3protein information resource, georgetown university, … · 2013-11-12 · ‘manual curation of...

‘Manual curation of Drosophila melanogaster in UniProtKB’ Elena Cibrián Uhalte 1 and UniProt Consortium 1,2,3 1 EMBL-European Bioinformatics Institute, Cambridge, UK 2 SIB Swiss Institute of Bioinformatics, Geneva, Switzerland 3 Protein Information Resource, Georgetown University, Washington DC & University of Delaware, USA Email: [email protected] URL: www.uniprot.org Funding UniProt is funded by the European Molecular Biology Laboratory, National Institutes of Health, European Union, Swiss Federal Government, British Heart Foundation and National Science Foundation. Drosophila melanogaster in UniProtKB Drosophila melanogaster manually curated entry Drosophila melanogaster is a priority model organism for UniProt Knowledgebase (UniProtKB) manual curation. The Drosophila protein annotation program focuses on the manual curation of characterised Drosophila melanogaster proteins with experimental data from the scientific literature. UniProtKB provides a complete non-redundant proteome for Drosophila melanogaster based on the translation of the Drosophila melanogaster completely sequenced genome, which currently comprises 19,721 entries and which can be downloaded from the UniProt website. All Drosophila melanogaster entries are cross-referenced with FlyBase with which UniProtKB keeps close contact in order to ensure data consistency between both databases. In addition to melanogaster, 11 other Drosophila species are currently present in UniProtKB as complete proteome sets. Database cross-references Annotation of biological information All Drosophila melanogaster entries are cross-referenced with FlyBase Manually curated FlyBase gene symbol Synonyms captured from literature Current ORF symbol Manual Referenced annotation Function References: Protein sequence features Drosophila melanogaster complete proteome Keywords and Gene Ontology annotation Drosophila complete proteome available on UniProt website Gene Ontology (GO) terms are assigned manually based on experimental data from the literature and also added based on automatic methods. In addition, GO terms are imported from other GO consortium members Nucleotide sequence Manual annotation protocol

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‘Manual curation of Drosophila

melanogaster in UniProtKB’

Elena Cibrián Uhalte1 and UniProt Consortium1,2,3

1EMBL-European Bioinformatics Institute, Cambridge, UK

2SIB Swiss Institute of Bioinformatics, Geneva, Switzerland

3Protein Information Resource, Georgetown University, Washington DC & University of Delaware, USA

Email: [email protected] URL: www.uniprot.org

Funding

UniProt is funded by the European Molecular Biology Laboratory, National Institutes of Health, European Union, Swiss Federal Government, British Heart Foundation and National Science

Foundation.

Drosophila melanogaster in UniProtKB

Drosophila melanogaster manually curated entry

Drosophila melanogaster is a priority model organism for UniProt Knowledgebase

(UniProtKB) manual curation. The Drosophila protein annotation program

focuses on the manual curation of characterised Drosophila melanogaster proteins

with experimental data from the scientific literature. UniProtKB provides a complete

non-redundant proteome for Drosophila melanogaster based on the translation of

the Drosophila melanogaster completely sequenced genome, which currently

comprises 19,721 entries and which can be downloaded from the UniProt website.

All Drosophila melanogaster entries are cross-referenced with FlyBase with which

UniProtKB keeps close contact in order to ensure data consistency between both