Vol. 269, No. 2 The Journal of January 14, 1994

Biological Chemistry Copyright 0 1994 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 U.S.A.

CONTENTS*

MINIREVIEW 787 Cellular responses to cisplatin. The roles of DNA-bind-

ing proteins and DNA repair. Gilbert Chu

COMMUNICATIONS 791 Dominant negative mutants of nitric oxide-sensitive

guanylyl cyclase. Peter S. T. Yuen, Lynda K. Doolittle, and David L. Garbers

794 Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits in- ter-cisternal transport in the Golgi stacks. Zvulun Ela- zar, Thomas Mayer, and James E. Rothman

798 Lipid hydroperoxides induce apoptosis in T cells dis- playing a HIV-associated glutathione peroxidase defi- ciency. Paul A. Sandstrom, Paul W. Tebbey, Steve Van Cleave, and Thomas M. Buttke

802 Active site mapping of affinity-labeled rat oxidosqual- ene cyclase. Ikum Abe and Glenn D. Prestwich

860 Functional coupling of Na+/H* and Na'/Ca2' exchan- gers in the al-adrenoreceptor-mediated activation of hepatic metabolism. Elena Urcelay, Nora Butta, Guodalupe

Parrilla Cipres, Angeles Martin-Requero, Matilde S. Aywo, and Roberto

868 Identification of Lys"' at the active site of Escherichia coli glycogen synthase. Application of affinity labeling combined with site-directed mutagenesis. Koji Furu- knwa, Mitsuo Tagaya, Katsuyuki Tanizawa, and Toshio Fukui

872 Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. Surender Kharbanda, Ahamed Sa- leem, Yutaka Emoto, Richard Stone, Ulf Rapp, and Donnld Kufe

879 Neutral sphingomyelinase action stimulates sig- nal transduction of tumor necrosis factor-a in the syn- thesis of cholesteryl esters in human fibroblasts. Subroto Chutterjee

805 A novel cytokine exhibiting megakaryocyte potentiat- 883 The interaction of GATA-binding proteins and basal ing activity from a human pancreatic tumor cell line transcription factors with GATA box-containing core HPC-YS. Nozomi Yamnguchi, Kunihiro Hattori, Masayoshi promoters. A model of tissue-specific gene expression. Oh-eda, Tetsuo Kojima, Nobw Imai, and Norimichi Ochi William C. Aird, Jeffrey D. Paruin, Phillip A. Sharp, and Robert

D. Rosenbere 809 Inhibition of human HL-60 cell responses to chemotac-

tic factors by antisense messenger RNA depletion of G proteins. Edward J . Goetzl, Richard S. Shames, Jinhong Yaw. Franz W. Birke. Ya Fane Liu. Paul R. Albert. and

Y

890 The directly repeated RG(G/T)TCA motifs of the rat

promiscuous binding sites for RAR, RXR, HNF-4, and and mouse cellular retinol-binding protein I1 genes are

SoGzhu An I I ARP-1 homo- and beterodimers. Harikrishna Nakshatri

813 Expression of a cloned protoporphyrinogen oxidase. Tamara A. Dailey, Peter Meissner, and Harry A. Dailey

816 Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by acti- vated protein C. Mikhail D. Smirnov and Charles T. Esmon

820 Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhab- ditis elegans. Weining Chen, Julian Blanc, and Louis Lim

824 Rat liver Kupffer and endothelial cells express differ- ent binding proteins for modified low density lipopro- teins. Kupffer cells express a 96-kDa membrane pro- tein as a specific binding site for oxidized low density lipoproteins. Yolanda B. de Rijke and The0 J . C. van Berkel

828 Brain-derived neurotroDhic factor increases neurotro-

and Pierre Chumbon

903 Roles of v-erbA homodimers and heterodimers in medi- ating dominant negative activity by v-erbA. Paul M. Yen, Masato Ikeda, Jill H. Brubaker, Marc Forgwne, Akira Sugawara, and William W. Chin

910 0-Glycosylation mimics N-glycosylation in the 16-kDa fragment of bovine pro-opiomelanocortin. The major 0-glycan attached to Thr-46 carries S04-4GalNAc@1- 4GlcNAcBl-, which is the archetypal non-reducing ep-

A. Siciliano, Howard R. Morris, Hugh P. J . Bennett, and Anne itope in the N-glycans of pituitary glycohormones. Rosa

Dell

921 Role of the cationic residues arginine 14 and lysine 48 in the function of the cardiotonic polypeptide antho- pleurin B. Paramjit K. Khera and Kenneth M. Blumenthal

phin-3 expression in cerebellar granule neurons. Axel Leingartner, Cad-Philipp Heisenberg, Roland Kolbeck, Hans 926 Characterization of the retention motif in the C-ter- Thoenen, and Dan Lindhnlm minal part of the long splice form of platelet-derived

831 Lys-17 is the amine-donor substrate site for transglu- growth factor A-chain. Maria Andersson, Arne &man,

taminase in BAS-crystallin. Patricia J. T. A. Groenen, Bengt Westermnrk, and Carl-Henrik Heldin

J o h n J . Grootjans, Nzcolette H. Lubsen, Hans Bloemendal, and Wilfried W. de Jong

834 Lead activation of protein kinase C from rat brain. Determination of free calcium, lead, and zinc by "F NMR. Gregory J . Long, John F. Rosen, and Francis A. X . Schanne

931 Specific heparan sulfate saccharides mediate the activ- ity of basic fibroblast growth factor. Andrew Walker, Jeremy E. Turnbull, and John T. Gallagher

936 Purified yeast RNA polymerase I1 reads through in-

TFIIS analogue, P37. Karen R. Christie, Donald E. Awrey, trinsic blocks to elongation in response to the yeast

Aled M. Edwards, and Caroline M. Kane ARTICLES 838 Activation and desensitization of phospholipase D in 944 Molecular mechanism of the synergistic phosphoryla-

intact rat hepatocytes. Giseh Moehren, Lena Gwtausson, tion of phosphatase inhibitor-2. Cloning, expression, and Jan B. Hoek and site-directed mutagenesis of inhibitor-2. In-Kyung

849 The role of cytosolic Cas', protein kinase C, and protein Park, Paris Roach, Jeffry Bondor, Stephen P. Fox, and Anna A. DeFaoli-Roach

kinase A in hormonal stimulation of phospholipase D in rat hepatocytes. Lena Gwtausson, Gisela Moehren, M. Eugenia Torres-Marquez, Christine Benistant, Raphael Rubin, and Jan B. Hoek

955 Phosphorylation of human erythrocyte band 3 by en- dogenous ~ 7 2 ~ ' . Marietta L. Harrison, Christina C. I s m - son, Debra L. Burg, Robert L. Geahlen, and Philip S. Low

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1994) J. Biol. Chern. 269, 777-785, and reprints may be obtained from the editorial office.

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A mechanism for divalent cation regulation of &-inte- grins. Jeffrey W. Smith, Randolph S. Pwtrowicz, and Danielle Mathis

Noncontiguous domains of the a-factor receptor of yeasts confer ligand specificity. Malini Sen and Lorraine Marsh

Metabolic processing of cyclobutyl pyrimidine dimers and (6-4) photoproducts in UV-treated human cells.

M. Gahway, Michel Liuzi , and Malcolm C. Paterson Evidence for distinct excision-repair pathways. Anne

Characterization of the calmodulin-binding domain of rat cerebellar nitric oxide synthase. Mingjie Zhang and Hans J. Vogel

Strand displacement activity of the human immunode- ficiency virus type 1 reverse transcri tase heterodimer

Palust, Roberta L. Thimmig, Charles McHenry, and Ulrich and its individual subunits. Michael Attiger, Vludimir N.

Hcibscher

Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse

Pwtr Zimniak, Sharad S. Singhal, Sanjay K. Sriuastaua, San- glutathione S-transferase mGSTA4-4 (GST 6.7).

jay Awasthi, Rashmi Shurma, Janet B. Hayden, and Yogesh C. Awasthr

Isolation and characterization of the mouse heme oxy-

induction by heme or heavy metals. Jawed Alam, Jing genase-1 gene. Distal 6' sequences are required for

Cui, and Ann Smith

Heme-heme oxygenase complex. Structure of the cata- lytic site and its implication for oxygen activation. Satoshi Takahashi, Jianling Wang, Denis L. Rousseau, Kazun- obu Ishiknwa, Tadashi Yoshida, Janette R. Host, and Masao Ikeda-Saito

onine y-lyase by molecular cloning. Nozomu Nishi, Hi- Identification of probasin-related antigen as cystathi-

myuki Tanabe, Haruyo @a, Masahide Urushihara, Hiroshi Miyamka, and Fumw Wada

Kinetic studies on the removal of extracellular hydro- gen peroxide by cultured fibroblasts. Nobuo Makino, Ya- suhim Mochizuki, Shim Bannai, and Yoshiki Sugita

Annexin VI, a marker protein of hepatocytic endo-

Friedrich Buck, Anke Grigoleit, Andreas Block, Ilka Groger, somes. Stefan Jlickle, Ulrike Beisiegel, Franz Rinninger,

Heiner Greten, and Eberhurd Windkr

Differential expression of an E-selectin ligand (SLex) by two Chinese hamster ovary cell lines transfected with the same a(l,3)-fucosyltransferase gene (ELFT). Susan Goelz, Rauindra Kumar, Barry Potuin, Subha Sun- daram, Margot Brickelmaier, and Pamela Stan&

Peter Bergsten, Anibal Sanchez Moura, Illani Atwater, and Ascorbic acid and insulin secretion in pancreatic islets.

Mark Leuine

by the transcription factor Spl. John W. Henson Regulation of the glial-specific JC virus early promoter

Low affinity acceleration of the phosphorylation reac- tion of the Na,K-ATPase by ATP. Ruben D. Peluffo, Ro- land0 C. Rossi, Patricw J. Garrahan, and Alcides F. Rega

virus latent origin of DNA replication by a DNA looping Stabilization of the EBNAl protein on the Epstein-Barr

mechanism. Lori Frappier, Kim Goldsmith, and Leslle Bendell

Replacement of alanine 68 by asparagine enables the

sugar transport to Na+. Hiroko Hama and T. Hastings melibiose carrier of Klebeidh pneumoniae to couple

Wilson

Identification and characterization of a novel tyrosine kinase from megakaryocytes. Brian D. Bennett, Sally Cow&, Shuriun Jiong, Roanna London, Bi'ia Deng, Jadwiga Grabarek, Jerome E. Groopman, Dauid V. doeddel, and Haua Auraham

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Enzymatic methylation of recombinant heterogeneous nuclear RNP protein Al. Dual substrate specificity for S-adenosy1methionine:histone-arginine N-methyl- transferase. Ramesh Rajpurohit, Soon Ok Lee, Jong Ok Park, Woon Ki Paik, and Sangduk Kim

structure of engineered distal myoglobin Hise' (E7) Val/ 'H NMR study of the solution molecular and electronic

ValQ ( E l l ) His double mutant. Coordination of Hise' (E l l ) a t the sixth position in both low-spin and high- spin states. Jun Qin, Gerd N. La Mar, Y i Dou, Suzanne J. Admiral, and Masao Ikeda-Saito

IFP 36 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistri- bution. Franz-Christoph Bange, Ulrich Vogel, T h o r n Flohr, Monika Kiekenbeck, Bernd Denecke, and Erik C. Bottger

protein-coupled receptor kinase GRK6. Priya Kunapuli, Expression, purification, and characterization of the G

James J. Onorato, M. Marlene Hosey, and Jeffrey L. Benouic

Molecular cloning of a possible cysteine proteinase pre- dominantly expressed in osteoclasts. Ken-ichi Tezuka,

Hiroshi Kamioka, Yoshiyuki Hakeda, and Masayoshi Yoko Tezuka, Akiko Maejima, Takuya Sato, Ken Nemoto,

Kumegawa

Endothelin- 1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade

in the integration of two signaling pathways leading to in cardiac myocytes. The potential role of the cascade

myocyte hypertrophy. Marie A. Bogoyeuitch, Peter E. Glen- non, Monica B. Andersson, Angela Clerk, Antigone Lazou, Christopher J . Marshall, Peter J. Parker, and Peter H. Sugden

cow-stimulated &cells from ob/ob mice. Linda Fournier, Cyclic AMP triggers large [Cam]i oscillations in glu-

James F. Whitfield, Jean-Louis Schwartz, and Nicole Begin- Heick

Inhibition of thrombin receptor signaling by a G-pro- tein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. Kenji Ishii, J i Chen, Maki Ishii, Walter J. Koch, Neil J. Freedman, Robert J . Lefkowitz, and S h u n R. Coughlin

Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hep- atocyte growth factor. Kensaku Mizuno, Hayao Inoue, Mi- chw Hagiya, Shin Shimizu, Takeru Nose, Yasuyuki Shimohi- gashi, and Toshikazu Nakamura

Characterization of rhoGAP. A GTPase-activating pro-

Pamela M. Taylor-Harris, Annette J. Self, Suzanne Brill, tein for RHO-related small GTPases. Carole A. Lamaster,

Helmy E. uan Erp, and Alun Hall

Growth factors differentially stimulate the phosphoryl-

in PC-12 pheochromocytoma cells. Masahide Ohmichi, ation of Shc proteins and their association with Grb2

Koozi Matuoka, Tadmmi Takenawa, and Alan R. Saltiel

Specific binding of the peroxisomal protein targeting sequence to glyoxysomal membranes. Nathan E. Wolins and Robert P. Donaldson

I n uitro synthesis of the iron-molybdenum cofactor of nitrogenase. Purification and characterization of NifB cofactor, the product of NIFB protein. Vimd K. Shah, Jeffrey R. Allen, Nathan J. Spangler, and Paul W. Ludden

ATF-aO, a novel variant of the ATF/CREB transcrip- tion factor family, forms a dominant transcription in-

Kaszubska, James Whelan, John F. DeLamarter, and Rob hibitor in ATF-a heterodimers. Rosanna Pescini, Wiweka

Hooft uan Huijsduijnen

A novel gene, Sl7'4, encodes a phosphatidylinositol 4- kinase in the PKCl protein kinase pathway of Saccha- romyces cerevisiae. Satoshi Yoshida, Yoshikazu Ohya, Mark Goebl, Akihiko Nakano, and Yasuhiro Anraku

428 East Preston Street, Baltimore, MD 21202, U.S.A. Volume 269 for 1994: Institutions: United States, $790; Foreign, $980. Students/Postdoctoral The Journal of Biological Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemistry and Molecular Biology, Inc.,

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Growth state- and cell cycle-dependent fluctuation in

and possible specific modification of the higher molec- the expression of two forms of DNA topoisomerase I1

ular weight form in the M phase. Keiji Kimura, Masafumi Sazjo, Michw Vi, and Takemi Enomoto

The transcri tion factor HNFl acts with C/EBPa to synergistical& activate the human albumin promoter through a novel domain. Kou-Jwy Wu, Deborah R. Wilson, Chiaho Shih, and Gretchen J . Darlington

The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of

Karsenty expression. Christelle Desbois, Deborah A. Hogue, and Girard

The calf 6’- to 3’-exonuclease is also an endonuclease with both activities dependent on primers annealed upstream of the point of cleavage. Richard S. Murante, Lin Hung, John J. Turchi, and Robert A. Bambara

Mevalonate kinase is predominantly localized in per- oxisomes and is defective in patients with peroxisome deficiency disorders. Lenka Biardi, Aparnu Sreedhar, A f - saneh Zokaei, Narendra B. Vartak, Renee L. Bozeat, Janis E. Shackelford, Gihrt-Andre Kelkr, and Skaidrite K. Krisans

Transcription and editing of cytochrome oxidase I1 RNAs in !&ypanosoma cruxi. Kwang S. Kim, Santuza M. R. Teixeira, Louis V. Kirchhofi and John E. Donelson

Hereditary myeloperoxidase deficiency due to a mis- sense mutation of arginine 669 to tryptophan. WiUiam M. Nauseef, Susan Brigham, and Melissa Cogley

The active site of hamster 3-hydroxy-3-methylglu- taryl-CoA reductase resides at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides. Kenneth Frimpong and Victor W. Rodwell

Primary structure, ligand binding, and localization of the human type 3 inositol 1.4,s-trisphosphate receptor expressed in intestinal epithelium. Anthony R. Maranto

Molecular characterization of a new metabotropic glu-

AMP signal transduction. Naoyuki Okamoto, Seiji Hori, tamate receptor mCluR7 coupled to inhibitory cyclic

Chihiro Akazawa, Yasunori Hayashi, Ryuichi Shigemto, No- boru Mizuno, and Shigetada Nakanishi

Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor

tein. Manus K. Majumdar, Lijun Feng, Eugene Medbck, Deniz cDNA yields biologically active, cell-associated pro-

Toksoz, and Dauid A. William

Transport of an export-defective protein by a highly hydrophobic signal peptide. Sharyn L. Rusch and Debra A. Kendall

rectly activates Raf-1 in murine hematopoietic cells. Protein kinase C-mediated serine phosphorylation di-

Michael P. Carroll and W. Stratford May

cinate synthetase in a murine macrophage cell line. Coinduction of nitric oxide synthase and argininosuc-

Implications for regulation of nitric oxide production. Andreas K. Nusskr, Timothy R. Billiar, Zhi-Ze Liu, and Sidney M. Morris, Jr.

Thrombospondin 3 is a developmentally regulated hep- arin binding protein. Aziz N . Qabar, Zhiwu Lin, Frederick W. Wolf, K. Sue O’Shea, Jack Lawler, and Vishua M. Dixit

Deletion of QCR6, the gene encoding subunit six of the

ration of cytochrome c1 and causes temperature-sensi- mitochondrial cytochrome b c l complex, blocks matu-

tive petite growth in Saccharomyces cerevisiae. Meijiu Yang and Bernard L. Trumpower

Suppressed collagen gene expression and induction of a281 integrin-type collagen receptor in tumorigenic

line. Pia Santala, Hannu Larjaua, Liisa Nissinen, Terhi Rii- derivatives of human osteogenic sarcoma (HOS) cell

konen, Arto Mi&ta, and Jyrki Heino

The purification and characterization of gene 69 pro- tein from bacteriophage T4. Tetsuro Yonesaki

Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatlc regulator of insulin secretion from islet B-cells. Toshihiko Yadq, Ma- saya Sakurada, Kaorr Ihlda, Masanorr Nakata, Fusayoshr Mur- ata, Akira Arimura, and Masatoshi Kikuchi

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Purple acid phosphatase of the human macrophage and

crystallization of the recombinant di-iron-oxo protein osteoclast. Characterization, molecular properties, and

secreted by baculovirus-infected insect cells. Alison R. H a y m n and Timothy M. Cox

essential for heparin-catalyzed inactivation by anti- Identification of basic amino acid residues in thrombin

thrombin 111. Zhong-Ru Gun, Yiping Li, Zhongguo Chen, Sidney D. Lewis, and Jules A. Shafer

Gl/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. Qing-Ping

Helin, and Arthur B. Pardee Dou, Shanchwn Zhao, Andrew H. Leuin, Jian Wang, Kristian

In uitro transcriptional studies of the roles of the thy- roid hormone (T,) response elements and minimal pro- moters in Ts-stimulated gene transcription. Chen-Shian Suen, Paul M. Yen, and WiUiam W. Chin

combinatorial operation of tissue-enriched transcrip- Determination of tissue specificity of the enhancer by

tion factors. Both HNF-4 and C/EBP@ are required for liver-specific activity of the ornithine transcarbamyl-

Kimura, Kiwamu Akngi, Ken-ichi Yamamura, Masataka Mori, ase enhancer. Atsushi Nishiyori, Hidetoshi Tashiro, Akira

and Masaki Takiguchi

Biochemical and assembly properties of GluR6 and

determined with subunit-specific antibodies. Robert J. KA2, two members of the kainate receptor family,

Wenthold, Valory A. Trumpy, Wen-Si Zhu, and Ronald S. Petralia

Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. Melissa H. Wong, Peter Oelkers, Ann L. Craddock, and Paul A. Dawson

Association of the regulatory &adrenergic receptor ki- nase with rat liver microsomal membranes. Irene Garcia- Higuera, Petronila Penela, Cristinu Murga, Gustauo Egea, Pedro Bonay, Jeffrey L. Benouic, and Federico Mayor, Jr.

Cloning and expression of a cDNA for mouse prosta- glandin F receptor. Yukihiko Sugimoto, Ken-yuh Hasumoto,

Negishi, Akira Kakizukq Shuh Narumiya, and Atsushi Tsunehisa Namba, Atsushi Irk, Masato Katsuyama, M a d u

Ichikawa

Lipopolysaccharide induction of tissue factor expres- sion in THP-1 monocytic cells. Protein-DNA interac- tions with the promoter. Maryann Donovan-Peluso, Lisa Dawn George, and Andrea Cortese Hassett

Horseshoe crab (1,3)-8-D-glucan-sensitiVe coagulation factor G . A serine protease zymogen heterodimer with similarities to 8-glucan-binding proteins. Yorek i Seki, Tatsushi Muta, Toshw Oda, Daisuke Iwaki, Ker-ichr Kuma, Takashi Miyata, and Sadaaki Iwanuga

Two lectins from the marine sponge Hdichondria o h - dai. An N-acetyl-sugar-specific lectin (HOL-I) and an N-acetyllactosamine-specific lectin (HOL-11). Hiroknzu

Atsua Kimura, and Seiya Chrba Kawagishi, Masamichi YaFwaki , Satoko Isobe, Taichi Usui,

Identification of discrete structural domains in the ret- inoblastoma protein. Amino-terminal domain is re- quired for its oligomerization. Carmel E. Hensey, Frank Hong, T im Durfee, Yue-Wei Qian, Eva Y.-H.P. Lee, and Wen-Hwa Lee

Modulation of HIV-1 reverse transcriptase function in

Jac ues, Birgitta M. W6hr1, Kathryn J. Howard, and Stuart “selectively deleted” p66/p61 heterodimers. Pamela S.

F. Le Grice

Cloning of a novel a2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. Hi- roshi Kztagawa and James C. Paulson

Molecular cloning and expression of G.alNAc a2,6- sialyltransferase. Nobuyukr Kurosawa, Toshrro Hammoto, Young-Chon Lee, Taknshi Nakaoka, Naoya Kojima, and Shui- chi Tsuji

A sarco/endoplasmic reticulum CaZ+-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells. Frank Wuytack, Bela Papp, Hrlde Verboo- men, Luc Raeymoekers, Leonard Dode, Rigis Bobe, Jocelyne Enouf, Shaila Bokkala, Kalwant S. Authr, and Rrk Casteels

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The rat platelet 97-kDa Ca” ATPase isoform is the sarcoendoplasmic reticulum Caa+ ATPase 3 protein. RPgis Bobe, Raymonde Bredoux, Frank Wuytack, Rozenn

Magnler, and Jocelyne Enouf Quarck, Tunde Kouircs, Bela P q p , Elisabeth Coruazier, Clarice

Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct

Minoru Fukuda metastatic potentials. Ritsuko Sawada, Shigeru Tsuboi, and

Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression

Dieter C. Gruenert, and Gwvanni Romeo of the MDR-1 gene. Andrea Rasola, Luis J . V. Galietta,

plasmic reticulum to Golgi transport and trigger dis- Dominant inhibitory mutants of ARFl block endo-

assembly of the Golgi apparatus. Christiane Dascher and William E. Bakh

Repression of mouse mammary tumor virus transcrip- tion by a transcription factor complex. Binding of in- dividual components to separated DNA strands. Ward Giffin, Heather Torrance, Holly Saffran, Heather L. MacLeod, and Robert J . G. Hachi

Thyroid hormone receptor modulates the expression of the rabbit cardiac sarco(endo)plasmic reticulum Cas+- ATPase gene. Angel Zarain-Herzberg, John Marques, and Drew Sukovich

Molecular cloning and characterization of the full-

lysosomal enzyme &glucosidase in Dictyoetelium dis- length cDNA encoding the developmentally regulated

coideum. John Bush, Jan Richardson, and James Cardelli

The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding. Dimitrios A. Skoufias, Douglas G. Cole, Karen P. Wedaman, and Jonathan M. Scholey

prenylcysteine-directed a carboxyl methyltransferase Characterization of a plasma membrane-associated

in human neutrophils. M i c h u e l H. Pillinger, Craig, Volker, Jeffry B. Stock, Gerald Weusmonn, and Mark R. Phrlcps

Analyses of &thalassemia mutant DNA interactions with erythroid Kriippel-like factor (EKLF), an eryth- roid cell-specific transcription factor. Waldo C. Feng, Cherie M. Southwood, and James J . Bieker

Coupled replication-translation of amplifiable messen- ger RNA. A cell-free protein synthesis system that mimics viral infection. Lubou Ryaboua, Elena Volianik, Oleg Kurnnsou, Alexander Spirin, Ying Wu, and Fred Russell Kramer

Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. Yogesh C. Patel, Rosemarie Panetta, Ernanuel Escher, Michael Greenwood, and Coimbatore B. Srikant

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bA4-amyloid protein precursor mRNA isoforms with- out exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. Rupert Sandbrink, Colin L. Masters, and Konrad Beyreuther

a-Actinin and vinculin are PIPz-binding proteins in- volved in signaling by tyrosine kinase. Kiyoko Fukami, Takeshi Endo, Michihiro Imamura, and Tadmmi Takenawa Mutation of the third intracellular loop of the CAMP receptor, cARl , of Dictyoetelium yields mutants im- paired in multiple signaling pathways. Michael J . Cater- zna, Jacqueline L. S. Milne, and Peter N. Deureotes

tions based on affinity of noncovalent association in Classification of az-macroglobulin-cytokine interac-

solution under apparent equilibrium conditions. Kendall P. Crookston, Donna J . Webb, Beni B. Wolf, and Steven L. Gonias Alteration of Na,K-ATPase subunit mRNA and protein levels in hypertrophied rat heart Daniele Charlemagne, John Orlowski, Patricia Oliuiero, Frawoise Rannou, Claude Sainte Beuue, Bernard Swynghedauw, and Lois K. Lane y-Aminobutyric acid-A (GABAA) agonists down-regu- late GABAhnzodiazepine receptor polypeptides from the surface of chick cortical neurons. Patricia A. Calkin and Eugene M. Barnes, Jr. Structure of the L-histidine decarboxylase gene. Kimio Yatsunami, Hiroshi Ohtsu, Motoko Tsuchikawa, Toshio Higu- chi, Kaname Ishibashi, Ayumi Shida, Youichiroh Shima, Sa- toshi Nakagawa, Kohei Yamauchi, Masayuki Yamamoto, Norio Hayashi, Takehiko Watanabe, and Atsushi Ichikawa A dual role for phosphatidylglycerol in protein trans- location across the Escherichia coli inner membrane. Ron Kusters, Eefjan Breukink, Andreas Gallusser, Andreas Kuhn, and Ben de Kruijff

ADDITIONS AND CORRECTIONS Functional domains of aromatase cytochrome P450 in-

quences and substantiated by site-directed mutagenesis ferred from comparative analyses of amino acid se-

experiments. Vol. 267 (1992) 22587-22594. Shiuan Chen and Dujin Zhou Protein kinase C-independent expression of stromely- sin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. Vol. 266 (1991) 22597-22602. Maria T. Diaz-Meco, Su- san Quinones, Maria M. Municw, Laura Sanz, Dolores Bernal, Esther Cabrero, Juan Sam, and Jorge Moscat Constitutively active mutants of the az-adrenergic receptor. Vol. 268 (1993) 16483-16487. Quen Ren, Hi- toshi Kurose, Robert J . Lefkowitz, and Susanna Cotecchia

Purification and characterization of an enzyme releas- ing lacto-N-biose from oligosaccharides with type 1

Kumi Hayakawa, and Ikunoshin Kat0 chain. Vol. 268 (1993) 18560-18566. Mutsumi Sam,

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The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

January 14,1994

MINIREVIEW Cellular responses to cisplatin. The roles of DNA-bind- ing proteins and DNA repair. Gilbert Chu

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Lipid hydroperoxides induce apoptosis in T cells dis- playing a HIV-associated glutathione peroxidase defi- ciency. Paul A. Sandstrom, Paul W. Tebbey, Steve Van Cleave, and Thomas M. Buttke

Neutral sphingomyelinase action stimulates sig- nal transduction of tumor necrosis factor-cr in the syn- thesis of cholesteryl esters in human fibroblasts. Subroto Chatterjee

0-Glycosylation mimics N-glycosylation in the 18-kDa fragment of bovine pro-opiomelanocortin. The major 0-glycan attached to Thr-46 carries SO4-4GaWAcB1-

itope in the N-glycans of pituitary glycohormones. Rosa 4GlcNAcB1-, which is the archetypal non-reducing ep-

A. Siciliano, Howard R. Morris, Hugh P. J . Bennett, and Anne Dell

Specific heparan sulfate saccharides mediate the activ-

Jeremy E. Turnbull, and John T. Gallugher ity of basic fibroblast growth factor. Andrew Walker,

Differential expression of an E-selectin ligand (SLe') by two Chinese hamster ovary cell lines transfected with the same a(l,3)-fucosyltransferase gene (ELFT).

daram, Margot Brickelmaier, and Pamela Stanley Susan Goelz, Ravindra Kumar, Barry Potvin, Subha Sun-

dai. An N-acetyl-sugar-specific lectin (HOL-I) and an Two lectins from the marine sponge Halichondria oka-

Kawagishi, Masamichi Yamawaki, Satoko Isobe, Taichi Usui, N-acetyllactosamine-specific lectin (HOL-11). Hirokazu

Atsuo Kimura, and Seiya Chiba

Cloning of a novel cr2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. Hi- roshi Kitagawa and James C. Paulson

sialyltransferase. Nobuyuki Kurosawa, Toshiro Hammoto, Molecular cloning and expression of GalNAc a2,8-

Young-Chon Lee, Takashi Nakaoku, Naoya K o j i w and Shui- chi Tsuji

Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct

Minoru Fukuda metastatic potentials. Ritsuko Sawada, Shigeru Tsuboi, and

ing lacto-N-biose from oligosaccharides with type 1 Purification and characterization of an enzyme releas-

chain. Vol. 288 (1993) 18580-18688. Mutsumi Sam, Kumi Hayakawa, and Ikunoshin Kat0

CELL BIOLOGY AND METABOLISM Dominant negative mutants of nitric oxide-sensitive

David L. Garbers guanylyl cyclase. Peter S. T. Yuen, Lynda K. Doolittle, and

Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits in- ter-cisternal transport in the Golgi stacks. Zvulun Ela- zar, Thomas Mayer, and James E. Rothman

Inhibition of human HL-80 cell responses to chemotac- tic factors by antisense messenger RNA depletion of G proteins. Edward J. Goetzl, Richard S. Shames, Jinhong

Songzhu A n Yang, Franz W. Birke, Ya Fang Liu, Paul R. Albert, and

Rat liver Kupffer and endothelial cells express differ- ent binding proteins for modified low density lipopro- teins. Kupffer cells express a 96-kDa membrane pro- tein as a specific binding site for oxidized low density lipoproteins. Yolanda B. de Rijke and The0 J . C. van Berkel

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Lead activation of protein kinase C from rat brain. Determination of free calcium, lead, and zinc by "F NMR. Gregory J. Long, John F. Rosen, and Francis A. X . Schanne

Activation and desensitization of phospholipase D in

and Jan B. Hoek intact rat hepatocytes. Gisela Moehren, Lena Gustausson,

The role of cytosolic Ca", protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes. Lena Gustausson, Gisela Moehren, M. Eugenia Torres-Marquez, Christine Benistant, Raphael Rubin, and Jan B. Hoek

Functional coupling of Na+/H+ and Na+/Ca2' exchan- gers in the crl-adrenoreceptor-mediated activation of hepatic metabolism. Elena Urcehy, Nora Butta, Guodalupe Cipres, Angeles Martin-Requero, Matilde S. Ayuso, and Roberto Parrilla

Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. Surender Kharbanda, Ahamed Sa- leem, Yutaka Emoto, Richard Stone, Ulf Rapp, and Donald Kufe

Characterization of the retention motif in the C-ter- minal part of the long splice form of platelet-derived growth factor A-chain. Maria Andersson, Arne &tman, Bengt Westerrnark, and Carl-Henrik Heldin

Phosphorylation of human erythrocyte band 3 by en- dogenous ~ 7 2 ~ ' . Marietta L. Harrison, Christina C. Isaac- son, Debra L. Burg, Robert L. Geahlen, and Philip S. Low

and (6-4) photoproducts in UV-treated human cells. Metabolic processing of cyclobutyl pyrimidine dimers

Evidence for distinct excision-repair pathways. Anne M. Galloway, Michel Liuzzi, and Malcolm C. Paterson

Kinetic studies on the removal of extracellular hydro-

suhiro Mochizuki, Shiro Bannai, and Yoshiki Sugita gen peroxide by cultured fibroblasts. Nobuo Makino, Ya-

Annexin VI, a marker protein of hepatocytic endo- somes. Stefan Jckkle, Ulrike Beisiegel, Franz Rinninger, Friedrich Buck, Anke Grigoleit, Andreas Block, I l k Groger, Heiner Greten, and Eberhard Windler

Ascorbic acid and insulin secretion in pancreatic islets.

Mark Levine Peter Bergsten, Anibal Sanchez Moura, Illani Atwater, and

Identification and characterization of a novel tyrosine kinase from megakaryocytes. Brian D. Bennett, Sally

Grabarek, Jerome E. Groopmn, David V. doeddel, and Hava Cowley, Shwian Jiang, Roanna London, Bi'ia Deng, Jadwiga

Auraham

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. Marie A. Bogoyeuitch, Peter E. Glen- non, Monica B. Andersson, Angela Clerk, Antigone LAZOU, Christopher J . Marshall, Peter J . Parker, and Peter H. Suga'Qn

Inhibition of thrombin receptor signaling by a G-pro- tein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. Kenlz Ishct, J i Chen, v a k i Ishii, Walter J. Koch, Neil J. Freedman, Robert J. Lefkowztz, and S h u n R. Coughlcn

Characterization of rhoGAP. A GTPase-activating pro- tein for RHO-related small GTPases. Carole A. Lancaster, Pamela M. Taylor-Harris, Annette J. Self, Suzanne Brc11, Helmy E. van Erp, and Alan Hall Growth factors differentially stimulate the phosphoryl- ation of Shc proteins and their association with Grb2

Koozi Matuoka, Tadaomi Takenawa, and Alan R. Saltlel in PC-12 pheochromocytoma cells. Masahide Ohmichi,

Specific binding of the peroxisomal protein targeting sequence to glyoxysomal membranes. Nathan E. Wolins and Robert P. Donaldson

Indicates a Communication

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I n vitro synthesis of the iron-molybdenum cofactor of nitrogenase. Purification and characterization of NifB

Jeffrey R. Allen, Nathan J. Spangler, and Paul W. Ludden cofactor, the product of NIFB protein. Vinad K. Shah,

A novel gene, SIzT4, encodes a phosphatidylinositol 4- kinase in the PKCl protein kinase pathway of Saccha- romyces cereuisiae. Satoshi Yoshida, Yoshikazu Ohya, Mark Goebl, Akihiko Nakano, and Yasuhiro Anraku

Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase I1 and possible specific modification of the higher molec-

Saijo, Michw Vi, and Takemi Enamoto ular weight form in the M phase. KeGi Kimura, Masafumi

oxisomes and is defective in patients with peroxisome Mevalonate kinase is predominantly localized in per-

deficiency disorders. Lenka Biardi, Aparna Sreedhar, Af- saneh Zokoei, Narendm B. Vartak, Renee L. Bozeat, Janis E. Shockelford, Gilbert-Andre Keller, and Skaidrite K. Krisans

Primary structure, ligand binding, and localization of

expressed in intestinal epithelium. Anthony R. Maranto the human type 3 inositol 1,4,5-trisphosphate receptor

Protein kinase C-mediated serine phosphorylation di- rectly activates Raf-1 in murine hematopoietic cells. Michael P. CarroU and W. Stratford May

Suppressed collagen gene expression and induction of a281 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. Pia Santah, Hannu Larjaua, Liisa Nissinen, Terhi Rii- konen, Arto MGtta, and Jyrki Heino

Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet @-cells. Toshihiko Yad5 Ma- saya Sakurada, Kaori Ihida, Masanori Nakata, Fusayoshr Mur- uta, Akira Arimura, and Masatoshi Kikuchr

Association of the regulatory @-adrenergic receptor ki- nase with rat liver microsomal membranes. Irene Garcia- Higuera, Petronih Peneh, Cristina Murga, Gustavo Egea, Pedro Bonay, Jeffrey L. Benouic, and Federico Mayor, Jr.

Dominant inhibitory mutants of ARFl block endo- plasmic reticulum to Golgi transport and trigger dis- assembly of the Golgi apparatus. Christiane Dascher and WiUiam E. Bakh

Characterization of a plasma membrane-associated prenylcysteine-directed a carboxyl methyltransferase

Jeffry B. Stock, Gem2 Weissmann, and Mark R. Philips in human neutrophils. Michael H. PiUinger, Craig Volker,

a-Actinin and vinculin are PIPa-binding proteins in- volved in signaling by tyrosine kinase. Kiyoko Fukami, Takeshi Endo, Michihim Imumura, and Tadoomt Takenawa

Mutation of the third intracellular loop of the CAMP receptor, cAR1, of Dictyostelium yields mutants im- paired in multiple signaling pathways. Michael J . Cater- i n a , Jacqueline L. S. Milne, and Peter N . Deureotes

y-Aminobutyric acid-A (GABAA) agonists down-regu- late GABAAenzodiazepine receptor polypeptides from

and Eugene M. Barnes, Jr. the surface of chick cortical neurons. Patricia A. Calkin

Protein kinase C-independent expression of stromely- sin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. Vol. 266 (1991) 22597-22602. Maria T. Dz'uz-Meco, Su- san Quinones, Maria M. Municw, Laura Sanz, Dolores Bernal, Esther Cabrem, Juan Sam, and Jorge Moscat

Constitutively active mutants of the ap-adrenergic receptor. Vol. 268 (1993) 16483-16487. Quen Ren, Hi- toshi Kurose, Robert J. kfkowitz, and Susanna Cotecchia

ENZYMOLOGY Expression of a cloned protoporphyrinogen oxidase. Tamara A. Dailey, Peter Meissner, and Harry A. Dailey

Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by acti- vated protein C. Mikhail D. Smirnou and Charles T. Esmon

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Lys-17 is the amine-donor substrate site for transglu- taminase in @AS-crystallin. Patricia J . T. A. Groenen, J o h n J . Grootjans, Nicolette H. Lubsen, Hans Bloemendal, and Wilfried W. de Jong

Identification of Lysa" at the active site of Escherichia coli glycogen synthase. Application of affinity labeling combined with site-directed mutagenesis. Koji Furu- kawa, Mitsuo Tagaya, Katsuyuki Tanizawa, and Toshw Fukui

Molecular mechanism of the synergistic phosphoryla- tion of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2. In-Kyung Park, Paris Roach, Jeffry Bondor, Stephen P. Fox, and Anna A. DePaoli-Roach

Enzymatic methylation of recombinant heterogeneous nuclear RNP protein Al. Dual substrate specificity for S-adenosy1methionine:histone-arginine N-methyl- transferase. R a m s h Rajpurohit, Soon Ok Lee, Jong Ok Park, Woon Ki Paik, and Sangduk Kim

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. Priya Kunapuli, J a m s J . Onorato, M. Marlene Hosey, and Jeffrey L. Benouic

The active site of hamster 3-hydroxy-3-methylglu- taryl-CoA reductase resides at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides. Kenneth Frimpong and Victor W. Rodwell

Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by anti- thrombin 111. Zhong-Ru Gun, Yiping Li, Zhongguo Chen, Sidney D. Lewis, and Jules A. Shafer

Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. Melissa H. Wong, Peter Oelkers, Ann L. Craddock, and Paul A. Dawson

Functional domains of aromatase cytochrome P460 in- ferred from comparative analyses of amino acid se- quences and substantiated by site-directed mutagenesis experiments. Vol. 267 (1992) 22587-22694. Sh iwn Chen and Dujin Zhou

MEMBRANES AND BIOENERGETICS

tion of the Na,K-ATPase by ATP. Ruben D. Peluffo, Ro- Low affinity acceleration of the phosphorylation reac-

hndo C. Rossi, Patricw J . Garrahan, and Alcides F. Rega

Replacement of alanine 58 by asparagine enables the

sugar transport to Na+. Hiroko Hama and T. Hastings melibiose carrier of Klebsiella pneumoniae to couple

Wilson

Cyclic AMP triggers large [Ca2+Ii oscillations in glu- cose-stimulated @-cells from ob/ob mice. Linda Fournier, James F. Whitfield, Jean-Louis Schwartz, and Nicole Begin- Heick

Transport of an export-defective protein by a highly hydrophobic signal peptide. Sharyn L. Rusch and Debra A. Kendall

mitochondrial cytochrome b c l complex, blocks matu- Deletion of QCRG, the gene encoding subunit six of the

ration of cytochrome c1 and causes temperature-sensi- tive petite growth in Saccharomyces cereuisiae. Meijia Yang and Bernard L. Trumpower

A sarco/endoplasmic reticulum Ca2+-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells. Frank Wuytack, Belo Papp, Hilde Verboo-

Emuf, S h i h Bokkah, Kalwant S. Authi, and Rik Casteels men, Luc Raeymaekers, Leonard Dode, Regis Bobe, Jocelyne

The rat platelet 97-kDa CaZ+ ATPase isoform is the sarcoendoplasmic reticulum CaZ+ ATPase 3 protein. Regis Bobe, Raymonde Bredoux, Frank Wuytack, Rozenn Qwrck, Tunde Kouircs, Beh Papp, Elisabeth Coruazier, Clarice Magnier, and Jocelyne Enauf

Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene. Andrea Rasoh, Luis J. V. Galietta, Dieter C. Gruenert, and Giouanni Romeo

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Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. Yogesh C. Patel, Rosemarie Panetta, Emanuel Escher, Michael Greenwood, and Coimbatore B. Srikant

Alteration of Na,K-ATPase subunit mRNA and protein levels in hypertrophied rat heart Daniele Charlemagne, John Orlowski, Patricia Oliuiero, Fraqoise Rannou, Claude Sainte Beuue, Bernard Swynghedauw, and Lois K. Lune

A dual role for phosphatidylglycerol in protein trans- location across the Escherichia coli inner membrane. Ron Kusters, Eefjan Breukink, Andreas Gallwsser, Andreas Kuhn, and Ben de Kruijff

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

Brain-derived neurotrophic factor increases neurotro-

Leingdrtner, Carl-Philipp Heisenberg, Roland Kolbeck, Hans phin-3 expression in cerebellar granule neurons. Axel

Thoenen, and Dan Lindholm

The interaction of CATA-binding proteins and basal

promoters. A model of tissue-specific gene expression. transcription factors with CATA box-containing core

William C. Aird, Jeffrey D. Paruin, Phillip A. Sharp, and Robert D. Rosenbeg

The directly repeated RC(C/T)TCA motifs of the rat and mouse cellular retinol-binding protein I1 genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers. Harikrishna Nakshatri and Pierre Chambon

Roles of v-erbA homodimers and heterodimers in medi- ating dominant negative activity by v-erbA. Paul M.

Sugawars and Wcllmm W. Chin Yen, Masato Ikee,. JiU H. Brubaker, Marc Forgione, Akira

Purified yeast RNA polymerase I1 reads through in- trinsic blocks to elongation in response to the yeast

Aled M. Edwards, and Caroline M. Kane TFIIS analogue, P37. Karen R. Christie, Donald E. Awrey,

Strand displacement activity of the human immunode-

and its individual subunits. Michael Hottiger, Vludimir N . ficiency virus type 1 reverse transcriptase heterodimer

Hribscher Podust, Roberta L. Thimmig, Charles McHenry, and Ulrich

expression, and enzymatic characterization of mouse Estimation of genomic complexity, heterologous

Pwtr Zimnek, Sharad S. Singhal, Sanjay K. Sriuastaua, San- glutathione S-transferase mGSTA4-4 (CST 5.7).

jay Awasthr, Rashmi Sharma, Janet B. Hayden, and Yogesh C. Awmthi

Isolation and characterization of the mouse heme oxy- genase-1 gene. Distal 5’ sequences are required for induction by heme or heavy metals. Jawed Alum, Jing Cui, and Ann Smith

by the transcription factor Spl. John W. Henson Regulation of the glial-specific JC virus early promoter

Stabilization of the EBNAl protein on the Epstein-Barr virus latent origin of DNA replication by a DNA looping mechanism. Lori Frappier, Kim Goldsmith, and Leslie Bendell

IFP 36 is an interferon-induced leucine zipper protein that undergoea interferon-regulated cellular redistri- bution. Franz-Christoph Bange, Ulrcch Vogel, Tho? Flohr, Mon ih Kiekenbeck, Bernd Denecke, and Errk C. Bottger

Molecular cloning of a possible cysteine proteinase pre- dominantly expressed in osteoclasts. Ken-ichi Tezuka, Yoko Tezuka, Akiko Maejima, Takuya Sato, Ken Nernoto,. Hiroshi Kamioh, Yoshiyuki Hak.edu, and Masayoshr Kumegawa

ATF-aO, a novel variant of the ATF/CREB transcrip- tion factor family, forms a dominant transcription in- hibitor in ATF-a heterodimers. Rosanna Pescrni, W i w e h Kaszubska, James Whelon, John F. DeLumarter, and Rob Hooft van Huijsduijnen

The transcri tion factor HNFl acts with. CEBPa to synergisticalfy activate the human albumin promoter through a,novel domain. Kou-Juey Wu, Deborah R. Wilson, Chiaho Shrh, and Gretchen J . Darlington

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The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. Christelle Desbois, Deborah A. Hogue, and Gerard Karsenty

The calf 5’- to 3’-exonuclease is also an endonuclease. with both activities dependent on primers annealed upstream of the point of cleavage. Richard S. Murante, Lin Hung, John J. Turchi, and Robert A. Bambara

Transcription and editing of cytochrome oxidase I1 RNAs in !lbypanosoma cruti. Kwang S. Kim, Santuza M. R. Teixeira, Louis V. Kirchhoff, and John E. Donelson

sense mutation of arginine 669 to tryptophan. William Hereditary myeloperoxidase deficiency due to a mis-

M. Nauseef, Susan Brigham, and Melissa Cogley

Molecular characterization of a new metabotropic glu- tamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Naoyuki Ohnoto, Seiji Hori,

boru Mizuno, and Shigetada Nahnishi Chihiro Akazawa, Yasunori Hayashi, Ryuichi Shigemto, No-

Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor

tein. Manus K. Majumdar, Lijun Feng, Eugene Medlock, Deniz cDNA yields biologically active, cell-associated pro-

Toksoz, and David A. William

Coinduction of nitric oxide synthase and argininosuc- cinate synthetase in a murine macrophage cell line.

Andreas K. Nussler, Timothy R. Billiar, Zhi-Ze Liu, and Sulney Implications for regulation of nitric oxide production.

M. Morris, Jr.

The purification and characterization of gene 69 pro- tein from bacteriophage T4. Tetsuro Yonesaki

to the mouse thymidine kinase gene promoter. Qing-Ping Cl/S-regulated E2F-containing protein complexes bind

Doy Shanchwn Zhm, Andrew H. Leuin, Jian Wang, Kristian Helin, and Arthur B. Pardee

In vitro transcriptional studies of the roles of the thy- roid hormone (Ts) response elements and minimal pro-

S w n , Paul M. Yen, and William w. Chin moters in Ts-stimulated gene transcription. Chen-Shian

Determination of tissue specificity of the enhancer by combinatorial operation of tissue-enriched transcrip- tion factors. Both HNF-4 and C/EBP@ are required for liver-specific activity of, the ornithine transcarbamyl- ase enhancer. Atswhc Nuhiyon, Huletoshr Toshiro, Akrra Kimura, Kiwarnu Akugc, Ken-ichi Yarnamura, Masatah Mori, and Masaki Takiguchi Cloning and expression of a cDNA for mouse prosta- glandin F receptor. Yukihiko Sugimoto, Ken-yuh Hasumoto,

Negishi, Akira Kakizuka, Shuh Narurncya, and Atsushr Tsunehisa Namba, Atsushi Irie, Masato Ka,tsuyama, Manabu

Ichikawa Lipopolysaccharide induction of tissue factor expres- sion in THP-1 monocytic cells. Protein-DNA interac- tions with the promoter. Maryann Donovan-Peluso, Lisa Dawn George, and Andrea Cortese Hassett Repression of mouse mammary tumor virus transcrip- tion by a transcription factor complex. Binding of in- dividual components to separated DNA strands. Ward Giffin, Heather Torrance, Holly Saffran, Heather L. Mach&, and Robert J . G. Hachi

Thyroid hormone receptor modulates the expression of the rabbit cardiac sarco(endo)plasmic reticulum Caz+- ATPase gene. Angel Zarain-Herzberg, John Marqws, and Drew Sukovich Molecular cloning and characterization of the full- length cDNA encoding the developmentally regulated lysosomal enzyme &glucosidase in Dictyostelium dis- coideum. John Bush, Jan Rcchardson, and James CardeUc

Analyses of &thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an eryth- roid cell-specific transcription factor. Waldo C. Few, Cherie M. Southwood, and James J. Bieker Coupled replication-translation of amplifiable messen-

mimics viral infection. Lybou Ryaboua, Elena Volianik, Oleg ger RNA. A cell-free protein synthesis system that

Kramer Kurasou, Alexander Spcrzn, Yzng Wu, and Fred Russell

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Structure of the L-histidine decarboxylase gene. Kimw Yatsunami, Hiroshi Ohtsu, Motoko Tsuchikwa, T0sh.w Higu- chi, Kaname Ishibashi, Ayumi Shida, YouFhtroh Shzm, Sa-

Hayashi, Takehiko Watanabe, and Atsushi Ichikawa toshi Nakugawq Kohei Yamuchi, Masayukt Yamnwto, Norw

PROTEIN CHEMISTRY AND STRUCTURE Active site mapping of affinity-labeled rat oxidosqual- ene cyclase. Ikuro Abe and Glenn D. Prestwzch

A novel cytokine exhibiting megakaryocyte potentiat- ing activity from a human pancreatic tumor cell line HPC-Y5. Nozomi Yamaguchi, Kunihiro Hattori, Masayoshi Oh-eda, Tetsuo Kojima, Nobua I m i , and Norimichi Ochi

Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhab- ditis elegan~. Weining Chen, Julian Blanc, and Louis Lim

Role of the cationic residues arginine 14 and lysine 48 in the function of the cardiotonic polypeptide antho- pleurin B. Paramjit K. Khera and Kenneth M. Blumenthal

A mechanism for divalent cation regulation of Bs-inte-

Mathis grins. Jeffrey W. Smith, Randolph S. Pktrowicz, and Danielle

Noncontiguous domains of the a-factor receptor of yeasts confer ligand specificity. Malini Sen and Lorraine Marsh

Characterization of the calmodulin-binding domain of rat cerebellar nitric oxide synthase. Mingiie Zhang and Hans J . Vogel

Heme-heme oxygenase complex. Structure of the cata- lytic site and its implication for oxygen activation. Satoshi Takahashi, Jianling Wang, Denis L. Rousseau, Kazun- obu Ishikawa, Tadashi Yoshida, Janette R. Host, and Masao Ikedn-Saito

Identification of probasin-related antigen as cystathi- onine y-lyase by molecular cloning. Nozomu Nishi, Hi-

Miyanaka, and Fumw Wada royuki Tanabe, Haruyo @a, Masahide Urushihara, Hiroshi

structure of engineered distal myoglobin Hise4 (E7) Val/ ‘H NMR study of the solution molecular and electronic

Val- ( E l l ) His double mutant. Coordination of Hise4 (E l l ) a t the sixth position in both low-spin and high- spin states. Jun Qin, Gerd N . La Mar, Yi Dou, Suzanne J. Admiraal, and Masao Ikeda-Saito

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Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hep- atocyte growth factor. Kensaku Mizum, Hayao Imue, Mi-

gashi, and Toshikazu Nakamura chi0 Hagiya, Shin Shimizy Takeru Nose, Yasuyuki Shimohi-

Thrombospondin 3 is a developmentally regulated hep- arin binding protein. Aziz N. Qabar, Zhiwu Lin, Frederick W. Wolf, K. Sue O’Shea, Jack Lawler, and Vishva M. Dixit

Purple acid phosphatase of the human macrophage and osteoclast. Characterization, molecular properties, and crystallization of the recombinant di-iron-oxo protein

H a y m n and Timothy M. Cox secreted by baculovirus-infected insect cells. Alison R.

Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies. Robert J .

Petralia Wenthold, Valory A. Trumpy, Wen-Si Zhu, and Ronald S.

Horseshoe crab (1,3)-/3-~-glucan-sensitive coagulation

similarities to j3-glucan-binding proteins. Noriaki Seki, factor G. A serine protease zymogen heterodimer with

Tatsushi Muta, Toshb Oda, Daisuke Iwaki, Kei-ichi Kuma, T a h h i Miyata, and Sadaaki Iwanaga Identification of discrete structural domains in the ret- inoblastoma protein. Amino-terminal domain is re-

Hong, Tim Durfee, Yue- Wei Qian, Eva Y . - H . P . L e , and quired for its oligomerization. Carmel E. Heme Frank

Wen-Hwa Lee

Modulation of HIV-1 reverse transcriptase function in

Jacques, Birgitta M. Wohrl, Kathryn J . Howard, and StLlart “selectively deleted” p66/p51 heterodimers. Pamela S.

F. J. Le Grice

The carboxyl-terminal domain of kinesin heavy chain

Dough G. Cole, Karen P. Wedamn, and Jonathan M. Scholey is important for membrane binding. Dimitrws A. Skoufias,

j3A4-amyloid protein precursor mRNA isoforms with- out exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. Rupert Sandbrink, Colin L. Masters, and Konrad Beyreuther Classification of az-macroglobulin-cytokine interac- tions based on affinity of noncovalent association in

P. Crookston, Donna J. Webb, Beni B. Wolf, and Steven L. solution under apparent equilibrium conditions. Kendall

Gonins

Abe, Ikuro, 802 Admiraal, Suzanne J., 1083 Aird, William C., 883

Akazawa, Chihiro, 1231 Akagi, Kiwamu, 1323

Alam, Jawed, 1001 Albert, Paul R., 809

An, Songzhu, 809 Allen, Jeffrey R., 1154

Andersson, Monica B., 1110 Andersson, Maria, 926

Anraku, Yasuhiro, 1166 Arimura, Akira, 1290

Authi, Kalwant S., 1410 Atwater, Illani, 1041

Avraham, Hava, 1068 Awasthi, Sanjay, 992 Awasthi, Yogesh C., 992 Awrey, Donald E., 936 Apso, Matilde S., 860 Balch, William E., 1437 Bambara, Robert A., 1191 Bange, Franz-Christoph,

Bannai, Shiro, 1020 1091

Barnes, Eugene M., Jr., 1548

Beisiegel, Ulrike, 1026 BBgin-Heick, Nicole, 1120

Bendell, Leslie, 1057 Benistant, Christine, 849 Bennett, Brian D., 1068 Bennett, Hugh P. J., 910 Benovic, Jeffrey L., 1099,

Bernal, Dolores, 1565 Bergsten, Peter, 1041

Beuve, Claude Sainte, 1541 Beyreuther, Konrad, 1510 Biardi, Lenka, 1197 Bieker, James J., 1493

Birke, Franz W., 809 Billiar, Timothy R., 1257

Blanc, Julian, 820 Block, Andreas, 1026 Bloemendal, Hans, 831 Blumenthal, Kenneth M.,

Bobe, Rigis, 1410,1417 Bogoyevitch, Marie A,, 1110 Bokkala, Shaila, 1410 Bonay, Pedro, 1348

1348

921

AUTHOR INDEX

Bondor, Jeffry, 944 Bottger, Erik C., 1091 Bozeat, Renee L., 1197 Bredoux, Raymonde, 1417 Breukink, Eefjan, 1560

Brigham, Susan, 1212 Brickelmaier, Margot, 1033

Brill, Suzanne, 1137 Brubaker, Jill H., 903

Burg, Debra L., 955 Buck, Friedrich, 1026

Bush, John, 1468 Butta, Nora, 860 Buttke, Thomas M., 798 Cabrero, Esther, 1565

Calkin, Patricia A,, 1548 Cai, Jing, 1001

Cardelli, James, 1468 Carroll, Michael P., 1249

Caterina, Michael J., 1523 Casteels, Rik, 1410

Chamhon, Pierre, 890 Charlemagne, Daniele, 1541 Chatterjee, Subroto, 879 Chen, Ji, 1125

Chen, Shiuan, 1564 Chen, Weining, 820 Chen, Zhongguo, 1301

Chin, William W., 903, 1314 Chiba, Seiya, 1375

Christie, Karen R., 936 Chu, Gilbert, 787

Clerk, Angela, 1110 Ciprb, Guadalupe, 860

Cole, Douglas G., 1477 Cogley, Melissa, 1212

Corvazier, Elisabeth, 1417 Cotecchia, Susanna, 1566

Cowley, Sally, 1068 Coughlin, Shaun R., 1125

Cox, Timothy M., 1294 Craddock, Ann L., 1340 Crookston, Kendall P., 1533

Dailey, Harry A,, 813 Dailey, Tamara A,, 813 Darlington, Gretchen J., 1177

Dawson, Paul A., 1340 Dascher, Christiane, 1437

de Jong, Wilfried W., 831 de Kruijff, Ben, 1560

DeLamarter, John F., 1159 Dell, Anne, 910 Denecke, Bernd, 1091 Deng, Bijia, 1068 DePaoli-Roach, Anna A,, 944 de Rijke, Yolanda B., 824 Desbois, Christelle, 1183 Devreotes, Peter N., 1523 Dim-Meco, Maria T., 1565

Dode, Leonard, 1410 Dixit, Vishva M., 1262

Donaldson, Robert P., 1149 Donelson, John E., 1206 Donovan-Peluso, Maryann,

Dou, Qing-Ping, 1306 Doolittle, Lynda K., 791

Dou, Yi, 1083 Durfee, Tim, 1380

Egea, Gustavo, 1348 Edwards, Aled M., 936

Emoto, Yutaka, 872 Elazar, Zvulun, 794

Enomoto, Takemi, 1173 Endo, Takeshi, 1518

1361