4th Annual Conference

Monday 21st and Tuesday 22nd November 2011

London Hilton Metropole Hotel

Conference Directors:Riccardo Cappato, Milan and Wyn Davies, London

DOCUMENTS FOR COMPLETION

PRELIMINARY

PROGRAMME

WelcomeWe are delighted to welcome you to the fourth meeting of Europe AF.

The importance of Atrial Fibrillation (AF) as a health-care problem cannot be overestimated and itsimpact is increasing as the population of Europe ages. The complexity that underpins the arrhythmiaoften makes the choices for individual patient management difficult. Added to this is the fact that theAF substrate evolves over time in all patients with increasing risks especially for stroke. Its presencedoubles the patients’ risk of death. Even for patients at low risk of stroke, AF significantly reducesquality of life and is associated with heart failure. It is important to remember that in thiseconomically challenging time, AF is a prominent consumer of health care resources. In recognitionof this, an entire session is dedicated to the economic issues with providing contemporary standardsof care for AF.

The management of AF is complex because of its heterogeneity. Thus a wide variety of therapiesexist that are often used in combination in a number of possible hybrids. These include strategies tocontrol the heart rate, to restore and maintain sinus rhythm, to anticoagulate, to pace, or to offervarious kinds of catheter ablation and surgical approaches. Selecting the most appropriate of thesein each patient can be difficult.

The aim of Europe AF is ultimately to improve patient management by ensuring that the latestinformation on the mechanisms of AF, its clinical manifestations and the treatment of AtrialFibrillation is presented to health-care professionals involved in delivering care to AF patients. To make sure this is achieved, the talks will be given by an internationally renowned faculty of theworld’s leading investigators in the field.

There have been a considerable number of new advances in drug treatments and interventionaltechniques in the last year and these will be featured prominently.

On the Sunday afternoon before the main meeting, there will be a course for EP fellows on ECGsand intra-cardiac EP tracings, not restricted to AF. This course was exceptionally highly regarded lastyear and attendees will be welcome to attend the main meeting afterwards.

Europe AF is intended to educate everyone including patients, cardiology trainees, generalphysicians, cardiologists, to specialist cardiac electrophysiologists and anyone affected in any wayby atrial fibrillation.

We look forward to welcoming you to London in November 2011.

With Best Wishes,

Riccardo Cappato Wyn DaviesPoliclinico San Donato, Milan St Mary's Hospital, London

Faculty Maurits Allessie University of Maastricht, Maastrict - The NetherlandsLucas Boersma St Antonius Hospital, Nieuwegein, NLHugh Calkins Johns Hopkins Hospital, Baltimore - USAA John Camm St George’s Hospital, London - UKRiccardo Cappato Policlinico San Donato, Milan - ItalyWyn Davies St Mary's Hospital, London - UKRoberto De Ponti Universit of Insubria, Varese - ItalySabine Ernst Royal Brompton Hospital, London - UKFiorenza Gaita University of Turin, Turin - ItalyGerard Guiraudon University of Western Ontario, Ontario - CanadaDavid Haines William Beaumont Hospital, Michigan - USAYen Ho Royal Brompton Hospital London - UKEllen Hoffman Bogenhausen Hospital, Munich – GermanyWarren Jackman University of Oklahoma Health Sciences Center, Oklahoma - USAPrapa Kanagaratnam St Mary's Hospital, London - UKJosef Kautzner Institute for Clinical and Experimental Medicine Praha - CZDavid Keane St Vincent's University Hospital, Dublin - IrelandGeorge Klein University of Western Ontario, Ontario - CanadaKarl-Heinz Kuck St Georg Hospital, Hamburg - GermanyMeleze Hocini Hopital Cardiologique du Haut-Leveque, Bordeaux - FranceSam Levy University of Marseille, Marseille - FranceThorsten Lewalter University of Bonn, GermanyGregory Lip Birmingham City Hospital, Birmingham - UKNasir Marrouche University of Utah School of Medicine, Utah - USAJose Merino Hospital General Universitario La Paz, Madrid - SpainAndrea Natale St David's Medical Center Austin, Texas - USAPetr Neuzil Homolka Hospital, Prague - CZAndre Ng Glenfield Hospital, Leicester - UKMark O'Neill King's College Hospital, London - UKDoug Packer Mayo Clinic, Minnesota - USANick Peters St Mary's Hospital, London - UKChristopher Piorkowski University Leipzig Heart Centre, Leipzig - GermanyAntonio Raviele Dell'Angelo Hospital, Venice-Mestre - ItalyRichard Schilling St Bartholomew's Hospital, London - UKBurghard Schumacher Chefarzt der Medizinischen Klinik II, Kaiserslautern, GermanyDipen Shah Hopital Cantonal Universitaire de Geneve, Geneva - SwitzerlandAtul Verma Southlake Regional Health Centre, Ontario - CanadaAlbert L Waldo University Hospitals Case Medical Center, Ohio - USADavid Wilber Loyola University Medical Centre, Chicago - USAFred Wittkampf University Medical Center, Utrecht - NLMatt Wright Guy's & St Thomas' Hospital, London - UKD George Wyse Libin Cardiovascular Institute of Alberta, Calgary - Canada

ProgrammeDay 1 – Monday 21st November

MORNING

08:55 Opening Wyn Davies andRiccardo Cappato

09:00 AF ANATOMY AND PATHOPHYSIOLOGY: ARE WE LEARNING WHAT WE NEED TO KNOW?

Chairs: George Klein and Gerard Guiradon

The anatomy of the heart with respect to understanding, mapping and ablating AF Yen Ho

What is the best way of learning trans-septal puncture? What are the training opportunities for those that did not learn trans-septal access as fellows? Roberto De Ponti

What have we learnt in the last year about the electrophysiology of AF that will help us understand and treat it better? Maurits Allessie

When do we start ablating non-PV targets? Atul Verma

10:20 USING DRUGS TO TREAT AF: HOW TO CHOOSE

Chairs: Sam Levy and Antonio Raviele

Dronedarone 1 year later. What is the experience? D George Wyse

Vernakalant: what to expect A John Camm

Why move from CHADS2 to CHADS2VASC2? Gregory Lip

11:20 Coffee and Visit the Exhibition

12:00 TREATING AF WITHOUT ABLATION

Chairs: A John Camm and D George Wyse

What are the alternatives for rhythm control? Sam Levy

LA appendage occlusion: when and how? Thorsten LeWalter

13:00 Lunch and visit the Exhibition

ProgrammeDay 1 – Monday 21st November

AFTERNOON

LUNCHTIME SESSION

ACUTE CEREBRAL MRI ABNORMALITIES AFTER AF ABLATION: A new area of concern

MRI lesions after AF ablation. How do the various energysources compare? Fiorenzo Gaita

MRI lesions after AF ablation. Is it the energy source or are there other factors? David Haines

MRI lesions after AF ablation. What do they mean and do they Matter?

14:00 FUTURE OF ORAL ANTICOAGULATION IN AF MANAGEMENTChairs: Albert L Waldo and David Haines

Initial clinical experience with Dabigatran

Apixaban. A careful look into Averroes

Roviroxaban: Sub-studies of Rocket-AF

15:00 IMAGING IN AF ABLATIONChairs: Nick Peters and Nasir Marrouche

Importance of imaging before AF ablation Nasir Marrouche

Advantages and limitations of imaging during AF ablation Doug Packer

Lessons from post-procedural imaging David Haines

Radiation Exposure in Cardiovascular Medicine - Optimising the trade-off between benefit and risk Ellen Hoffman

16:15 Tea and Visit Exhibition

16:45 DEBATESChairs: Hugh Calkins and Meleze Hocini

This house believes that ablation should not be offered to Pro: Albert L Waldopatients with asymptomatic AF Con: Andrea Natale

This house believes that catheter ablation should be Pro: Richard Schillingoffered as first line therapy for patients with paroxysmal Con: Josef KautznerAF aged under 50

19:00 Drinks Reception

19:30 Gala Dinner

ProgrammeDay 2 – Tuesday 22nd November

MORNING

09:00 AF ABLATION: HOW DO WE APPLY IT AND MONITORSAFETY AND EFFICACY?

Chairs: Doug Packer and George Klein

Is incomplete success an unacceptable outcomeafter AF ablation? Prapa Kanagaratnam

Is there still Consensus? Hugh Calkins

Recognition of a previously undocumentedcomplication of AF ablation Riccardo Cappato

Long term follow-up of AF ablation:how do the curves decay? David Keane

10:30 Coffee and visit Exhibition

11:00 DEBATES

Chairs: Albert L Waldo and Dipen Shah

This house believes that interventional cardiologistsshould be trained to offer a balloon-based first ablationprocedure for paroxysmal AF Pro: Karl-Heinz Kuck

Con: Mark O’Neill

This house believes that ablation of persistentAF is not cost effective Pro: A John Camm

Con: David Wilber

12:45 Lunch

Day 2 – Tuesday 22nd November

AFTERNOON

13:45- RECENT EXPERIENCE AND DEVELOPMENTS IN:

15:45 Chairs: Prapa Kanagaratnam and Warren Jackman

Remote NavigationHansen Josef KautznerStereotaxis Sabine ErnstAmigo Andre NgMagnetecs Jose Merino

Mapping & AblationRhythmia Warren JackmanCARTO3 Richard SchillingEnSite Velocity and EnSite NavX includingMediGuide technology Christopher PiorkowskiElectroNav Matt WrightEndosense Tacticath Dipen ShahBack to DC current? Fred Wittkampf

15:45 Tea

16:15 PVI using “SINGLE-SHOT” DEVICES. PROMISES FULFILLED?

Chairs: Riccardo Cappato and Wyn Davies

PVac Lucas BoersmaMesh ablator David KeaneCryoballoon Burghard SchumacherLaser Balloon A John CammThe ‘Toray’ Hot Balloon David Haines

17:45 The Klein Conclusion George J Klein

18:10 Closing Remarks D Wyn Davies and Riccardo Cappato

Programme

General Information

VENUEEurope AF will take place in the Kings and Monarch Suites in the West Wing of the LondonHilton Metropole Hotel.

London Hilton Metropole HotelEdgware Road, London W2 1JU

Tel: +44 (0) 207 402 4141Fax: +44 (0) 207 724 8866

www.hilton.co.uk/londonmet

LOCATION DETAILS AND TRANSPORTThe nearest underground station to the Hilton Metropole is Edgware Road or alternatively,Paddington which is also the nearest main line station and has an express trainlink to HeathrowAirport. Gatwick Airport has a direct rail link to Victoria Station. Waterloo International Stationhas an underground link to Hyde Park Corner or is fifteen minutes from the hotel by taxi.

London City Airport is approximately 45 minutes away by taxi & Heathrow and Gatwick airports arealso served by a regular shuttle bus service to hotels in Central London.

Parking is available at the hotel at NCP rates.

General Information

REGISTRATION FOR EUROPE AFRegistration should take place in advance of the conference wherever possible. A registrationform is enclosed and should be completed and sent together with the registration fee toMillbrook Medical Conferences Ltd.

Alternatively, registration will be available at www.EuropeAF.com with offers secure onlineregistration and payment facilities.

PLEASE NOTE THAT THE REGISTRATION FEE WILL INCREASE AFTERFRIDAY 23rd SEPTEMBER 2011 AND AGAIN ON THE REGISTRATION DAY.The registration fees are detailed on the Registration form which can be found at the back of thisbooklet. The registration fee for Europe AF includes:

• Admission to all Scientific Sessions• Admission to the Exhibition• Use of the Internet Café• Refreshments and Lunch on each day• All materials relating to the Conference• Ticket to the Gala Dinner on Monday 21st November 2011.

HOTEL ACCOMMODATIONA special rate has been negotiated with the London Metropole Hotel (conference venue) and itis hoped that the rates quoted are attractive enough to encourage all delegates to be resident inthe conference venue for the duration of the conference.

An accommodation reservation form is enclosed in this booklet and should be returned directlyto the hotel.

Additional hotel accommodation in London can be found and booked throughwww.visitlondon.com

PAYMENTPayment must be in Sterling by cheque, bank draft or transfer, VISA or Mastercard and senttogether with your completed registration form to Millbrook Medical Conferences Ltd.

Details for bank transfers are as follows:Account Name Millbrook Medical Conferences Ltd - Europe AFBank Address Lloyds TSB, 14 Church Street, Rugby, Warks CV21 3PLAccount Number 004410024Sort Code 30-97-17BIC LOYDGB21226IBAN GB16 LOYD 3097 1700 4100 24

General Information

CANCELLATION OF REGISTRATIONThe registration fee paid will be refunded less 25% (to cover the cost of administration) shoulddelegates cancel their registration prior to 28th October 2011. No refund will be made forcancellations after this date. If requested, conference material will be sent to delegates whohave paid the registration fee.

CPD ACCREDITATIONCPD Accreditation has been applied for. Please ensure you sign the attendance register.

DISCLAIMERAll information provided on www.europeaf.com and all printed literature is provided forinformation purposes only and does not constitute a legal contract between Europe AF and anyperson or entity unless otherwise specified. Information on www.europeaf.com and all printedliterature is subject to change without prior notice. Although every reasonable effort is made topresent current and accurate information Europe AF makes no guarantees of any kind.

www.europeaf.com and all printed literature may contain information that is created andmaintained by a variety of sources. Europe AF does not control, monitor or guarantee theinformation contained in links to other external websites, and does not endorse any viewsexpressed or products or services offered therein. In no event, shall Europe AF be responsible orliable, directly or indirectly, for any damage or loss caused or alleged to be caused by orthrough any such site or resource.

All lectures remain the property of their authors. Downloadable pdfs are provided for private useonly. Public use is forbidden without authorisation. Video and voice recording of the sessionsduring the conference is strictly prohibited.

Link Disclaimer: any links to external websites and/or non Europe AF information provided onwww.europeaf.com and all printed literature are provided as a courtesy. They should not beconstrued as an endorsement by Europe AF of the content or views of linked materials.

ORGANISING SECRETARIATFor further details concerning this conference please contact -

Millbrook Medical Conferences Ltd,Suite 3, Elizabethan House, Leicester Road, Lutterworth, Leics LE17 4NJ UKT: +44 (0) 1455 552559 F: +44 (0) 1455 550098email: EuropeAF@millbrookconferences.co.uk

Registration FormMonday 21st & Tuesday 22nd November

Full Name:

Job Title:

Hospital:

Address:

Telephone:

Email:

Yes I wish to request accommodation at the London Hilton Metropole Hotel Please tick and complete accommodation form

PAYMENT DETAILS:

Registration before Please Registration after PleaseFriday 23 September Tick Friday 23 September Tick

Two Day Registration

Consultant £295.00 £395.00

Jnr Medical and Allied Professionals £145.00 £245.00

One Day Registration

Consultant £180.00 £225.00

Jnr Medical and Allied Professionals £90.00 £150.00

Credit Card: VISA / MASTERCARD / MAESTRO Please circle

Name on card:

Card Number:

Expiry Date: Valid From:

Issue No: Security No:

Currency: GBP Sterling

Registration can also be paid by cheque to Millbrook Medical Conferences Ltd or registration can be done online at www.EuropeAF.com

Please complete and return to Millbrook Medical Conferences LimitedFax to +44 (0) 1455 550098 or post to:

Millbrook Medical Conferences Ltd, Suite 3, Elizabethan House, Leicester Road, Lutterworth, Leicestershire LE17 4NJ

(last 3 digits on signature strip on back of card)

THE REGISTRATION FEE INCLUDES THE FOLLOWING:

• Admission to all Scientific Sessions • Refreshments and Lunch

• Admission to the Exhibition • All materials relating to the Conference

• Use of the Internet Café • Ticket to the Gala Dinner on Monday 21 November 2011(for those paying for 2 day registration)

TO BE COMPLETED BY ONE DAY REGISTRANTS ONLY - I will be attending the following day:

Please Tick Box: Monday 21 November Tuesday 22 November

Accommodation Booking FormMonday 21st & Tuesday 22nd November

HOTEL BOOKING CODE: GEURAPlease complete and return to the hotel directly by Friday 4th November 2011

Full Name:

Job Title:

Hospital:

Address:

Telephone:

Email:

London Hilton Metropole Hotel 4* (conference venue)

Standard room including breakfast and VAT - £178.80

ARRIVAL DATE

DEPARTURE DATE

SPECIFIC REQUIREMENTS

Tick Tick Tick

Double occupancy* Twin occupancy* Disabled Access

Smoking Non Smoking

*If double/twin sharing with: Please note a supplement of £20 will be payable for double/twin occupancy

PAYMENT DETAILS:

Credit Card: VISA / MASTERCARD / MAESTRO Please circle

Card Number: ISSUE NO:

Expiry Date: Security No:

Name on card:

(last 3 digits on signature strip on back of card)

The credit card is given only as a guarantee for the reservation. Payment is due on arrival.In the event of cancellation, and to avoid cancellation charges, please advise the hotel in writing by fax or email no laterthan Friday 4th November 2011. Cancellations after this date may be subject to a cancellation charge.

Please complete and return to:Group Reservations Office, Hilton London Metropole Hotel, Edgware Road, London, W2 1JUTel: + 44 (0) 207 616 6570 Fax: +44 (0) 207 262 2921Email: guillermo.rubio@hilton.com