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    SAINT LOUIS UNIVERSITYCOLLEGE OF NURSING

    CASE PRESENTATION: NON-HODGKINS LYMPHOMA,METABOLIC ACIDOSIS, ANEMIA, HYPOCALCEMIA,

    ANEMIA

    Submitted To:MAAM DYMONDE F. CATILING

    Clinical Instructor

    Submitted By:BSN 3-B2

    BAGUILAT, Mark AmielBAUTISTA, Irish DanicaCLERIGO, Kezia Lianne

    EGALLA, NicanorEMPERADOR, Julienne Jill

    ISURITA, Rizza DonnaMAPPALA, Charisse

    ORIBELLO, JenniferORTIZ, Jan Phillip

    SADURAL, AngelicaTELIAKEN, Jovie AnnYAGYAGEN, Justin

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    PATIENTS DATA

    Name: Lopez, Eduardo Oneill

    Age: 81 years old

    Date of Birth: December 28, 1928

    Place of Birth: Manila City

    Sex: Male

    Address: 29 PNB Village, Bakakeng Central, Marcos Highway, Baguio City

    Occupation: Unemployed

    Next of Kin: Maria Teresa Lopez Tabuena

    Relationship to the Patient: Daughter

    Occupation: Employee

    Employer: Rustans

    Latest Hospitalization Date: February 16, 2010

    Admitting Physician: Dr. Oliver

    Attending Physician: Dr. Candelario, Dr. Demyttenaere, Dr. Revilla

    Date of Admission: February 19, 2010

    Time of Admission: 3:00 pm

    Impression or Diagnosis: Upper gastrointestinal bleeding, small intestinal tumor

    probably malignant

    Final Diagnosis: Non-Hodgkins Lymphoma at the small intestines upper GI bleeding

    severe anemia, metabolic acidosis, hypocalcemia

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    PAST MEDICAL HISTORY

    On 2001, patient had been diagnosed as having a cardiovascular disease at the LMCA

    territory. He also has Hypertension and is maintained on Amlodipine 5mg 1 tab once a

    day. He also has Diabetes Mellitus and is maintained on Diamicron. On May 2009,

    patient underwent endoscopy and was found out that there are multiple polyps and

    hemorrhoids on the gastrointestinal tract. He was also diagnosed as having gastritis.

    On February 2010, he was then diagnosed with small intestinal cancer. There were no

    known allergies to food or medications.

    FAMILY HISTORY

    Patient has heredofamilial disease of hypertension and diabetes mellitus. No family

    history of cancer, pulmonary tuberculosis and asthma.

    SOCIAL AND ENVIRONMENTAL HISTORY

    Patient is an occasional alcoholic beverage drinker and a non-smoker

    HISTORY OF PRESENT ILLNESS

    The present condition started about one day prior to admission when the patient

    manifested body malaise after being discharged in this institution. There was dizziness

    and headache noted. The condition persisted until about 12 hours prior to admission,

    patient had melena about 2 episodes that day. The patient ignored it thinking it was

    just a side effect of the suppository given to him. About 4 hours prior to admission, the

    patient had 4 episodes of melena. There was still associated body malaise, headache

    and dizziness. About 2 hours prior to admission, condition persisted now associated

    with 1 episode of vomiting. Vomitus was however non-blood streaked amounting to

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    cup. He was then brought back in this institution for consult hence the subsequent

    admission.

    PHYSICAL ASSESSMENT

    I. HEALTH PERCEPTION-HEALTH MANAGEMENT PATTERN

    The patient perceives that his current health situation now is already incurable since it

    had already progressed. But despite of this condition, he does his best to stick to the

    treatment regimen offered to him like taking his medications even if he does not like the

    taste of it. Generally, he is weak as manifested by needing assistance from his family

    friend in changing his position.

    II. NUTRITIONAL-METABOLIC PATTERN

    Prior to admission, the patient usually eats foods with meat and meat products. He also

    verbalized that he is an occasional drinker and a non-smoker. He eats 3 times a day,

    sometimes with break or merienda meals at between. Two hours prior to admission, he

    experienced nausea and vomiting and passed out vomitus which is non-blood streaked

    and approximately cup in volume. He has difficulty in digesting fish products. Upon

    assessment, the patient has a bloated abdomen. The patient manifested a good skin

    turgor, about 1-2 seconds. His mucosal membranes are moist and no unusual lesions

    were identified. No edema, jugular vein distention, and enlargement of thyroid gland

    are present. The lung fields of the patient are clear upon auscultation and the patient

    exhibits symmetrical chest wall expansion. The latest oxygen saturation of the patient

    is at 89-90%, and he is on oxygen at 1 liter per minute/ nasal cannula. There were no

    associated pain, soreness, ulcer, bleeding, and difficulty in swallowing when it comes

    to the patients mouth. The teeth of the patient are yellowish in color, and his tongue is

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    pale pink in color, both with no unusual lesions observed. The patient exhibits

    hyperactive bowel sounds upon auscultation. There is also the presence of 3 incisions:

    one at the umbilicus area, approximately 5 inches long, vertical and 2 at the left and

    right lower quadrant, each measuring about 1 inch, diagonal. There were no signs of

    infection manifested on these 3 incisions.

    III.ELIMINATION PATTERN

    Prior to admission, patient urinates for 3-4 times a day. Urine is characterized as

    yellowish in color, with no unusual odor. When it comes to defecation, the patient

    usually defecates at 1-2 times a day. Stool is characterized as soft, brownish in color,

    and with no unusual discoloration and odor. During our shift, the patient defecated 2

    times, the stool is reddish in color, soft in consistency, with no unusual odor. The

    patient had melena or defecated a black, tarry stool indicative of upper gastrointestinal

    bleeding 12 hours prior to admission. Upon performing endoscopy on the patient,

    hemorrhoids and small intestinal tumors were identified. The abdomen is flappy, soft

    and firm upon palpation, with tympanitic palpable mass at the hypogastric areameasuring about 4x5cm , firm, movable, and non-tender.

    IV.ACTIVITY-EXERCISE PATTERN

    The patient is currently unemployed. His usual activities are limited in the house since

    he is already feeling weak. This includes watching television, reading magazines, and

    the like. For him, he considers walking as a form of exercise. Upon assessment of his

    respiratory status, the patient has productive cough and passed out sputum with

    characteristics of purulent or yellowish in color, and with no unusual odor. Whenever

    the patient coughs, he experiences pain. The patient has clear lung fields, and he has

    a symmetrical chest wall expansion. The latest oxygen saturation obtained from him is

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    89-90%, and he is on medical oxygen regulated at 1 liter per minute/ nasal cannula.

    His muscle strength on all extremities are 5/5, and his reflexes are normal. Upon

    auscultation of the heart, the point of maximal impulse can be heard at the 5th

    intercostals space, left midclavicular line. There were no murmurs heard, and the rate

    and rhythm of the heart beats are normal.

    V. SLEEP REST-PATTERN

    The patient can sleep for 8 hours but with interruptions in between. He sleeps for an

    hour, then wakes up, then goes back to sleep again. Lately, he cannot get a good

    sleep since the wound on his abdomen is painful but tolerable. Before he goes to rest

    he prays. His level of consciousness is awake and oriented to time and place. There

    were no tremors observed.

    VI. COGNITIVE-PERCEPTUAL PATTERN

    The patient is awake, conscious, coherent, aware of his surroundings and relatives,

    and oriented to time and place. He does not experience dizziness, headache

    numbness, and tremors. He experiences pain on the abdominal area due to the woundmade by the incisions of the procedure he underwent which is emergency explore

    laparotomy. He has an anicteric sclera, and is palpebral conjunctiva is pink in color.

    The pupils were symmetrical, equally round and reactive to light and accommodation,

    and is about 2-3 mm. The extra-ocular movement and the sense of sight are also

    intact. There were no pain, redness or blurring of vision noted. For the ears, there were

    no unusual discharges, pain, and decrease in hearing noted. For the nose, the

    olfactory nerve (cranial nerve 1) is intact as manifested by patient being able to

    distinguish different types of scents. The patient is not manifesting any colds

    obstruction, pain and congestion in his nose. The nostrils are also patent. The patient

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    is positive for having a gag reflex, is able to shrug shoulders, and able to protrude

    tongue. There were no diminished senses, and his reflexes are normal, with no

    Babinski and ankle clonus reflexes.

    VII. SELF-PERCEPTION / SELF-CONCEPT PATTERN

    The patient perceives that since he is already diagnosed with stage IV non-Hodgkins

    lymphoma, his time is almost up. But still he is calm and verbalized that he accepts

    whatever may happen to him. He also verbalized that he had done his responsibilities

    as an employee, a friend, a parent, and the like. He did not have any regrets in the

    past, and is very grateful to his family friend for taking good care of him. Although his

    daughter is in Manila and the other daughter is in America, he verbalized that he

    understood the situation since they have their own family to look after, and that life is

    very hard nowadays. He feels lonely at times because he is living alone in their

    household, without any relatives to take care of him

    VIII. ROLE-RELATIONSHIP PATTERN

    The patients wife died a long time ago, while his second wife left him and did notreturn anymore. As a husband, he told us that he is not that satisfied since he felt that

    he did not fulfill his duties as a husband. As a parent, he verbalized that he is satisfied

    since he saw his daughters grew up and become successful in their lives.

    IX. COPING-STRESS TOLERANCE PATTERN

    Whenever the patient is faced with a distress, like for example, misunderstandings with

    his relatives, he lets them cool off by not talking to them for a day and when both of

    them are ready, they talk about the problems in a nice way. He also prays to the Lord

    for guidance and wisdom.

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    X. VALUE-BELIEF PATTERN

    The patient is a Roman Catholic. Being a Roman Catholic, he has no restrictions when

    it comes to the food they eat, only at times like the Holy week when they do not eat

    meat. He recognizes this as having a little bearing with regards to his current health.

    He usually goes to church every Sunday when he has time and when his body is able

    to move.

    DRUG STUDY

    1. METRONIDAZOLE

    Classification: Trichomonacide and amebicide

    Mechanism of Action: Direct-acting trichomonaside and amebicide that works inside

    and outside the intestines. Its thought to enter the cells of microorganisms that contain

    nitroreductase, forming unstable compounds that bind to DNA and inhibit synthesis,

    causing cell death.

    Indication: To prevent postoperative infection in contaminated or potentially

    contaminated colorectal surgery.

    Adverse Effects: Headache, fever, dizziness, weakness, nausea, vomiting, abdomina

    cramping or pain

    Nursing Responsibilities:

    Monitor liver function test results carefully in elderly patients.

    Give oral form with meals. Ensure safety by raising siderails.

    Monitor vital signs especially temperature.

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    Tell patient to avoid alcohol and alcohol-conatining drugs during and for at least 3

    days after treatment course.

    2. CEFUROXIME SODIUM (ZINACEF)

    Classification: Second generation cephalosporin

    Mechanism of Action: Inhibits cell-wall synthesis, promoting osmotic instability

    usually bactericidal

    Indication: Perioperative prevention

    Adverse Effects: Phlebitis, thrombophlebitis, nausea, vomiting, diarrhea

    Nursing Responsibilities:

    Monitor intake and output

    Assess characteristics of stool

    Absorption of oral drug is enhanced by food

    Tell patient to notify prescriber about loose stools or diarrhea

    Monitor site of IV insertion for signs of thrombophlebitis.

    3. CELECOXIB (CELEBREX)

    Classification: Nonsteroidal anti-inflammatory drug

    Mechanism of Action: Thought to inhibit prostaglandin synthesis, impeding

    cyclooxygenase-2 (COX-2) to produce anti-inflammatory, analgesic, and antipyretic

    effects.

    Indication: Acute pain

    Adverse Effects: Dizziness, headache, insomnia, abdominal pain, diarrhea

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    Nursing Responsibilities:

    Provide rest periods by clustering nursing care.

    Ensure safety by raising siderails

    Monitor intake and output

    Instruct patient to promptly report signs of gastrointestinal bleeding such as blood

    in vomit, urine, stool; or black, tarry stools.

    4. TRAMADOL HYDROCHLORIDE

    Classification: Centrally acting non-opioid analgesic

    Mechanism of Action: A centrally acting synthetic analgesic not chemically related to

    opioids. Thought to bind to opiate receptors and inhibit reuptake of norepinephrine and

    serotonin.

    Indication: Moderate to moderately severe pain

    Adverse Effects: Dizziness, headache, malaise, nausea, vomiting

    Nursing Responsibilities:

    Reassess patients level of pain at least 30 minutes after administration.

    Monitor intake and output

    Raise side rails of the bed

    Warn patient not to stop the drug abruptly

    5. ACETYLCYSTEINE (FLUIMUCIL)

    Classification: Mucolytic

    Mechanism of Action: Mucolytic that reduces the viscosity of pulmonary secretions by

    splitting disulfide linkages between mucoprotein molecular complexes. Also, restores

    liver stores of glutathione to treat acetaminophen toxicity

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    Indication: Abnormal viscid or thickened mucous secretions

    Adverse Effects: Nausea, vomiting, fever, rashes

    Nursing Responsibilities:

    Monitor cough type and frequency

    Monitor vital signs especially temperature

    Encourage patient to cough out secretions

    Warn patient that drug may have a foul taste that may be distressing

    6. METOCLOPRAMIDE (PLASIL)

    Classification: Antiemetic

    Mechanism of Action: Stimulates motility of the upper gastrointestinal tract, increases

    lower esophageal sphincter tone, and blocks dopamine receptors at the chemoreceptor

    trigger zone.

    Indication: To prevent and reduce postoperative nausea and vomiting

    Adverse Effects: Restlessness, drowsiness, fatigue, diarrhea

    Nursing Responsibilities:

    Monitor bowel sounds

    Tell patient to avoid activities that require alertness for 2 hours after doses

    7. ESOMEPRAZOLE MAGNESIUM (NEXIUM)

    Classification: Proton pump inhibitor

    Mechanism of Action: Reduces gastric acid secretion and decreases gastric acidity

    Indication: To reduce the risk of gastric ulcers in patients receiving continuous NSAID

    therapy

    Adverse Effects: Headache, dry mouth, diarrhea, abdominal pain, nausea, vomiting

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    Nursing Responsibilities:

    Give drug at least 1 hour before meals

    Monitor patient for rash or signs and symptoms of hypersensitivity

    Monitor bowel sounds

    Warn patient not to chew or crush drug because this inactivates the drug

    8. FUROSEMIDE (LASIX)

    Classification: Loop diuretic

    Mechanism of Action: Inhibits sodium and chloride reabsorption at the proximal and

    distal tubules and the ascending loop of Henle

    Adverse Effects: Headache, dizziness, fever, weakness, restlessness

    Nursing Responsibilities:

    Monitor vital signs especially temperature

    Ensure safety by raising side rails

    Assist patient in changing position

    Monitor weight early in the morning

    Advise patient to take drug with food to prevent gastrointestinal upset

    9. CALCIUM CARBONATE (CALTRATE PLUS)

    Classification: Calcium replacement

    Mechanism of Action: Replaces calcium and maintains calcium level

    Indication: Hypocalcemia

    Adverse Effects: Bradycardia, nausea, vomiting, abdominal pain

    Nursing Responsibilities:

    Monitor calcium levels frequently

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    Monitor vital signs especially heart rate

    Tell patient to take oral calcium with a full glass of water

    10. VITAMIN K

    Classification: Vitamins and minerals

    Mechanism of Action: An antihemorrhagic factor that promotes hepatic formation of

    active coagulation factors

    Indication: Hypoprothrombinemia caused by vitamin K malabsorption, drug therapy

    Adverse Effects: Dizziness, diaphoresis

    Nursing Responsibilities:

    Give fresh frozen plasma once severe bleeding occurs

    Tell patient to avoid hazardous activities if dizziness occurs

    11. PARECOXIB SODIUM (DYNASTAT)

    Classification: Nonsteroidal anti-inflammatory drug

    Mechanism of Action: Thought to inhibit prostaglandin synthesis, impeding

    cyclooxygenase-2 (COX-2) to produce anti-inflammatory, analgesic, and antipyretic

    effects.

    Indication: Acute pain

    Adverse Effects: Dizziness, headache, insomnia, abdominal pain, diarrhea

    Nursing Responsibilities:

    Provide rest periods by clustering nursing care.

    Ensure safety by raising siderails

    Monitor intake and output

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    Instruct patient to promptly report signs of gastrointestinal bleeding such as blood

    in vomit, urine, stool; or black, tarry stools.

    LABORATORY RESULTS

    Biopsy (February 25,2010)

    GROSS DESCRIPTION: Specimen consists of a segment of small intestine measuring

    36cm long, previously sectioned at the site of the mass. The resection margins

    (proximal and distal), measure 4.5 cm in circumference and are both grossly

    unremarkable. There is circumferential, gray-white, firm mass measuring 9.8x4x2cm

    completely obstructing the intestinal lumen. Cut sections of the mass show a gray-

    white firm mass involving the entire thickness of the intestinal wall (approximately

    measuring 1.4-2.8cm). This lesion is seen 13-14cm away. The adjacent, uninvolved

    intestinal mucosa is flattened and hemorrhagic. There are tumor nodules formed in the

    adjacent, serosal fat measuring from 1.5cmx1cm to 5x3cm. Representative sections

    submitted for study labeled: A- resection margins (1- proximal, 2- distal), B- mass,

    C- random sections of the ileum and D and E- tumor nodules

    MICROSCOPIC DEFINITION: Sections reveal a diffuse proliferation of lymphocytes

    predominantly of the large cell type, having pleomorphic, vesicular nuclei with

    prominent nucleoli and scanty amount of cytoplasm. These atypical cells are mainly

    seen in the submucosa and are almost completely effacing the mucosa. The tumor is

    extending up to the serosal layer with formation of tumor nodules. There are nogerminal centers seen. Scattered areas of tumor necrosis are noted. Occasional mitotic

    figures are seen.

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    DIAGNOSIS: Segment of small intestine (distal ileum) Non-Hodgkins lymphoma

    large cell type diffusely infiltrating the entire intestinal wall thickness with formation of

    tumor nodules. Resection margins (proximal and distal), negative for tumor. Random

    sections of the uninvolved colon, mucosal flattening, negative for tumor. Nine lymph

    nodes: non-hodgkins lymphoma, large cell type.

    Interpretation: This test diagnosed the specific disease of the patient which is Non-

    Hodgkins lymphoma. Some of the characteristics of Non-Hodgkins lymphoma are as

    follows: multiple peripheral nodes are involved, noncontiguous spread, rarely localized

    extent of disease, extranodal involvement are commonly involved.

    X-Ray (February 21, 2010)

    RESULTS: Clear and normovascular lung fields, cardiac shadow is unenlarged

    atherosclerotic aortic knob, prominent ascending and descending aorta, intac

    diaphragm, clear costophrenic angles

    Interpretation: The x-ray results showed that there is the fatty deposition in the aortic

    knob, which may predispose the patient in having increased blood pressure in that

    area, which may further predispose the patient to have hypertension.

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    Complete Blood Count (February 27, 2010)

    RESULTS NORMAL RANGE

    WBC: 10.5x10e9/L* 5-10

    81.5%N* 45-70

    4.29%L* 20-40

    10.8%M 0-12

    2.05%E 0-8

    1.29%B 0-2

    RBC: 4.01x10e12/L* 4.5-6

    Hgb: 115g/L* 120-170

    Hct: 0.332L/L* 0.40-0.54

    MCV: 82.8fL 76-96

    MCH: 28.7pg 27-32

    MCHC: 347g/L 320-360

    Platelet: AdequateComments: Normocytic, normochromic

    Interpretation: The patient undergone complete blood count in order to confirm the

    presence of an infection. White blood cells are increased whenever there is an

    infectious process going on to the patient. This is also accompanied by an increase in

    the neutrophils and the decrease of lymphocytes (lymphopenia). The red blood cells of

    the patient are decreased, confirming his diagnosis of anemia. It also follows that the

    patient has low hemoglobin or the oxygen-carrying capacity of the red blood cells. This

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    can be manifested as general body weakness since there is impairment in the tissue

    perfusion in the body.

    Serum Calcium Level (February 27, 2010)

    RESULTS:

    Calcium (ionized)* - 1.07 mmol/L

    Normal Range: 1.13-1.32

    Interpretation: This test confirms the diagnosis of the patient which is hypocalcemia.

    This may manifest in the patient as having tetany, in which there is an increase in the

    neural excitability of the patient.

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    PATHOPHYSIOLOGY

    Neoplastic growth of lymphoid

    tissue in the intestines

    Cell immortalization andincrease in malignant cells

    Intestinal obstruction

    Sequestration of gas and fluid

    roximal to obstruction

    Pressure on diaphragm Colicky abdominal pain Acute pain

    Distention

    Nausea and vomiting due todecreased food intakeDecreased nutrient absorptionDecreased carbohydratereserves

    Decreased respiratory volume

    Loss of water and electrolytes

    HypocalcemiaMetabolic Acidosis

    Deficient fluid volume

    Imbalanced nutrition:

    less than body

    requirements

    Age of greater than 65,

    alcohol intake, obesit

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    Ineffective

    airway clearance

    Body weakness

    Difficulty of breathing

    Activity IntoleranceImpaired physical mobility

    Ineffective tissue perfusion Anemia

    Decreased plasma volume

    Decreased central venous

    pressureDecreased extracellular fluid

    volume

    Impaired skin integrity Dehydration

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    PRIORITIZATION AND JUSTIFICATION

    Prioritization Justification1. Ineffective airway clearance

    related to retained secretions

    at the tracheobronchial tree

    According to ABCD prioritization, A

    goes first which is Airway

    establishment. This is the first

    prioritized problem since adequate

    perfusion to other parts of the body

    is necessary to maintain normal

    bodily functions.

    2. Imbalanced nutrition: less than

    body requirements related to

    inability to absorb nutrients

    secondary to intestinal tumors

    In Hendersons 14 Fundamental

    Needs of Man, this is the first listed

    need of man which is to eat and

    drink adequately. This is prioritized

    as second because although the

    patient eats adequately, the

    nutrients are not absorbed properly

    because of the ongoing disease

    process and the intestines are thesites where absorption of nutrients

    take place.

    3. Deficient fluid volume related

    to inability to reabsorb water

    secondary to intestinal tumors

    This is also the first listed need of

    man in Hendersons 14 fundamental

    needs. This is prioritized as third

    because without correcting the

    nutrition of the patient, correcting the

    fluid volume would not be essential.

    4. Ineffective tissue perfusion

    related to decreased number

    This is the fourth prioritized problem

    since we can increase the perfusion

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    of circulating red blood cells in

    the body

    of oxygen in the body by offering

    iron-rich foods for the patient, which

    is addressed in the secondprioritized problem. This is also C in

    ABCD which is circulation.

    5. Acute pain related to lack of

    blood supply to the abdomen

    secondary to gastritis

    According to ABCD prioritization,

    this is D which is disability. This is

    also the chief complaint of the

    patient. This is the fifth prioritized

    problem because it does not

    significantly affect the patients

    activities of daily living such as

    eating and sleeping.

    6. Activity intolerance related to

    lack of circulating oxygen to

    the body

    This is the fourth listed need of man

    in Hendersons theory. This is the

    sixth prioritized problem since the

    patient is unable to change his

    position without assistance. This is

    also in relation to lack of oxygen

    adequately perfusing the body due

    to his severe anemia.

    7. Impaired physical mobility

    related to distention of

    abdomen secondary to

    gastritis

    This is also in relation to the sixth

    prioritized problem. It is also listed

    as number 4 in Hendersons 14

    Fundamental Needs of Man. This is

    prioritized as seventh because if thedisease entitiy is suppressed or

    resolved, this would follow as being

    solved.

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    8. Impaired skin integrity related

    to continuous fluid loss

    This is the seventh listed need of

    man that needs to be addressed

    according to Virginia Henderson.This is the last prioritized problem

    because with adequate nutrition and

    adequate hydration, the patient

    would not manifest problems in his

    integumentary system.