2nd annual cell based assays (2011) pp

6

Click here to load reader

Upload: piyush-patel

Post on 11-Jun-2015

1.327 views

Category:

Documents


1 download

DESCRIPTION

Email [email protected] for early bird discount

TRANSCRIPT

Page 1: 2nd Annual Cell Based Assays (2011) Pp

11th – 13th October 2011, Visiongain Conference Centre, London, UK

Organised By

Optimising methods and integrating new platforms for drug discovery, development and toxicity testing

To Book Call: +44 (0) 20 7336 6100 | www.visiongain.com/cell-based-assays

Julie Holder, Preclinical Director, Stem Cell DPU, GlaxoSmithKline

Stefan Otto Mueller, Director, Early, Genetic and Molecular Toxicology, Merck Serono

Rachel Russell, Director, Primary Pharmacology Group, Pfizer

Darren Cawkill, Associate Director, Primary Pharmacology Group, Pfizer

Miroslav Cik, Research Fellow, Janssen Pharmaceutica (Johnson & Johnson)

Joanne Bowes, Principal Scientist, AstraZeneca

Magalie Rocheville, Investigator, GlaxoSmithKline

Stephen Minger, Global Head of R&D, Cellular Technologies, GE Healthcare

Frank W. Bonner, Chief Executive, Stem Cells for Safer Medicines

Mark Slack, Group Leader, Cellular Assays, Evotec

Jasmin Fisher, Researcher, Executable Biology, Microsoft Research Cambridge

Molly Stevens, Professor of Biomedical Materials and Regenerative Medicine, Imperial College London

David C. Hay, Principal Investigator, MRC Centre for Regenerative Medicine, University of Edinburgh

Stefan Przyborski, Founder and Chief Scientific Officer, Reinnervate

Key Speakers

BOOK NOW!

2nd Annual Cell-Based Assays

Driving the Industry Forward | www.futurepharmaus.com

Media Partners

Pre-conference Workshop, Tuesday 11th October, 2011

Industrial application of pluripotent stem cells and their derivatives- High-content screening as a valuable tool for drug discovery and toxicity testing

Led by: Mikael Englund, Senior Scientist, Site Manager, Cellartis, Daniella Steel, Senior Scientist, Project Leader, Cellartis, Paul Andrews, Senior Scientist, Drug Discovery Unit, University of Dundee

Panellists: Petter Björquist, Senior Principal Scientist, Project Manager, Cellartis, Anders Aspegren, Senior Scientist, Production Manager, Cellartis

Associate SponsorP H O T O N I S O U R B U S I N E S S

Page 2: 2nd Annual Cell Based Assays (2011) Pp

Conference Introduction2nd Annual Cell-Based Assays

11th - 13th October 2011, London, UK

Dear Colleague, Ittakeswellover£500millionandbetween10and12yearstodevelopanewdrug.

For every million compounds screened, approximately 250 make it to pre-clinicaltesting,10advancetoclinicaltrialsandjustoneisapprovedforpatientuse.Industrycanill-affordtocontinuesuchawastefulprocess.

Cancerousandanimalcells,manyhavingbeen incontinuousculture fordecades,poorly reflectpatientphysiology.These,finally,areyieldingtomorerepresentativemodels that better reflect the intended recipients of new molecular entities.Advances in label-free technologies, human primary, 3D and embryonic-stem cellderived lines are heralding a paradigm shift in drug discovery, development andtoxicitytesting.

Focussing on these, the future tools that better reflect PK/PD, genomic andphenotypic differences within and between human populations,Visiongain bringsyouitssecondCell-BasedAssaysconference.

Attending this event will empower you to: •Utilisenewtechniquesinhighthroughputscreening. •Identify intracellular transduction cascades for G-protein coupled receptors and

kinases. •Acceleratehigh-contentscreeningusingprimarycells. •Incorporate computationalmodels to study the effects of drugs on intracellular

networks. •Use3D cell assays formore relevant testingof the effects of drugsonorgans,

includingtheliver,heartandbraincells. •Harness human embryonic, adult and induced pluripotent stem cells for drug

discovery,developmentandtoxicitytesting. Ilookforwardtomeetingyouattheconference Bestregards

Nicholas Stone Head of Conferences

Who should attend?Presidents, Chief Executive Officers, VPs, Global Heads, Chief Scientific Officers, Directors, Principal Scientists, Franchise Heads and Investigators in:

• High-Throughput/High-Content Screening Operations• Bioanalytical Development • Compound Profiling • Drug Discovery/Validation• Cellular Imaging• Lead Generation• In Vitro Sciences• ADMET• Pre-clinical Development• Medicinal Chemistry• Toxicology• Stem Cell Technologies & Platforms• Pharmacovigilance and Safety Testing• Chemistry and Bioapplications• GPCR/Kinases/Molecular Pharmacology• External/Contract Research• Pharmacokinetics/Pharmacodynamics• Cellular Research and Development• Business Development• Investment and Venture Capital

Associate Sponsor:

InvivoSciencesLLCisafrontierindevelopingnextgeneration3Dcellcultureandassaysystems,providingunprecedentedsolutionsforbiomedicalresearch,cosmetics,discovery,andtoxicologyscreening.Two-dimensionalcellculturesusedduringearlyphaseresearchdonotreflectthereal,internal,3Denvironment,andfalselyindicatepotentialresultsfromanimalstudies.Applicationofourproducts,ahigh-throughput

screeningdevice(PalpatorTM)andplasticconsumablesfor3Dcellculturesystems,cannarrowthisgap.Thesystemprecisely,rapidly,andcost-effectivelyquantifiestheeffectsofdrugcandidates,chemicals,andgeneproductsonthephysiologicalpropertiesofreconstitutedtissues(3Dcellcultures),betterreflectinginvivotissue/organfunctions.For further information please visit: www.invivosciences.com

Lonzaisoneoftheworld’sleadingsupplierstothepharmaceutical,healthcareandlifescienceindustries.Lonza’sBioscienceDivisionprovidesinnovative,reliableproductsandservicesfordrugdiscoverycell

biologyandmolecularbiologyresearchandpreclinicalscreening.Wefocusonprimarycellsupply,includingdiseasedcells,stemcellderivedcells,immortalizedcells,biosensorcells,transfectionofdifficultcellsandcellexpansionservices.Wealsoofferimprovedpredictionfromcellmodels,includingcontextualcell-basedassaysfortoxicityandmechanism-of-actionassessment.WemakereagentproductioneasierforourcustomerswithourCellsonDemand™Servicesandputtingtheassaysyoualreadyuseintobiologicallyrelevantprimarycells.For further information please visit: www.lonza.com

ScottishBiomedicaloffersafullrangeofbiologyservicesfromproteinexpressionandexpressionoptimisationthroughtoinvitroscreening,cellbasedassaysandinvivomodels.Ourteam

willdesignandvalidateuniqueassaystosuityourspecificneeds,usingprimarycellsorcustommadecelllinesofyourchoice.Asexpertsincellsignaling,wespecialiseincell-basedandinvitroassaystodeterminecompoundeffectsontargetssuchasPDEs,HDACs,ionchannels,GPCRs,andkinases.For further information please visit: www.scottish-biomedical.com

HamamatsuPhotonicsisaworld-leadingmanufacturerofoptoelectroniccomponentsandsystemsandprovidessolutionsforawidevarietyofapplicationsincludingimagingdevicesforLife

Sciences.Wewillintroduceourcamera-baseddispensingandimagingrange,theFDSSseriesforfluorescenceandluminescence.TheFDSS7000isafullymodularHTSsystemandtheFDSSµCELLisspecificallydesignedforsmallthroughputandassaydevelopment.BasedonourfamouscamerarangetheFDSSseriesprovideshighsensitivityandfastreadouttimesofafewminutes.For further information please visit: www.hamamatsu.co.uk

MerckMilliporeistheLifeSciencedivisionofMerckKGaAofGermanyandoffersabroadrangeofinnovative,performanceproducts,servicesandbusinessrelationshipsthatenableourcustomers’successinresearch,developmentandproductionofbiotechandpharmaceuticaldrugtherapies.Throughdedicatedcollaborationonnewscientificand

engineeringinsights,andasoneofthetopthreeR&DinvestorsintheLifeScienceToolsindustry,MerckMilliporeservesasastrategicpartnertocustomersandhelpsadvancethepromiseoflifescience.HeadquarteredinBillerica,Massachusetts,thedivisionhasaround10,000employees,operationsin64countriesandproforma2009revenuesof$2.9billion.MerckMilliporeoperatesasEMDMilliporeintheU.S.andCanada.For further information please visit: www.merckmillipore.com

Media Partners:PharmiWeb.comistheleadingindustry-sponsoredportalforthepharmaceuticalsector.Supportedbymostoftheleading

pharmaceuticalcorporations,PharmiWeb.comprovidesdynamicreal-timenews,features,eventslistingsandinternationaljobstoindustryprofessionalsacrossEuropeandtheUS.For further information please email: [email protected]

BIOTECHNOLOGYEUROPEisownedbyBIOTECHNOLOGYWORLD.ItisbasedandlocatedinWarsaw,Poland.BiotechnologyWorldwasfoundedin2007toprovidetheworld’sbiotechandpharma

informationandmarkettomakeituniversallyaccessibleandusefulforscientificandbusinessprocesses.ItsfirststeptofulfillingthatmissionwasbuildingtheBIOTECHNOLOGYEUROPEplatformthatwillallowaquickspreadofinformationindifferentchannels.BIOTECHNOLOGYEUROPEofferscompaniescompletedinternetpublicrelations,publicationandmarketingsolutions.OneofthemainsgoalsofBIOTECHNOLOGYEUROPEistointegratetheBiotechandPharmaSectorinEuropetoglobalbiotechnology,pharmaceuticalandlifescienceactivities.For further information please visit: www.biotechnology-europe.com

FuturePharmaceuticalshasforgedpowerfulrelationshipswithkeyindustryleaderstoprovideaplatformforsuccessfulbrandrecognition,andforseniordecision-makerstohavethemeans

toprocureandplanimplementationstrategiesbasedonthetopicscovered.Positionedtobeanauthoritativeresourcewithintoppharmacompaniesaswellassmall,specialty,andbiotech,FuturePharmaceuticalsmagazineisgearedtocreateadeeppenetrationintoahighlytargetedandresponsiveaudience,bridgingthegapbetweentheindustries’topissuesandthesolutionstop-tiervendorscanprovide.For further information please visit: www.futurepharmaus.com

InPharmistheonlineplatformforexclusivepharmaceuticalnews,comment,contracts,services,jobsandeventsandishometoInPharmjobs.com,PharmafileandPharmafocus.

For further information please visit: www.In-Pharm.com

Driving the Industry Forward | www.futurepharmaus.com

Sponsorship and exhibition opportunitiesThiseventoffersauniqueopportunitytomeetanddobusinesswithsomeofthekeyplayersinthepharmaceuticalandbiotechindustries.Ifyouhaveaserviceorproducttopromote,youcandosoatthiseventby:

•Hostinganetworkingdrinksreception•Takinganexhibitionspaceattheconference•Advertisinginthedelegatedocumentationpack•Providingbrandedbags,pens,gifts,etc.

Ifyouwouldlikemoreinformationontherangeofsponsorshiporexhibitionpossibilitiesforvisiongain's2ndAnnualCell-BasedAssaysConference,pleasecontactus:

Damian Gorman, +44 (0)20 7549 9934 [email protected]

P H O T O N I S O U R B U S I N E S S

Page 3: 2nd Annual Cell Based Assays (2011) Pp

Pre-Conference Interactive Workshop2nd Annual Cell-Based Assays

Tuesday 11th October 2011

Industrial application of pluripotent stem cells and their derivativesHigh-content screening as a valuable tool for drug discovery and toxicity testing

Mikael Englund, SeniorScientist,SiteManager, Cellartis

Daniella Steel, SeniorScientist,ProjectLeader, Cellartis

Paul Andrews, SeniorScientist,DrugDiscoveryUnit, University of Dundee

Petter Björquist, SeniorPrincipalScientist,ProjectManager, Cellartis

Anders Aspegren, SeniorScientist,ProductionManager, Cellartis

Led by:

About your workshop leaders:

Mikael Englund

Mikael Englund has been part of Cellartis’ stem cell team since 2001 and moved to develop UK operations in Dundee 2007. The UK site manufactures large scale volumes of human ESCs and develops advanced culture technology and engineering tools, e.g. for drug screening and other applications. The facility also partners with Novo Nordisk to find a cure for diabetes.

Mikael’s responsibilities at Cellartis have ranged from fundamental hESC research to industrial production of hESCs for screening. He has a large network in the field and more than nine years experience of the challenges of commercial stem cell business. He has a M.Sc. in molecular biology and a Ph.D. in Medicine.

Daniella Steel

Daniella Steel is a senior scientist at Cellartis, within R&D at the Gothenburg site, Sweden. Daniella is involved in the differentiation and application of stem cell-derived cardiomyocytes. Her interests include the innovation and commercialision of stem cell based tools for drug discovery and safety assessment. Through developing industrial applications, Daniella has worked closely with pharmaceutical industry and biosensor technology providers.

Daniella earned her Ph.D. in electrophysiology from the faculty of Medicine, Imperial College, London. Her background in establishing cellular disease models continued with international experience at McGill University, Canada, and at Chalmers University of Technology, Sweden.

Paul Andrews

I obtained a Biochemistry B.Sc and Ph.D in Molecular Biology from the University of Sheffield. In 1993 I moved to the University of Dundee, to pursue my interest in signalling, first using budding yeast and, later, using human cells. Since 2007 I have been leading the Stem Cell Programme in the Drug Discovery Unit at Dundee. I established the high-content screening capabilities and headed several successful screening campaigns using human ES cells or their derivatives. My current interests lie in targeting signalling pathways using small molecules to: engineer cell fate; induce nuclear reprogramming and target cancer stem cells.

Timings: 09:30 Registration and coffee An introduction to pluripotent stem cells, Industrialisation of stem cells Introduction to high-content screening and assay design Screen execution and follow-up12:40 Lunch13:40 Case studies, lessons learnt, Stems cells in predictive toxicology Stem cell derivatives in screening15:00 Panel discussion Q1: How predictive are stem cell based discovery systems? Is there

added value above existing systems? Q2: Are stem cell based platforms compatible with the time lines and

automation systems required in an industrial environment? Q3: What is the future for stem cell based discovery systems in the drug

discovery pipeline

About the workshopDemands for better models of human disease and more predictive screening assays to reduce late stage drug attrition, have promoted a growing interest in applying pluripotent stem cells (PSCs) and their derivatives at various points in the drug discovery pipeline. Furthermore, the use of PSCs in identifying small molecules active in directing cellular reprogramming or differentiation, is a particularly promising tool for the regenerative medicine field. This workshop will review recent advances in the field including issues surrounding cell quality, supply and banking, assay development and the screening process. It will evaluate the benefits of using 3D models, as well as address the efficacy of PSC-based models for assessing human developmental, cardiac and hepatic toxicity. Case studies of different compound screening campaigns using PSCs and their derivatives, will permit exploration of the field in detail.

Lessons learned:• Examples of scaled up pluripotent stem cell culture for industrial applications

• Assay design considerations

• Examination of screening platforms and strategies

• A review of stem cell derivatives for screening

About Cellartis:Cellartis AB is a Swedish/British biotechnology company focused on pluripotent stem cells and technology for drug discovery research, toxicity testing and regenerative medicine. Since 2001, Cellartis has worked globally with industry and academia, platform providers and end users, to develop the next generation of advanced stem cell products and technologies. The company leverages deep experience in stem cell handling, scale up and differentiation into mature and functional human cells. The company was first in the world to bring to the market human embryonic stem (hES) cell-derived hepatocytes and cardiomyocytes for use as drug discovery tools today.

About The Drug Discovery Unit, University of DundeeThe Drug Discovery Unit (DDU) based in the College of Life Sciences at the University of Dundee, is a unique example of academic drug discovery. The remit of the DDU is to tackle high-risk and/or novel targets in areas of unmet medical need. The DDU has all of the capabilities required for early phase drug discovery: from assay development, HTS and cell biology, to medicinal chemistry, structural biology, computational chemistry and ADME/DMPK. All of these capabilities operate under one management structure to ensure an integrated approach and rapid progress.Currently the team is about 30 people and includes substantial experience from the pharmaceutical/ biotech sector. Since 2007 the DDU has collaborated with Cellartis using hES cells and their derivatives in high-throughput screening campaigns, to find small molecules able to manipulate stem cell fate.

Panellists:

Page 4: 2nd Annual Cell Based Assays (2011) Pp

09:00 Registration and refreshments

09:30 Opening address from the Chair Rachel Russell

Director,PrimaryPharmacologyGroupPfizer

09:40 Impact of new technologies for cellular screening along the drug value chain

•Primary,stemcell,3Dandlabel-freescreensemployingcellularassays •Ionchannelscreening •Atomicforcemicroscopyindrugdiscoveryanddevelopment

Mark Slack, GroupLeader,CellularAssays,Evotec

Clemens Möller, ProfessorofBiophysics,Albstadt-Sigmaringen University

10:20 A novel, rapid and automated method for creating 3D tissue models to study complex cell behaviour

•Whattypeofinformationcan3Dtissuemodelsprovide? •Whatispreventingwidespreadadoptionof3Dtissuemodels? •Theroutetoscalableandtuneable3Dtissuemodels

Rosemary Drake ChiefScientificOfficerTAP Biosystems

11:00 Morning refreshments

11:20 Unlocking the potential of 3D cell culture with Alvetex technology

•2Dvs3Dcellculture •Developmentofuniquescaffold •Optimizingroutine3Dcellculture

Stefan Przyborski FounderandChiefScientificOfficerReinnervate

11:40 Application of a 3D tumour cell culture model to compound screening

•Threedimensionalgrowthassayandimageanalysis •Plate-based,label-free,high-contentanalysisevaluation •Screeningvalidationandpre-clinicalresults

Miroslav Cik ResearchFellowJanssen Pharmaceutica (Johnson & Johnson)

12:20 Integration of label-free detection methods in GPCR drug discovery

•Comparisonofimpedanceandopticalread-outs •RecombinantcellsvsendogenousGPCRsignalling •Nativereceptoractivityindisease-relevantcells

Magdalena Birker-Robaczewska SeniorLabHead,Cardiovascular&FibrosisBiologyActelion Pharmaceuticals

13:00 Networking lunch

14:00 Rapid non-invasive analysis of live cells •GlobalfingerprintingofcellswithlivecellRamanspectroscopy •Applicationsintoxicology •Applicationsincelldifferentiation

Molly Stevens ProfessorofBiomedicalMaterialsandRegenerativeMedicineImperial College London

14:40 Label-free methods- where are we and what are the prospects for the future?

Despitetheirincreasingimportance,whenwillitbecommerciallyviabletointegratenon-invasivemethodsintoHTscreening?Canrelevantquantitiesofprimarycellsbesecuredtoenablethis?Theutilityoflabel-freemethodstoreduceattritionratesandtheconditionsnecessarytoobtainreal-time,quantitativemeasurementswillbethoroughlyassessed.Jointhislivelysessionandemailyourquestionsto:[email protected].

Chair: Magalie Rocheville,Investigator,GlaxoSmithKline

Mark Slack, GroupLeader, Cellular Assays, Evotec

Miroslav Cik, ResearchFellow,Janssen Pharmaceutica (Johnson & Johnson)

Molly Stevens, ProfessorofBiomedicalMaterialsandRegenerativeMedicine,Imperial College London

15:20 Development of cell-based methodologies relevant to ion channel drug discovery

•Directandindirectmeasurementofligand-andion-gatedchannelsinrecombinantlines

•Electrophysiologyusingstemcellderivedneurons •Nativetissueelectrophysiology

Fiona Harris SeniorScientistScottish Biomedical

15:40 Afternoon refreshments

16:00 Development of a multiplexed gene expression assay in primary neurons

•Quantificationofcompound-inducedchangestoexpressionofpain-relatedgenes •Challengesofusingnativeneuronalcellsasreagentsforprimaryscreening •Applicationoftheassayforcompoundprofilingandnewtargetidentification

Darren Cawkill AssociateDirector,PrimaryPharmacologyGroupPfizer

16:40 The FDSS series: a versatile platform for HTS and assay development

•Primarycultureandcelllineassaysinfluorescenceandluminescence •Wholedispensingandimagingscreeningsystemsforcell-basedassays •Applications:newepilepsymodelandluminescencemultiplexing

Christelle Catone FDSSApplicationScientist,SystemsDivisionHamamatsu Photonics

17:00 Executable cell biology •Mathematicalversuscomputationalmodels •Modelsforexecutablebiology •Challengesfortestingdynamicsincomplexsystems

Jasmin Fisher Researcher,ExecutableBiologyMicrosoft Research Cambridge

17:40 Closing remarks from the Chair

17:50 Networking drinks Take your discussions further and build new

relationships in a relaxed and informal setting

Day 12nd Annual Cell-Based Assays

Wednesday 12th October 2011

Due to unforeseen circumstances the programme may change and visiongain reserves the right to alter the venue and/or speakers c Copyright visiongain Ltd, 2011

PAN

EL D

ISC

USS

ION

Page 5: 2nd Annual Cell Based Assays (2011) Pp

Day 22nd Annual Cell-Based AssaysThursday 13th October 2011

09:00 Registration and refreshments

09:30 Opening address from the Chairs Joanne Bowes

PrincipalScientist/TeamLeader,SafetyandSecondaryPharmacologyAstraZeneca

09:40 Early toxicity testing: prediction and tissue-specific models

•Earlytoxicitytestingparadigms •Cellularmodelsfortoxicitytesting,focusingontheliver,lungandheart •Predictionmodelsusingglobalexpressionprofiling

Stefan Otto Mueller Director,Early,GeneticandMolecularToxicologyMerck Serono

10:20 Protein-fragment complementation assays and compound profiling

Anthony Pitt TechnicalDirectorAssaysandTechnologyDevelopmentLonza

10:40 Key considerations in the development of stem cell assays in predictive toxicology

•Theneedforimproveddrugscreeningmodelstopredictriskforman •Prerequisitesforsuccessfuldevelopmentofstemcellsassaysintoxicitytesting •SC4SMPredictiveToxicologyConsortium:challengesand

futureopportunities

Frank W. Bonner ChiefExecutiveStem Cells for Safer Medicines

11:20 Morning refreshments

11:40 Therapeutic and research potential of human stem cells (hSCs) – the GE Healthcare perspective

•HowhSCswillrevolutionisemedicalcarethroughregenerativestrategies •HowhSCswillimprovequality,priceandaccessibilityofnewpharmaceuticals •MaximisinghSCuseinbigpharmadrugdiscoveryandsafetyassessmentstudies

Stephen Minger GlobalHeadofR&D,CellularTechnologiesGE Healthcare

12:20 Human pluripotent stem cells (hPSCs) and their use in drug discovery and cellular assays

•Importanceofscaleablesystemsforindustrialstemcellproduction •CellulartoxicitytestingusinghPSCderivedcardiomyocytesandhepatocytes •hPSCtechnologiescomparedtotraditionalinvitroandinvivoassays

Petter Björquist SeniorPrincipalScientist,ProjectManagerCellartis

13:00 Networking lunch

14:00 Enabling technology to enhance cell differentiation and function in vitro

•Celldifferentiationin3DcultureusingprimaryMSCsandpluripotentstemcells •Developmentofsmallmoleculestocontrolreproduciblehumanneural

differentiationinvitro •Useofsmallmoleculestodifferentiatea3Dskinequivalentmodelwith

humankeratinocytes

Stefan Przyborski FounderandChiefScientificOfficerReinnervate

14:20 Predicting idiopathic cardiotoxicity with 3D heart tissues: combining rodent and human models

•Cardiaccontractilityresponsetoapanelofcardio-toxicdrugswithiPSCandESCbased3Dengineeredhearttissues

•Cost-effectiveandthemostpredictivescreeningapproach •Identifyingidiopathiccardiotoxicitymechanismsforsearchingpreventive

strategies

Tetsuro Wakatsuki Co-FounderandChiefScientificOfficerInvivoSciences

14:50 Generating metabolically active hepatocytes from pluripotent stem cells

•Stemcellsofferanunlimitedsourceofhepaotcytesforhumandrugscreening •Stemcellderivedhepatocytesexhibitphenotypicinstabilityinculture •Wehaveidentifiedanovelsupportwhichstabiliseshepatocellularphenotype

David C. Hay PrincipalInvestigator,MRCCentreforRegenerativeMedicineUniversity of Edinburgh

15:30 Afternoon refreshments

15:50 Opportunities and challenges for human stem cells in drug screening

WillhESandhPS/iPS-derivedspecialisedcellsbetterreflecthumanvariationtotoxicagentsandmatchbiologicalpossibilitieswithend-userconstraints?Canidiopathicandethniclibrariesaidpatientstratification,orwillcellularmodelsremainoversimplifications?Whatnewinsightswillorganogenesisanddiseasemodelsprovide?Answerstotheseandothermatters,includingregulatoryrequirementsandup-scalingforrobustindustrialproductionwillbeaddressed.Pleaseemailyourquestionsforthepanelto:[email protected].

Chair: Julie Holder, PreclinicalDirector,StemCellDPU,GlaxoSmithKline

Stephen Minger, GlobalHeadofR&D,CellularTechnologies,GE Healthcare

Petter Björquist, SeniorPrincipalScientist,ProjectManager,Cellartis

Frank W. Bonner, ChiefExecutive,Stem Cells for Safer Medicines

David C. Hay, PrincipalInvestigator,MRCCentreforRegenerativeMedicine,University of Edinburgh

16:30 Chair’s closing remarks

16:40 End of conference

PAN

EL D

ISC

USS

ION

Page 6: 2nd Annual Cell Based Assays (2011) Pp

How to bookEmail:[email protected] Web:http://www.visiongain.com/cell-based-assays

UK Office:Tel: +44 (0) 20 7549 9961 Fax:+44(0)2075499932 VisiongainLtd230CityRoadLondonEC1V2QYUK

General informationVenue:Venue:Directions:VisiongainConferenceCentre230CityRoad,London,EC1V2TT.UnitedKingdom.ClosesttubestationisOldStreet(NorthernLine).Accommodation:ThistleCityBarbican,CentralStreet,Clerkenwell,London,EC1V8DS,Phone:08713769004/+448453058304,Fax:08713769104/+448453058343http://www.thistle.com/en/hotels/united_kingdom/london/thistle_city_barbican/index.htmlTravelodgeLondonCityRoadHotel,7-12CityRoad,London,EC1Y1AE,Tel:08719846333,Fax:02076282503,http://www.travelodge.co.uk/search_and_book/hotel_overview.php?hotel_id=340

Payment terms:Visiongainrequirethefullamounttobepaidbeforetheconference.VisiongainLtdmayrefuseentrytodelegateswhohavenotpaidtheirinvoiceinfull.Acreditcardguaranteemayberequestedifpaymenthasnotbeenreceivedinfullbeforetheevent.VisiongainLtdreservestherighttochargeinterestonunpaidinvoices.

Substitutions/name changes or cancellations: Thereisa50%liabilityonallbookingsoncemade,whetherbypost,fax,emailorweb.Thereisanorefundpolicyforcancellationsreceivedonorafteronemonthbeforethestartoftheevent.Shouldyoudecidetocancelafterthisdate,thefullinvoicemustbepaid.Conferencenoteswillthenbesenttoyou.Unfortunately,weareunabletotransferplacesbetweenconferences.However,ifyoucannotattendtheconference,youmaymakeasubstitution/namechangeatanytime,aslongasweareinformedinwritingbyemail,faxorpost.Namechangesandsubstitutions must be from the same company or organisation and are not transferable betweencountries.Pleasenotethatdiscounteddelegatesplacesatavisiongaineventarenonrefundable.

Invoice alterations:Therewillbeanadministrationchargeof£50foranychangestoaninvoice,excluding substitutions/name changes, requested by the customer. This will be charged to thecustomerbycreditcardpriortothechangesbeingmade.

Indemnity: Visiongain Ltd reserves the right to make alterations to the conference/executivebriefingcontent,timing,speakersorvenuewithoutnotice.TheeventmaybepostponedorcancelledduetounforeseeneventsbeyondthecontrolofvisiongainLtd.Ifsuchasituationarises,wewilltrytorescheduletheevent.However,visiongainLtdcannotbeheldresponsibleforanycost,damageorexpenses,whichmaybeincurredbythecustomerasaconsequenceoftheeventbeingpostponedorcancelled.Wethereforestronglyadviseallourconferenceclientstotakeoutinsurancetocoverthecostoftheregistration,travelandexpenses.

Data Protection: Visiongain Ltd gathers and manages data in accordance with the DataProtectionAct1988.YourpersonalinformationcontainedinthisformmaybeusedtoupdateyouonvisiongainLtdproductsandservicesviapost,telephone,faxoremail,unlessyoustateotherwise.Wemayalsoshareyourdatawithexternalcompaniesofferingcomplementaryproductsorservices.Ifyouwishforyourdetailstobeamended,suppressedornotpassedontoanyexternalthirdparty,pleasesendyourrequesttotheDatabaseManager,visiongainLtd,BSGHouse,226-236CityRoad,London,EC1V2QY.Alternatively,youcanvisitourwebsiteatwww.visiongain.comandamendyourdetails.Pleaseallowapproximately30daysforyourremovalorupdaterequesttobeappliedtoourdatabase.Followingyourremovalorupdaterequest,youmayreceiveadditionalpiecesofcommunicationfromvisiongainLtdduringthetransitionalperiod,whilstthechangesarecomingintoeffect.

Fee: Theconferencefeeincludeslunch,refreshmentsandconferencepapersprovidedontheday.This feedoesnot include travel, hotel accommodation, transfersor insurance, (whichwe stronglyrecommendyouobtain).

VAT: VATwillbechargedatthelocalrateoneachconference.DelegatesmaybeabletorecoverVATincurredbycontactingEurocashCorporationplc+44(0)1273325000,eurocash@eurocashvat.com.Eurocashspecialiseinrecoveringcross-borderVAT.

How we will contact you: VisiongainLtd’spreferredmethodofcommunicationisbyemailandphone.Pleaseensurethatyoucompletetheregistrationforminfullsothatwecancontactyou.

Unable to attendObviouslynothingcomparestobeingtherebutyouneednotmissout.Simplyticktheboxandsendwithyourpayment.YouwillreceivespeakertalksinPDFstwoweeksaftertheevent.

Yes, please send me speaker talks Price£550 VAT:£110 Total:£660

Conf.codePP

Standard PricesConference and workshop Fee: £1699 VAT: £339.80 Total: £2038.80

Conference only Fee: £1299 VAT: £259.80 Total: £1558.80

Workshop only Fee: £599 VAT: £119.80 Total: £718.80

Number of bookings: Total cost:

Promotional Literature DistributionDistribution of your company’s promotional literature to all conference attendees

Fee: £999 VAT: £199.80 Total: £1198.80

Details

Forename: Surname:

JobTitle: Company:

MainSwitchboardNumber:

Address:

Country: Postcode:

Phone: Fax:

Email:

Signature:

IconfirmthatIhavereadandagreetothetermsandconditionsofbooking

Methods of payment

Paymentmustbemadeinsterling

By Mail: Completeandreturnyoursignedregistrationformtogetherwithyourchequepayable

toVisiongainLtdandsendto:visiongainLtd,BSGHouse,226-236CityRoad,London,EC1V2QY,UK

By Fax: Completeandfaxyoursignedregistrationformwithyourcreditcarddetails

to+44(0)2075499932

By Phone:Calluson+44(0)2073366100withyourcreditcarddetails

By Credit Card:Fillinyourcarddetailsbelowandfaxbackto+44(0)2075499932

By Bank Transfer:

VisiongainLtd A/C:visiongainLtd

BarclaysBank SortCode:20-71-64

PiccadillyBranch AccountNo:60387118

48RegentStreet SwiftCode:BARCGB22

London,W1B5RA IBAN:GB80BARC20716460387118

Please debit my credit card:

Access MasterCard Visa AmericanExpress

Cardnumber:

ExpiryDate:

Securitynumber(last3digitsonbackofcreditcard):

Signature:

Cardholder’sname:

News updates

Pleasetickifyoudonotwanttoreceiveemailnewsupdatesinthefuture

Registration Form2nd Annual Cell-Based Assays

11th - 13th October 2011, London, UK

www.visiongain.com/cell-based-assays

2nd Annual Cell-Based Assays 11th - 13th October 2011Location:VisiongainConferenceCentre

Address:230CityRoadLondonEC1V2TTUK

City Road

Old Street

City Road

Pentonville Road

Old Street

Angel