27th annual0 may...general medicine 2 proinsulin misfolding is an early event in the progression to...

MEDICINE

SYMPOSIUM

INTERNAL

RESEARCH

27th Annual M AY9 1 0

KEYNOTE SPEAKER

GUILLERMO E. UMPIERREZ, MD, CDE Professor of Medicine Division of Endocrinology and Metabolism Emory University School of Medicine Chief of Diabetes and Endocrinology Grady Memorial Hospital

Dr. Umpierrez is a professor of medicine in the Division of Endocrinology and clinical director

of the Diabetes and Metabolism Center at Emory University School of Medicine, and director of the diabetes and endocrinology section and clinical research unit at Grady Memorial Hospital, Atlanta, Georgia. Dr. Umpierrez is the recipient of numerous teaching awards for Best Clinical Teacher and Best Mentor of Endocrine Fellows and Junior Faculty at Emory University, as well as national awards from the ACP, AACE and ADA. He is a member of AACE Diabetes Scientific Council and Board of Directors of AACE, Chair of the Global Task Force and member of the Endocrine Society Council, and member of the ADA Professional Practice Recommendation Committee. He is the Editor-in-Chief of the Editor-in-Chief of the BMJ Open Diabetes Research & Care and the Editor-in-Chief of the ADA Medical Management of Diabetes clinical series. He has published more than 260 scientific manuscripts and book chapters, and has presented over 250 abstracts at national and international scientific meetings.

DEPARTMENT OF INTERNAL MEDICINE

2 7 t h A n n u A l R e s e A R c h s y m p o s i u m

Poster # Abstract Title Presenter

1 Tobacco Use Is Associated With Increased Left Ventricular and Ascending Aortic Size Daniel Chun

2 Real-World Application of Next Generation Sequencing to Guide Therapeutic Options in Lymphoma Molly Tokaz (1)

3 Doing More With Less: Optimizing Add-On Labs (Part 1) Khalid Abdul Majeed

4 Doing More With Less: Optimizing Add-On Labs (Part 2) Kaitlyn Vitale

5 Sensitivity and Specificity of D-Dimer for Venous In-Stent Stenosis Andrew Badalamenti

6Polypharmacy and Potentially Inappropriate Medication Use Are Universal Among Patients With Heart Failure With Preserved Ejection Fraction

Lina Brinker

7 Mind the Gap: Addition of the Anion Gap to Results Review Katie Chakrabarti

8 Risk Factors, Management, and Outcomes Among Pregnant Women With Atrial Fibrillation

Maya Dassanayake

9 Colorectal Neoplasia in Lynch Syndrome Patients Henry Dust

10 Long Term Biochemical Follow Up in Sporadic and Hereditary Medullary Thyroid Carcinoma At the University of Michigan

Matthew Ettleson

11Mood Disorders Do Not Appear to Impact Discontinuation of Chronic Pharmacotherapy for IBS With Constipation and Chronic Constipation

Jessica Jou

12 Sarcomere Gene Mutation Hypertrophic Cardiomyopathy Exhibits Distinct Age-Dependent Adverse Remodeling Samat Kabani

13 Examining Attitudes and Preferences of Chinese Medical Students and Residents Towards International Rotations Mark Kluk

14 Near-Peer Led Outpatient Teaching and Resident Confidence Kayla McAleenan

THURSDAY, MAY 9, 2019

Towsley Dining Room - Resident Research Symposium1:00-5:00 pm Electronic Poster Presentations

Poster # Abstract Title Presenter

15 Pain Location and Widespread Pain in Youth With Orthopedic Conditions: Exploration of the Reliability and Validity of a Body Map Anne Murphy

16 Improving MRI Wait Times: Making Stat Actually Stat Jackson Murrey-Ittmann

17Prevalence and Characteristics of Systemic Sclerosis-Associated Interstitial Lung Disease - Analysis From the University of Michigan Scleroderma Cohort

Annie Park

18 Treatment and Genetic Counseling Implications of Mioncoseq Analysis In Lymphoma Anthony Scott

19 Design and Evaluation of an Evidence -Based Clinical Adjudication Tool For the Diagnosis of Bacterial Pneumonia Ginny Sheffield

20 Variation in Cardiac Rehabilitation Referrals Following Cardiac Intensive Care Unit Admissions Michael Sola

21 Characteristic MRI Findings in Immunotherapy-Treated Melanoma Patients With Brain Metastases Receiving Stereotactic Radiosurgery Justin Sovich

22 Limited Progress in Hepatorenal Syndrome (HRS) Reversal and Survival 2002-2016 Arthur Taylor

23 Feasibility and Impact of a Visual Arts Curriculum Imbedded Within a Clinical Clerkship: A Randomized, Controlled Trial Molly Tokaz (2)

24 Liver Injury During Pembrolizumab Treatment Is Most Commonly Due To Hepatic Metastases Rather Than Drug-Induced Hepatotoxicity Irene Tsung

25 A Novel Post-Dilution CVVHDF-RCA With Personalized Initial Calcium Dosing and Fixed Citrate To Blood Flow Ratio Benjamin Wagner

26 Incidence of Prematurely Terminated MRI Exams Catherine Wilson

27 Effect of Required Rapid Response Evaluation in Pediatric Intensive Care Admissions Jessica Wummel

28 Genotype-Phenotype Analysis of 523 Patients By Genetics Evaluation and Whole Exome Sequencing Mark Ziats



THURSDAY, MAY 9, 2019



Ford Lobby9:00 am CONTINENTAL BREAKFAST / PLENARY POSTER SESSION

Ford Auditorium10:00 WELCOME AND OPENING REMARKS John Carethers, MD, MACP Benjamin Margolis, MD

10:05 PLENARY SPEAKER SESSION

12:00 pm

Towsley Lobby1:00 POSTER SESSION - REFRESHMENTS

FRIDAY, MAY 10, 2019

Alveolar Macrophage-Derived Extracellular Vesicles Defend Against Influenza Infection of Epithelial Cells. Daniel Schneider, MD PhD, Pulmonary & Critical Care MedicineFibro-Adipogenic Remodeling of the Diaphragm in Obesity-Associated Respiratory Dysfunction Eric Buras, MD, PhD, Metabolism,Endocrinology & DiabetesForced Vital Capacity Trajectories for Systemic Sclerosis-Associated Interstitial Lung Disease — Analysis from the University of Michigan Scleroderma Cohort Mirette Habib, BS, RheumatologyIn a Murine Model of Oxygen-Induced Lung Injury, Lung Inflammation Correlates with Gut Bacterial Diversity Blake Haller, MD, MPH, Residency ProgramGenome-Wide DNA Methylation Analysis in Primary Antiphospholipid Syndrome Neutrophils Emma B. Weeding, MD, Residency ProgramGenotyping of Young Onset Colorectal Cancers Reveals Novel NOTCH1 Variants Anand Venugopal, MD, PhD, Residency ProgramGlobal RNA Sequencing of T Cells After Hematopoietic Stem Cell Transplant Identifies Linc00402 as a Novel Regulator of Mouse and Human T Cell Function Daniel Peltier, MD, PhD, Hematology & OncologyMegakaryocyte Ablation Ameliorates Bone Marrow Fibrosis by Reducing Myofibroblast Differentiation in a Mouse Model of Primary Myelofibrosis Yutein Chung, PhD, Hematology & OncologyMultidrug-Resistant Organism Burden of Common Area and Rehabilitation Equipment Surfaces in Skilled Nursing Facilities Kyle Gontjes, BS, Geriatric & Palliative Medicine

“Management of Hyperglycemia and Diabetes in Hospitalized Patients” Guillermo E. Umpierrez, MD, CDE Professor of Medicine Division of Endocrinology and Metabolism Emory University School of Medicine Chief of Diabetes and Endocrinology Grady Memorial Hospital

KEYNOTE ADDRESS - GRAND ROUNDS - LUNCH ANNUAL STEPHEN FAJAN LECTURE





Towsley Dining Room / Sheldon Auditorium2:00 RESIDENT ORAL COMMUNICATIONS Towsley Dining Room Low Neutrophil to Lymphocyte Ratios (NLR) & High Lymphocyte to Monocyte Ratios (LMR) Associated With Improved Overall Survival & Response to Induction Chemotherapy (IC) When Used to Select Patients (Pts) With Locally Advanced Squamous Cell of the Larynx (LSCC) for Combined Chemoradiation (CRT) Zachary Risch, MD

Maintenance Sorafenib in FLT3-LTD Acute Myeloid Leukemia Following Allogeneic Hematopoietic Cell Transplant Favorably Impacts Relapse and Overall Survival Marcus Geer, MD

When Perception is Reality: An Assessment of the Representation of Women on an Internal Medicine Residency Program Teaching Faculty Nicole Hadeed, MD

PTDM in Lung Transplant: Prevalence and Outcomes Thomas Hurst, MD

Retrospective Study of Neurologic, Behavioral, and Ophthalmologic Side Effects of Dinuxutimab Therapy at a Single Institution Hannah Lust, MD

What Happens During Outpatient Visits Immediately Prior to Sepsis Hospitalization? H. Catherine Miller, MD

Specialty-Based Variability in Diagnosing and Managing Heart Failure With Preserved Ejection Fraction David Saxon, MD

Patients’ Perspectives on Enrollment in Research Using the Exception From Informed Consent: An Integrated Survey Victoria Scicluna, MD, MPH

Evaluating Why and When Patients Discontinue Chronic Therapy for IBS With Constipation and Chronic Constipation: A Real-World Experience Suraj Suresh, MD

Escherichia Coli Heat-Stable Toxin Impairs Colonic Epithelial Barrier Function Via CGMP-Induced Oxidative Stress, Apoptosis, and NF-ΚB Activation Johnny Zheng, MD

Sheldon Auditorium Explaining the Process of Determining Futility Increases Lay Public Acceptance Kunal Bailoor, MD

“Two Will Do” – A Nuanced Alert to Reduce Daily Phlebotomy Christopher Grondin, MD

Variation in and Resident Perception of Code Status Ordering Across Specialties Emily Jacobson, MD Bedside Ultrasound: How Senior Residents Learn to Rule Out Life Threatening Diagnoses Kayla Kolbe, MD Dermatomyositis Skin Shares Type 1 Interferon Overlap With Cutaneous Lupus But Displays Many Unique Expression Changes That May Serve as Biomarkers for Skin Disease Tori Nault, MD

Atorvastatin May Be Associated With a Lower Risk of Discontinuation Due to Muscle Pain and/or Weakness Compared With Other Statins Daniel Perry, MD

Association Between Increasing Tidal Volume Exposure and Mortality in Patients Receiving Invasive Mechanical Ventilation David Rose, MD

Breakthrough Invasive Fungal Infections (IFI) in Acute Leukemia (Al) Patients Receiving Antifungal Prophylaxis Anastasia Wasylyshyn, MD

Do Computed Tomography Scans Improve the Reliability of the Acute Respiratory Distress Syndrome Diagnosis? Max Wayne, MD

FRIDAY, MAY 10, 2019

Poster # Plenary Poster Session Presenter

P1 Relationship Between Diffusion Capacity and Small Airway Abnormality in COPDGene

Rachel Criner, MD Residency Program

P2 Functional investigation of disease-associate regions in the diabetes protein Clec16a

Morgan Gingerich, PhD Candidate MEND

P3 Sec23b-dependent COPII Pathway in T cells Regulates Immunity

Stephanie Kim, BS Hematology & Oncology

P4 Lamin mutations in familial partial lipodystrophy point to phosphorylation as a therapeutic target

Eric Lin, MD Gastroenterology & Hepatology

P5The Use of Quantitative Morphometrics in Nephrectomy Specimens to Understand Focal Segmental Glomerulosclerosis

Christopher O'Connor, BSNephrology

P6Kruppel-like factor 4 (KLF4): a brake on fibroblast activation and a target for pharmacologic induction in pulmonary fibrosis

Loka Penke, PhD Pulmonary & Critical Care Medicine

P7 Is Sucrase-Isomaltase Deficiency an Under-Recognized Cause of IBS-D Symptoms?

Stephen G. Simmer, MD Residency Program

P8Staphylococcus aureus colonization is increased on lupus skin lesions and is promoted by interferon-mediated barrier disruption

Sirisha Sirobhushanam, PhDRheumatology

P9Alveolar macrophage secretion of vesicle-encapsulated suppressor of cytokine signaling 3: inhibitor of tumor cell function and platform for therapeutics in lung cancer

Jennifer Speth, PhD Pulmonary & Critical Care Medicine

P10 Toll-like Receptor 7 Agonism as a Model of Antiphospholipid Syndrome in BALB/c Mice

Kristen Gilley Rheumatology

P11Ultrasensitive Genomic Minimal Residual Disease Detection in Peripheral Blood after Allogeneic HSCT for MDS Is Associated with Increased Relapse Risk and Inferior Survival

Leo Thompson Hematology & Oncology

P12 Improving Transitions of Care for Acute Myocardial Infarction (AMI) Patients

Raymond Y. Yeow, MD Residency Program



Plenary Poster Session - Ford Lobby, 9:00 -10:00 am

Poster # Poster Title Presenter

1 VTE Prophylaxis Varies Widely Between Specialties in Setting of Intracranial Bleeding and Malignancy

Christina Arens, BS General Medicine

2 Proinsulin Misfolding is an Early Event in the Progression to Type 2 Diabetes

Anoop Arunagiri, PhD MEND

3

Low Rates of Influenza Vaccine and Higher Occurrence of Acute Type A Aortic Dissection in the Winter Months - a call for action to incorporate influenza vaccine into preventive strategies for high risk patients

Carmel Ashur, MD Cardiovascular Medicine

4 Altered alveolar macrophage expression of Axl and Mertk in COPD: SPIROMICS Immunophenotyping Sub-study

Melissa Bates, PhD Pulmonary & Critical Care Medicine

5 Airway Microbiota Demonstrate Increased Growth Rates Upon Exposure to Corticosteroids Used to Treat Chronic Airway Disease

Lesa Begley, MS Pulmonary & Critical Care Medicine

6Polypharmacy and Potentially Inappropriate Medication Use Are Universal Among Patients With Heart Failure With Preserved Ejection Fraction

Lina Brinker, MD General Medicine

7 Patterns of Care in the Management of Eosinophilic EsophagitisJoy Chang, MD, MS Gastroenterology & Hepatology

8 Medicaid Expansion and Prescription Trends: Opioids, Addiction Therapies, and Other Drugs

Benjamin Cher, MS General Medicine

9 In vivo islet imaging reveals that GLP-1 paradoxically increases insulin content

Corentin Cras-Méneur, PhD MEND

10 Interferon alpha negatively regulates reactive oxygen species in the skin.

Shannon Estadt, BS Rheumatology

11 Interruption of Warfarin for Low-Risk ProceduresAustin Foote, BS Cardiovascular Medicine

12 Improving vein graft durability through the vascular ectonucleotidase CD39

Brianna Giese Cardiovascular Medicine

13 Identification of host-microbial interaction networks that mediate intestinal epithelial barrier function in necrotizing enterocolitis

David Hill, PhD Gastroenterology & Hepatology



Poster Session - Towsley Lobby, 1:00-2:00 pm

Poster # Plenary Poster Session Presenter

P1 Relationship Between Diffusion Capacity and Small Airway Abnormality in COPDGene

Rachel Criner, MD Residency Program

P2 Functional investigation of disease-associate regions in the diabetes protein Clec16a

Morgan Gingerich, PhD Candidate MEND

P3 Sec23b-dependent COPII Pathway in T cells Regulates Immunity

Stephanie Kim, BS Hematology & Oncology

P4 Lamin mutations in familial partial lipodystrophy point to phosphorylation as a therapeutic target

Eric Lin, MD Gastroenterology & Hepatology

P5The Use of Quantitative Morphometrics in Nephrectomy Specimens to Understand Focal Segmental Glomerulosclerosis

Christopher O'Connor, BSNephrology

P6Kruppel-like factor 4 (KLF4): a brake on fibroblast activation and a target for pharmacologic induction in pulmonary fibrosis

Loka Penke, PhD Pulmonary & Critical Care Medicine

P7 Is Sucrase-Isomaltase Deficiency an Under-Recognized Cause of IBS-D Symptoms?

Stephen G. Simmer, MD Residency Program

P8Staphylococcus aureus colonization is increased on lupus skin lesions and is promoted by interferon-mediated barrier disruption

Sirisha Sirobhushanam, PhDRheumatology

P9Alveolar macrophage secretion of vesicle-encapsulated suppressor of cytokine signaling 3: inhibitor of tumor cell function and platform for therapeutics in lung cancer

Jennifer Speth, PhD Pulmonary & Critical Care Medicine

P10 Toll-like Receptor 7 Agonism as a Model of Antiphospholipid Syndrome in BALB/c Mice

Kristen Gilley Rheumatology

P11Ultrasensitive Genomic Minimal Residual Disease Detection in Peripheral Blood after Allogeneic HSCT for MDS Is Associated with Increased Relapse Risk and Inferior Survival

Leo Thompson Hematology & Oncology

P12 Improving Transitions of Care for Acute Myocardial Infarction (AMI) Patients

Raymond Y. Yeow, MD Residency Program




14 Effect of Cytochrome b5 on the 17,20 Lyase Activity of Human Cytochrome P450 17A1

Sangchoul Im, PhD MEND

15Impact of 6th World Symposium on Pulmonary Hypertension on the Definition of Pulmonary Arterial Hypertension: Analysis of Two Scleroderma Cohorts

Sara Jaafar, MD Rheumatology

16Characteristics of Early Disease in Systemic Sclerosis-associated Interstitial Lung Disease — Analysis from UM Scleroderma Cohort

Sara Jaafar, MD Rheumatology

17 The LD Lync Study: Natural History Study of Lipodystrophy Syndromes

Abdelwahab Jalal Eldin, MBBS, MS MEND

18 Eccrine Porocarcinoma - Avoiding the Misadventure Christine Jarocki, DPM MEND

19Small Intestinal Bacterial Overgrowth is Common in Chronic Pancreatitis (CP) and Associated with Diabetes, CP Severity, Low Zinc Levels, and Opiate Use

Allen Lee, MD Gastroenterology & Hepatology

20Identifying Differences in Demographics, Management, and Outcomes between Type 1 and Type 2 NSTEMI Patients

Madeline Leyden, Cardiovascular Medicine

21 Expression and Function of A Novel Citrullinated Form of Interleukin 6 In Rheumatoid Arthritis

Chenyang Lu, MD PhD Rheumatology

22 Analysis of Quality Measures Before and After Switching Care Models in MAQI2 Anticoagulation Clinics.

Joey Maniaci, Cardiovascular Medicine

23 Support Opportunities for Second Victims (SOS) Ruby Marr, MD General Medicine

24Multicenter Double-Blind, Proof-of-Concept, Randomized Placebo-Controlled Trial of Riociguat in Systemic Sclerosis-associated Digital Ulcers

Vivek Nagaraja, MBBS Rheumatology

25Use of handheld device to enhance patient reported outcome measures (PROMIS®) data collection in rheumatology clinics

Vivek Nagaraja, MBBS Rheumatology

26Gender-Specific Differences in Behavioral and Physiological Risk Factors Associated with Childhood Obesity

Liliana Pfeifer, Cardiovascular Medicine



General Poster Session - Towsley Lobby, 1:00-2:00 pm


27 New Murmur of Aortic Insufficiency in Acute Aortic Dissection Stephen Philip, MD Cardiovascular Medicine

28Predictors of Clinical Outcomes in Patients Diagnosed with Cardiac Sarcoidosis in the International Cardiac Sarcoidosis Consortium Registry

Eric Puroll, BS Cardiovascular Medicine

29 The Role of the CD6-CD318 Interaction in the Immune Response to Human Carcinomas

Stephanie Rasmussen, BS Rheumatology

30 Exemplar-based Classification of Subsets in Systemic Sclerosis-associated ILD

David Roofeh, MD Rheumatology

31 The IRE1-α pathway mediates neutrophil stress and NETosis in lupus

Gautam Sule, PhD Rheumatology

32 The Great Imposter: A Case Study of Classic Kaposi Sarcoma Misdiagnosed as a Diabetic Foot Ulcer in an Atypical Patient

Garneisha Torrence, DPM MEND

33Differential Post-Translational Modification of Polymorphic MSH3 and Novel Binding Partner Nemo Is Associated with Its Nuclear-To-Cytosol Shuttling

Stephanie Tseng-Rogenski, PhD Gastroenterology & Hepatology

34A potential gene therapy for cardiac disease: exogenously expressed antibody fragments targeting cardiac potassium channels

Chiamaka Ukachukwu, MS Cardiovascular Medicine

35Disruption of Endosomal Trafficking of Membrane Bound Nephrin Results in an Earlier Phenotype in Nephrin Deleted Adult Mice.

Rakesh Verma, PhD Nephrology

36 Murine Modeling of Deployment-Related Chronic Bronchiolitis by Conditional Depletion of Airway Club Cells

Steven Viglianti, BS Pulmonary & Critical Care Medicine

37 Experimental microRNA target gene discovery and relevance for human disease

Debra Walter, PhD Nephrology

38 Monocyte-dependent Interleukin-6 Trans-signaling Induces Lung Allograft Fibrosis

David Wheeler, MD, PhD Pulmonary & Critical Care Medicine



General Poster Session - Towsley Lobby, 1:00-2:00 pm

27th annual0 may...general medicine 2 proinsulin misfolding is an early event in the progression to...

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