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AIM AND OBJECTIVE

AIM AND OBJECTIVES

Review of literature for Tramadol gave information regarding its physical and

chemical properties, various analytical methods that were conducted alone and in

combination with other drugs.

Literature survey reveals that certain chromatographic methods were reported for

the estimation of Tramadol and single method is available for such estimation by

RP-HPLC.

n view of the need for a suitable RP-HPLC method for routine analysis of

Tramadol in formulations, attempts were made to develop simple, precise and

accurate analytical method for the estimation of Tramadol and e!tend it for their

determination in formulation.

"alidation is a necessary and important step in both framing and documenting the

capabilities of the developed method.

The utility of the developed method to determine the content of drug in commercial

formulation was also demonstrated. "alidation of the method was done in

accordance with #$P and CH guideline for the assay of active ingredient. The

method was validated for parameters li%e system suitability, linearity, precision,

accuracy, specificity, ruggedness, robustness, limit of detection and limit of

&uantification. This method provides means to &uantify the component. This

proposed method was suitable for the analysis of Pharmaceutical dosage forms.

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AIM AND OBJECTIVE

The primary objective of proposed or! is"

To develop new simple, sensitive, accurate and economical analytical method for

the estimation of Tramadol.

To validate the proposed method in accordance with #$P and CH guidelines for

the intended analytical application i.e., to apply the proposed method for analysis

of the Tramadol in dosage form.

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