2015 11-27 bootcamp radboudumc student meets innovation, alain van gool
TRANSCRIPT
Stakeholders at stake in implementing personalized healthcare
Prof Alain van Gool
Bootcamp Student meets innovation 27 Nov 2015
My background
8 years academia (NL, UK)
(molecular mechanisms of disease)
13 years pharma (EU, USA, Asia)
(biomarkers, Omics)
4 years med school (NL)
(personalized healthcare, Omics, biomarkers)
4 years applied research institute (NL, EU)
(biomarkers, personalized health, nutrition)
A person / citizen / family man
(adventures in EU, USA, Asia)
1991-1996 (PhD)
1996-1998 (post-doc)
2009-2012 (visiting prof)
1999-2007 2007-2009 2009-2011
2011-now
2011-now (prof)
2
Professor of Personalized Healthcare Head Radboud Center for Proteomics, Glycomics and Metabolomics Coordinator Radboud Technology Centers
Senior Scientist Integrator Biomarkers
Collaboration towards teamwork
3
• Not easy to achieve
• If done well: great energy, good focussed output
• If done badly: ineffective, no desired output
Collaboration starts with understanding
4
• Stakeholders can have (very) different interests, motivations, struggles
• Select your discussion partner
• Know his/her background
• Respect
• Discuss with open questions
• Listen, Learn, Adapt
• Be open for input & critisism
• Maintain big picture goal
• Aim for 1+1=3
Semantics
5
Translational science
• Molecular Biologist - Biochemistry to cell
• Pharmacologist - Cell to animal
• Clinical pharmacologist - Animal to man
• Clinician - Healthy person to patient
• Enterpreneur - Innovation beta version to product
Preclinical Clinical
• Cell, animal - Man
• Healthy person - Patient
• Research - Implemented product
Semantics
6
Intervention
• Pharmaceutical drug developer - Drug
• Psychologist - Provide right information to individual so he/she can take better informed decision about own health
Innovation
• Patent
• New product
• New implemented procedure
Part of my world • Glycoproteomics profiling in plasma • Detection of ~12.000 unique deconvoluted monoisotopic masses
per single analysis (> 50% are glycopeptides)
500
1000
1500
2000
m/z
5 10 15 20 25 30 35 40 Time [min]
Proof of principle study:
7
Part of my world
8
Systems biology view on metabolic health and disease to map pharma-nutrition effects
Part of my world
9
Radboudumc Technology Centers
About 250 dedicated people working in 18 Technology Centers, ~2000 users (internal, external), ~140 consortia www.radboudumc.nl/research/technologycenters/
Different worlds: molecular biologist and patient
“I’m afraid you’re
suffering from an
increased IL-1β and
an aberrant miR843
expression”
Adapted from:
?
11
People are more than molecular pathways
Source: Barabási 2007 NEJM 357; 4}
• People are different • Different networks and influences • Different risk factors • Different preferences
12
Personalized Healthcare @ Radboudumc
People are different Stratification by multilevel diagnosis
+ Patient’s preference of treatment
Exchange experiences in care communities Select personalized therapy
Population
Man
Molecule
Alain van Gool, Workshop Neuroinformatics and personalized health care , Nijmegen, 26 Nov 2015 13
Lab values Clinical outcomes
Pain Mobility Fatigue
INTEGRATE-HTA
Objectives patient and clinican may be different
R van Hoorn, W Kievit, M Tummers, GJ van der Wilt
How to do optimal shared decision making?
Intervention
Minor Personalized Health(care)
22
• Opinion: Team work is only possible when you understand your partner’s motivation
• Task: get to know the stakeholders in Personalized Health(care)
o Patient o Clinician o Nurse o Basic researcher o Applied researcher o Care provider o Health insurer o Pharmaceutical developer o Nutrition developer o Health economist Teams Background check 10 Question-based interviews
Minor Personalized Health(care)
23
• Task: pitch your 2025 innovation in Personalized Health(care)
+ involvement of stakeholders
Collaboration starts with understanding
24
• Stakeholders can have (very) different interests, motivations, struggles
• Select your discussion partner
• Know his/her background
• Respect
• Discuss with open questions
• Listen, Learn, Adapt
• Be open for input & critisism
• Maintain big picture goal
• Aim for 1+1=3
Available as innovation expert
Personalized Healthcare
Biomarkers
Molecular biology
Genomics / proteomics
www.radboudumc.nl/personalizedhealthcare
www.radboudumc.nl/research/technologycenters
www.radboudresearchfacilities.nl
www.linkedIn.com
www.slideshare.net/alainvangool
26
Collaboration
Communication
Innovation
Validation
Pharmaceutical industry
Academia
Hospital
Spin-off companies