23.08.2011 Copyright® Raisio

A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients

Plat et al. J Nutr 2009

2Plat et al. 2009

Background I

Patients with metabolic syndrome are at an increased risk of cardiovascular disease. Several factors contribute to the risk apart from the ”traditional” high LDL-cholesterol, including high TG, low HDL and proinflammatory profile, all present in metabolic syndrome.

Meta-analysis by Naumann et al. 2008 suggested that plant stanol ester may also lower elevated serum TG concentration.

Plat et al. 2009 3

Background II

The aim of the study was to evaluate if plant stanol ester can improve the lipid-profile in metabolic syndrome patients.

Effects of plant stanol ester were studied alone and in combination with low-dose Simvastatin.

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Methods I

36 metabolic syndrome patients 3-week run-in with placebo yogurt drink and placebo tablet randomized into 4 treatment groups for 8 weeks• placebo group (n=9); placebo yogurt drink + placebo

tablet• plant stanol ester group (n=9); yogurt drink with 2 g/d

plant stanols + placebo tablet• statin group (n=10); placebo yogurt drink + 10 mg

simvastatin• combination group (n=8); yogurt drink with 2 g/d

plant stanols + 10 mg simvastatin

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Methods II

Fasting blood samples• week 2 & 3 (run-in)• week 10 & 11 (experimental period)

Analyses for • lipids and lipoproteins • markers of inflammation and endothelial function• clinical safety variables

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Results I

Participants had a clear atherogenetic phenotype that did not differ among the groups

Compliance to the study protocol was excellent

No changes in dietary parameters, weight or inflammation markers

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Results II

In metabolic syndrome patients, plant stanol ester, Simvastatin or the combination lowered non-HDL-cholesterol concentration by 12.8 %, 30.7 % and 35.4 % respectively, compared to placebo

TGs were lowered by 27.5 %, 21.7 % and 32.7 %, respectively, compared to placebo

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CHANGES IN CHOLESTEROL AND TG CONCENTRATIONS

Control

Plant stanol ester

%

Total cholesterol

Simvastatin

Plant stanol ester +simvastatin

Non-HDLCholesterol TG

a a

a

a

bb

b

b

bc

c c

c

Effects of plant stanol ester, Simvastatin, or the combination on serum cholesterol and triglyceride concentrations

Values between each group carrying a different letter are significantly different (p<0.05)

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Conclusions

In addition to lowering serum non-HDL-cholesterol concentration, consumption of plant stanol ester lowered serum TG concentrations by 27 % in metabolic syndrome patients.

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Thank You!