25 major scientific breakthroughs - tocris bioscience
TRANSCRIPT
Product TypeSmall MoleculescGMP Small MoleculesPeptidesAptamersChemogenetics Controlled SubstancesCompound LibrariesFluorescent ImagingLigand SetsOptopharmacologyTargeted Protein DegradationReagentsToxins
Research AreaCancerCardiovascular SystemCell and Gene TherapyEndocrinologyImmunologyNeurosciencePain & InflammationRespiratory System
Pharmacology7-TM ReceptorsEnzyme-Linked ReceptorsEnzymesIon ChannelsNuclear ReceptorsTransporters
Cell BiologyAngiogenesisCell CycleCell MetabolismCytoskeleton & Motor ProteinsECM & Adhesion MoleculesEpigeneticsRegulated Cell DeathSignal TransductionStem Cells
For more details on each discovery and to request or download your free poster visit Tocris.com/25-years
Tyr
Tyr
Gly
Gly
Gly
Glu
Glu
Lys
Lys LysCOOH
Lys
LysSer
Gln
Asn
Asn
Ala
Ala
lle
lle
ThrProLeu
LeuValThr
Phe
Phe
Met ThrSer
NH2
hPSCsSomatic cells
What’s next?
Screening
Leadenzyme
Mutagenesis
1927Big Bang Theory
Lemaître
1929 Discoveryof PenicillinFleming
1933+X Ray Crystallography of Biological Molecules AdvancesHodgkin
1951Protein Amino Acid Sequence
Sanger
1859 Theory of EvolutionDarwin and Wallace
1869Periodic TableMendeleev
1861 Germ TheoryPasteur
2003 HumanGenome Project
Completed
2006 Adult Human Cells are Reprogrammed into PSCsTakahashi and Yamanaka 2012 Immune Checkpoint Therapy
Allison and Honjo
2014 Robotic Limb Controlled by the BrainOrtiz-Catalan et al.
2012Discovery of
CRISPRDoudna andCharpentier
2012 Higgs BosondiscoveredATLAS and CMScollaboration
1952 Polio Vaccine Salk
1953DNA Structure Resolved
Watson, Crick, Wilkins and Franklin
1971Discovery of Place Cells
Moser, Moser and O’Keefe
1985 PCR InventedMullis
1985 DNA ProfilingJeffrey et al.
1990Cryo-Electron Microscopy
Dubochet, Frank and Henderson
1993 The Directed Evolutionof Enzymes Arnold
1996Dolly the Sheep Cloned
Campbell et al.
1998 RNA InterferenceFire and Mello
1977MRI Used on First Live Person
1954First Kidney
TransplantMurray
1898Discovery of RadiumCurie
1850 1860 1870 1880 1890 1900 1910 1920 1930 1940
1950196019701980
1990 2000 2010 2020
25 years ago Tocris Neuramin and Cookson Chemicals merged to become Tocris Cookson, and ever since then we have been supplying researchers with high quality innovative life science reagents to help them make new discoveries. To celebrate our quarter century we have selected our 25 favorite scientific breakthroughs. How do they compare with yours? Did we miss your favorite? Let us know on social media.
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25 Major Scientific Breakthroughs