Ikeda Scientific Co., Ltd.

JP http://www.ikedarika.co.jp/product/original/ThalesNano/h‐cube‐pro.html

CM Corporation Ltd. KR http://www.cm‐corp.co.kr/ UTEK International Corporation

TW

For more detailed information, please visit our website at https://thalesnano.com/our‐distributors/ address.

33

Service and Maintenance We can provide our services for your H‐Cube®, H‐Cube Pro™, H‐Cube Mini Plus™, Phoenix Flow Reactor™, Gas Module™ or IceCube™ upon your preferences, for Preventive Maintenance or fully comprehensive post‐warranty support, Service Plus. Our team of service engineers is always at your service. Feel free to ask questions or share your eventual request with them!

The available service packages

Contact

ThalesNano HQ

Service line: +36 1 8808 589 Service line is working: from 8 am to 6 pm CET/CEST E‐mail: [email protected]

North America

Alan Boyle Director of Operations and Service

E‐mail: [email protected] Service line: +1 215 534 3365 Service line is working: from 8 am to 6 pm EST

34

Care Platform™ Memberships

Heading towards a more personalized approach of customer care, we doubled up on the number of specialists who are eager to help addressing your challenges. Our new product selector tool also meant to be a convenient option to find the best fit to your lab’s needs.

In line with our intention taking customer care to the next level, we are also launching Care Platform™ Memberships. On top of an annual preventive maintenance visit, complimentary software updates and the second to none technical support, extensive set of services and allowances are now also on offer:

Remote AskTheChemist™ specialist support, workflow optimization and training

Complimentary Journal of Flow Chemistry subscription

Pre‐release access to Application Notes

Assistance with your Centre of Excellence accreditation

Flexible finance solutions to support your purchase and ease on the Capex budget

On‐site AskTheChemist™ flow chemistry knowledge support in your lab at reduced rates

Solving flow chemistry challenges in our own laboratory with a discount

Reduced CatCart® prices and fastest delivery from the widest selection in our webshop

Preferential rates with our chemical CRO sister company, ComInnex

We remain at your disposal in terms of sharing knowledge and expertise, acquired over nearly two decades, to help you make the most of flow chemistry. Feel free to contact us for further details and introductory offers.

35

Care Platform™ Memberships Value added and service components

36

CatCart® General product information

CatCart® is ThalesNano’s packed catalyst cartridge system. The heterogeneous catalysts are filled in a stainless steel tube and sealed on both sides with a complex sealing system, containing graphite filled PTFE sealing rings, SS filters and PTFE membrane.

CatCarts® are available in different sizes, depending on which instrument the chemists like to use and how big the reaction scale is:

37

Advised particle sizes to fill the cartridges with

For H‐Cube type CatCarts® (30x4mm, 70x4mm, MicroCart): 40‐200 µm

For MidiCarts™: 100‐400 µm

For MMS cartridges: 40‐500 µm, depending on column size

CatCart® filled chamber sizes and inner volumes (empty cartridge): Cartridge type Length ID Volume

(empty) Instrument

MicroCart™ 6 mm 4 mm 75 µL H‐Cube Pro™, H‐Cube Mini Plus™, H‐Cube® SS/PEEK, Phoenix Flow Reactor™

30x4 mm 18 mm 4 mm 226 µL H‐Cube Pro™, H‐Cube Mini Plus™, H‐Cube® SS/PEEK, Phoenix Flow Reactor™

70x4 mm 58 mm 4 mm 728 µL H‐Cube Pro™, H‐Cube Mini Plus™, H‐Cube® SS/PEEK, Phoenix Flow Reactor™

MidiCart™ 90 mm 9.5 mm 6376 µL H‐Cube MIDI™, Phoenix Flow Reactor™ 125 mm 1/8” MMS 101 mm 1.65 mm 216 µL Phoenix Flow Reactor™ 125 mm 1/4” MMS 99 mm 3.8 mm 1122 µL Phoenix Flow Reactor™ 125 mm 1/2” MMS 97 mm 9.4 mm 6728 µL Phoenix Flow Reactor™ 250 mm 1/8” MMS 226 mm 1.65 mm 483 µL Phoenix Flow Reactor™ 250 mm 1/4” MMS 224 mm 3.8 mm 2539 µL Phoenix Flow Reactor™ 250 mm 1/2” MMS 220 mm 9.4 mm 15260 µL Phoenix Flow Reactor™

Custom Cartridges In the case of Phoenix Flow Reactor™, all cartridges of ThalesNano can be applied. Moreover, when the customer needs a unique size cartridge, our team is happy to develop and manufacture the required parts. The CatCart columns are made of stainless steel, but our company also manufactures cartridges from Hastelloy or PTFE, following customer requirements.


Technical features

The CatCart® technology is designed to keep the heterogeneous catalysts inside the cartridge during the whole process. The chemist does not have to work directly with the hazardous materials at the beginning of the reaction, and also does not have to filter out the active and often pyrophoric catalyst during the work‐up.

All shipped CatCarts® come with a deactivating solution filled additional tube. The chemist has to place the used CatCart® into the deactivating solution, and it poisons the transition metal, preventing it to cause any trouble after the reaction.

38

The used CatCarts® can be shipped back to ThalesNano for processing.


CatCarts® are made of SS316 alloy. Since this alloy contains nickel, we advise to avoid mineral acid or base containing solutions during the reaction.

For further information please contact us at [email protected] or at [email protected] e‐mail addresses.

How to acquire CatCarts®?

1) Ordering from ThalesNano Inc. or from local distributor

A) ThalesNano has more than 100 types of catalyst off the shelf to fill CatCarts® with. All the catalysts are tested for activity, and the filled batches are tested for physical parameters to match the criteria our instruments require to run seamlessly. For official quotation or information about our services and prices, please contact us at [email protected], [email protected] or [email protected]. In Europe, local distributors are helping our work, to serve customers faster. The list of distributors and countries please look for page 31.

B) CatCarts® are directly available from our webshop: www.webshop.thalesnano.com.

2) Custom catalyst filling A) When you cannot find the catalyst you would like to use in our list, we can order and fill cartridges

if the catalyst is commercially available. In this case delivery times can be longer than usual. B) ThalesNano Inc. also offers fill‐for‐fee service that makes possible for the users to send their own

catalysts to us and our team can pack the CatCarts® with the catalyst in the requested amount for a certain fee. This option creates opportunity for catalyst researcher groups to test their catalyst in flow. This service always works under CDA (confidential disclosure agreement). Please find more information about the fill‐for‐fee prices and regulations below.

C) The third option is to buy a CatCart® Closer or CatCart® Packer. In this case the customer can use their own instrument to fill and close the CatCarts® on site. Empty cartridges and the corresponding sealing system can be bought from ThalesNano Inc. or from local distributors.

39

Fill‐for‐fee prices and rules

30x4mm CatCart®: 35 EUR or 40 USD/pc

70x4mm CatCart®: 60 EUR or 70 USD/pc

Physical testing (optional): 610 EUR or 700 USD/catalyst type

‐ For every catalyst type the customer has to send the MSDS documentation. ‐ The filled CatCarts® are only for in‐house use for the customer, they cannot sell it further to a

third party. ‐ Shipping cost must be covered by the customer for both directions. ‐ Without physical testing option ThalesNano does not warrant the flow compatibility of the filled

cartridges. ‐ There is no minimal amount of CatCart® for this service.

CatCart® warranty and shelf‐life

ThalesNano guarantees the quality of the CatCarts® for one year. The warranty’s starting date is indicated on the side of the delivery box.

CatCarts® should be held in a dry and cold place to prolong the shelf‐life of the catalyst. However, after the warranty period expires, ThalesNano cannot take responsibility for the activity of the CatCarts®.

Safety and hazards

CatCarts® are sealed containers of catalysts. Opening the cartridges can be dangerous due to the pyrophoric nature of the catalysts inside. Our company does not take any responsibility for the accidents and injuries made by an opened cartridge.

For every piece of CatCart® our shipments contain a deactivating vial. After using a CatCart® we recommend to place the cartridge in the deactivating solution (sodium metabisulfite aqueous solution) to neutralize the activated catalyst.

Disposing the used cartridges

ThalesNano Inc. provides an opportunity to accept back the used cartridges for handling the waste. Every customer has the opportunity to send back the used goods for disposal to our headquarters.

The used CatCarts® should be considered as hazardous chemical waste and should be send to the correspondent company for disposal, closed and placed in the neutralizing tubes.

40

CatCart® Packages Starter package – THS‐01050

CatCart® THS Code Pcs in the package Reference page 10% Pd/C THS‐01111 6 46

Raney Nickel THS‐01112 3 76 5% Rh/C THS‐01114 3 81

20% Pd(OH)2/C THS‐01115 3 47 5% Ru/C THS‐02115 3 89

5% Pt/C (S) THS‐02117 3 72 5% Pt/C THS‐08112 3 75

70x4mm Starter Package – THS‐61060

CatCart® THS Code Pcs in the package Reference page 10% Pd/C THS‐01131 3 46

Raney Nickel THS‐01132 3 76 20% Pd(OH)2/C THS‐01135 3 47

5% Ru/C THS‐02135 3 89

These packages are selections of the most popular and often used catalysts. The packages contain several pieces of each catalyst types to allow the chemists to run parallel projects or optimize the reaction on a specific cartridge. More information about the individual CatCarts® can be found on the given reference page.

41

CatCart® “call for papers” The CatCart® is ThalesNano’s packed catalyst cartridge system. Naturally, there are preferred, favorite catalysts that the industry and research groups are applying more often than the other types. These catalysts, like Pd/C or Raney Nickel, have a wide range of literature with our instruments.

In this catalogue we listed the literature of each CatCarts® and picked one or two to show the chemistry at the bottom of the catalyst page. When you are starting your work and you are curious which catalyst you should use, we hope this list will help you decide and find the initial parameter set.

However, more extreme or rarely used CatCarts® have no literature as we know it. We try to make these catalysts more appealing for our customers so we decided to start a competition which benefits both our customers and our company.

Rules of the “game” When you are working with our instruments and CatCarts®, and you publish an article about your results, we kindly ask you to send us a reminder or copy of your accepted manuscript. Let us mention here, that only those manuscripts count that contains the commercial CatCart® and the work was done on a ThalesNano instrument.

‐ The first incoming manuscript’s writers and company get 20% discount for their next CatCart® order.

‐ The second incoming manusript’s writers and company get 15% discount for their next CatCart® order.

‐ The third incoming manusript’s writers and company get 10% discount for their next CatCart® order.

We hope that with this action we can encourage researchers and chemists to step out from the comfort zone of catalytic transformations and try a bit more extreme catalyst to achieve their goal with more sophisticated and selective ways.

42

Choosing the right catalyst for tuning the reaction outcome Transition metal catalysts have different reaction activities and selectivity towards saturated products when the staring compound has more sensitive groups attached. While planning the reaction chemists have to think also picking the optimal catalyst for the reaction to synthesize the required material and the same time avoid side‐product formation. Applying the same conditions, changing the catalyst has significant effect on the reaction outcome. (Figure 1)

Figure 1: different catalytic effect on the same parameter set. (Viviano et al., RSC Adv., 2015,5, 1268‐1273)

As will be seen in this catalogue, considering the amount of publications, the most used catalyst is still palladium on charcoal. However, other catalysts have different attributes and selectivity for fine‐tuned chemical reactions.

ThalesNano’s instruments also give the chemists opportunity for quick and safe reaction condition optimization. As in the CatCarts® contains super‐stoichiometric amount of catalyst, the reactions happen fast with even very small amount of starting material. This property offers a fast reaction condition screening, even with automated systems connected. Changing the parameter sets and the catalyst from the same starting material a variety of product can be synthesized easily. (Figure 2)

Figure 2: fast optimizing with easy catalyst and parameter changes. (Spare et al., Adv. Synth. Catal., 2018, 360(6), 2109‐1217)

43

Other chemical examples Complex screening with catalyst and parameter scope:

Cossar et al., Org. Biomol. Chem., 2015, 13, 7119‐7130

Thorough catalyst screening with the same parameter set:

Catalyst A B C D 10% Pd/C 0 % 0 % 15 % 85 % Pd Tetrakis 6 % 0 % 83 % 11 % 20% Pd(OH)2/C 0 % 0 % 31% 69 % RuO2 0 % 0 % 42 % 58 % Raney Nickel 40 % 15 % 45 % 0 % 5% Rh/C 66 % 3 % 0 % 31 % 5% Rh/Al2O3 42 % 2 % 0 % 56 % 5% Pt/C (Sulfided) 87 % 0 % 7 % 6 % 5% Re/C 100 % 0 % 0 % 0 % Re2O7 100 % 0 % 0 % 0 % 0.5% Ir/C 100 % 0 % 0 % 0 %

Hizartzidis et al., RSC Adv., 2014, 4, 56743‐56748

44

Commercially available CatCarts® From ThalesNano

45

Ti, Quartz sand – Inert materials CAS No: 7440-32-6 (Ti)

7631-86-9 (SiO2)

Available sizes and specifications for Ti

Part No. Size Filling mass Particle size Void Volume

Max. working temp.

Instrument

THS‐01110 30x4 mm 190±5 mg 40‐100 µm 65 µL 250 °C H‐Cube Mini Plus™, H‐Cube Pro™, PHX


THS‐D1140 MidiCart 4130±20 mg 200‐800 µm 2000 µL 150 °C H‐Cube MIDI™, PHX

Available sizes and specifications for quartz sand


Max. working temp.

Instrument

THS‐01049 microCC 210±5 mg 40‐100 µm 20 µL 150 °C H‐Cube Mini Plus™, H‐Cube Pro™, PHX




This product is also available in Metal‐Metal Sealed (MMS) cartridges made for PHX reactor in various sizes (length and outer diameter data can be found at the CatCart® introduction page). The parameters and physical data vary according to the chosen cartridge.

Inert materials have no catalytic effect on the reaction. However, when going with homogeneous catalysts or catalyst free, the CatCart® provides excellent mixing in the reaction zone which gives better performance on the reaction.

INER

T

46

Chemical examples

Spare et al., Adv. Synth. Catal., 2018, 360(6), 2109‐1217

Vaddula et al., J. Flow Chem. 2015, 5(3), 172–177

INER

T

47

10% Pd/C – Palladium on charcoal CAS No: 7440-05-3

Available sizes and specifications


Max. working temp.

Instrument






Chemical examples

Ponomarev et al., Bioorganic Chemistry, Vol. 76, 2018, 392‐399

Tsagris et al., Bioorganic & Medicinal Chemistry Letters, Vol. 28, 19, 2018, 3168‐3173

PALLAD

IUM

48

20% Pd(OH)2/C – Pearlman’s catalyst CAS No: 12135-22-7



Max. working temp.

Instrument






Chemical examples

Cloutier et al., Natural Products Reports, 2018, DOI: 10.1039/C8NP00046H

Nishimura et al., Journal of Medicinal Chemistry, 61, 2018, 5949−5962

PALLAD

IUM

49

5% Pd/Al2O3 – Palladium on alumina CAS No: 7440-05-3



Max. working temp.

Instrument






Chemical examples

Gutmann et al., Eur. J. Org. Chem. 2017, 914–927

PALLAD

IUM

50

10% Pd/CaCO3 – Palladium on calcium carbonate CAS No: 7440-05-3



Max. working temp.

Instrument




Chemical examples

Spare et al., Adv. Synth. Catal., Vol. 360, (6), 2018, 1209‐1217

PALLAD

IUM

51

5% Pd/CaCO3 – Palladium on calcium carbonate CAS No: 7440-05-3



Max. working temp.

Instrument




Chemical examples According to our research, there are no literature including this kind of CatCart®. Be the first who publishes an article about your work on this CatCart® and get discount for your next order.

For further information please look at page 41.

PALLAD

IUM

52

5% Pd/BaCO3 – Palladium on barium carbonate CAS No: 7440-05-3



Max. working temp.

Instrument






PALLAD

IUM

53

5% Pd/C (S) – Palladium on charcoal (sulfided) CAS No: 7440-05-3



Max. working temp.

Instrument







PALLAD

IUM

54




Max. working temp.

Instrument






Chemical examples

Garcia‐Olmo et al., Catal. Sci. Technol., 2016, 6, 4705–4711

Feiz et al., Sci. Rep. 2016, 6, 32719

PALLAD

IUM

55

5% Pd/CaCO3‐Pb – Lindlar’s Catalyst CAS No: 7440-05-3



Max. working temp.

Instrument





Chemical examples

Moreno‐Marrodan et al., Beilstein Journal of Organic Chemistry. 2017, 13, 734–754

Ötvös et al., ChemPlusChem, Vol. 83, 2, 2018, 72‐76

PALLAD

IUM

56

5% Pd/BaSO4 – Palladium on barium sulfate CAS No: 7440-05-3



Max. working temp.

Instrument






Chemical examples

Mándity et al., Chem. Rec. 2016, 16, 1018–1033

Ötvös et al., Molecules 2016, 21, 318

PALLAD

IUM

57




Max. working temp.

Instrument








PALLAD

IUM

58




Max. working temp.

Instrument





Chemical examples

Spare et al., Adv. Synth. Catal., Vol. 360, (6), 2018, 1209‐1217

Örkényi et al., Eur.J. Org. Chem. 2017,6525---6532

PALLAD

IUM

59

Pd/C – ethylenediamine CAS No: 7440-05-3



Max. working temp.

Instrument





Chemical examples

Manikowski et al., Carbohydrate Research, 2012, 361, 155‐161

PALLAD

IUM

60

5% Pd/SiO2 – Palladium on silica CAS No: 7440-05-3



Max. working temp.

Instrument








PALLAD

IUM

61




Max. working temp.

Instrument





Chemical examples

Favia et al., J. Med. Chem. 2012, 55, 20, 8807‐8826

PALLAD

IUM

62

2% Pd/SrCO3 – Palladium on strontium carbonate CAS No: 7440-05-3



Max. working temp.

Instrument







PALLAD

IUM

63

PdO – Palladium oxide CAS No: 1314-08-5



Max. working temp.

Instrument








PALLAD

IUM

64

Pd Black – Palladium metal CAS No: 7440-05-3



Max. working temp.

Instrument








PALLAD

IUM

65

10% Pt/C – Platinum on charcoal CAS No: 7440-06-4



Max. working temp.

Instrument






Chemical examples

Letavic et al., J. Med. Chem. 2017, 60, 4559−4572

Keränen et al., J. Chem. Theory Comput. 2017, 13, 1439−1453

PLAT

INUM

66

1% Pt/SiO2 – Platinum on silica CAS No: 7440-06-4



Max. working temp.

Instrument








PLAT

INUM

67

1% Pt/SiO2 polyethyleneimine – Platinum on modified silica CAS No: 7440-06-4



Max. working temp.

Instrument








PLAT

INUM

68

5% Pt/C (Bi) – Platinum on charcoal, doped with bismuth CAS No: 7440-06-4 (Pt),

7440-69-9 (Bi)



Max. working temp.

Instrument








PLAT

INUM

69

1% Pt/C (V) – Platinum on charcoal, doped with vanadium CAS No: 7440-06-4 (Pt),

7440-62-2 (V)



Max. working temp.

Instrument








PLAT

INUM

70

5% Pt/CaCO3 – Platinum on calcium carbonate CAS No: 7440-06-4 (Pt)



Max. working temp.

Instrument






PLAT

INUM

71

1% Pt/SBA – Platinum on mesoporous silica CAS No: 7440-06-4 (Pt)



Max. working temp.

Instrument






PLAT

INUM

72

5% Pt/Al2O3 – Platinum on alumina CAS No: 7440-06-4



Max. working temp.

Instrument






Chemical examples

Ötvös et al., Molecules 2016, 21, 318

Varnes et al., Tetrahedron Letters, 2016, 57, 4718–4722

PLAT

INUM

73

5% Pt/C (S) – Platinum on charcoal, poisoned with Sulphur CAS No: 7440-06-4



Max. working temp.

Instrument





Chemical examples

Spare et al., Adv. Synth. Catal.,. 2018, 360 (6), 1209‐1217


PLAT

INUM

74

1% Pt/Al2O3 – Platinum on alumina CAS No: 7440-06-4



Max. working temp.

Instrument







PLAT

INUM

75

1% Pt/C – Platinum on charcoal CAS No: 7440-06-4 (Pt)



Max. working temp.

Instrument








PLAT

INUM

76

5% Pt/C – Platinum on charcoal CAS No: 7440-06-4



Max. working temp.

Instrument






Chemical examples

Rubulotta et al., ACS Sustainable Chem. Eng. 2017, 5, 3762−3767

Brunlaux et al., Synthesis 2018, 50, 1849–1856

PLAT

INUM

77

Raney Nickel – Al/Ni CAS No: 7440-02-0



Max. working temp.

Instrument






Chemical examples

Sipőcz et al., Journal of Flow Chmeistry, 2015, 6(2), 117–122

Fehér et al., Chemical Engineering and Technology, Vol. 41, 3, 2018, 496‐503

NICKEL

78

Nickel Sponge CAS No: 7440-02-0



Max. working temp.

Instrument




This product is also available in other cartridge types also in various sizes. Please contact as at [email protected] or at [email protected] addresses.




NICKEL

79

Pricat™ Nickel 55/5P – Nickel catalyst on Diatomaceous earth CAS No: 7440-02-0



Max. working temp.

Instrument

THS‐03143 MicroCart 60±5 mg 40‐100 µm 65 µL 250 °C H‐Cube Mini Plus™, H‐Cube Pro™, PHX



This catalyst has advanced resistance to catalyst poisoning. Typical catalyst type for petrol related reactions and matrixes which contains catalyst poisons such as sulphur contaminations.





NICKEL

80

Nickel Sponge with 1% Mo CAS No: 7440-02-0 (Ni) 7439-98-7 (Mo)



Max. working temp.

Instrument








NICKE

L

81

Ni/SiO2‐Al2O3 – Nickel on Silica‐alumina support CAS No: 7440-02-0



Max. working temp.

Instrument





Chemical examples

Garcia‐Olmo et al., Catal. Sci. Technol., 2016, 6, 4705

NICKEL

82

5% Rh/C – Rhodium on charcoal CAS No: 7440-16-6



Max. working temp.

Instrument






Chemical examples

Viviano et al., RSC Adv., 2015,5, 1268‐1273

Sundén et al., ChemMedChem., 2013, 8(8), 1283‐1294 RH

ODIUM

83

1% Rh/SiO2‐Polyethyleneimine – Rhodium on modified silica CAS No: 7440-16-6



Max. working temp.

Instrument






RHODIUM

84

5% Rh/Al2O3 – Rhodium on alumina CAS No: 7440-16-6



Max. working temp.

Instrument






Chemical examples

Barlaam et al., Bioorg. Med. Chem. Lett., Vol. 27(9), 2017, 1949‐1954

Newman et al., Green Chem., 2013, 15, 1456 RH

ODIUM

85

1% Au/Fe2O3 – Gold on Iron Oxide CAS No: 7440-57-5



Max. working temp.

Instrument




Chemical examples

Sipos et al., J. Flow Chem. 2013, 3(2), 51–58

GOLD

86

1% Au/C – Gold on charcoal CAS No: 7440-57-5



Max. working temp.

Instrument







GOLD

87

1% Au/TiO2 – Gold on Titanium dioxide CAS No: 7440-57-5



Max. working temp.

Instrument





Chemical examples

Sipos et al., J. Flow Chem. 2013, 3(2), 51–58

Vilé et al., Nanoscale, 2014, 6, 13476

GOLD

88

Ru black – Ruthenium metal CAS No: 7440-18-8



Max. working temp.

Instrument







RUTH

ENIUM

89

5% Ru/Al2O3 – Ruthenium on Alumina CAS No: 7440-18-8



Max. working temp.

Instrument






Chemical examples

Zotova et al., Green Chem. 2010, 12, 2157‐2163

RUTH

ENIUM

90

5% Ru/C – Ruthenium on charcoal CAS No: 7440-18-8



Max. working temp.

Instrument






Chemical examples

O’Boyle et al., Chem. Res. Toxicol. 2014, 27, 1002−1010

Viviano et al., RSC Adv., 2015,5, 1268‐1273

RUTH

ENIUM

91

RuO2 – Ruthenium oxide CAS No: 12036-10-1



Max. working temp.

Instrument





Chemical examples


RUTH

ENIUM

92

5% Re/C – Rhenium on charcoal CAS No: 7440-15-5



Max. working temp.

Instrument








RHEN

IUM

93

Raney‐Cu – Raney type Copper CAS No: 7440-50-8



Max. working temp.

Instrument






Chemical examples

Jones et al., Chemistry Today, 2008, 26(3), 10‐13

COPP

ER

94

CuO/Al2O3 – Copper(II)oxide on alumina CAS No: 1317-38-0



Max. working temp.

Instrument




Chemical examples

Nuzhdin et al., Cat. Comm., Vol. 102, 2017, 108‐113

Bermudez et al., Green Chemistry, 2013, 15(10), 2786‐‐‐2792

COPP

ER

95

5% Cu in graphite – Copper metal powder mixed with graphite powder CAS No: 7440-50-8



Max. working temp.

Instrument




Chemical examples

Ötvös et al., Beilstein J. Org. Chem. 2013, 9, 1508–1516

Ötvös et al., Chem. Asian J. 2013, 8, 800 – 808

COPP

ER

96

Raney Cobalt CAS No: 7440-48-4



Max. working temp.

Instrument






Chemical examples

Garcia‐Olmo et al., Catal. Sci. Technol., 2016, 6, 4705

Flores et al., Org. Biomol. Chem., 2014, 12, 5278–5294

COBA

LT

97

0.5% Ir/C – Iridium on charcoal CAS No: 7439-88-5



Max. working temp.

Instrument






IRIDIUM

98

1% Ir/C – Iridium on charcoal CAS No: 7439-88-5



Max. working temp.

Instrument







IRIDIUM

99

IrO2 – Iridium oxide CAS No: 12030-49-8

IrO2



Max. working temp.

Instrument







IRIDIUM

100

5% Ir/CaCO3 – Iridium on calcium carbonate CAS No: 7439-88-5



Max. working temp.

Instrument







IRIDIUM

101

Zinc powder CAS No: 7440-66-6



Max. working temp.

Instrument







ZINC

102

1% Pd – 0.3% Cu/Al2O3– Palladium and copper on alumina CAS No: 7440-05-3 (Pd) 7440-50-8 (Cu)



Max. working temp.

Instrument






MIXED

METALS

103

Pricat™ CZ 30/18T – Copper and Zinc on Diatomaceous earth CAS No: 7440-66-6 (Zn) 7440-50-8 (Cu)



Max. working temp.

Instrument





This catalyst has advanced resistance to catalyst poisoning. Typical catalyst type for petrol related reactions and matrixes which contains catalyst poisons such as sulphur contaminations.




MIXED

METALS

104

5% Pd – 1% Fe/C – Palladium and Iron on charcoal CAS No: 7440-05-3 (Pd) 7439-89-6 (Fe)



Max. working temp.

Instrument







MIXED

METALS

105

2.5% Pd – 2.5% Pt/C – Palladium and platinum on charcoal CAS No: 7440-05-3 (Pd) 7440-06-4 (Pt)



Max. working temp.

Instrument







MIXED

METALS

106

4.5% Ru – 0.5% Pd/C – Ruthenium and palladium on charcoal CAS No: 7440-05-3 (Pd) 7440-18-8 (Ru)



Max. working temp.

Instrument







MIXED

METALS

107

Pt(0) EnCat® – Platinum encapsulated catalyst CAS No: n/a



Max. working temp.

Instrument



A safer and more user friendly alternative to classical Pt/C used in hydrogenation reactions; with minimal metal contamination by the catalyst which can be removed by filtration. Highly selective in the hydrogenation of nitro aromatics bearing halogen substitution.

0.12 mmol/g loading, matrix: encapsulated nanoparticles, support (wet); Platinum (0), microencapsulated in polyurea matrix




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

108

Rh(COD)(dppf)/SiO2 – Rhodium complex catalyst on silica CAS No: n/a



Max. working temp.

Instrument



THS‐X1121 70x4 mm 400±5 mg 40‐100 µm 200 µL 120 °C X‐Cube™

Complex Rhodium catalyst binded on silica surface.




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

109

Pd(0) EnCat® NP30 – Palladium encapsulated catalyst CAS No: n/a



Max. working temp.

Instrument




Encapsulated Pd catalyst reduction of aryl ketones and benzyl ethers. Matrix content 30%.

0.35‐0.43 mmol/g loading, matrix: encapsulated nanoparticles, support (wet); Palladium(0), microencapsulated in polyurea matrix




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

110

Pd(II) EnCat® 30 – Palladium encapsulated catalyst CAS No: n/a



Max. working temp.

Instrument





Recyclable, immobilized catalyst system that simplifies removal of Pd in C‐C bond forming and reduction processes. Pd EnCat 30, with lower matrix content, shows similar performance but with improved kinetics while maintaining the mechanically robust nature of Pd EnCat 40 under similar conditions.

0.37‐0.44 mmol/g loading, matrix: encapsulated nanoparticles, support (wet); Palladium acetate, microencapsulated in polyurea matrix




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

111

Pd(II) EnCat® TPP30 – Palladium encapsulated catalyst CAS No: n/a



Max. working temp.

Instrument





Pd EnCat® TPP30 may be used as a catalyst for the microwave‐assisted Sonogashira cross‐coupling of:

• Aryl iodides and bromides with terminal alkynes to form the corresponding coupling products under copper‐free conditions. • Bromobenzotriazoles and arylacetylenes in the presence of 1,5‐diazabicyclo[5.4.0]undecene‐5‐ene (DBU) and copper iodide to form 2H‐benzo[d][1,2,3]triazole derivatives.

0.37‐0.44 mmol/g loading (Pd) and 0.26‐0.35 mmol/g (phosphorous), matrix: encapsulated nanoparticles, support (wet); Palladium acetate and triphenylphosphine, microencapsulated in polyurea matrix




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

112

Pd(II) EnCat® BINAP30 – Palladium encapsulated catalyst CAS No: n/a



Max. working temp.

Instrument





Pd EnCat® catalyst, wherein palladium acetate and 1,1′‐binaphthalene‐2,2′‐diylbis(diphenylphosphine) (BINAP) are microencapsulated within a polyurea matrix, which prevents palladium leaching.

0.39 mmol/g loading (Pd) and 0.25 mmol/g (BINAP), matrix: encapsulated nanoparticles, support (wet); Palladium acetate and BINAP, microencapsulated in polyurea matrix




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

113

Pd(PPh3)4 – Palladium Tetrakis – DVB resin bound CAS No: 14221-01-3



Max. working temp.

Instrument





Chemical examples

Csajági et al., Org. Lett., 2008, 10(8), 1589‐1592

Hizartzidis et al., RSC Adv., 2014,4, 56743‐56748

HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

114

Pd(II) EnCat® TOTP30 – Palladium encapsulated catalyst CAS No: n/a



Max. working temp.

Instrument




Pd EnCat® catalyst, Palladium acetate and tri‐o‐tolylphosphine, microencapsulated in polyurea matrix.

0.40‐0.47 mmol/g loading (Pd) and 0.15‐0.20 mmol/g (phosphorous), matrix: encapsulated nanoparticles, support (wet); Palladium acetate and tri‐o‐tolylphosphine, microencapsulated in polyurea matrix




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

115

RhCl(PPh3)3 – polymer bound – Wilkinson’s catalyst CAS No: n/a



Max. working temp.

Instrument




Complex Rhodium catalyst binded on 2% Styrene‐Divinylbenzene polymer. Approximately 1% Rh concentration.




HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

116

Pd(Cl)2(PPh3)2 ‐ DVB – Palladium complex on PS‐DVB resin CAS No: 13965-03-2



Max. working temp.

Instrument




Chemical examples

Trinh et al., Org. Biomol. Chem., 2014, 12, 9562–9571

Borcsek et al., ARKIVOC, 2012 (v) 186‐195

HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

117

SiliaCat® DPP‐Pd – immobilized complex Pd CAS No: n/a



Max. working temp.

Instrument

THS‐08818 30x4 mm 140±5 mg 63 ‐ 250 µm 65 µL 250 °C H‐Cube Mini Plus™, H‐Cube Pro™, PHX

THS‐08838 70x4 mm 320±5 mg 63 ‐ 250 µm 200 µL 250 °C H‐Cube Mini Plus™, H‐Cube Pro™, PHX


Chemical examples

Ciriminna et al., Catal. Sci. Technol., 2016, 6, 4678

Mai et al., J. Flow Chem. 2015, 5(1), 6–10

HETERO

GEN

EOUS CO

MPLEX

CAT

ALYST

118

Triamine tetraacetate, silica‐supported (TAA) CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Pd(0), Ni(0), and Cu

> 0.41 mmol/g loading, 60 Å pore size, surface area: 500 m2/g, store temperature: 2‐8°C




SCAV

ENGER

S AN

D RE

SINS

119

Quadrapure® TU – Immobilized Thiourea CAS No: 147754‐40‐3



Max. working temp.

Instrument

THS‐01313 30x4 mm 130±5 mg 400‐600 μm 65 µL 120 °C H‐Cube Mini Plus™, H‐Cube Pro™, PHX

Scavenger for: Pd, Pt, Ru, Rh, Au, Ag, Cu, Hg, Pb, Cd, Ni, Co, Fe, V, Zn

QuadraPure® TU is a thiourea‐based metal scavenger resin that can be used to prevent metal contamination that occurs during pharmaceutical or fine chemical processing.


Chemical examples

Britton et al., Chem. Soc. Rev., 2017, 46, 1250‐‐1271

SCAV

ENGER

S AN

D RE

SINS

120

Quadrapure®‐AEA, Immobilized Aminoethyl aminobut‐2‐enoate ester CAS No: n/a



Max. working temp.

Instrument



Scavenger for: Pd, Rh, V, Cu, Fe

1.3 mmol/g loading




SCAV

ENGER

S AN

D RE

SINS

121

Quadrapure®‐AMPA, Aminomethylphosphonic acid CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Fe, Cu, Ni, V, Al, Co




SCAV

ENGER

S AN

D RE

SINS

122

Quadrapure®‐IDA, Immobilized Iminodiacetate CAS No: n/a



Max. working temp.

Instrument


THS‐X1165 70x4 mm 130±5 mg 350‐750 µm 65 µL 120 °C H‐Cube Mini Plus™, H‐Cube Pro™, PHX

Scavenger for: Fe, Al, Ga, In, Cu, V, Pb, Ni, Zn, Cd, Be, Mn, Co, Sr, Ba




SCAV

ENGER

S AN

D RE

SINS

123

Quadrapure®‐IMDAZ, Immobilized Imidazol‐1‐yl propylaminobut‐2‐enoate ester CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Pd, Ru, Os, Co, Ni, Rh, V, Fe, Cu, Sn

1.5 mmol/g loading




SCAV

ENGER

S AN

D RE

SINS

124

Quadrapure®‐MPA, Immobilized Mercaptophenylaminobut‐2‐enoate ester CAS No: n/a



Max. working temp.

Instrument



Scavenger for: Pd, Ru, Rh, Hg, Au, Ag, Cu, Ni, Sn, Pb, Pt, Cd

1.5 mmol/g loading




SCAV

ENGER

S AN

D RE

SINS

125

Quadrasil®‐AP, Aminopropyl CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Co, Cu, Cd, Fe, Ni, Pd, Rh, Ru, Pb, Hg, Zn

1.5‐2.0 mmol/g loading




SCAV

ENGER

S AN

D RE

SINS

126

Quadrasil®‐TA, Triamine CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Au, Cd, Co, Cu, Fe, Pd, Pt, Rh, Ru, V, Zn, Pb

0.5‐1.5 mmol/g loading




SCAV

ENGE

RS AND RE

SINS

127

Quadrasil®‐MTU, Methylthiourea CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Co, Cu, Fe, Pb, Pd, Rh, Ru, Ag, Au, Pt, Hg

1‐1.5 mmol/g loading




SCAV

ENGER

S AN

D RE

SINS

128

Quadrasil®‐MP, Mercaptopropyl CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Pd (with or without phosphines), Rh, Cu, Ru, Pt, Pb, Ag, Hg

1‐1.5 mmol/g loading




SCAV

ENGE

RS AND RE

SINS

129

Quadrasil®‐PHI, phenolic functionalized silica gel CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Fe(ΙΙΙ), Pd(ΙΙ), Rh(ΙΙΙ)

20‐100 µmol/g loading




SCAV

ENGER

S AN

D RE

SINS

130

Quadrapure®‐PHE, phenolic functionalized polystyrene CAS No: n/a



Max. working temp.

Instrument


Scavenger for: Fe(ΙΙΙ), Pd(ΙΙ), Rh(ΙΙΙ)




SCAV

ENGER

S AN

D RE

SINS

131

Mercaptopropyl modified silica CAS No: 112926‐00‐8



Max. working temp.

Instrument



Metal scavenger silica catalyst.




SCAV

ENGER

S AN

D RE

SINS

132

Amberlite® IR‐120 – Hydrogen form CAS No: 39389‐20‐3

Amberlite®



Max. working temp.

Instrument


Matrix: sytrene‐divinylbenzene gel Active group: sulfonic acid


Chemical examples

Cukalovic et al., J. Flow Chem. 2012, 2, 43‐46

SCAV

ENGE

RS AND RE

SINS

133

QuadraPure™‐BZA – Immobilized benzylamine CAS No: 960620‐60‐4



Max. working temp.

Instrument

THS‐X1164 70x4 mm 400±5 mg 400‐1100 µm 200 µL 120 °C X‐Cube

Quadrapure™ BZA is a primary amine‐functionalized resin with an effective loading of ~5.5 mmol/g.

Scavenger for: Rh, Pd, Cu, Co, Ni




SCAV

ENGER

S AN

D RE

SINS

134

Amberlyst® 36 resin CAS No: 39389‐20‐3



Max. working temp.

Instrument



51‐57% Moisture content (H+ form), composition: water: 55%, surface area: 33 m2/g, pore size: 0.20 mL/g total pore volume, Shrinkage: Water to phenol: 45%, Water to dry: 54%.




SCAV

ENGER

S AN

D RE

SINS

135

Amberlite® IRA‐910, chloride form CAS No: 37264‐66‐7



Max. working temp.

Instrument


Strongly basic (type II) anion exchange resin for water conditioning and deionization, removal of sulfuric acid and color, etc. The type II base provides improved regeneration efficiency over type I base resin.

moisture: 54‐61%, matrix: styrene‐divinylbenzene (macroreticular), active group: methylethanolamine functional group




SCAV

ENGER

S AN

D RE

SINS

136

Amberlyst® 35 Dry resin CAS No: n/a



Max. working temp.

Instrument



Strongly Acidic Catalyst, H+ form.

Matrix: styrene‐divinylbenzene (macroreticular), active group: Sulfonic acid, surface area: 50 m2/g, pore size: 300 Å, swelling: Dry → Phenol : 27%




SCAV

ENGER

S AN

D RE

SINS

137

NaIO4 – Sodium Periodate CAS No: 7790-28-5



Max. working temp.

Instrument




Chemical examples

Monbaliu et al., Tetrahedron Letters, 2010, 51, 5830–5833

OTH

ER

138

n‐Bu4NIO4 – Tetrabutylammonium (meta) periodate CAS No: 65201-77-6



Max. working temp.

Instrument






OTH

ER

139

Catalyst portfolio of ThalesNano Inc.

Catalyst type

THS Codes for ordering

MicroCart 30x4mm CatCart

70x4mm CatCart MidiCart

Inert Quartz sand THS‐01049 THS‐01010 THS‐01030 THS‐D1040

Titanium ‐ THS‐01110 THS‐01130 THS‐D1140

Palladium

10% Pd/C THS‐01141 THS‐01111 THS‐01131 THS‐D1141

20% Pd(OH)2/C THS‐01145 THS‐01115 THS‐01135 THS‐D1145

5% Pd/Al2O3 THS‐01148 THS‐01118 THS‐01138 THS‐D1148

10% Pd/CaCO3 ‐ THS‐01511 THS‐01531 ‐

5% Pd/CaCO3 ‐ THS‐01512 THS‐01532 ‐

5% Pd/BaCO3 ‐ THS‐01513 THS‐01533 ‐

5% Pd/C (sulfided) THS‐01841 THS‐01811 THS‐01831 ‐

5% Pd/C THS‐02141 THS‐02111 THS‐02131 THS‐D2141

5% Pd/CaCO3 (Pb) / Lindlar's THS‐02144 THS‐02114 THS‐02134 ‐

5% Pd/BaSO4 THS‐03142 THS‐03112 THS‐03132 THS‐D3142

1% Pd/Al2O3 THS‐03148 THS‐03118 THS‐03138 THS‐D3148

10% Pd/Al2O3 THS‐03149 THS‐03119 THS‐03139 ‐

Pd/C‐ethylenediamine THS‐04142 THS‐04112 THS‐04132 ‐

5% Pd/SiO2 THS‐04144 THS‐04114 THS‐04134 THS‐D4144

1% Pd/C THS‐04145 THS‐04115 THS‐04135 ‐

2% Pd/SrCO3 THS‐04146 THS‐04116 THS‐04136 ‐

PdO THS‐04148 THS‐04118 THS‐04138 THS‐D4148

Pd black THS‐04149 THS‐04119 THS‐04139 THS‐D4149

Platinum

10% Pt/C THS‐01143 THS‐01113 THS‐01133 THS‐D1143

1% Pt/SiO2 THS‐01444 THS‐01414 THS‐01434 THS‐D1444

1% Pt/SiO2 ‐ polyethyleneimine THS‐01445 THS‐01415 THS‐01435 THS‐D1445

5% Pt/C (doped with Bi) THS‐01446 THS‐01416 THS‐01436 THS‐D1446

1% Pt/C (doped with V) THS‐01449 THS‐01419 THS‐01439 THS‐D1449

5% Pt/CaCO3 ‐ THS‐01519 THS‐01539 ‐

1% Pt/SBA ‐ THS‐01617 THS‐01637 ‐

5% Pt/Al2O3 THS‐02143 THS‐02113 THS‐02133 THS‐D2143

5% Pt/C (sulfided) THS‐02147 THS‐02117 THS‐02137 ‐

1% Pt/Al2O3 THS‐04147 THS‐04117 THS‐04137 ‐



Nickel

Raney Nickel THS‐01142 THS‐01112 THS‐01132 THS‐D1142

Nickel Sponge ‐ THS‐01417 THS‐01437 THS‐D1447

PriCat® Ni 55/5P THS‐03143 THS‐03113 THS‐03133 ‐

Nickel Sponge (1% Mo) THS‐03144 THS‐03114 THS‐03134 THS‐D3144

Ni/SiO2‐Al2O3 THS‐04143 THS‐04113 THS‐04133 ‐

For further information please contact us at [email protected]

140


Catalyst type




Rhodium 5% Rh/C THS‐01144 THS‐01114 THS‐01134 THS‐D1144

1% Rh/SiO2 ‐ polyethyleneimine ‐ THS‐01412 THS‐01432 ‐

5% Rh/Al2O3 THS‐02148 THS‐02118 THS‐02138 THS‐D2148

Ruthenium

Ru Black ‐ THS‐01518 THS‐01538 ‐

5% Ru/Al2O3 THS‐02142 THS‐02112 THS‐02132 THS‐D2142

5% Ru/C THS‐02145 THS‐02115 THS‐02135 THS‐D2145

RuO2 THS‐05148 THS‐05118 THS‐05138 ‐

Gold 1% Au/Fe2O3 ‐ THS‐01616 THS‐01636 ‐

1% Au/C ‐ THS‐01618 THS‐01638 ‐

1% Au/TiO2 ‐ THS‐01619 THS‐01639 THS‐D1649

Copper Raney Copper THS‐01147 THS‐01117 THS‐01137 THS‐D1147

CuO/Al2O3 ‐ THS‐01311 THS‐01331 ‐

Copper powder in graphite ‐ THS‐01819 THS‐01839 ‐

Cobalt Raney Cobalt THS‐01146 THS‐01116 THS‐01136 THS‐D1146

Iridium 0.5% Ir/C ‐ THS‐01413 THS‐01433 ‐

1% Ir/C THS‐04141 THS‐04111 THS‐04131 ‐

IrO2 THS‐05149 THS‐05119 THS‐05139 ‐

5% Ir/CaCO3 THS‐06146 THS‐06116 THS‐06136 ‐

Zinc Zinc powder ‐ THS‐08112 THS‐08132 ‐

Rhenium 5% Re/C THS‐02146 THS‐02116 THS‐02136 ‐

Mixed Metals

1% Pd ‐ 0.3% Cu/Al2O3 ‐ THS‐01514 THS‐01534 ‐

PriCat® CZ 30/18T (Cu+Zn) THS‐01943 THS‐01913 THS‐01933 THS‐D1943

5% Pd ‐ 1% Fe/C THS‐03145 THS‐03115 THS‐03135 ‐

2.5% Pd ‐ 2.5% Pt/C THS‐03146 THS‐03116 THS‐03136 ‐

0.5% Pd ‐ 4.5% Ru/C THS‐03147 THS‐03117 THS‐03137 ‐

Complex Catalysts

Pt(0) EnCat® ‐ THS‐01515 THS‐01535 ‐

Rh(COD)(dppf)/SiO2 ‐ THS‐01615 THS‐01635 ‐

Pd(0) EnCat® NP30 THS‐03141 THS‐03111 THS‐03131 ‐

Pd(II) EnCat® 30 THS‐05141 THS‐05111 THS‐05131 ‐

Pd(II) EnCat® TPP30 THS‐05142 THS‐05112 THS‐05132 ‐

Pd(II) EnCat® BINAP30 THS‐05143 THS‐05113 THS‐05133 ‐

Pd(PPh3)4 ‐ DVB bounded THS‐05144 THS‐05114 THS‐05134 ‐

Pd(II) EnCat® TOTP30 THS‐05145 THS‐05115 THS‐05135 ‐

RhCl(PPh3)4 THS‐05147 THS‐05117 THS‐05137 ‐

PdCL2(PPh3)2 ‐ DVB bounded ‐ THS‐06117 THS‐06137 ‐

SiliaCat® ‐ DPP‐Pd ‐ THS‐08818 THS‐08838 ‐


141


Catalyst type




Scavengers

Triamine tetraacetate, silica‐supported (TAA) ‐ THS‐01312 ‐ ‐

Quadrapure® TU ‐ THS‐01313 ‐ ‐

Quadrapure®‐AEA ‐ THS‐01314 ‐ ‐

Quadrapure®‐AMPA ‐ THS‐01315 ‐ ‐

Quadrapure®‐IDA ‐ THS‐01316 ‐ ‐

Quadrapure®‐IMDAZ ‐ THS‐01317 ‐ ‐

Quadrapure®‐MPA ‐ THS‐01318 ‐ ‐

Quadrasil®‐AP ‐ THS‐01319 ‐ ‐

Quadrasil®‐TA ‐ THS‐01320 ‐ ‐

Quadrasil®‐MTU ‐ THS‐01321 ‐ ‐

Quadrasil®‐MP ‐ THS‐01322 ‐ ‐

Quadrasil®‐PHI ‐ THS‐01323 ‐ ‐

Quadrapure®‐PHE ‐ THS‐01324 ‐ ‐

Mercaptopropyl modified silica ‐ THS‐01710 THS‐01730 ‐

Amberlite® IR‐120 ‐ THS‐01716 ‐ ‐

Amberlyst® 36 resin ‐ THS‐08113 THS‐08133 ‐

Amberlite® IRA‐910 ‐ THS‐08114 ‐ ‐

Amberlyst® 35 Dry resin ‐ THS‐08117 THS‐08137 ‐

QuadraPure™‐BZA ‐ ‐ THS‐X1164 ‐

Other NaIO4 ‐ THS‐01813 THS‐01833 ‐

n‐Bu4NIO4 ‐ THS‐01814 THS‐01834 ‐


142

Full list of ThalesNano Inc’s CatCart® technology enabled literatures

Inert materials (Titanium THS‐011X0, Quartz sand THS‐010X0)

Adv. Synth. Catal., 2018, 360(6), 2109‐2117 J. Flow Chem., 2015, 5(3), 172‐177 Mol. Divers., 2011, 15, 639‐643

10% Pd/C (THS‐011X1)

Multiple bond reductions

C=C AND C≡C BOND REDUCTION

Analytical and Bioanalytical Chemistry, 2015, 407, 803‐812 Beilstein J. Org. Chem., 2011, 7, 1141‐1149 Bioorg. Med. Chem., 2013, 21, 693‐702 Bioorg. Med. Chem., 2014, 22, 6826‐6836 Chem. Commun., 2011, 47, 9804‐9806 Chem. Eur. J., 2016, 22, 10393‐10398 Chem. Eur. J., 2016, 22, 14390‐14396 Chem. Eur. J., 2015, 21, 395‐401 Chem. Eur. J., 2015, 21, 4551‐4555 Chem. Eur. J., 2017, 23, 1676‐1685 Chem. Eur. J., 2017, 23, 4750‐4755 Chemistry ‐ A European Journal, 24(41), 10443‐10451 ChemMedChem, 2008, 3, 1922‐1935 ChemMedChem, 2014, 9, 1602‐1614 Chirality, 2014, 26, 200‐208 Eur. J. Med. Chem., 2012, 54, 573‐581 Eur. J. Med. Chem., 2014, 85, 127‐138

143

Eur. J. Med. Chem., 2016, 122, 339‐351 Eur. J. Med. Chem., 2017, 127, 250‐262 Eur. J. Org. Chem., 2009, 1327‐1334 Eur. J. Org. Chem., 2011, 3938‐3945 Eur. J. Org. Chem., 2012, 8, 1633‐1638 Eur. J. Org. Chem., 2015, 5856–5863 Eur. J. Org. Chem., 2017, 2824‐2830 Eur. J. Org. Chem., 2017, 6505‐6510 Food Chemistry, 2016, 190, 487‐494 Future Med. Chem., 2009, 1(9), 1593–1612 Green Chem., 2010, 12, 1687‐1703 J. Chem. Educ., 90, 930‐933 J. Chem. Tech. Biotechnol., 2013, 88, 519‐552 J. Med. Chem., 2016, 59, 6059−6069 J. Med. Chem., 2010, 53, 1876‐1880 J. Med. Chem., 2010, 53, 3675‐3684 J. Med. Chem., 2011, 54(7), 2320‐2330 J. Med. Chem., 2012, 55(16), 7193‐7207 J. Med. Chem., 2012, 55(21), 9069‐9088 J. Med. Chem., 2013, 56, 46‐59 J. Med. Chem., 2013, 56, 6917‐6934 J. Med. Chem., 2014, 57, 1046‐1062 J. Med. Chem., 2015, 58, 401‐418 J. Med. Chem., 2015, 58, 9754‐9767 J. Med. Chem., 2017, 60, 3405‐3421 J. Org. Chem., 2014, 79, 2993‐3029 J. Org. Chem., 2014, 79, 11179‐11193 J. Org. Chem., 2016, 81(21), 10302‐10320 J. Org. Chem., 2017, 82, 13093‐13108 JACS, 2011, 133(3), 582‐594 JACS, 2015, 137, 11950‐11953 Marine Drugs, 2014, 12, 799‐821 Med. Chem. Commun., 2011, 2, 31‐37 Med. Chem. Commun., 2014, 5, 159‐164 Metabolic Engineering, 2015, 28, 82‐90 Molecules, 2013, 18, 15080‐15093 Org. Biomol. Chem., 2012, 10, 4215‐4219 Org. Biomol. Chem., 2013, 11, 5147‐5155 Org. Biomol. Chem., 2014, 12, 1440‐1447 Org. Lett., 2008, 10(14), 3089‐3092 Org. Lett., 2013, 15, 1922‐1925 Polym. Chem., 2010, 1, 730‐738 Russ. Chem. Bull., 2015, 64, 112‐126 Synthesis, 49(16), 3749‐3767

144

Tetrahedron Lett., 2010, 51(7), 1091‐1094 Tetrahedron Lett., 2011, 52(14), 1583‐1586 Tetrahedron Lett., 2015, 56(42), 5705‐5708 Tetrahedron, 2010, 66, 2843‐2854 Tetrahedron, 2014, 70, 4790‐4798 Tetrahedron, 2016, 72, 6356‐6362

C=N BOND REDUCTION

Adv. Synth. Catal., 2012, 354, 17‐57 Beilstein J. Org. Chem., 2017, 13, 960‐987 Bioorg. Chem., 2018, 392‐399 Bioorg. Med. Chem., 2017, 6242‐6247 Chem. Comm., 2005, 23, 2909‐2911 Chem. Comm., 2006, 2566‐2586 Chem. Eur. J., 2006, 12, 5972‐5990 Chem. Soc. Rev., 2013, 42, 8849‐8869 Org. Biomol. Chem., 2012, 10, 7863‐7868 Org. Biomol. Chem., 2013, 11, 6806‐6813

O‐ and N‐debenzylation

ACS Comb. Sci., 2011, 13, 405‐413 Adv. Synth. Catal., 2007, 349, 535‐538 Analytical Chemistry, 2015, 87, 11460‐11467 Angew. Chem. Int. Ed., 2016, 55, 3823‐3827 Antimicrob. Agents Chemother., 2011, 55(5), 2379‐2389 Bioorg. Med. Chem. Lett., 2013, 23, 5091‐5096 Bioorg. Med. Chem. Lett., 2015, 25, 3984‐3991 Bioorg. Med. Chem., 2011, 19, 1802‐1815 Bioorg. Med. Chem., 2012, 20, 1779‐1793 Bioorg. Med. Chem., 2012, 20, 6403‐6415 Bioorg. Med. Chem., 2012, 20, 6687‐6708 Carbohydrate Research, 2013, 379, 26‐29 Carbohydrate Research, 2014, 384, 51‐55 Carbohydrate Research, 2014, 394, 26‐31 Carbohydrate Research, 2014, 400, 9‐13 Carbohydrate Research, 2015, 402, 25‐34 Carbohydrate Research, 2015, 406, 65‐70 Carbohydrate Research, 2015, 414, 65‐71 Carbohydrate Research, 2018, 470, 13‐18 Chem. Eur. J., 2012, 18, 14860‐14866 Chem. Eur. J., 2013, 19, 9343‐9350 Chem. Eur. J., 2016, 22, 4206‐4217 ChemBiochem, 2012, 13(9), 1319‐1326

145

ChemMedChem, 2012, 7(9), 1551‐1566 ChemMedChem, 2014, 9, 85‐108 ChemMedChem, 2014, 9, 350‐370 ChemMedChem, 2014, 9, 798‐812 Eur. J. Med. Chem., 2015, 106, 144‐156 Eur. J. Org. Chem., 2011, 3938‐3945 Eur. J. Org. Chem., 2014, 7405‐7412 Frontiers in Chemistry, 2013, 1, 15 Future Med. Chem., 2009, 1(9), 1593–1612 J. Carbohydrate Chem., 2011, 30, 249‐280 J. Carbohydrate Chem., 2015, 34(4), 173‐182 J. Carbohydrate Chem., 2015, 34(5), 247‐262 J. Chem. Tech. Biotechnol., 2013, 88, 519‐552 J. Comb. Chem., 2008, 10, 88‐83 J. Comb. Chem., 2009, 11(4), 640‐644 J. Med. Chem., 2011, 54(15), 5540‐5561 J. Med. Chem., 2013, 56, 301‐319 J. Med. Chem., 2013, 56, 3518‐3530 J. Med. Chem., 2013, 56, 6917‐6934 J. Med. Chem., 2015, 58, 8920‐8937 J. Med. Chem., 2016, 59, 9473‐9488 J. Mol. Catal. Enz., 2016, 123, 107‐112 J. Org. Chem., 2017, 82, 12346‐12358 Nature Communications, 2015, 6, 1‐11 New J. Chem., 2018, 42, 12403‐12411 Org. Biomol. Chem., 2012, 10, 3448‐3454 Org. Biomol. Chem., 2014, 12, 2675‐2685 Org. Biomol. Chem., 2016, 14, 3221–3233 Org. Biomol. Chem., 2017, 15, 9475‐9496 RSC Advances, 2013, 3, 201‐207 RSC Advances, 2015, 5, 98033‐98040 Synlett, 2006, 889‐892 Synthesis, 2017, 49(24), 5320‐5334 Tetrahedron Asymmetry, 2010, 21(17), 2172‐2176 Tetrahedron Asymmetry, 2014, 25, 238‐244 Tetrahedron Asymmetry, 2014, 25, 1138‐1145 Tetrahedron Lett., 2011, 52(16), 1839‐1841 Tetrahedron Lett., 2012, 53, 959‐961 Tetrahedron, 2009, 65, 6696‐6709 Tetrahedron, 2010, 66, 5623‐5636 Tetrahedron, 2011, 67, 9588‐9594 Tetrahedron, 2012, 68, 1507‐1514 Tetrahedron, 2012, 68, 7456‐7462 Tetrahedron, 2012, 68, 9448‐9455

146

Tetrahedron, 2013, 69, 8857‐8864 Tetrahedron, 2013, 69, 10337‐10350 Tetrahedron, 2018, 74, 2634‐2640

Other deprotections

Eur. J. Org. Chem., 2017, 39‐44 Eur. J. Org. Chem., 2017, 3265‐3273 J. Comb. Chem., 2008, 10, 88‐83 J. Flow Chem., 2014, 4(1), 18‐21 Org. Biomol. Chem., 2012, 10, 4215‐4219

Functional group reductions

C=O REDUCTION

Analytical and Bioanalytical Chemistry, 2015, 407, 803‐812 Angew. Chem. Int. Ed., 2009, 48, 1494‐1497 Org. Lett., 2012, 14(16), 4035–4037 Synthesis, 2012, 44, 2469‐2473 Tetrahedron, 2014, 70, 4790‐4798

C‐N3 REDUCTION

Amino Acids, 2016, 48(11), 2619‐2633 Bioorg. Med. Chem., 2013, 21, 3680‐3688 Chem. Eur. J., 2011, 17, 13146‐13150 Chem. Eur. J., 2015, 21, 11408‐11416 Chemistry Select, 2018, 3, 648‐652 Inorganica Chimica Acta, 2013, 398, 83‐88 J. Biomat. Sci., 2017, 28, 925‐938 J. Med. Chem., 2015, 58, 6151‐6178 J. Med. Chem., 2017, 60, 7897‐7909 Journal of Molecular Catalysis B Enzymatic, 2013, 97, 196‐202 Org. Biomol. Chem., 2014, 12, 4218‐4232 Synthesis, 2012, 4, 635‐647 Tetrahedron, 2014, 70, 4790‐4798

DEHALOGENATION

Chem. Eur. J., 2016, 22, 14390‐14396 J. Med. Chem., 2009, 52, 7706‐7723 J. Org. Chem., 2017, 82, 13093‐13108 Mol. Divers., 2012, 16, 81‐90. Org. Biomol. Chem., 2016, 14, 6398–6402 Tetrahedron Letters, 2013, 54, 6703‐6707

147

C≡N REDUCTION

J. Med. Chem., 2014, 57, 8099‐8110 Med. Chem. Commun., 2014, 5, 1834‐1842

C=N‐OH REDUCTION

Beilstein J. Org. Chem., 2013, 9, 2022‐2027

NO2 REDUCTION

Adv. Synth. Catal., 2010, 352, 3089‐3097 Angew. Chem. Int. Ed., 2017, 129, 4354‐4358 Angew. Chem. Int. Ed., 2017, 129, 8868‐8871 Arch. Pharm. Chem. Life Sci., 2016, 349, 1‐13 Bioorg. Med. Chem. Lett., 2011, 21, 7325‐7330 Bioorg. Med. Chem. Lett., 2012, 22, 7371‐7375 Bioorg. Med. Chem., 2010, 18(15), 5576‐5592 Bioorg. Med. Chem., 2018, 26, 798‐814 Chem. Commun., 2013, 49, 8755‐8757 Chem. Today, 2005, Jan‐Feb., 36‐39 ChemPlusChem, 2014, 79, 1605‐1613 Doklady Chemistry, 2017, 475, 159‐163 Drug Discovery Today, 2013, 18, 795‐802 Eur. J. Med. Chem., 2013, 66, 450‐465 Eur. J. Med. Chem., 2014, 85, 127‐138 Eur. J. Med. Chem., 2017, 127, 250‐262 Eur. J. Org. Chem., 2009, 687‐698 Future Med. Chem., 2009, 1(9), 1593–1612 J. Chem. Tech. Biotechnol., 2013, 88, 519‐552 J. Flow Chem., 2011, 1(2), 68‐73 J. Flow Chem., 2015, 5(2), 74‐81 J. Heterocyclic Chem., 2017, 54(6), 3527‐3537 J. Med. Chem., 2009, 52, 1081‐1099 J. Med. Chem., 2011, 54(9), 3331‐3347 J. Med. Chem., 2012, 55(5), 1978–1998 J. Med. Chem., 2012, 55(5), 2163–2172 J. Med. Chem., 2012, 55(17), 7392–7416 J. Med. Chem., 2014, 57, 495‐506 J. Med. Chem., 2014, 57, 1995‐2012 J. Med. Chem., 2014, 57, 7293‐7316 J. Med. Chem., 2015, 58, 7381‐7399 J. Med. Chem., 2015, 58, 9309‐9333 J. Med. Chem., 2016, 59, 2452‐2467 J. Med. Chem., 2016, 59, 8924‐8940

148

J. Org. Chem., 2011, 76, 6657‐6669 Macroheterocycles, 2015, 8(4), 409‐414 Molecules, 2014, 19, 9736‐9759 Molecules, 2016, 21, 1257 Org. Biomol. Chem., 2014, 12, 7551‐7560 Org. Biomol. Chem., 2015, 13, 7119‐7130 Org. Biomol. Chem., 2015, 13, 8016‐8028 Org. Biomol. Chem., 2016, 14, 6398–6402 Org. Biomol. Chem., 2016, 14, 8732‐8742 Org. Process Res. Dev., 2014, 18, 1427‐1433 Org. Process Res. Dev., 2017, 21, 125‐132 RSC Advances, 2015, 5, 93433‐93437 Synlett, 2010, 4, 505‐508 Tetrahedron Lett., 2011, 52(45), 5905‐5909 Tetrahedron Lett., 2012, 53, 5833‐5836 Tetrahedron Lett., 2014, 55, 5144–5146 Tetrahedron, 2017, 73, 6887‐6893 Tetrahedron, 2018, 74, 1253‐1268

Deuteration

Green Chem., 2010, 12, 1687‐1703 Tetrahedron Lett., 2009, 50, 4372‐4374

Reductive amination

Arch. Pharm. Chem. Life Sci., 2016, 349, 1‐13 Eur. J. Org. Chem., 2017, 6511‐6517 Green Chem., 2010, 12, 1000‐1006 J. Med. Chem., 2013, 56, 46‐59

Reductive cyclisation

Beilstein J. Org. Chem., 2017, 13, 2549‐2560 Bioorg. Med. Chem. Lett., 2009, 19(22), 6463‐6466 Carbohydrate Research, 2007, 342, 1953‐1959 Eur. J. Org. Chem., 2011, 3938‐3945

Reductive ring openings

Eur. J. Org. Chem., 2012, 8, 1633‐1638 J. Org. Chem., 2014, 79, 10226‐10239 JACS, 2015, 137, 11950‐11953 Org. Biomol. Chem., 2016, 14, 3221–3233 Org. Lett., 2010, 12, 1592‐1595 Tetrahedron, 2018, 74(38), 5032‐5039

149

Ring saturation

Bioorg. Med. Chem. Lett., 2017, 1949‐1954 Chem. Eur. J., 2017, 23, 4750‐4755 Eur. J. Org. Chem., 2009, 1327‐1334 Eur. J. Org. Chem., 2017, 6511‐6517 Green Chem., 2010, 12, 1687‐1703 J. Flow Chem., 2017, 7(2), 41‐45 J. Med. Chem., 2017, 60, 695‐709 Org. Process Res. Dev., 2014, 18, 1560‐1566 Rapid Commun. Mass Spectrom., 2014, 28, 1023‐1032

Raney Nickel (THS‐011X2)

Alkylation

J. Flow Chem., 2015, 6(2), 117–122

Deprotections

Bioorg. Med. Chem., 2012, 20, 6687‐6708 Chem. Commun., 2011, 47, 6512‐6535 J. Med. Chem., 2011, 54(9), 3331‐3347 Synthesis, 2017, 49(24), 5320‐5334

Double bond reduction

Angew. Chem. Int. Ed., 2015, 54, 678‐682 Bioorg. Med. Chem. Lett., 2015, 25, 1310‐1317 Eur. J. Org. Chem., 2012, 8, 1633‐1638 Monatsh. Chem., 2016, 147, 509‐521 Org. Biomol. Chem., 2015, 13, 7119‐7130


C=O REDUCTION

Org. Biomol. Chem., 2015, 13, 7119‐7130 RSC Adv., 2017, 7, 31401‐31407

150

NO2 REDUCTION

ACS Comb. Sci., 2011, 13, 405‐413 ACS Omega, 2017, 2, 3839‐3857 Bioorg. Med. Chem., 2011, 19, 1802‐1815 Bioorg. Med. Chem., 2017, 162‐167 Carbohydrate Research, 2013, 367, 1‐4 Chem. Today, 2005, Jan‐Feb., 36‐39 Eur. J. Med. Chem., 2012, 58, 543‐556 Future Med. Chem., 2010, 2(2), 161‐168 Heterocycles, 2011, 82(2), 1297‐1316 J. Med. Chem., 2013, 56, 3033‐3047 J. Org. Chem., 2011, 76, 6657‐6669 J. Org. Chem., 2015, 80, 5588–5599 J. Org. Chem., 2015, 80, 11755‐11767 Mol. Divers., 2011, 15, 613‐630 Org. Process Res. Dev., 2015, 19, 1605‐1633 PLOS One, 2012, 7(10), e45964 Synlett, 2010, 5, 749‐752 Tetrahedron Lett., 2011, 52(31), 3963‐3968 Tetrahedron Lett., 2013, 54, 5378‐5382 Tetrahedron, 2012, 68, 9272‐9277

C≡N REDUCTION

Angew. Chem. Int. Ed., 2015, 54, 678‐682 Bioorg. Med. Chem. Lett., 2012, 22, 6665‐6670 Bioorg. Med. Chem. Lett., 2013, 23, 119‐124 Bioorg. Med. Chem., 2012, 20, 6687‐6708 Chem. Eur. J., 2013, 19, 2450‐2456 Future Med. Chem., 2009, 1(9), 1593–1612 Org. Biomol. Chem., 2008, 6, 4120–4124 Org. Biomol. Chem., 2014, 12, 3288‐3302 Org. Biomol. Chem., 2015, 13, 7119‐7130 Tetrahedron Lett., 2011, 52(14), 1583‐1586 Tetrahedron Lett., 2012, 53, 1656‐1659

C=N‐OH REDUCTION

Chirality, 2015, 27(1), 39‐52 Future Med. Chem., 2009, 1(9), 1593–1612

Ring saturation

J. Chrom. A, 2015, 1378, 74‐87 RSC Adv., 2017, 7, 31401‐31407

151

Hydrogenolysis

Org. Biomol. Chem., 2013, 11, 5147‐5155

10% Pt/C (THS‐011X3)

J. Chem. Theory Comput., 2017, 13, 1439‐1453 Adv. Synth. Catal., 2010, 352, 3089‐3097 eLife, 2016, 5, e11878 Eur. J. Org. Chem., 2011, 4623‐4633 J. Med. Chem., 2010, 53, 7682‐7698 J. Med. Chem., 2016, 59, 1727‐1746 J. Med. Chem., 2017, 60, 4559‐4572 Org. Biomol. Chem., 2015, 13, 7119‐7130 Tetrahedron Lett., 2012, 53, 5660‐5662

5% Rh/C (THS‐011X4) ChemCatChem, 2013, 5, 724‐727 ChemMedChem, 2013, 8, 1283‐1294 J. Med. Chem., 2015, 58, 978‐993 RSC Advances, 2015, 5, 1268‐1273 Tetrahedron Lett., 2012, 53, 5660‐5662

20% Pd(OH)2/C (THS‐011X5)

Multiple bond reductions

C=C AND C≡C BOND REDUCTION

Adv. Synth. Catal., 2014, 356, 1007‐1020 ARKIVOC, 2016, 1, 111‐149 Bioorg. Med. Chem. Lett., 2013, 23, 4591‐4596 Bioorg. Med. Chem. Lett., 2015, 25, 1318‐1323 ChemCatChem, 2015, 7, 1380‐1385

152

Chem. Eur. J., 2010, 16(37), 11471‐11480 Chem. Soc. Rev., 2013, 42, 8849‐8869 Eur. J. Org. Chem., 2011, 3938‐3945 Eur. J. Org. Chem., 2012, 15, 2990‐3000 J. Med. Chem., 2012, 55(20), 8685‐8699 Org. Biomol. Chem., 2015, 13, 7119‐7130 Tetrahedron Lett., 2011, 52(48), 6457‐6459 Tetrahedron Lett., 2016, 57, 1804–1806


ChemMedChem, 2017, 12, 905‐912 Eur. J. Org. Chem., 2011, 1266‐1270 Eur. J. Org. Chem., 2011, 3938‐3945 Eur. J. Org. Chem., 2013, 809‐829 J. Med. Chem., 2012, 55(13), 6176‐6193 J. Med. Chem., 2013, 56, 301‐319 J. Med. Chem., 2015, 58, 1569‐1574 J. Org. Chem., 2013, 78, 4049‐4064 J. Org. Chem., 2014, 79, 4615‐4634 J. Org. Chem., 2015, 80, 10386‐10396 Nat. Prod. Rep., 2018, 35, 1251‐1293 Nature Comm., 2017, 8, 115 New J. Chem., 2011, 35, 476‐482 Tetrahedron Asymmetry, 2013, 25, 238‐244 Tetrahedron Lett., 2012, 53, 2493–2495 Tetrahedron Lett., 2014, 55, 1255‐1257 Tetrahedron, 2012, 68, 1507‐1514


J. Org. Chem., 2014, 79, 4615‐4634 Tetrahedron, 2013, 69, 4563‐4577

Reductive amination

ACS Med. Chem. Lett., 2015, 6 (12), pp 1204–1208 Synthesis, 2012, 44, 2469–2473

Reductive cyclisation

Eur. J. Org. Chem., 2011, 3938‐3945

Ring saturation

Analytical Chemistry, 2015, 87, 8457‐8465

153

Bioorg. Med. Chem. Lett., 2015, 25, 1318‐1323

Raney Cobalt (THS‐011X6)

Catal. Sci. Technol., 2016, 6, 4705‐4711 Org. Biomol. Chem., 2014, 12, 5278‐5294

Raney Copper (THS‐011X7)

Chemistry Today, 2008, May‐June, 26(3), 10‐13

5% Pd/Al2O3 (THS‐011X8)

ACS Sustainable Chem. Eng., 2016, 4(11), 6048‐6061 Eur. J. Org. Chem., 2017, 914‐927

CuO/Al2O3 (THS‐013X1) Catal. Sci. Technol., 2016, 6, 4705‐4711 Catalysis Communications, 2017, 102, 108‐113 Green Chemistry, 2013, 15, 2786‐2792 Org. Chem. Front., 2014, 1, 1067‐1071

Triamine‐tetraacetate on SiO2 (THS‐013X2) There is no literature available.

QuadraPure™ TU (THS‐01313)

Adv. Synth. Catal., 2010, 352, 3089‐3097 Chem. Soc. Rev., 2011, 40, 5010‐5029 Chem. Soc. Rev., 2017, 46, 1250‐1271 Chemical Science, 2010, 675‐680 J. Med. Chem., 2012, 55(9), 4062−4098

154

QuadraPure™ AEA (THS‐01314)

There is no literature available.

QuadraPure™ AMPA (THS‐01315) There is no literature available.

QuadraPure™ IDA (THS‐01316) There is no literature available.

QuadraPure™ IMDAZ (THS‐01317) There is no literature available.

QuadraPure™ MPA (THS‐01318) There is no literature available.

QuadraSil™ AP (THS‐01319) There is no literature available.

QuadraSil™ TA (THS‐01320) There is no literature available.

QuadraSil™ MTU (THS‐01321) There is no literature available.

QuadraSil™ MP (THS‐01322) There is no literature available.

155

QuadraSil™ PHI (THS‐01323) There is no literature available.

QuadraPure™ PHE (THS‐01324)


1% Rh/SiO2‐polyethyleneimine (THS‐014X2)


0.5% Ir/C (THS‐014X3) There is no literature available.

1% Pt/SiO2 (THS‐014X4) There is no literature available.

1% Pt/SiO2‐polyethyleneimine (THS‐014X5) There is no literature available.

5% Pt/C (Bi) (THS‐014X6) There is no literature available.

Nickel sponge (THS‐014X7) There is no literature available.

156

1% Pt/C (V) (THS‐014X9) There is no literature available.

10% Pd/CaCO3 (THS‐015X1)

Adv. Synth. Catal., 2018, 360(6), 2109‐1217

5% Pd/CaCO3 (THS‐015X2) There is no literature available.

5% Pd/BaCO3 (THS‐015X3) There is no literature available.

1% Pd‐0.3% Cu/Al2O3 (THS‐015X4) There is no literature available.

Pd EnCat (THS‐015X5) There is no literature available.

Ru Black (THS‐015X8) There is no literature available.

5% Pt/CaCO3 (THS‐015X9) There is no literature available.

157

Rh(COD)(dppf)/SiO2 (THS‐016X5) There is no literature available.

1% Au/Fe2O3 (THS‐016X6)

J. Flow Chem., 2013, 3(2), 51‐58

1% Pt/SBA (THS‐016X7) There is no literature available.

1% Au/C (THS‐016X8) There is no literature available.

1% Au/TiO2 (THS‐016X9)

J. Flow Chem., 2013, 3(2), 51‐58

Mercaptopropyl modified silica (THS‐017X0) There is no literature available.

Amberlite™ IR‐120 (THS‐01716)

J. Flow Chem., 2012, 2(2), 43‐46

5% Pd/C (S) (THS‐018X1)


Zinc powder (THS‐018X2)


158

NaIO4 (THS‐018X3)

Tetrahedron Lett., 2010, 51(44), 5830‐5833

Cu powder (THS‐018X9)

Beilstein J. Org. Chem., 2013, 9, 1508‐1516 Chem. Asian J., 2013, 8, 800‐808 Org. Lett., 2010, 12, 2774‐2777

PriCat CZ 30/18T (THS‐019X3)


5% Pd/C (THS‐021X1)


J. Med. Chem., 2011, 54 (16), 5820–5835 J. Org. Chem., 2007, 72, 1803‐1806 Tetrahedron, 2006, 62. 4651‐4664 Tetrahedron, 2012, 68, 1507‐1514

C=C bond reduction

J. Med. Chem., 2014, 57, 7061‐7072 J. Org. Chem., 2007, 72, 1803‐1806 Metabolic Engineering, 2015, 28, 82‐90


Catal. Sci. Technol., 2016, 6, 4705‐4711 J. Flow Chem., 2011, 1(2), 68‐73 Org. Process Res. Dev., 2014, 18, 1427‐1433

Reductive alkylation

Synthesis, 2018, 50, 1849‐1856

159

Coupling reaction

Sci. Rep., 2016, 6, 32719

Ring opening

Catal. Sci. Technol., 2016, 6, 4705‐4711 Ring saturation

Catal. Sci. Technol., 2016, 6, 4705‐4711 OPRD, 2010, 14, 393‐404 Talanta, 2016, 146, 621‐640

5% Ru/Al2O3 (THS‐021X2)

Green Chem., 2010, 12, 2157‐2163

5% Pt/Al2O3 (THS‐021X3) App. Catal. A General, 2010, 382, 263‐271 Catal. Comm., 2010, 12, 14‐19 Green Chem., 2010, 12, 1687‐1703 Mol. Divers., 2011, 15, 605‐611 Molecules, 2016, 21, 318 Org. Biomol. Chem., 2015, 13, 7119‐7130 Tetrahedron Lett., 2016, 57, 4718‐4722

5% Pd/CaCO3(Pb) – Lindlar’s (THS‐021X4) Beilstein J. Org. Chem., 2017, 13, 734‐754 Chem. Eur. J., 2011, 17, 3398‐3405 ChemPlusChem, 2018, 83(2), 72‐76 J. Med. Chem., 2015, 58, 3859‐3874 Org. Lett., 2017, 19, 3414‐3417 Tetrahedron Lett., 2011, 52(30), 3865‐3867

160

5% Ru/C (THS‐021X5)

Catal. Sci. Technol., 2016, 6, 4705‐4711 Chem. Res. Toxicology, 2014, 27, 1002‐1010 RSC Advances, 2013, 3, 16283‐16287 RSC Advances, 2015, 5, 1268‐1273

5% Re/C (THS‐021X6)


5% Pt/C (S) (THS‐021X7) Adv. Synth. Catal., 2018, 360(6), 2109‐1217 Org. Biomol. Chem., 2015, 13, 7119‐7130 RSC Advances, 2014, 4, 56743‐56748

5% Rh/Al2O3 (THS‐021X8)

Bioorg. Med. Chem. Lett., 2017, 1949‐1954 Green Chemistry, 2013, 15, 1456‐1472 Green Process. Synth., 2013, 2, 211‐230 J. Heterocyclic Chem., 2011, 48, 11‐29 OPRD, 2010, 14, 393‐404 Org. Biomol. Chem., 2010, 8, 1588‐1595 RSC Advances, 2014, 4, 56743‐56748

Pd EnCat 30NP (THS‐031X1)


5% Pd/BaSO4 (THS‐031X2)

Green Chem., 2010, 12, 1687‐1703 Mol. Divers., 2011, 15, 605‐611 Molecules, 2016, 21, 318

161

Org. Biomol. Chem., 2015, 13, 7119‐7130 Tetrahedron Asymmetry, 2014, 25, 1138‐1145 Tetrahedron Lett., 2009, 50, 4372‐4374 The Chemical Records, 2016, 16, 1018‐1033

PriCat Ni 55/5P (THS‐031X3)


Nickel sponge 1% Mo (THS‐031X4)


5% Pd ‐ 1% Fe/C (THS‐031X5)


2.5% Pd ‐ 2.5% Pt/C (THS‐031X6)


4.5% Ru ‐ 0.5% Pd/C (THS‐031X7)


1% Pd/Al2O3 (THS‐031X8)


10% Pd/Al2O3 (THS‐031X9) Adv. Synth. Catal., 2018, 360(6), 2109‐1217 Eur. J. Org. Chem., 2017, 6525–6532 J. Org. Chem., 2011, 76, 6657‐6669 Org. Biomol. Chem., 2015, 13, 7119‐7130 Org. Proc. Res. Dev., 2014, 18, 1560‐1566

162

1% Ir/C (THS‐041X1)


Pd/C‐ethylenediamine (THS‐041X2) Carbohydrate Research, 2012, 361, 155‐161

Ni/Si‐Al (THS‐041X3)

Catal. Sci. Technol., 2016, 6, 4705‐4711

5% Pd/SiO2 (THS‐041X4)


1% Pd/C (THS‐041X5)

J. Med. Chem., 2012, 55(20), 8807‐8826

2% Pd/SrCO3 (THS‐041X6)


1% Pt/Al2O3 (THS‐041X7)


Pd black (THS‐041X9)


Pd EnCat 30 (THS‐051X1)


163

Pd EnCat TPP30 (THS‐051X2)


Pd EnCat BINAP30 (THS‐051X3)


Pd‐tetrakis on DBV (THS‐051X4) Green Chem., 2014, 16, 2042‐2050 J. Mol. Cat. A, 2009, 302, 76‐79 Org. Lett., 2008, 10(8), 1589‐1592 Org. Process Res. Dev., 2016, 20, 327‐360 RSC Adv., 2014, 4, 56743‐56748 Tetrahedron, 2012, 68, 9867‐9923

Pd EnCat TOTP30 (THS‐051X5)


Rh(Cl)(PPh3)3 DVB (THS‐051X7)


RuO2 (THS‐051X8) RSC Adv., 2014, 4, 56743‐56748

IrO2 (THS‐051X9)


FibreCat® 1001 (THS‐061X1) ARKIVOC, 2012 (v) 186‐195 Org. Biomol. Chem., 2014, 12, 9562‐9571 Org. Proc. Res. Dev., 2013, 17, 760‐791

164

1% Pt/C (THS‐061X5)


5% Ir/CaCO3 (THS‐061X6)


Pd(Cl)2(PPh3)2 on DVB (THS‐061X7) ARKIVOC, 2012 (v) 186‐195 Org. Biomol. Chem., 2014, 12, 9562‐9571 Org. Proc. Res. Dev., 2013, 17, 760‐791

5% Pt/C (THS‐081X2) ACS Comb. Sci., 2015, 17(11), 682‐690 ACS Sustainable Chem. Eng., 2017, 5, 3762‐3767 Chem. Eur. J., 2013, 19, 8309‐8320 Eur. J. Org. Chem., 2017, 914‐927 RSC Advances, 2015, 5, 1268‐1273 Tetrahedron Lett., 2017, 582‐585

Amberlyst™ 36 (THS‐081X3)


Amberlite™ IRA‐910 (THS‐081X4)


Amberlyst™ 35 Dry (THS‐081X7)


165

SiliaCat®‐DPP‐Pd (THS‐081X8)

ACS Catal., 2015, 5, 1303‐1312 Catal. Sci. Technol., 2016, 6, 4678‐4685 J. Flow Chem., 2014, 4(1), 18‐21 J. Flow Chem., 2015, 5(1), 6‐10 J. Flow Chem., 2015, 5(3), 145‐147 Org. Process Res. Dev., 2015, 19, 755‐768

166

Certifications of ThalesNano Products Thalesnano Inc. works under the quality certificate ISO 9001:2015

Every CatCart® of ThalesNano Inc. comes with an MSDS sheet included in the package for all the catalyst cartridge types in the box.

The safety directives are indicated for every instrument of ThalesNano Inc. on the Declaration of Conformity sheet, which are the following:

Pressure Equipment Directive – 97/23 EC

Low Voltage Directive – EN 61010‐1 : 2001

Electromagnetic Directive (EMC) – 2004/108/EK

The CE mark is placed at the back of the products.

167

ThalesNano Inc.

Budapest, Hungary

1031, Záhony utca 7.

Tel.: +36 1 8808 500

thalesnano.com 5% rh/al 2o 3 – rhodium on alumina...

Documents