3/10/2003 patent ductus arteriosus occlusion device oral presentation #3 group 6 david brogan, darci...
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3/10/2003
Patent Ductus Arteriosus Occlusion DeviceOral Presentation #3
Group 6David Brogan, Darci Phillips & Daniel Schultz
Advisor: Dr. Thomas Doyle
3/10/2003
Patent Ductus Arteriosus (PDA) Ductus arteriosus (DA) allows
blood to bypass pulmonary and enter systemic
DA normally closes within 10-18 hrs of delivery (if not deemed abnormal/patent)
PDA affects 1800 babies/year in USA alone
Many adverse effects growth retardation,
breathlessness or lack of appetite
Most common problem is congestive heart failure
3/10/2003
Current Treatments
Drug therapy (indomethacin)
Implantable devices (most common are coils) Usually need 3-4 coils Difficult to remove and
reposition
Invasive surgery (ligate the PDA to inhibit blood flow)
3/10/2003
Project GoalsTo design, develop and patent a PDA
occlusion device that can… Be delivered via a catheter Conform to the shape of the PDA and
cause occlusion Can be repositioned easily Be cost effective (<$200) Provide an initial success rate of 100% More patient friendly procedure
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Current Best Competitor
Amplatzer Duct Occluder Most effective, has
highest success rate of current devices
Drawback - Not pliable PDA must conform to
shape of ADO
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Effect of Occlusion Device
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Our Design
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Delivery Path of Device
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Foam Issues We can make a polyurethane foam with
methylene bisphenyl diisocyanate (MDI), polytetramethylene glycol (PTMEG), 1,4-butanediol and water.
Have ordered MDI and 1,4-butanediol, but have not found a vendor yet to supply the PTMEG.
Contacted DuPont but was unable to secure a sample due to company restrictions.
3/10/2003
Work Completed Conducted extensive research on other treatment
methods (to avoid short comings on our design) Met with Dr. Doyle to discuss our progress and
future goals Have placed order for foam chemicals (will arrive
by Wednesday) Have ordered and received Nitinol memory wire in
two different diameter thicknesses Have secured an In-Vitro PDA Simulation device
for testing
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Foam Molds
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Current Status Making final design refinements to device Developing life-size PDA device prototype Developing equations to model PDA testing
apparatus Making arrangements with Mechanical
Engineering professor to have Nitinol wire machined here at Vanderbilt
Completing Design Safe and Innovation Work Bench assignments
Making necessary modifications to website
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In-Vitro Modeling Specs.Pressure Drop : 100 mm HgCalculate flow inside PA using Hagen-
Poiseuille Eqn. Q = -ΔP * *r4/(8*μ*L)
All variables are known, thus Q can be calculated easily
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Needs
Obtain missing foam ingredient (PTMEG)
Make arrangements to machine Nitinol wire
Meet with Dr. Doyle to discuss further progress
3/10/2003
Future Direction
Build scaled prototype with correct biomaterials Figure out best way to secure Nitinol within device
Begin conducting pressure and durability tests in PDA simulated environment
Refine design based on testing Talk with Dr. Doyle/Office of Technology
Transfer about patenting this PDA Occlusion Device
3/10/2003
Contact Information
David Brogan [email protected] 1-210-364-4546
Darci Phillips [email protected] 1-615-386-9015
Daniel Schultz [email protected] 1-615-421-6067