3rd line of defense
DESCRIPTION
worst presentation on Immune System's 3rd Line Of Defense everTRANSCRIPT
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Immune System
Third Line of Defense – Specific Immunity
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called into action when nonspecific methods are not enough and infection becomes widespread
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FUNCTION mounts attacks against
specific foreign substances
specific foreign
substances
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FEATURES………………
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Self/non-self discrimination - it normally distinguishes between self and non-self and only reacts against non-self.
non-self
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When a nonself (foreign) body is detected, mitotic activity in B and T lymphocytes is stimulated
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While mitosis is occurring, the daughter populations become subdivided into…
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Effector cells when fully differentiated,
they will seek and destroy foreign materials
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Memory cells
become dormant, but can be triggered to rapid mitosis if pathogen encountered again
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Memory - it demonstrates memory. The immune system "remembers" if it has seen an antigen before and it reacts to secondary exposures to an antigen in a manner different than after a primary exposure. Generally, only an exposure to the same antigen will trigger this memory response.
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Specificity - there is a high degree of specificity in its reactions. A response to a particular antigen is specific for that antigen or a few closely related antigens.
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CELLS INVOLVED
………………
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Macrophages engulf foreign objects inform T lymphocytes at a
specific antigen is present
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Helper T cells
produce and secrete chemicals which promote large numbers of effector and memory cells
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Cytotoxic T cell T lymphocytes
that eliminate infected body cells and tumor cells
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B Cells produce antibodies (secrete them
in the blood or position them on their cell surfaces)
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The process can be simplified into three
events:
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(1) Recognition of a specific invader
SPECIFIC INVADER
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(2) Repeated cell divisions that form huge lymphocyte populations
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(3) Differentiation into subpopulations of effector and memory cells
Effector Memory