5 lower kent ridge road - singapore accreditation … light chains (free kappa & nephlometry...

National University Hospital Certificate No. : LA-2002-0258-H

Department of Laboratory Medicine (Part 1 of 2)

5 Lower Kent Ridge Road

Singapore 119074 Issue No. : 15

Date : 20 October 2017 Page : 1 of 22

FIELD OF TESTING : Medical Testing

DISCIPLINE/ SUBJECTIONS

TESTS / PROPERTIES STANDARD METHODS /

TECHNIQUES / EQUIPMENT

CHEMISTRY 1. Acetaminophen Enzymatic/Colorimetry 2. Adrenocorticotrophic Hormone Chemiluminescence Enzyme (ACTH) Immunoassay 3. Anti- Mullerian Hormone Electrochemiluminescence 4. Alanine Transaminase (ALT, GPT) Multiple-Point Rate Test 5. Albumin Colorimetry 6. Aldolase Enzymatic 7. Alkaline Phosphatase (ALP) Multiple-Point Rate Test 8. Allergens, IgE, specific Chemiluminescence Enzyme Immunoassay 9. Alpha-1-Antitrypsin (AAT) Immunoturbidimetry 10. Alphafoetoprotein (AFP) Chemiluminometric Immunoassay 11. Amikacin Particle Enhanced Turbidimetric Immunoassay (PETIA) 12. Ammonia (NH3) Kinetic Endpoint 13. Amylase, Serum ) Multiple-Point Rate Test ) 14. Amylase, Urine ) 15. Anti-Cyclic Citrullinated Peptide Chemiluminescence Microparticle Immunoassay

Certificate No. : LA-2002-0258-H Issue No. : 15 (Part 1 of 2) Date : 20 October 2017 Page : 2 of 22




16. Anti-Microsomal Antibody See Anti-Thyroid Peroxidase Antibody (Anti-TPO) 17. Anti-Thyroglobulin Antibody (Anti-Tg) TRACE(Time Resolved Amplified Cryptate Emission) 18. Anti-Thyroid Peroxidase Antibody ) Chemiluminometric (Anti-TPO) ) Immunoassay 19. Apolipoprotein A1 & B Immuno Turbidimetry 20. Aspartate Transaminase (AST, GOT) Multiple-Point Rate Test 21. Barbiturates, Serum ) Enzyme Multiplied ) Immunoassay Technique 22. Benzodiazepines, Serum ) 23. Beta-2-Microglobulin Particle Enhanced Turbidimetric Immunoassay 24. Beta-hydroxybutyrate Plasma Enzymatic Assay 25. Bilirubin, Paediatric Spectrophotometry 26. Bilirubin, Total Oxidation / Colorimetry 27. Blood Gases, Arterial Potentiometry 28. CA 125 (Tumour Marker) ) Chemiluminescence ) Immunoassay 29. CA 15-3 (Tumour Marker) ) ) 30. CA 19-9 (Tumour Marker) ) 31. Caeruloplasmin Immunoturbidimetry 32. Calcium, Ionised Potentiometry 33. Carbamazepine Cloned Enzyme Donor Immunoassay (CEDIA) 34. Calcium, Total ) Colorimetry ) 35. Calcium, Urine ) 36. Carbon Dioxide (CO2) Enzymatic Test





37. Carboxyhaemoglobin, Blood (COHb) Oximetry 38. Carcinoembryonic Antigen (CEA) Chemiluminometric Immunoassay 39. Chloride (Cl) ) Potentiometry ) 40. Chloride, Urine ) 41. Cholesterol Colorimetry 42. Cholinesterase Multiple-Point Rate Test 43. Complement 3 (C3) ) Immuno Turbidimetry ) 44. Complement 4 (C4) ) 45. Cortisol, Serum ) Electrochemiluminescence ) Immunoassay 46. Cortisol, Urinary Free ) 47. C-Peptide Chemiluminometric Immunoassay 48. C-Reactive Protein (CRP) Immuno Turbidimetry 49. C-Telopeptide (CTX) Electrochemiluminescence Immunoassay 50. Creatine Kinase – MB (CKMB) Chemiluminescence Enzyme Immunoassay 51. Creatine Kinase (CK) Multiple-Point Rate Test 52. Creatinine ) Enzymatic ) 53. Creatinine, Urine )

54. CSF Panel Colorimetry 55. Cyclosporin A (Parent) Chemiluminescence Microparticle Immunoassay 56. Dengue Duo Lateral Flow Chromatographic Immunoassay 57. Dehydroepiandrosterone Sulphate Chemiluminescence Immunoassay (DHEAS)





58. Digoxin Chemiluminescence Enzyme Immunoassay 59. Drug Screen, Urine Lateral Flow Chromatographic Immunoassay 60. Estradiol (E2) Chemiluminometric Immunoassay 61. Erythropoietin Chemiluminescence Immunoassay 62. Ethanol Screen Enzymatic 63. Ferritin Chemiluminometric Immunoassay 64. First Trimester testing (free-beta TRACE HCG, PAPP-A) 65. Folate ) Chemiluminometric ) Immunoassay 66. Follicle Stimulating Hormone (FSH) ) 67. Gamma Glutamyl Transferase (GGT) Multi-point rate test 68. Gastrin Chemiluminescent Immunoassay 69. Gentamicin Cloned Enzyme Donor Immunoassay (CEDIA) 70. Glucose, Fasting or Random Enzymatic UV (Hexokinase) 71. Glycated Haemoglobin A1c, Rapid Immuno Turbidimetry 72. Growth Hormone Chemiluminescence Enzyme Immunoassay 73. 25 Hydroxy Vitamin D Electrochemiluminescence 74. Haptoglobin Immuno Turbidimetry 75. HDL-Cholesterol Colorimetry 76. High Sensitive CRP Immuno Turbidimetry 77. Homocysteine, Plasma Enzymatic





78. Human Epididymis protein 4 (HE4) Electrochemiluminescence antigen, serum 79. Human Chorionic Gonadotropin Monoclonal Antibody-based (hCG), (Rapid Urine) Immunoassay 80. Human Chorionic Gonadotropin Monoclonal Antibody-based (hCG), (Rapid) Immunoassay 81. Human Chorionic Gonadotropin Chemiluminometric Immunoassay (hCG), (Quantitation) 82. Immunoglobulin A (IgA) Immuno Turbidimetry 83. Immunoglobulin E (IgE) Chemiluminometric Immunoassay 84. Immunoglobulin G (IgG) ) Immuno Turbidimetry ) 85. Immunoglobulin M (IgM) ) 86. Insulin Chemiluminescene Immunoassay 87. Iron Colorimetry 88. Lactate Colorimetry 89. Lactate Dehydrogenase (LDH) Enzymatic/Rate 90. Lactate, CSF Colorimetry (End Point) 91. LDL - Cholesterol, measured Enzymatic/Colorimetry (End Point) 92. Lithium Colorimetry (End Point) 93. Lipase Colorimetry / Rate 94. Luteinising Hormone (LH) Chemiluminometric Immunoassay 95. Magnesium ) Colorimetry ) 96. Magnesium, Urine ) 97. Methotrexate Chemiluminescence 98. Microalbumin Immuno Turbidimetry





99. Myoglobin, Serum Immuno Turbidimetry 100. Mycophenolic Acid Cloned Enzyme Donor Immunoassay (CEDIA) 101. NT-proBNP Chemiluminescence 102. Osmolality, Serum ) Freezing Point Osmometry ) 103. Osmolality, Urine ) 104. Parathyroid Hormone, Intact Chemiluminometric Immunoassay 105. pH, Fluid Potentiometry 106. Phenobarbital ) Cloned Enzyme Donor ) Immunoassay (CEDIA) 107. Phenytoin ) 108. Phosphate (P04) ) Rate (End Point) ) 109. Phosphate, Urine ) 110. Potassium (K) ) Potentiometry ) 111. Potassium, Urine ) 112. Plasma Haemaglobin Spectrophotometry 113. Prealbumin (Transthyretin) ) Immuno Turbidimetry 114. Procalcitonin TRACE 115. Progesterone ) Chemiluminometric ) Immunoassay 116. Prostate Specific Antigen (PSA) ) 117. Prostate specific antigen, pro Chemiluminescence (p2PSA) 118. Protein, Total ) Colorimetry ) 119. Protein, Urine ) 120. PSA, Free Chemiluminometric Immunoassay





121. Rheumatoid Factor (RF) Immuno Turbidimetry 122. Salicylate EMIT 123. Sex Hormone Binding Globulin Chemiluminescence (SHBG) Immunoassay 124. Sirolimus Chemiluminescence microparticle Immunoassay 125. Sodium (Na) ) Potentiometry ) 126. Sodium, Urine ) 127. Tacrolimus (FK506) Chemiluminescence microparticle Immunoassay 128. Testosterone Chemiluminometric Immunoassay 129. Theophylline Cloned Enzyme Donor Immunoassay (CEDIA) 130. Thyroglobulin TRACE 131. Thyroid Stimulating Hormone (TSH) ) Chemiluminometric ) Immunoassay 132. Thyroxine (T4) ) ) 133. Thyroxine, Free ( Free T4 ) ) 134. Transferrin Immuno Turbidimetry 135. Tricyclic Antidepressants (TAD) Enzyme Multiplied Immunoassay Technique 136. Triglycerides Enzymatic/Colorimetry (End Point) Immunoassay 137. Triiodothyronine (Total T3) ) Chemiluminometric ) Immunoassay 138. Triiodothyronine, Free (Free T3) ) 139. Troponin I, Quantitative Chemiluminometric Immunoassay





140. Urea ) Enzymatic/Rate ) Enzymatic / Colorimetry 141. Urea, Urine ) 142. Uric Acid ) Colorimetry ) 143. Uric Acid, Urine ) 144. Urine Formed Elements Image Analysis 145. Valproic Acid (Valproate) Cloned Enzyme Donor Immunoassay (CEDIA 146. Vancomycin Particle Enhanced Turbidimetric Immunoassay (PETIA) 147. Vitamin B12 Chemiluminometric Immunoassay 148. Free Light Chains (Free Kappa & Nephlometry Free Lambda) 149. Kappa/lambda Ratio Nephelometry CHEMISTRY 1. Bence Jones Protein (BJP) Immunofixation Electrophoresis (SPECIAL CHEMISTRY) 2. Calculi Analysis Biochemical test 3. Catecholamines, Urine High Performance Liquid Chromatography (HPLC) 4. Citrate, Urine Enzymatic 5. Creatine Kinase Isoenzyme Colorimetry Electrophoresis, Densitometry 6. Glycated Haemoglobin A1c ) High Performance Liquid (HbA1c) ) Chromatography (HPLC) ) 7. Hydroxyindoleacetic Acid (5- HIAA) ) 8. Hydroxyprogesterone-17 Radioimmunoassay 9. Immunofixation Electrophoresis Immunofixation Electrophoresis (Serum/Urine) 10. Immunoglobulin D (IgD) Radial Immunodiffusion





11. Indocyanine Green Test Spectrophotometry 12. Insulin Growth Factor-1 Radioimmunoassay 13. LDH Isoenzymes Electrophoresis, Densitometry, Multi-Point Rate Test 14. Metanephrines High Performance Liquid Chromatography (HPLC) 15. Oligoclonal Bands, CSF Isoelectric Focusing, Immunofixation 16. Oxalate, Urine Spectrophotometry 17. Protein Electrophoresis, Serum ) Electrophoresis ) 18. Protein Electrophoresis, Urine ) 19. Reducing Sugars Screen Thin Layer Chromatography 20. Renin (Plasma Renin Activity) ) Radioimmunoassay ) 21. Testosterone, Free ) 22. Vanillyl Mandelic Acid (VMA) High Performance Liquid Chromatography (HPLC) 23. Adenosine Deaminase (ADA) Colorimetry

CHEMISTRY 1. Anti-aquaporin-4-antibodies (AQP-4) Immunofluorescence (IMMUNO- CHEMISTRY 2. Anti-EBV VCA-IgG ) Enzyme Immunoassay & SEROLOGY) ) 3. Anti-EBV VCA-IgM ) 4. Anti-ds-DNA Indirect Immunofluorescence 5. Anti-glutamate receptor antibodies Immunofluorescence (NMDA) 6. Anti-Glutamic Acid Decarboxylase ELISA 7. Anti-GBM ) Indirect enzyme linked ) immunoassay





8. Anti-SSA, Anti-SSB, Anti-Sm and ) Indirect enzyme linked Anti-RNP 70 ) immunoassay 9. Anti-extractable Nuclear Antigen Enzyme Immunoassay Identification (Anti-ENA) 10. Anti-Hepatitis A Antibody ) Chemiluminescence (Anti- HAV), IgM & IgG ) Microparticle Immunoassay ) (CMIA) 11. Anti-Hepatitis B Core Antibody ) (Anti-HBc), Total ) ) 12. Anti-Hepatitis B Surface Antibody ) (Anti-HBs) ) ) 13. Anti-Hepatitis C Antibody (Anti-HCV) ) ) 14. Anti-Human Immunodeficiency Virus ) Antigen-Antibody ) 15. Anti-EBV VCA-IgG ) Enzyme Immunoassay ) 16. Anti-EBV VCA-IgM ) 17. Anti-ds-DNA Indirect Immunofluorescence 18. Anti-Intrinsic Factor Enzyme-Linked Immunosorbent Assay (ELISA) 19. Hepatitis B e Antigen (HBeAg) ) Chemiluminescence ) Microparticle Immunoassay 20. Hepatitis B Surface Antigen (HBsAg) ) (CMIA) ) 21. Hepatitis B Surface Antigen, ) Quantitative ) 22. Dengue fever antibody ELISA 23. Leptospira IgM ) Enzyme Immunoassay ) 24. Measles IgG ) ) 25. Measles IgM ) ) 26. Mumps IgG )





27. Mumps IgM Enzyme Immunoassay 28. Rubella IgG ) Chemiluminescence ) Microparticle Immunoassay 29. Rubella IgM ) (CMIA) ) 30. Syphilis Screen ) ) 31. Toxoplasma IgG ) ) 32. Toxoplasma IgM ) 33. TSH Receptor Antibody Enzyme Immunoassay 34. TB Quantiferon (4 Tube method) Immunoassay

35. Varicella zoster IgG ) Enzyme Immunoassay ) 36. Varicella zoster IgM ) HAEMATOLOGY 1. Activated Partial Thromboplastin PhotometricClot Detection Time (APTT) 2. AML/MDS Basic panel ) Flow Cytometry ) 3. AML aberrant markers panel ) 4. Anti - Xa (LMWH) Assay Chromogenic Assay 5. Anti-Cardiolipin Antibody, IgG ) Enzyme-Linked ) Immunoassay 6. Anti-Cardiolipin Antibody, IgM ) 7. Anti-Platelet factor 4 / Heparin- ELISA induced thrombocytopenia 8. Antithrombin III Chromogenic Assay 9. APT's Test for Foetal Haemoglobin Alkaline Haematin Method 10. Beta 2-Glycoprotein, IgG, IgM Enzyme Linked Immunosorbent Assay 11. Blood Film Microscopy





12. Bone Marrow Aspirate May-Grunwald Giemsa Stain, Perl's Stain 13. CD34+ Cell Count Flow Cytometry 14. Cell Count/Cytospin (CSF/Fluids) Cytospin (CSF & Peritoneal Fluid only), Microscopy 15. Coagulation Inhibitor Screen APTT-Based Coagulation Tests 16. D-Dimer Test Immunoturbidimetry 17. Disseminated Intravascular Includes PT, APTT, TCT, D-Dimer Coagulation (DIC) Screen and Fibrinogen. See individual tests 18. Erythrocyte Sedimentation Rate StatPlus ESR (ESR) 19. Factor Assay, APTT-Based Coagulation Tests (Intrinsic & Extrinsic Factor) 20. Factor VIII Inhibitor Assay APTT-Based Coagulation Tests (Coagulation) 21. Factor XII Assay ) APTT-Based Coagulation Tests ) Clot Solubility 22. Factor XllI Assay ) 23. Fibrinogen Clauss Method 24. Full Blood Count Light Scattering Flow Cytometry, Cytochemistry 25. Glucose-6-Phosphate Enzyme Colourimetic Dehydrogenase (G6PD), Quantitative 26. Heinz Bodies Methyl Violet Stain, Microscopy 27. Hereditary spherocytosis EMA Flow Cytometry binding test 28. Immunophenotyping - PNH Flow Cytometry 29. Kleihauer Test Kleihauer-Betke Method, Acid Elution 30. Lupus Anticoagulant Screen DRVVT and mixing test





31. Malaria Screen Thick Film Microscopy, Thin Film Microscopy, 32. NK-Cell Chronic Lymphoproliferative Flow Cytometry Disease (NK- CLPD) 33. Platelet Aggregation Studies Aggregometry 34. Protein C Functional Chromogenic Assay 35. Protein S Immunoturbidimetry 36. Prothrombin Time ) Photometricclot detection ) 37. Prothrombin Time (INR) ) 38. Reticulocyte Count Oxazine 750 stain, Flow Cytometry 39. Ristocetin Cofactor (RiCoF) Assay Immunoturbidimetry 40. Ristocetin Induced Platelet Platelet Aggregometry Aggregation 41. Screening for Leukaemia ) Flow Cytometry ) 42. Screening for Lymphoma ) 43. Sickling Test Reduction Test (Sodium Dithionite) 44. T-ALL panel ) Flow Cytometry ) 45. T-Cell Chronic Lymphoproliferative ) Disease (T-CLPD) ) 46. Thalassemia Screen Electrophoresis, Brilliant Cresyl Blue stain, Microscopy 47. Thrombin Clotting Time (TCT) Photometric clot detection 48. Unstable Haemoglobin Screen Heat Stability Test 49. Urine Haemoglobin Biochemical Reaction 50. Urine Haemosiderin Perl's Prussian Blue Stain 51. von Willebrand Factor Antigen Immunoturbidimetry





52. 8C Flow Cytometry – B-CLPD ) Flow Cytometry Panel ) ) 53. 8C Flow Cytometry – Plasma Cell ) Panel ) CYTOGENETICS 1. Amniotic Fluid ) Chromosome Culture 2. Blood ) 3. Bone Marrow ) 4. Chorionic Villi ) 5. Foetal Blood ) 6. Lymph Node/ Solid Tumour ) 7. Products of Conception ) 8. Tissue ) 9. Other Tissues ) 10. Fluorescence-in-situ hybridization ) Fluorescence-in-situ hybridization test for constitutional disorders, ) non- paraffin embedded ) ) 11. Fluorescence-in-situ hybridization ) test for neoplastic disorders, non- ) paraffin embedded ) MICROBIOLOGY 1. Acid Fast Bacilli (AFB) C&S ) Automated MGIT, ) conventional culture 2. Blood culture, Fungus ) 3. Culture and sensitivity, blood, aerobic ) Automated BacTalert, ) conventional culture 4. Culture and sensitivity, blood, ) aerobic & anaerobic ) 5. Acanthamoeba C&S ) Conventional culture ) 6. Culture and sensitivity, aerobic ) & anaerobic, other sites ) ) 7. Culture and sensitivity, aerobic, other ) Sites ) ) 8. Culture and sensitivity, CSF. Aerobic ) ) 9. Culture and sensitivity, Fluid, aerobic )





10. Culture and sensitivity, Fluid, aerobic ) Conventional culture & anaerobic ) ) 11. Culture and sensitivity, Gonococcus ) ) 12. Culture and sensitivity, Helicobacter ) pylori ) ) 13. Culture and sensitivity, other ) ) 14. Culture and Sensitivity, ) Respiratory tract, aerobic ) ) 15. Culture and Sensitivity, Respiratory ) for Cystic Fibrosis, aerobic ) ) 16. Culture and Sensitivity, stool, ) enteric pathogens ) ) 17. Culture and Sensitivity, Tissue, ) Biospy or Bone, Aerobic & Anaerobic ) ) 18. Culture and Sensitivity, Urine, ) Aerobic ) ) 19. Culture and Sensitivity, Wound, ) aerobic ) ) 20. Culture and Sensitivity, Wound, ) Aerobic & Anaerobic ) ) 21. Culture, Fungus ) ) 22. Streptococcus Group B Screening ) 23. Aspergillus galactomannan Enzyme immunoassay Antigen Test 24. Clostridium difficile toxin ) Immunochromatographic ) 25. Legionella Antigen, urine ) ) 26. Occult Blood ) ) 27. Rotavirus (Stool) )





28. Streptococcus pneumonia antigen Immunochromatographic 29. MALDI-TOF for Bacterial ID Mass Spectrophotometry 30. Mycoplasma IgG Haemagglutination 31. Influenza A+B IF ) Immunofluorescence ) 32. Respiratory Panel ) Immunofluorescence ) 33. Anti-Streptolysin O Titre (ASO Titre) ) Latex Agglutination ) 34. Cryptococcal Antigen Detection, CSF ) ) 35. Cryptococcal Antigen Detection, ) serum ) 36. Acid Fast Bacilli (AFB) Smear ) Microscopy ) 37. Cryptosporidium, Cyclospora, ) Isospora ) ) 38. Faecal Fat ) ) 39. Fungus Smear ) ) 40. Gram Smear ) ) 41. Others: Microsporidium ) ) 42. Urine Red Cell Morphology ) 43. Trichomonas, Candida & Bacterial DNA Probe vaginosis 44. Clostridium difficile Toxin, PCR ) Polymerase Chain Reaction ) (PCR) Xpert 45. Mycobacterium tuberculosis, (PCR), ) pulmonary ) 46. Ova, Cysts and Trophozoities Sedimentation and Formalin Ether Concentration 47. Adenovirus isolation Tissue culture





48. Cytomegalovirus Isolation (CMV) ) Tissue culture ) 49. Herpes Virus Isolation ) ) 50. Respiratory Panel Isolation ) 51. Methicilline-Resistant S. aureus Agar Breakpoint Method Screen 52. Vancomycin-Resistant Enterococcus Agar Breakpoint Method Screen 53. Molecular detection of Rifampicin Line Probe Assay and Isoniazid resistance in Mycobacterium tuberculosis complex isolate - HAIN test MOLECULAR 1. Adenovirus PCR ) Real Time PCR DIAGNOSIS CENTRE ) (INFECTIOUS 2. Chlamydia trachomatis ) DISEASES) (Qualitative, PCR) 3. Chlamydia trachomatis/ Neiserria ) PCR gonorrhoeae panel ) 4. Neiserria gonnorhoeae ) Real Time PCR (Qualitative PCR) 5. Dengue virus RNA (Qualitative, Real Time Reverse species-specific) Transcription PCR 6. Human Papillomavirus 16/18 Real time-PCR genotyping 7. Dermatophyte PCR ) PCR, Gel-electrophoresis 8. Malaria parasite species-specific Real-time PCR PCR 9. Cytomegalovirus drug resistance PCR, Gel-electrophoresis 10. HIV-1 Drug resistance PCR, Sequencing 11. YMDD (HBV DNA Polymerase Reverse Line-Probe Assay Mutations





12. HCV Genotyping Reverse Line-Probe Assay 13. Malaria parasite screening PCR Real-time PCR 14. Aspergillus PCR (Qualitative, PCR) ) Real time PCR ) 15. Bordetella pertussis/ Bordetella ) parapertussis PCR ) ) 16. Chikungunya virus RT-PCR ) ) 17. Enterovirus PCR ) ) 18. H5 avian influenza virus PCR ) ) 19. Parvo B19 virus PCR ) ) 20. Norovirus PCR ) ) 21. Toxoplasma gondii PCR ) ) 22. Varicella-Zoster virus (Qualitative, ) PCR) ) ) 23. JC virus ) ) 24. Middle East Respiratory Syndrome ) Coronavirus (MERS) ) 25. BK virus (Quantitative, PCR) ) Quantitative Real-time PCR ) 26. Cytomegalovirus Q-PCR ) ) 27. Epstein-Barr Virus Q-PCR ) ) 28. HIV-1 Viral Load ) ) 29. HBV Viral Load ) ) 30. HCV Viral Load ) ) 31. Hepatitis E Viral Load ) ) 32. Herpes Simplex Virus (HSV) Q-PCR ) ) 33. Human Herpes 6 virus Q-PCR )





34. Human Herpes 8 Virus Q-PCR Quantitative Real-time PCR 35. Meningitis / Encephalitis PCR Panel Real time PCR (CSF) 36. Multiplex reverse transcription Multiplex RT-PCR polymerase chain reactions respiratory panel (RESMUX) 37. Zika Virus RT-PCR MOLECULAR 1. Androgen Receptor (AR) Mutation ) PCR, direct sequencing DIAGNOSIS CENTRE ) (MUTATION 2. Gene-mapping (Beta thalassaemia, ) ANALYSIS) prenatal) ) ) 3. Leber’s Hereditary Optic ) Neuropathy (LHON) ) ) 4. Trinucleotide repeat in Androgen ) receptor ) 5. Haemachromatosis mutations PCR-RFLP, Gel electrophoresis (C282/H63) 6. HLA-B*1502 genotype, Real-time PCR Carbamazepine hypersensitivity 7. Apo-E Genotyping ) PCR-HRM (High Resolution ) Melt) 8. Factor V Leiden Thrombophilia ) ) 9. Methylenetetrahydrofolate ) reductase (MTHFR) variant ) ) 10. Prothrombin G20210-A ) thrombophilia ) ) 11. Venous Thrombosis panel ) 12. Gene-mapping (Alpha thalassaemia, Multiplex PCR, Gel electrophoresis prenatal) 13. HLA-B27 typing Allele-specific PCR, Gel electrophoresis





14. Fragile X PCR PCR 15. Prader-Willi / Angelman Syndrome Methylation sensitive PCR 16. Thalassaemia genotyping Multiplex PCR, PCR Direct (Carrier testing) Sequencing 17. Hearing impairment, genetic PCR direct sequencing, causes 18. Y Chromosome deletion PCR, gel-electrophoresis 19. ATP7B Mutation Screen (Wilson ) Direct dideoxy-sequencing Disease) ) analysis ) 20. ATP7B Known Mutation (Wilson ) Disease) ) ) 21. TGFBI mutation screen ) ) 22. MODY 1/2/3 (Maturity onset Diabetes ) of the young) ) 23. IL28B (Interleukin 28B) Genotyping PCR-HRM (High Resolution Melt) 24. Chromosomal SNP Microarray Microarray (postnatal) MOLECULAR 1. Flt-3 Mutation (ITC & D835) and ) PCR, Capillary electrophoresis DIAGNOSIS CENTRE NPM1 detection ) (ONCOLOGY ) TESTING) 2. IgH gene Rearrangement (PB,BM) ) ) 3. TCR Gamma Chain Gene ) Rearrangement (PB, BM) ) 4. t(9;22) Translocation (bcr-abl mRNA) RT-PCR (Quantitative BCR-ABL MRNA detection) 5. MGMT Promoter Methylation Methylation-specific polymerase chain reaction 6. ALL Panel ) Real time PCR ) 7. AML Panel )





8. Single oncogene fusion transcript ) Real time PCR ) 9. EGFR Mutation Plasma Test ) 10. c-kit mutation deletion PCR direct sequencing 11. JAK2 exon 12 & 13 mutation PCR, Sequencing 12. MPL mutation detection PCR, Sequencing 13. JAK2 mutation detection ddPCR 14. Epidermal growth factor receptor ) PCR direct sequencing (EGFR) mutation detection ) ) 15. Kras mutation detection ) ) 16. Multiple Endocrine neoplasia ) MEN2A/FMTC ) ) 17. CEBPα mutation detection ) ) 18. Thiopurine S-methyltransferase ) deficiency seq ) ) 19. CML t(9;22) BCR-ABL 1 drug ) resistance (ABL Kinase domain ) mutation screen) ) ) 20. Multiple Endocrine neoplasia MEN2B ) ) 21. BRAF Mutation detection ) ) 22. Calreticulin CALR exon 9 mutation ) screening ) 23. MYD88 Leu265 Pro mutation Pyrosequencing detection (OTHERS) 1. Chimerism Studies PCR, Capillary electrophoresis 2. QF-PCR for trisomies 13, 18 and 21 Quantitative fluorescence PCR, capillary electrophoresis 3. FlashFISH™ FISH





TRANSFUSION 1. ABO Group and Rh Type ) Immune Agglutination SERVICES ) 2. Antibody Identification (Red Cell) ) ) 3. Antibody Titre, Others, Specify ) ) 4. Blood Group and Antibody Screen ) ) 5. Direct Antiglobulin (Coomb's) Test ) ) 6. Red Cell Phenotype ) 7. Cold Agglutinin Haemagglutination 8. Type and Screen See Blood Group & Antibody Screen

Note: A medical laboratory's fulfilment of the requirements of ISO 15189: 2012 means the laboratory meets both the technical competence requirements and the management system requirements that are necessary for it to consistently deliver technically valid test results. The management system requirements in ISO 15189 (Section 4) are written in a language relevant to a medical laboratories operations and meet the principles of ISO 9001:2008 Quality management systems - Requirements and are aligned with it pertinent requirements.

5 lower kent ridge road - singapore accreditation … light chains (free kappa & nephlometry...

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