4.2 sexual reproduction - ms. ho-lau's...
TRANSCRIPT
4.2 SEXUAL REPRODUCTION
SEXUAL REPRODUCTION requires 2 parents
produces genetically distinct offspring
fertilization: fusion of a male reproductive cell with a female reproductive cell. (gametes)
zygote
each gamete has one set of homologous chromosomes - haploid (n)
a cell with two sets is diploid (2n)
The human diploid number is 2n = 46.
MEIOSIS process that produces gametes (haploid)
2 outcomes:
1. genetic reduction: a form of cell division that produces daughter cells with half the number of chromosomes of the parent cell
2. genetic recombination: the products of meiosis have different combinations of alleles
involves two complete cycles of the four phases
1. meiosis I: prophase I, metaphase I, anaphase I, and telophase I
2. meiosis II: prophase II, metaphase II, anaphase II, and telophase II
MEIOSIS I• interphase: replication of the DNA
• prophase I:
• homologous chromosomes line up side-by-side in an alignment called synapsis.
• some segments are exchanged, increases genetic diversity (genetic recombination)
• metaphase I: homologous chromosomes lined up together along the equator.
• anaphase I: homologous chromosomes are separated
• telophase I: homologous chromosomes uncoil and spindle fibres disappear
• cytokinesis: a nuclear membrane forms around each group of chromosomes, haploid cells
MEIOSIS II
• prophase II and metaphase II: similar to mitosis
• anaphase II: sister chromatids are separated
• telophase II and cytokinesis four haploid cells
Meiosis involves two
complete cycles of four
phases. Notice that each
cell contains some
chromosomes from the
mother (yellow), some
chromosomes from the
father (blue), and some
chromosomes with
segments that have been
exchanged (yellow and
blue).
Magnification: 200x
MEIOSIS
COMPARING MITOSIS AND MEIOSIS
GAMETE FORMATION IN ANIMALS Male:
Spermatogenesis: process that produces sperm in male animals
starting at puberty, the spermatogonia reproduce by mitosis and then meiosis
4 sperms
Female:
oogenesis: produces eggs in females.
the oogonia reproduce by mitosis before birth, begin meiosis, stop at prophase I.
after puberty, each month, one cell completes meiosis.
cytoplasm is unequally distributed, and only one cell matures, 1 egg (not four).
MULTIPLE BIRTHS
GENETIC VARIATION
TWO ways:
1. independent assortment
2. crossing over
INDEPENDENT ASSORTMENT gametes carry different combinations of maternal and paternal chromosomes
during metaphase I, each homologous chromosome is randomly oriented towards one of the poles
223 over 8 million different chromosome combinations.
CROSSING OVER
genetic material between maternal and paternal chromosomes is exchanged
during prophase I, non-sister chromatids exchange genetic material in multiple sections.
ERRORS IN CHROMOSOME STRUCTURE during crossing over, chemical bonds are re-formed
errors can occur that can result in the following:
ERRORS IN CHROMOSOME NUMBER
non-disjunction: homologous chromosomes or sister chromatids do not separate during meiosis (anaphase I or anaphase II)
produces gametes that have too many or too few chromosomes
Eg. Trisomy 21 (three copies of chromosome 21) Down Syndrome
Monosomy is the term used for a single chromosome copy error.
ERRORS IN CHROMOSOME NUMBER
PRENATAL GENETIC TESTING
all ages may request or be referred
older more frequent
possibility of pregnancy termination with some procedures
HOMEWORK
p.181 #1-8, 11