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Molecular Oncology Research Center - BARRETOS CANCER HOSPITAL1
This annual report describes the Molecular Oncology Research Center (CPOM) from the Barretos Cancer Hospital, and its research activities for the year 2013.
2013 Annual Report
Molecular Oncology Research Center
Molecular Oncology Research Center - BARRETOS CANCER HOSPITAL2
Index
1) Mission....................................................................................................................................32) Team.......................................................................................................................................43) Research Lines.........................................................................................................................74) Productivity.............................................................................................................................95) Conferences and Congresses................................................................................................176) Science Communication to general public............................................................................267) Supervision of PhD, Master and Initiation to Trainee Fellows..............................................268) Prizes....................................................................................................................................309) Participation in International Networks................................................................................3110) Participation in National Networks.....................................................................................3211) Organization of Conferences and Meetings........................................................................3212) Lectures / Seminars at Conferences and Meetings............................................................3213) Funding...............................................................................................................................3614) Patents................................................................................................................................4115) Jury participation................................................................................................................4216) National and International Collaborations:.........................................................................4417) Molecular Diagnostics Center.............................................................................................4518) Perspectives for 2014.........................................................................................................45
3 Molecular Oncology Research Center – Barretos Cancer Hospital
Introduction
The Molecular Oncology Research Center “Centro de Pesquisa em Oncologia Molecular”
(CPOM) was inaugurated on August 19, 2010, by the former Minister of Health, Dr. José
Temporão. The CPOM is framed at the Institute for Research and Education “Instituto de
Ensino e Pesquisa” (IEP) of Barretos Cancer Hospital, which in conjunction with other
clinical departments of the Hospital, as well as the Department of Clinical Research and Post-
graduation in Oncology, are the basic foundations in developing the future of oncology
medicine - personalized medicine.
The CPOM is installed in the new building of the IEP, with an area of 1,000 m2. The project
design was based on the most modern research centers, emphasizing the convenience of
movement, sharing of technological resources and the supervision of experience professionals.
The complex infrastructure of CPOM counts with state-of-the-art laboratories of cytogenetics,
molecular genetics, and molecular and cellular biology, allowing the development of different
research lines of in the field of molecular oncology.
During 2013, the third year of CPOM, we observed the growing of the projects generated in
the first couple of years, and the increased number of approved grants by Funding Agencies,
as well as the implementation of numerous and varied scientific partnerships. A steady
increased of the number of researchers was also observed during this year.
To evaluate and guide their steps, the CPOM was an External Advisory Board, which consists
of the following members:
- Jorge Reis-Filho (MSKCC, USA)
- Jorge Gomez (NCI, USA)
- Luisa Villa (INCT-CNPq, Brazil)
- Manuel Sobrinho-Simões (IPATIMUP, Portugal)
- Oliver Bogler (MDAnderson, USA)
1) Mission
To promote knowledge and innovation in order to apply molecular oncology in cancer control.
- Knowledge of the causes, biological mechanisms and targets,
4 Molecular Oncology Research Center – Barretos Cancer Hospital
- Innovation in detection, diagnostic, treatment and prognosis,
- Application in prevention and assistance to patient.
2) Team
Senior Researcher
Adhemar Longatto-Filho, PhD – Coordinator of Post-graduation
André Lopes Carvalho, MD, PhD – IEP Executive Director
Benedito Mauro Rossi, MD, PhD – External Collaborator
Ismael Dale Cotrim Guerreiro da Silva, MD, PhD – External Collaborator
José Humberto Tavares Guerreiro Fregnani, MD, PhD – IEP Scientific Diretor
Luiz Fernando Lopes, MD, PhD – Pediatric Hospital Coordinator
Rui Manuel Reis, PhD – Molecular Oncology Research Center Coordinator
Visitant Professor
Kari J Syrjanen, MD, PhD – University of Turku, Finland
Junior Researcher
Céline Marques Pinheiro, PhD – External Collaborator, FACISB
Cristovam Scapulatempo-Neto, MD, PhD – Department of Pathology Coordinator
Daniel Onofre Vidal, PhD – Researcher
Denise Peixoto Guimarães, MD, PhD – Departament of Endoscopy
Edenir Inêz Palmero, PhD – Researcher
Eduardo Anselmo Garcia, PhD - External Collaborator, FACISB
Fernanda Scarnato de Rosa, PhD - External Collaborator, UNIFEB
Henrique César Santejo Silveira, PhD – Researcher
Lucas Tadeu Bidinotto, PhD - External Collaborator, FACISB
Márcia Maria Chiquitelli Marques Silveira, PhD – Researcher
Marjori Leiva Camparoto, PhD – Researcher
Olga Martinho, PhD - External Collaborator, ICVS/UMinho
Vinicius de Lima Vazquez MD, PhD – Clinical Diretor.
Post-doc
Adriane Feijó Evangelista, PhD
Ana Carolina Carvalho, PhD
Matias Eliseo Melendez, PhD
5 Molecular Oncology Research Center – Barretos Cancer Hospital
Vânia Sanmartino Mariano, PhD
Viviane Silva, PhD
PhD students
Adriana Tarlá Lorenzi
Aline Becker
Lidia Maria Rebolho Batista Arantes
Master students
Camila Martinelli
Carla Aparecida Pinheiro
Flávia Coltri Eguchi
Larisa Kuil
Natalia Campacci
Nathalia Campanella
Paula Roberta Aguiar Pastrez
Taciane Macedo
Vanessa Uzan
Biologists / Bioinformaticians / Technical support
Aline Tansine, PhD
Adriana Cruvinel Carloni (master student)
Alessandra Paulino dos Santos
André Escremim de Paula
André Van Helvoort Lengert
Flávia Escremim de Paula, PhD
Gabriela Carvalho Fernandes (master student)
Gustavo Noriz Berardinelli (PhD student)
Maicon Fernando Zanon da Silva (master student)
Marcela Nunes
Maressa Ferreira Neto, PhD
Raul Torrieri
Renato José da Silva Oliveira (PhD student)
Research Initiation / Trainee
6 Molecular Oncology Research Center – Barretos Cancer Hospital
Anna Luiza Silva Almeida Vicente
Cintia Batista de Oliveira
Fernanda Costa Ferreira
Fernanda Cury
Karina Pepineli de Mello
Karla Rodrigues de Assis
Livia Marques dos Santos
Marina Schimidt Carrijo
Manoela Catarina Aguena Souza Ramos
Tereza Victoria de Castilho Niero Simoes
Verônica Crissatti
Weder Pereira de Menezes
Administrative/IT/Comercial
Ednise Woyciechowski –IEP manager
Tamiris Regina Ribeiro de Moraes – Administrative Assistant - CPOM
Marcella Marchioretto – Financial Analyst - EPIT
Osmar Alves – IT support
Raphael Alves Ramos Assunção – Administrative Assistant - Molecular Diagnostic
Amanda Costa – Administrative Assistant - EPIT
Paulo Ferreira – Marketing and Comercial
7 Molecular Oncology Research Center – Barretos Cancer Hospital
3) Research Lines
- Cellular Signaling
One of the hallmarks of cancers is the oncogenic upregulation of the signaling cascades that
govern the transduction of extracellular growth factors to cellular nuclear response. Among
these plethora of players, receptor tyrosine kinases (RTKs) and intracellular MAPK,
PI3KCA/AKT and JAK/STAT pathways, have a crucial impact in cancer development,
behavior and currently, there is also an attractive therapeutic target. Our group is focused in
evaluate the major genetic alterations that disrupt these cellular circuits, and understand their
impact on patient prognosis and therapeutic response. Additionally, using tumor cell line and
primary culture models we intend to understand their function and biological impact on
cancer.
- Biomarkers
We now know that cancer is a disease of the genome and this new vision has introduced a
new paradigm. In this scenario, the genome of the cancer can be more objectively in the
stratification of patients with cancer, leading to the emerging personalized medicine in
oncology. In order to achieve this aim, it is necessary to identify from the myriad of cancer
genomic changes, which ones have a clinical value - biomarkers. The diagnosis based on the
genome, it should present a high sensitivity and specificity, and detection of these biomarkers
should be possible not only in tumor tissue, but also extended to other body fluids such as
plasma, serum, urine, saliva, strokes cavity, allowing so early detection and the ability to
monitor tumor development. With a huge bank of tissues and fluids of cancer patients in
Barretos Hospital of Cancer (CrioBio) and a detailed medical history, our group intends to
validate potential biomarkers known in the Brazilian population, as well as identify new
biomarkers.
- Functional Genomics of Cancer
The genomic science aims to understand how genes and genetic information is organized
within the genome (structural genomics) and how the organization determines its function
(functional genomics). The functional genomics applied to cancer aims to evaluate
systematically and simultaneously, the expression of genes (mRNA), microRNAs or proteins
to a better understanding of the molecular genetic basis governing the process of
carcinogenesis. Our research group intends to use the functional genomics resources for
transcriptional signatures mRNA and microRNAs expression in order to point out potential
molecular biomarkers of tumor progression. Additionally, using tumor cell line we can
validate the miRNA-mRNA interactions through functional tests using silencing of miRNAs
(using anti-miRNAs or anti-MIRs) and thus assess the impact of these new biomarkers in the
progression cancer.
8 Molecular Oncology Research Center – Barretos Cancer Hospital
- Environmental factors and Cancer
The exposure to different types of environmental factors such as: food, occupational
conditions, medications, hormones, radiation, viruses, bacteria, chemical agents, air pollution
and water are intrinsically linked to the occurrence of cancer in exposed populations. The
determination of the potential cancer risk in the exposure to environmental factors can
contribute to public policies and preventive measures. Therefore, our research group aims to
assess populations exposed to chemical or environmental factors using genetic biomarkers.
Considering the susceptibility of each individual to metabolize carcinogenic agents, we intend
to reveal the molecular mechanisms involved in the resistance to these compounds,
polymorphisms, gene-environment interactions and its implications in carcinogenesis.
- Hereditary Cancer
Several cancers developed in higher than normal frequencies may be related to inherited
genetic alterations, present in predisposed families. Around 10% of most cancer types are due
to the presence of germline mutations, leading to an increased lifetime cancer risk. The
recognition of a hereditary cancer-affected individual is crucial for the identification of other
at-risk family members and their inclusion in cancer risk reduction strategies. The focus of
our research group is to prematurely identify, characterize and analyze, clinically and
molecularly, these at-risk individuals. Genetic modifiers that may contribute to an increased
cancer development risk, such as genetic polymorphisms, rearrangements, copy number
variations are also part of our research work.
- Epigenetics
Epigenetics are related to reversible events that do not produce modification in the genomic
DNA sequence, but rather alters its phenotype, influencing mechanisms related to gene
expression. Methylation is the most common epigenetic event, being a very important
biologic process involved in gene silencing. The study of hypermethylation can give vital
information on the understanding of carcinogenesis, as well as the evaluation of its pattern can
be used as a biomarker for diagnosis, treatment planning and prognosis of an individual.
- Pediatric Tumor Biology
Although considered rare, childhood cancer is the leading cause of disease-related mortality in
children. Cancer in the childhood often is more devastating and aggressive than their
counterparts in adults. Despite the progress in cure rates and survival improvement achieved
in the last Decades, there is a group of tumors that still do not respond to any available
standard treatment. Our goal is to apply the knowledge and tools of molecular biology to
clarify and understand the biology and pathogenesis of pediatric tumors, in order to identify
9 Molecular Oncology Research Center – Barretos Cancer Hospital
potential biological markers that may support diagnosis and/or indicate prognosis of pediatric
patients. As well, we are looking for the altered pathways/genes that can be targets for new
therapy strategies.
4) Productivity
4.1) Books or Book Chapters
1. de Mello R, Araújo A, Reis RM, Hespanhol V. The role of genetic polymorphisms in the
angiogenesis pathway and non-small cell lung cancer tumor behavior: implications in risk
assessment and clinical outcome. In: Mehta JL, Dhalla NS. (Org.). Biochemical Basis and
Therapeutic Implications of Angiogenesis, Advances in Biochemistry in Health and Disease,
381-403, 2013.
2. Fregnani JH. Future Strategies for Cervical Cancer Prevention in Developing Countries:
HPV vaccine and Its Implementation around the World. In: Breast and Gynecological
Cancers. An Integrated Approach for Screening and Early Diagnosis in Developing
Countries.1st ed.New York: Springer, 320-329, 2013.
3. Branca M, Longatto-Filho A. A Manual for Cervical Cancer Screening and Control:
Principles, Practice and New Perspectives NOVA Publishers Publishers, New York, 2013.
4. Paixao Becker A, Scapulatempo-Neto C, Neder L, Chimelli L, Reis RM. Pilocytic
Astrocytoma: Anatomic, pathological and molecular aspects. Clinical Management and
Evolving Novel Therapeutic Strategies for Patients with Brain Tumors, InTech, p.127-143,
2013.
5. Scapulatempo-Neto C, Costa H. Câncer de esôfago. Manual De Padronização de Laudos
Anátomo Patológicos, 4 edição, Editora Manole, 602-615, 2013.
4.2) Publications in International Journals
1. Abrahão-Machado LF, Jacome AA, Wohnrath DR, Dos Santos JS, Carneseca EC, Fregnani
JH, Scapulatempo-Neto C. HER2 in gastric cancer: Comparative analysis of three different
antibodies using whole-tissue sections and tissue microarrays. World Journal of
Gastroenterology. 6438-46, 2013. IF: 2,594
10 Molecular Oncology Research Center – Barretos Cancer Hospital
2. Afonso J, Longatto-Filho A, Martinho O, Lobo F, Amaro T, Reis RM, Santos LL. RKIP
downregulation associates with poor prognosis in bladder cancer patients. Virchows Archiv.
445-53, 2013. IF: 2.676
3. Amorim R, Martins S, Longatto-Filho,A, Preto A, Baltazar F. Exploiting monocarboxylate
transporters as new molecular targets for colorectal carcinoma therapy. BMC Proceedings.
7(2), 60, 2013. IF: NA
4. Azevedo MM, Pinheiro C, Yaphe J, Baltazar F (2013). Assessing the Impact of a School
Intervention to Promote Students’ Knowledge and Practices on Correct Antibiotic Use.
International Journal Environmental Research Public Health. 2920-31. IF: 1.998
5. Azevedo MM, Miranda IM, Ricardo E, Silva AP, Pinheiro C, Pina-Vaz C, Rodrigues AG
(2013). Input of University Júnior 2012 to Science Education: a cross study among
Portuguese students. Education Research Journal 50- 58, 2013. IF: NA
6. Benberin V, Bektayeva R, Karabayeva R, Lebedev A, Akemeyeva K, Paloheimo L,
Syrjänen K. Prevalence of H. pylori infection and atrophic gastritis among symptomatic and
dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum
biomarkers. Anticancer Research. 4595-602, 2013. IF: 1.713
7. Campanella NC, de Oliveira AT, Scapulatempo-Neto C, Peixoto-Guimarães D, Reis RM.
Biomarkers and novel therapeutic targets in gastrointestinal stromal tumors (GISTs). Recent
Patents on Anti-Cancer Drug Discovery. 288-297, 2013. IF: 2.700
8. Campos M, DE Campos SG, Ribeiro GG, Eguchi FC, Silva SR, DE Oliveira CZ, DA Costa
AM, Curcelli EC, Nunes MC, Penna V, Longatto-Filho A. Ki-67 and CD100
immunohistochemical expression is associated with local recurrence and poor prognosis in
soft tissue sarcomas, respectively. Oncology Letters. 1527-1535, 2013. IF: 0.237
9. Carneseca EC, Mauad EC, Araújo MA, Dalbo RM, Longatto-Filho A, Vazquez VL. An
analysis of cancer survival at a single institution in Brazil over a 10-year period. BMC
Research Notes, 141, 2013. IF: NA
10. Cássio Zequi SD, Fregnani JH, Favaretto RL, Costa WH, Madeira Campos RS, Fonseca
FP, Guimaraes GC, Soares FA, da Cunha IW, Lopes A. The impact of immunohistochemical
expression of nitric oxide synthases on clinical and pathological features of renal cell
carcinoma. World Journal of Urology. 1197-203, 2013. IF: 2.888
11. Carvalho TG, De Carvalho AC, Maia DC, Ogawa JK, Carvalho AL, Vettore AL. Search
for mutations in signaling pathways in head and neck squamous cell carcinoma. Oncology
Reports. 334-40, 2013. IF: 2.297
11 Molecular Oncology Research Center – Barretos Cancer Hospital
12. Colleoni JL, Rodrigues LM, Junior GS, Scapulatempo C, Abreu LC, Valenti VE, Fujiki E,
Camargo RC, Oliveira FR, Alves MT, Cohen M. Immunohistochemical analysis of
mechanoreceptors in the human posterior cruciate ligament: association with aging male.
Aging Male. 73-8, 2013. IF: 1.711
13. de Castro Mattos JS, Mauad EC, Syrjänen K, Longatto-Filho A, Haikel RL, Da Costa
Vieira RA, Silva TB, De Barros N. The impact of breast cancer screening among younger
women in the Barretos Region, Brazil. Anticancer Research. 2651-5, 2013. IF: 1.713
14. de Mello RA, Ferreira M, Pires FS, Costa S, Luis M, Pozza DH, Cunha J, Oliveira P,
Hespanhol V, Reis RM. The impact of polymorphic variations in the 5p15, 6p12, 6p21 and
15q25 loci on the risk and prognosis of Portuguese patients with non-small cell lung cancer.
PlosOne. 2013. IF: 3.730
15. de Mello RA, Araújo A, Hespanhol V, Reis RM. Loci identified through genome-wide
association studies and lung cancer risk: is there anything more? Sao Paulo Medical Journal.
135-6, 2013. IF: NA
16. de Oliveira CM, Fregnani JH, Carvalho JP, Longatto-Filho A, Levi JE. Human
papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil. BMC
Cancer. 357, 2013. IF: 3.333
17. Emerenciano M, Meyer C, Mansur MB, Marschalek R, Pombo-de-Oliveira MS; Brazilian
Collaborative Study Group of Infant Acute Leukaemia. The distribution of MLL breakpoints
correlates with outcome in infant acute leukaemia. British Journal of Haematology. 224-36,
2013. IF: 4.942
18. Filassi JR, Zonta MA, Trinconi A, Calvagno D, Velame de Oliveira F, Ricci MD, Baracat
E, Longatto-Filho A. Can breast nipple fluid collected with automated aspiration and
preserved in based-liquid solution improve the cytological samples? Acta Cytologica. 276-80,
2013. IF: 0.693
19. Fregnani JH, Carvalho AL, Eluf-Neto J, Ribeiro Kde C, Kuil Lde M, da Silva TA,
Rodrigues SL, Mauad EC, Longatto-Filho A, Villa LL. A school-based human papillomavirus
vaccination program in Barretos, Brazil: final results of a demonstrative study. PLoS One.
62647, 2013. IF: 3.730
20. Fregnani JH, Scapulatempo-Neto C, Haikel RL Jr, Saccheto T, Campacci N, Mauad EC,
Longatto-Filho A. Could alarmingly high rates of negative diagnoses in remote rural areas be
minimized with liquid-based cytology? Preliminary results from the RODEO study team.
Acta Cytologica. 69-74, 2013. IF: 0.693
21. Garcia EA, Simões K, Wakamatsu A, Cirqueira SC, Alves VAF, Longatto-Filho, A,
12 Molecular Oncology Research Center – Barretos Cancer Hospital
Camargo RS. Pro and Anti-Angiogenic Vascular Endothelial Growth Factors Expression in
Benign and Malignant Thyroid Lesions. Journal of Thyroid Disorders & Therapy, v. 2, 1-6,
2013. IF: NA
22. Giacomazzi J, Koehler-Santos P, Palmero EI, Graudenz MS, Rivero LF, Lima E, Pütten
AC, Hainaut P, Camey SA, Michelli RD, Neto CS, Fitarelli-Kiehl M, Geyer G, Meurer L,
Geiger A, Azevedo MB, da Silva VD, Ashton-Prolla P. A TP53 founder mutation, p.R337H,
is associated with phyllodes breast tumors in Brazil. Virchows Archiv. 17-22, 2013. IF: 2.676
23. Goss PE, Lee BL, Badovinac-Crnjevic T, Strasser-Weippl K, Chavarri-Guerra Y, Louis
JS, Villarreal-Garza C, Unger-Saldaña K, Ferreyra M, Debiasi M, Liedke PE, Touya D,
Werutsky G, Higgins M, Fan L, Vasconcelos C, Cazap E, Vallejos C, Mohar A, Knaul F,
Arreola H, Batura R, Luciani S, Sullivan R, Finkelstein D, Simon S, Barrios C, Kightlinger R,
Gelrud A, Bychkovsky V, Lopes G, Stefani S, Blaya M, Souza FH, Santos FS, Kaemmerer A,
de Azambuja E, Zorilla AF, Murillo R, Jeronimo J, Tsu V, Carvalho AL, Gil CF, Sternberg C,
Dueñas-Gonzalez A, Sgroi D, Cuello M, Fresco R, Reis RM, Masera G, Gabús R, Ribeiro R,
Knust R, Ismael G, Rosenblatt E, Roth B, Villa L, Solares AL, Leon MX, Torres-Vigil I,
Covarrubias-Gomez A, Hernández A, Bertolino M, Schwartsmann G, Santillana S, Esteva F,
Fein L, Mano M, Gomez H, Hurlbert M, Durstine A, Azenha G. Planning cancer control in
Latin America and the Caribbean. Lancet Oncology. 391-436, 2013. IF: 25.117
24. Jácome AA, Wohnrath DR, Scapulatempo Neto C, Fregnani JH, Quinto AL, Oliveira AT,
Vazquez VL, Fava G, Martinez EZ, Santos JS. Effect of adjuvant chemoradiotherapy on
overall survival of gastric cancer patients submitted to D2 lymphadenectomy. Gastric Cancer.
233-238, 2013. IF: 3.989
25. Jácome AA, Wohnrath DR, Scapulatempo Neto C, Carneseca EC, Serrano SV, Viana LS,
Nunes JS, Martinez EZ, Santos JS. Prognostic value of epidermal growth factor receptors in
gastric cancer. A survival analysis by Weibull model incorporationg long-term survivors.
Gastric Cancer. 2013. IF: 3.989
26. Liberman PH, Schultz C, Goffi-Gomez MV, Lopes LF. Speech recognition and frequency
of hearing loss in patients treated for cancer in childhood. Pediatric Blood Cancer. 1709-13,
2013. IF: 2.353
27. Linhares P, Carvalho BM, Figueiredo R, Reis RM, Vaz R. Early Pseudo-progression
Following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation.
Journal of Oncology. 2013. IF: NA
13 Molecular Oncology Research Center – Barretos Cancer Hospital
28. Linhares P, Martinho O, Carvalho B, Castro L, Lopes JM, Vaz R, Reis RM. Analysis of a
synchronous gliosarcoma and meningioma with long survival: A case report and review of the
literature. Surgical Neurology International, 2013. IF: NA
29. Lorenzi AT, Fregnani JH, Possati-Resende JC, Neto CS, Villa LL, Longatto-Filho A.
Self-collection for high-risk HPV detection in Brazilian women using the careHPV™ test.
Gynecologic Oncology. 131-4, 2013. IF: 3.929
30. Koskela HM, Syrjänen K, Korkeila EA. Disease outcome of patients with pancreatic
cancer in a cohort treatedoutside clinical trials. Anticancer Research. 5491-4, 2013. FI: 1.713
31. Macedo C, Evangelista AF, Marques MMC, Octacilio-Silva S, Donadi EA, Sakamoto-
Hojo ET, Passos GAS. Autoimmune regulator (Aire) controls the expression of microRNAs
in medullary thymic epithelial cells. Immunobiology. 554-60, 2013. IF: 2.814
32. Martinho O, Silva-Oliveira R, Miranda-Gonçalves V, Clara C, Almeida JR, Carvalho AL,
Barata JT, Reis RM. In vitro and in vivo analysis of RTKs inhibitors efficacy and
identification of its novel targets in glioblastomas. Translational Oncology. 187-96, 2013. IF:
2.943
33. Martinho O, Simões K, Longatto-Filho A, Jacob CE, Zilberstein B, Bresciani C, Gama-
Rodrigues J, Cecconello I, Alves V, Reis RM. Absence of RKIP expression is an independent
prognostic biomarker for gastric cancer patients. Oncology Reports. 690-6, 2013. IF: 2.297
34. Martinho O, Pinto F, Granja S, Miranda-Gonçalves V, Moreira MAR, Ribeiro LJF, di
Loreto C, Rosner MR, Longatto-Filho A, Reis RM. RKIP inhibition in cervical cancer is
associated with higher tumor aggressive behavior and resistance to cisplatin therapy. PLoS
One. 8, 2013. IF: 3.730
35. Martino A, Sainz J, Reis RM, Moreno V, Buda G, Lesueur F, Marques H, García-Sanz R,
Ríos R, Stein A, Dumontet C, Gemignani F, Rossi AM, Landi S, Jurado M, Petrini M,
Jamroziak K, Campa D, Canzian F. Polymorphisms in regulators of xenobiotic transport and
metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in
the context of IMMEnSE consortium. Journal of Human Genetics. 155-9, 2013. IF: 2.365
36. Martins S, Garcia EA, Luz MA, Pardal F, Rodrigues M, Longatto-Filho A.
Clinicopathological Correlation and Prognostic Significance of VEGF-A, VEGF-C, VEGFR-
2 and VEGFR-3 Expression in Colorectal Cancer. Cancer Genomics Proteomics. 55-67, 2013.
IF: NA
37. Martins S, Amorim R, Reis RM, Pinheiro C, Rodrigues M, Baltazar F, Longatto-Filho A.
A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital,
Northern Portugal. Journal of Gastrointestinal & Digestive System. 146, 2013. IF: NA
14 Molecular Oncology Research Center – Barretos Cancer Hospital
38. Miranda-Gonçalves V, Honavar M, Martinho O, Pires MM, Pinheiro C, Cordeiro M,
Bebiano G, Costa P, Palmeirim I, Reis RM, Baltazar F. Monocarboxylate transporters (MCTs)
in gliomas: expression and exploitation as therapeutic targets. Neuro-Oncology. 172-88, 2013.
IF: 6.180
39. Moniz S, Martinho O, Pinto F, Sousa B, Loureiro C, Oliveira MJ, Moita LF, Honavar M,
Pinheiro C, Pires M, Lopes JM, Jones C , Costello JF, Paredes J, Reis RM, Jordan P. Loss of
WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-
mediated tumour cell invasiveness. Human Molecular Genetics. 84-95, 2013. IF: 7.692
40. Morais-Santos F, Miranda-Gonçalves V, Pinheiro S, Vieira AF, Paredes J, Schmitt FC,
Baltazar F, Pinheiro C (2013). Differential sensitivities to lactate transport inhibitors of breast
cancer cell lines. Endocrine-Related Cancer. 27-38, 2013. IF: 5.261
41. Oliveira RDR, Fontana V, Junta CM , Marques MM, Macedo C, Rassi DM, Passos GAS,
Donadi EA, Louzada-Jr P. Differential gene expression profiles Maio differentiate responder
and non-responder rheumatoid arthritis patients for methotrexate monotherapy and
methotrexate plus TNF-blocker combined therapy. The Journal of Rheumatology. 1524-32,
2013. IF: 3.690
42. Osório NS, Rodrigues F, Garcia EA, Costa MJ. Drawings as snapshots of student cellular
anatomy understanding. Medical Education, 1120-1121, 2013. IF: 3.546
43. Paugh BS, Zhu X, Qu X, Endersby R, Zhang J, Bax DA, Carvalho D, Reis RM, Onar-
Thomas A, Broniscer A, Wetmore C, Jones C, Zhang J, Ellison DW, Baker SJ. Novel
Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas. Cancer Research. 6219-
6229, 2013. IF: 8.650
44. Polli CD, Toledo KA, Franco LH, Mariano VS, Oliveira LL, Bernardes ES, Roque-
Barreira MC, Pereira-da-Silva G. Monocyte Migration Driven by Galectin-3 Occurs through
Distinct Mechanisms Involving Selective Interactions with the Extracellular Matrix. ISRN
Inflammation. 28, 2013. IF: NA
45. Rettori MM, de Carvalho AC, Bomfim Longo AL, de Oliveira CZ, Kowalski LP,
Carvalho AL, Vettore AL. Prognostic significance of TIMP3 hypermethylation in post-
treatment salivary rinse from head and neck squamous cell carcinoma patients.
Carcinogenesis. 20-7, 2013. IF: 5.635
46. Rettori MM, de Carvalho AC, Longo AL, de Oliveira CZ, Kowalski LP, Carvalho AL,
Vettore AL. TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased
incidence of second primary tumors. Journal of Translational Medicine. 316, 2013. IF: 3.46
47. Roncaglia MT, Fregnani JH, Tacla M, DE Campos SG, Caiaffa HH, Ab'saber A, DA
15 Molecular Oncology Research Center – Barretos Cancer Hospital
Motta EV, Alves VA, Baracat EC, Longatto Filho A. Characterization of p16 and E6 HPV-
related proteins in uterine cervix high-grade lesions of patients treated by conization with
large loop excision. Oncology Letters. 63-68, 2013. IF: 0.237
48. Scapulatempo C, Fregnani JH, Campacci N, Possati-Resende JC, Longatto-Filho A. The
significance of augmented high-grade squamous intraepithelial lesion detection on pap test
examination: partial results from the RODEO study team. Acta Cytologica. 489-94, 2013. IF:
0.698
49. Silva AG, Maschietto M, Vidal DO, Peliçario LM, Velloso ED, Lopes LF, Krepischi AC,
Rosenberg C. Array-CGH as an adjuvant tool in cytogenetic diagnosis of pediatric MDS and
JMML. Medical Oncology. 734, 2013. IF: 2.147
50. Silva TB, Mauad EC, Carvalho AL, Jacobs LA, Shulman LN. Difficulties in
implementing an organized screening program for breast cancer in Brazil with emphasis on
diagnostic methods. Rural Remote Health. 2013. IF: 0.979
51. Silveira HCS, Carrijo MS, Seidel EH, Scapulatempo Neto C, Longatto Filho A, Carvalho
AL, Reis RM, Saldiva PH. Emissions generated by sugarcane burning promote genotoxicity
in rural workers: a case study in Barretos, Brazil. Environmental Health. 87, 2013. IF: 2.714
52. Sonaglio V, de Carvalho AC, Toledo SRC, Salinas-Souza C, Carvalho AL, Petrilli AS, de
Camargo B, Vettore AL. Aberrant DNA methylation of ESR1 and p14ARF genes could be
useful as prognostic indicators in osteosarcoma. OncoTargets and Therapy. 713-23, 2013. IF:
2.073
53. Stein MD, Fregnani JH, Scapulatempo C, Mafra A, Campacci N, Longatto-Filho A;
RODEO Study Team From Barretos Cancer Hospital. Performance and Reproducibility of
Gynecologic Cytology Interpretation Using the FocalPoint System: Results of the RODEO
Study Team. American Journal of Clinical Pathology. 567-71, 2013. IF: 2.88
54. Trigo G, Martins TG, Fraga AG, Longatto-Filho A, Castro AG, Azeredo J, Pedrosa. J.
Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad
Model. PLoS Neglected Tropical Diseases. 2183, 2013. IF: 4.569
55. Valente V, Serafim B R, Oliveira C L, Adorni S F, Torrieri R, Tirapelli C P D, Espreafico
M E, Oba-Shinlo M S, Marie N K S, Paçó-Larson L M, Carloti Jr. G C. Modulation of
HJURP (Holliday Junction-Recognizing Protein) Levels Is Correlated with Glioblastoma
Cells Survival. Plos One 25, 2013. IF: 3.730
56. Vecchiatti SM, Guzzo ML, Caldini EG, Bisi H, Longatto-Filho A, Lin CJ. Iodine
increases and predicts incidence of thyroiditis in NOD mice: Histopathological and
ultrastructural study. Experimental and Therapeutic Medicine. 603-607, 2013. IF: 0.344
16 Molecular Oncology Research Center – Barretos Cancer Hospital
57. Viana RC, Scapulatempo-Neto C, Kerr LM, Palmero EI, Marques MMC, Colacoiavo T,
Queiroz Junior AF, Carvalho AL, Siqueira SAC. The interference of cold isquemia time in
the quality of total RNA from frozen tumor samples. Cell & Tissue Banking. 167-73, 2013. IF:
1.171
58. Vidal DO, Marques MMC, Lopes LF, Reis RM. The Role of miRNAs in
Medulloblastoma. Pediatric Hematology and Oncology. 367-78, 2013. IF: 0.891
59. Vinagre J, Almeida A, Populo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R,
Prazeres H, Lima L, Melo M, Rocha A, Preto A, Castro P, Castro P, Pardal F, Lopes JM, Lara
Santos L, Reis RM, Cameselle-Teijeiro J, Sobrinho-Simões M, Lima J, Máximo V, Soares P.
Frequency of TERT promoter mutations in human cancers. Nature Communications. 26, 2013.
IF: 10.015
60. Wang SJ, Patel SG, Shah JP, Goldstein DP, Irish JC, Carvalho AL, Kowalski LP,
Lockhart JL, Holland JM, Gross ND. An Oral Cavity Carcinoma Nomogram to Predict
Benefit of Adjuvant Radiotherapy. JAMA Otolaryngol Head Neck Surgery. 1-6, 2013. IF:
1.63
4.3) Publications in Brazilian Journals
1. Abud J, Izetti PR, Moreira MA, M, Achatz MIW, Vargas FR, Palmero EI, Cossio SL,
Prolla JC, Ashton PP. Study Group on Hereditary Breast and Colorectal Cancer. CHEK2
1100DELC germline mutation: a frequency study in hereditary breast and colon cancer
Brazilian families. Arquivos de Gastroenterologia. 273-278, 2013. IF: 0.0238
2. Heinke T, Espiríto Santo KS, Longatto Filho A, Stavale JN. Vascular endothelial growth
factor and KIT expression in relation with microvascular density and tumor grade in
supratentorial astrocytic tumors. Acta Cirurgica Brasileira. 48-54, 2013. IF: 0.626
3. Passos-Filho O, Cangussu HC, Lopes RH, Oliveira AT, Vazquez VL, Galvão CN.
Síndrome de Boerhaave: relato de caso. Revista do Colégio Brasileiro de Cirurgiões. 83-84,
2013. IF: 0.0317
4. Velloso ED, Chauffaille ML, Peliçario LM, Tanizawa RS, Toledo SR, Gaiolla
RD, Lopes LF. Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases:
challenges and difficulties in a large and emerging country. Brazilian Journal of Medical
Biological Research. 85-90, 2013. IF: 1.139.
17 Molecular Oncology Research Center – Barretos Cancer Hospital
5) Conferences and Congresses
5.1) Oral Communications
1. Berardinelli GN, Souza NCN, Scapulatempo-Neto C, Melanni R, Reis RM. Mutational
profile of Colorectal Cancer Patients: Implication in Anti-EGFR Therapies. III Simpósio
em Oncologia Translacional do Hospital de Câncer de Barretos. August 2013, Barretos,
Brazil.
2. Bidinotto LT, MacKay A, Caravina G, Becker A, Viana-Pereira M, Clara C, Jones C, Reis
RM. Profile of genomic alterations of gliomas. XVI Jornada de Patologia do
A.C.Camargo Cancer Center / VI Encontro Internacional de Patologia Investigativa. 7-10,
2013. São Paulo, Brazil.
3. Campacci N, Lima JO, Ramadan L, Michelli R, Viana DV, Mauad EC, Haikel JRR, Rossi,
BM, Palmero EI. Identification of at-risk families for hereditary colorectal cancer through
a Brazilian Cancer Prevention Network in a population-based sample. In: International
Society for Gastrointestinal Hereditary Tumours - 5th Biennial Meeting, 2013, Cairns,
Australia.
4. de Paula AE, Mendes DRP, Fernandes GC, Berardineli GN, Reis RM, Oliveira JC, Viana
DV, Andrade CEMC, Scapulatempo-Neto C, Palmero EI. Caracterização Molecular de
Famílias em Risco para Câncer Colorretal Hereditário – Importância da realização do
Teste Genético. XXV Congresso Brasileiro de Genética Médica. 11-15, 2013.
Florianópolis, Brazil.
5. de Paula AE, Mendes DRP, Fernandes GC, Legnaro CC, Michelli R, Reis RM, Viana DV,
Andrade CEMC, Palmero EI. Caracterização molecular dos genes BRCA1 e BRCA2 em
famílias com Risco de Câncer de Mama e Ovário Hereditário. XXV Congresso Brasileiro
de Genética Médica. 11-15, 2013. Florianópolis, Brazil.
6. Guimarães DP, Yamane L, Scapulatempo-Neto C, Alvarenga L, Cunha T, Almodova E,
Fava G, Reis RM. Caracterização Endoscópica de Adenomas Serrilhados Sésseis. XII
Semana Brasileira do Aparelho Digestivo. 24-27 November de 2013. Goiânia, Brazil.
7. Lacerda CF, Carloni AC, Scapulatempo-Neto C, Crema E, de Arruda Henry M, Rodrigues
MA, de Oliveira AT, Guimaraes DP, Reis RM. TP53 Gene Mutations in Squamous Cells
Carcinoma of the Esophagus Associated with Chagasic Megaesophagus. Global
Academic Program Meeting, 2013. Houston, USA.
8. Oliveira-Silva RJ, Martinho O, Berardinelli GN, Viana L, Carvalho AL, Reis RM. The
importance of molecular characterization of head and neck cancer cell lines for the
18 Molecular Oncology Research Center – Barretos Cancer Hospital
prediction of anti-EGFR therapies resistance. III Simpósio em Oncologia Translacional do
Hospital de Câncer de Barretos. 29-30 August de 2013, Barretos, Brazil.
9. Silva-Correia J, Pereira H, Yan LP, Miranda-Gonçalves V, Espregueira-Mendes J,
Oliveira AL, Reis RM, Oliveira JM, Reis RL. Development of Anatomical
Silk/Methacrylated Gellan Gum Scaffolds for Controlling Segmental Vascularization in
Meniscus Tissue Regeneration – TERMIS-EU 2013. Istanbul, Turkey.
10. Silva-Correia J, Pereira H, Yan L-P, Miranda-Gonçalves V, Oliveira AL, Oliveira JM,
Reis RM, Espregueira-Mendes J, Reis RL. Novel Silk-based Scaffolds for Meniscus
Tissue Engineering: The Relevance of Controlling Segmental Vascularization by
Methacrylated Gellan gum Hydrogels – 14th EFORT Congress, 2013. Istanbul, Turkey.
11. Zanon MF, Almeida GC, Matsushita MM, Reis RM, Squire JA, Camparotto ML.
Evaluation of 1p/19q codeletion using FISH analysys in pure and mixed oligodendroglial
tumors at the routine pathology of the Barretos Cancer Hospital-SP, Brazil. 3ª Reunião
Brasileira de Citogenética e IV Simpósio Latino-Americano de Citogenética e Evolução.
26- 29 may 2013. Guarujá, SP, Brazil.
5.2) Posters
1. Almeida M, Portela C, Nabiço R, Ferreira A, Pardal F, Costa S, Ferreira M, Costa P,
Viana-Pereira M, Reis RM. Association of ESR1 polymorphisms with tamoxifen response in
women with estrogen receptor-positive breast cancer. IMPAKT Breast Cancer Conference,
May 2013. Brussels, Belgian.
2. Andrade C, Palmero EI, Viana DV, Michelli R, Fregnani JH. Criteria to screening
endometrial cancer for Lynch Syndrome in a Public Health System. In: 2013 SGO Annual
Meeting on Women s Cancer. 2013, Flórida, USA.
3. Becker A, Bidinotto L, Mackay A, Clara C, Scapulatempo-Neto C, Jones C, Reis RM.
Avaliação de alterações cromossomicas em astrocitomas pilocíticos através da técnica de
array-CGH: Estudo piloto de 4 pacientes do HCB. XXIX Congresso Brasileiro de Patologia.
13-16 November de 2013, Florianópolis, Brazil.
4. Becker A, Clara C, Scapulatempo-Neto C, Reis RM. Caracetrização clinicoepidemiológica
e construção de TMA de uma série de astrocitomas pilocíticos do HCB. XXIX Congresso
Brasileiro de Patologia. November de 2013, Florianópolis, Brazil.
5. Berardinelli GN, Scapulatempo Neto C, Campanella NC, Melani A, Guimaraes DP, Lima
JP, Reis RM. Study of microsatellite instability (MSI) and mutations of MSI-target genes in
19 Molecular Oncology Research Center – Barretos Cancer Hospital
large cohort of Brazilian colorectal cancer patients. Global Academic Program Meeting. April
2003, Houston, USA.
6. Bezerra F, Cunha M, Miranda-Gonçalves V, Pinheiro C, Baltazar F. Monocarboxylate
transporters as mediators in tumor-endothelial cell crosstalk. XXII Porto Cancer Meeting.
2013, Porto, Portugal.
7. Campacci N, de Lima JO, Rissatti V, de Toledo EMP, Ramadan L, Palmero EI. O uso de
uma ferramenta de baixo custo para rastreamento de Câncer Hereditário. XXV Congresso
Brasileiro de Genética Médica. Jun 2013. Florianópolis, Brazil.
8. Campanella NC, Scapulatempo-Neto C, de Oliveira AT, Guimarães DP, Reis RM. Study of
microsatellite instability and potential target genes in GISTs. Translating Molecular Biology
into Cancer Treatment. SPSAS – São Paulo School of Advanced Sciences, Advances in
Molecular Oncology. February 2013. São Paulo, Brazil.
9. Campanella NC, Scapulatempo-Neto C, de Oliveira AT, Guimarães DP, Reis RM.
Mutações na região promotora da telomerase reverse transcriptase (TERT) ocorrem em uma
parcela dos GISTs. V Encontro Científico do Hospital de câncer de Barretos. 13-14 Decembre
2013. Barretos, São Paulo, Brazil.
10. Camparotto ML, Castro NS, Gonçalves IZ, Squire JA. Impact of cytogenetic for
evaluation of different diagnostic approach in acute lekemia: a case report. 3º Reunião
Brasileira de Citogenética. May 2013. Águas, Guarujá, São Paulo, Brazil.
11. Carloni AC, Oliveira RJS, Clara C, Camparotto ML, Squire JA, Reis RM. Cytogenetic
and molecular characterization of gliomas primary culture. Translating Molecular Biology
into Cancer Treatment. SPSAS – São Paulo School of Advanced Sciences, Advances in
Molecular Oncology. February 2013. São Paulo, Brazil.
12. Carloni AC, Oliveira R, Bidinotto L, Clara C, Almeida GC, Camparotto ML, Squire JA,
Reis RM. Establishment and cytogentic and molecular characterization of glioblastomas
primary cultures. III Simpósio em Oncologia Translacional do Hospital de Câncer de Barretos.
29-30 de August 2013. Barretos, Brazil.
13. Carvalho Al, Penna V, Pinheiro C A, Reis RM, Squire J, Camparoto ML. Centrosome
clustering in primary sarcomas cultures and its association with malignant behavior in tumor”.
III Simpósio Internacional de Oncologia Translacional do Hospital de Câncer de Barretos. 29-
30 de August 2013. Barretos, Brazil.
14. Carvalho D, Mackay A, Burford A, Chen LBL, Kozarewa I, Lord C, Ashworth A, Reis
RM, Jones C. Integrated whole genome and RNA sequencing identifies novel expressed
fusion transcripts in paediatric high grade glioma. May 2013. Fort Lauderdale, Flórida, USA.
20 Molecular Oncology Research Center – Barretos Cancer Hospital
15. Costa A, Oliveira MJ, Martinho O, Pinto F, Jordan P, Reis RM. WNK2 as a modulator of
MMP-2 and MMP-9 expression and activity in Gliomas. VI Congresso Nacional da
Associação Portuguesa de Neuro-Oncologia. 15-16 November 2013. Almada, Portugal.
16. Couto E, Portela C, Almeida M, Nabiço R, Ferreira M, Costa S, Costa P, Viana-Pereira M,
Reis RM. Association of SMAD7 single nucleotide polymorphisms with risk and prognosis of
colorectal cancer in a Portuguese population. ESMO 15th World Congress on Gastrointestinal
Cancer. July de 2013. Barcelona, Spain.
17. Cury FP, Ramos MC, Silveira HC. Assessment of micronuclei frequency in civil
construction workers. III Simposio em Oncologia Translacional do Hospital de Câncer de
Barretos. 29-30 August de 2013, Barretos, Brazil.
18. Cury FP, Ramos MC, Silveira HC. Assessment of micronuclei frequency in civil
construction workers. 59º Congresso Brasileiro de Genética, 2013. 16-19 September 2013.
Águas de Lindóia, Brazil.
19. Cury FP, Ramos MC, Scapulatempo-Neto C, Silveira HC. Assessment of genotoxic
damages in civil construction workers using micronucleus assay. V Encontro Científico do
Hospital de Câncer de Barretos, 2013. July 2013, Barretos, Brazil.
20. de Carvalho AC, Maia DCC, Carvalho AL, Scapulatempo-Neto C, Vettore AL. High
accuracy of microRNAs expression in the detection of lymph node metastasis in patients with
oral squamous cell carcinomas. AACR 104th Annual Meeting 2013. 2013, Washington, USA.
21. de Carvalho AC, Maia DCC, Carvalho AL, Scapulatempo-Neto C, Vettore AL.
Concordance of pathologic examination and qRT-PCR for microRNA expression in lymph
nodes from oral squamous cell carcinoma patients. 4th World Congress of the International
Academy of Oral Oncology, 2013. Greece.
22. Evangelista AF, Macedo T, Oliveira RJS, Marques MMC. MicroRNA-mRNA Networks
for Identification of Biomarkers for Breast Cancer. III Simpósio em Oncologia Translacional
do Hospital de Câncer de Barretos. 29-30 August de 2013, Barretos, Brazil.
23. Evangelista AF, Macedo T; Oliveira RJS, Marques MMC. MicroRNA-mRNA networks
of identification of biomarkers for breast cancer. International Congress of Markers in
Cancer.7–9 de November de 2013. Brussels, Belgian.
24. Evangelista AF, Macedo T; Oliveira RJS, Marques MMC. Integrative analysis of
microRNAs:mRNA expression for breast cancer biomarker discovery. SELECTBIO
Exosomes and Circulating Biomarkers Summit. 12-13September 2013. San Diego, California,
USA.
21 Molecular Oncology Research Center – Barretos Cancer Hospital
25. Fernandes GC, Fonseca TCB, Michelli RAD, Mendes DRP, de Paula AE, Viana DV,
Scapultempo-Neto C, Palmero EI. Associação entre triplo-negatividade para câncer de mama,
história familiar positiva e presença de mutações germinativas nos genes BRCA1 e BRCA2.
XXV Congresso Brasileiro de Genética Médica. 11-15 June 2013. Florianópolis, Brazil.
26. Fernandes GC, Mendes DRP, de Paula AE, Michelli RAD, Viana DV, Palmero EI. Padrão
heterogêneo de desenvolvimento tumoral em famílias portadoras da mutação germinativa
p.R337H no gene TP53: implicações para o Aconselhamento Genético e seguimento. XXV
Congresso Brasileiro de Genética Médica. 11-15 June de 2013, Florianópolis, Brazil.
27. Giacomazzi J, Graudenz M, Osorio CA, Koehler-Santos P, Palmero EI, Michelli R,
Fernandes GC, Scapulatempo-Neto C, Achatz MIW, Martel-Planche G, Soares FA, Caleffi M,
Goldim JR, Hainaut P, Camey SA, Ashton-Prolla P. Association between the founder
brazilian TP53 p.R337H mutation and HER2-positive status. In: ASCO Annual 2013 Meeting
- Building Bridges to Conquer Cancer, 2013, Chicago, USA.
28. Guimarães DP, Carvalho E, Cunha T, Oliveira K, Viel A, Fava G. Combinação entre
Mitomicina-C e Prótese Plástica Auto-expansivel no Tratamento Endoscópico das Estenoses
Benignas Refratárias à Dilatação Endoscópica: Relato de Caso. XII Semana Brasileira do
Aparelho Digestivo. 24-27 November 2013, Goiânia, Brazil.
29. Lacerda CF, Carloni AC, Scapulatempo-Neto C, Crema E, de Arruda Henry M, Rodrigues
MA, de Oliveira AT, Guimaraes DP, Reis RM. TP53 Gene Mutations in Squamous Cells
Carcinoma of the Esophagus Associated with Chagasic Megaesophagus. III Simpósio em
Oncologia Translacional do Hospital de Câncer de Barretos. 29-30 August de 2013, Barretos,
Brazil.
30. Lourenço T, Gonçalves CS, Xavier-Magalhães A, Pinto F, Reis RM, Costa BM.
Relevance of HES1 expression in human gliomas: molecular and clinical correlates. XXII
Porto Cancer Meeting. 11-12 April 2013, Porto, Portugal.
31. Macedo T, Evangelista AF, Marino AFL, Oliveira RJS, Vieira RAC, Longatto AF, Silva
VAO, Vidal DO, Marques MMC. Functional assays of mir-183 and mir-494 in breast cancer
cell lines. III Simpósio em Oncologia Translacional do Hospital de Câncer de Barretos. 29-30
August de 2013, Barretos, Brazil.
32. Macedo T, Evangelista AF, Marino AFL, Vieira RAC, Longatto AF, Silva VAO, Vidal
DO, Marques MMC. miR-183 and miR-494 as risk biomarkers for breast cancer development.
International Congress of Markers in Cancer. 7–9 November de 2013. Brussels, Belgian.
33. Marino ALF, Macedo T, Longatto AF, Kerr LM, Vieira RAC, Evangelista AF, Silveira
HCS, Marques MMC. MicroRNA profiling as a risk biomarker in the development of breast
22 Molecular Oncology Research Center – Barretos Cancer Hospital
cancer metastasis. III Simpósio em Oncologia Translacional do Hospital de Câncer de
Barretos. 29-30 August de 2013, Barretos, Brazil.
34. Martinho O, Reis RM. Role of AXL knockdown in the prediction of sunitinib therapy
response in glioblastoma. VI Congresso Nacional da Associação Portuguesa de Neuro-
Oncologia. 15-16 November 2013, Almada, Portugal.
35. Miranda-Gonçalves V, Honavar M, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa
P, Reis RM, Baltazar F. MCT1 plasma membrane expression at hypoxic regions could be a
mediator of cellular aggressiveness in glioblastoma. VI Congresso Nacional da Associação
Portuguesa de Neuro-Oncologia. 15-16 November 2013, Almada, Portugal.
36. Morais-Santos F, Pinheiro C, Vieira A, Paredes J, Schmitt F, Baltazar F. Exploitation of
Monocarboxylate Transporter 1 (MCT1) as target in breast cancer therapy. XXII Porto Cancer
Meeting. 2013, Porto, Portugal.
37. Morais-Santos F, Pinheiro C, Vieira A, Paredes J, Schmitt F, Baltazar F.
Monocarboxylate Transporters as therapeutic targets in breast cancer. Advances in Molecular
Oncology: Translating Molecular Biology into Cancer Treatment. 2013, São Paulo, Brazil.
38. Morais-Santos F, Pinheiro C, Vieira A, Paredes J, Schmitt F, Baltazar F. Contribution of
monocarboxylate transporters to the aggressive phenotype of breast cancer. 11th International
Congress on Targeted Anticancer Therapies. 2013, Paris, France.
39. Oliveira-Silva RJ, Martinho O, Carvalho AL, Reis RM. Testing a novel irreversible anti-
EGFR drug for head and neck cancer treatment. XLII Reunião Anual da SBBq. May 2013,
Foz do Iguaçu, Brazil.
40. Oliveira K, Guimarães DP, Cunha T, Almodova E, Viel A, Scapulatempo-Neto C, Barro
G, Fava G. O Papel da Colonoscopia em Pacientes Submetidos ao Transplante de Medula
Óssea Alogênico com Diagnóstico de Doença do Enxerto Contra Hospedeiro Agudo. XII
Semana Brasileira do Aparelho Digestivo. 24-27 Novembers. 2013, Goiânia, Brazil.
41. Osório NS, Rodrigues F, Garcia EA, Costa MJ. Medical Students Cell Drawings as
Snapshots of Cellular Anatomy Understanding. Association for Medical Education in Europe
(AMEE). 24-28 August 2023, Prague, Czech Republic.
42. Pereira MS, Viana-Pereira M, Jones C, Reis RM. SPINT2 hypermethylation – a common
event in high-grade gliomas. Translating Molecular Biology into Cancer Treatment. SPSAS –
São Paulo School of Advanced Sciences, Advances in Molecular Oncology. February 2013,
São Paulo, Brazil.
43. Pereira MS, Viana-Pereira M, Pardal F, Amorim J, Melo-Pires, Pinheiro C, Lopes JM,
Honavar M, Costa P, Pimentel J, Jones C, Reis RM. Unraveling the Biological Role of
23 Molecular Oncology Research Center – Barretos Cancer Hospital
SPINT2 in Gliomas. VI Congresso Nacional da Associação Portuguesa de Neuro-Oncologia,
15-16 November 2013, Almada, Portugal.
44. Pojo M, Gonçalves SC, Xavier-Magalhães A, Fernandes R., Gonçalves T, Rodrigues AJ,
Costa S, Pinto L, Reis R M, Rocha M, Costello JF, Sousa N, Costa B. M. A Transcriptomic
Signature Mediated by HOXA9 Sustains Human Glioblastoma Aggressiveness, Resistance to
Chemotherapy and Glioma Initiation. EACR Summer Conference: Cancer Genomics. 25-28
June 2013, Cambridge, England.
45. Pojo M, Gonçalves SC, Xavier-Magalhães A, Fernandes R, Gonçalves T, Rodrigues J,
Costa S, Pinto L, Reis RM, Rocha M, Costello J F, Sousa N, Costa B. M. HOXA9 Promotes
Glioma Initiation and Sustains Human Glioblastoma Aggressiveness and Resistance to
Therapy. XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting. 11-12 April2013,
Porto, Portugal.
46. Ramos MC, Cury FP, Scapulatempo-Neto C, Silveira HC. Análise comparativa para
seleção de Micronúcleos em células esfoliadas da mucosa bucal preparados por citologia de
base liquida. V Encontro Científico do Hospital de Câncer de Barretos, 2013. Barretos, Brazil.
47. Rodrigues AL, Evangelista AF, Macedo T, Oliveira RJS, Mota AL, Reis RM, Marques
MM. Molecular signatures of microRNAs on human breast cancer cell lines exposed to
Cediranib. III Simpósio em Oncologia Translacional do Hospital de Câncer de Barretos. 29-
30 August 2013. Barretos, Brazil.
48. Rosa MN, Silva VAO, Tansini A, Jones C, Lima JP, Pianowski LF, Reis RM. In Vitro
Activity of euphol from Euphorbia tirucalli on a large panel of human cancer cell lines. XLII
Reunião Anual da SBBq. May 2013, Foz do Iguaçu, Brazil.
49. Scapulatempo-Neto C, Carlos C, Viana L, Miziara JE, Pereira R, Reis RM. Frequência de
mutação de EGFR e KRAS em carcinoma não pequenas células do pulmão na população
brasileira e sua correlação com marcadores genéticos de ancestralidade. XXIX Congresso
Brasileiro de Patologia. 13-16 November 2013, Florianópolis, Brazil.
50. Scapulatempo-Neto C, Faria EF, Saber G, Fregnani JH, Záccaro-Silva LC. Achados
histopatológicos de biópsia prostática: Análise da concordância entre a avaliação de um
centro não oncológico e sua revisão em um centro oncológico numa instituição brasileira.
XXIX Congresso Brasileiro de Patologia. 13 -16 November 2013, Florianópolis, Brazil
51. Scapulatempo-Neto C, Stein MD, Fregnani JH, Carvalho TS, Kerr L, Silva SM, Abrahão-
Machado L, Mateus FP, Mafra A, Campacci N, Silva ET, Mauad EC, Longatto-Filho A.
Desempenho do rastreio citológico cérvico-vaginal em pacientes submetidas à radioterapia
pélvica e braquiterapia vaginal, utilizando o sistema computadorizado Focal Point: Resultado
24 Molecular Oncology Research Center – Barretos Cancer Hospital
do estudo RODEO. XXIX Congresso Brasileiro de Patologia. 13-16 November 2013,
Florianópolis, Brazil.
52. Scapulatempo-Neto C, Watanabe A, Pereira CAA, Vieira RA, Silva ECA, Yamashita T,
Relato de caso: Amiloidose primária da mama formando massa e microcalcificações suspeitas
à mamografia. XXIX Congresso Brasileiro de Patologia. 13-16 November 2013,
Florianópolis, Brazil.
53. Silva ECA, Abrahão-Machado L, Carvalho TS, Souza W, Almeida GC, Matsushita M,
Santana IV, Scapulatempo-Neto C. Carcinoma hepatóide primário do ovário: Um raro relato
de caso. XXIX Congresso Brasileiro de Patologia. 13-16 November 2013, Florianópolis,
Brazil.
54. Silva ECA, Abrahão-Machado L, Santana IV,, Scapulatempo-Neto C, Souza W, Silva
SFA. Tumor sólido pseudopapilífero do pâncreas em uma mulher de meia idade: Relato de
um caso com apresentação clínico-patológica incomum. XXIX Congresso Brasileiro de
Patologia. 13-16 November 2013, Florianópolis, Brazil.
55. Silva V, Rosa MN, Tansini A, Lima JP, Jones C, Pianowski LF, Reis RM. Cytotoxic
activity of semi-synthetic ingenol derived from Euphorbia tirucalli on a large panel of human
cancer cell lines. 2013 ASCO Annual Meeting. May 2013, Chicago, USA.
56. Silva VAO, Rosa MN, Tansini A, Lima JP, Jones C, Pianowski LF, Reis RM. Cytotoxic
effect of euphol from Euphorbia tirucalli on a large panel of human cancer cell lines. 2013
ASCO Annual Meeting. May 2013, Chicago, USA.
57. Silva VAO, Rosa MN, Tansini A, Vazquez V, Pianowski LF, Reis RM. Cytotoxic effect
of euphol and semi-synthetic ingenol derived from Euphorbia tirucalli on human melanomas
cell lines. 8th World Congress of Melanoma. July 2013, Hamburg, Germany.
58. Silva VAO, Rosa MN, Tansini A, Costa AM, Oliveira-Silva R, Martinho O, Pianowski L,
Reis RM. The semi-synthetic ingenol c derived from Euphorbia tirucalli induces cell death via
autophagy but not apoptosis in human glioma cancer cells. III Congresso Luso-Brasileiro de
patologia experimental (XIII Simpósio Internacional sobre técnicas experimentais). 23-25
October 2013, Tiradentes, Minas Gerais, Brazil.
59. Silva VAO, Rosa MN, Tansini A, Pianowski LF, Reis RM. In vitro cytotoxic activity of
am11 and semi-synthetic ingenol derived from Euphorbia tirucalli on a large panel of human
cancer cell lines. III Congresso Luso-Brasileiro de patologia experimental (XIII Simpósio
Internacional sobre técnicas experimentais). 23-25 October 2013, Tiradentes, Minas Gerais,
Brazil.
25 Molecular Oncology Research Center – Barretos Cancer Hospital
60. Silva VAO, Rosa MN, Tansini A, Costa AM, Oliveira-Silva R, Martinho O, Pianowski L,
F, Reis RM. The semi-synthetic ingenol c derived from Euphorbia tirucalli induces cell death
via autophagy but not apoptosis in human glioma cancer cells. V Encontro Científico do
Hospital de câncer de Barretos . 13-14 Decembre 2013, Barretos, SP, Brazil.
61. Torrieri R, Lima JP, Reis RM. In silico analysis of the raf kinase inhibitory protein (RKIP)
expression impact in breast cancer patients. III Simpósio em Oncologia Translacional do
Hospital de Câncer de Barretos. 29-30 August 2013, Barretos, Brazil.
62. Xavier-Magalhães A, Gonçalves SC, Lourenço T, Pojo M, Rocha M, Lopes MC, Crespo I,
Rebelo O, Tão H, Moreira R, Pinto AA, Reis RM, Costello JF, Sousa N, Costa BM. Long
Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is Associated
with Poor Prognosis in Glioblastoma. XXII Porto Cancer Meeting & III Porto-Bordeaux Joint
Meeting. 11-12 April 2013, Porto, Portugal.
63. Xavier-Magalhães A, Gonçalves SC, Lourenço T, Pojo M, Rocha M, Lopes MC, Crespo I,
Rebelo O, Tão H, Moreira R, Pinto AA, Reis RM, Costello JF, Sousa N, Costa BM. Long
Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is Associated
with Poor Prognosis in Glioblastoma. Non-coding RNA, epigenetics and transgenerational
inheritance. 11-12April 2013, Cambridge, England.
64. Xavier-Magalhães A, Gonçalves SC, Lourenço T, Pojo M, M, Rocha Lopes M C, Crespo
I, Rebelo O, Tão H, Moreira R. Pinto A A, Reis RM, Costello JF, Sousa N, Costa BM. Long
Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is Associated
with Poor Prognosis in Glioblastoma. SPSAS - Advances in Molecular Oncology: Translating
Molecular Biology into Cancer Treatment. 3-8 February 2013, São Paulo, Brazil.
65. Viana DV, Viana-Pereira M, Almeida G, Clara C, Palmero E, Scapulatempo Neto C,
Jones C, Bertuzzo CS, Reis RM. Biallelic mutations in MMR gene in a retrospective series of
CNS tumors. IV Annual IMPPC Conference/1st ICO-IDIBELL Hereditary Cancer Program
Meeting. Hereditary and Familial Cancer In The Personal Genomics Era.14-15 March 2013,
Barcelona, Spain.
66. Volpe FAP, Doretto AS, Rezende FF, Freitas JA, Garcia EA. Public health units as
learning scenario for medical students. Association for Medical Education in Europe (AMEE).
24 -28 August 2013, Prague, Czech Republic.
67. Zanon MF, Almeida GC, Matsushita MM, Reis RM, Squire JA, Camparotto ML.
Evaluation of 1p/19q codeletion using FISH analysys in pure and mixed oligodendroglial
tumors at the routine pathology of the Barretos Cancer Hospital-SP, Brazil. III Simpósio em
26 Molecular Oncology Research Center – Barretos Cancer Hospital
Oncologia Translacional do Hospital de Câncer de Barretos. 29-30 August 2013, Barretos,
Brazil.
6) Science Communication to general public
1. Reis RM, Carvalho AL: Revista Hospital do Futuro, HdF Nº15, Portugal – O Hospital de
Câncer de Barretos.
2. Lacerda CF, de Oliveira AT, Guimaraes DP, Reis RM. Câncer de Esôfago, da Clínica a
Biologia Molecular. Revista Onco& – oncologia para todas as especialidades. Nov/Dec, 2013
3. Palmero EI. Hereditariedade e Câncer de Mama” Revista Onco & – oncologia para todas as
especialidades. Sept/Oct, 2013
4. Silveira HCS, Lopes LF. Alunos acompanham luta contra o câncer em Hospital de Barretos.
Portal G1, Barretos, 15 July, 2013.
5. Silveira HCS . Concurso de Redação do HC. O Diário, Barretos, 14 July, 2013.
6. Silveira HCS . I Concurso de Redação. Jornal de Barretos, Barretos, 06 July. 2013.
7) Supervision of PhD, Master and Initiation to Trainee Fellows
7.1) PhD
1. Adriana Lorenzi. Valor do teste careHPV de captura híbrida em Unidade Móvel no rastreio
do câncer cervical em áreas rurais e remotas. HCB (Supervision - Longatto Filho, A.). 2011 –
present.
2. Aline Nazareth de Paiva Paixão Becker. Avaliação da via MAPK na oncogênese dos
astrocitomas pilocíticos. HCB (Supervision – Reis RM, Co-supervision- Scapulatempo-Neto
C). 2012 – present.
3. Filipe Pinto. Learning from the embryo: Understanding early embryonic T gene -
Brachyury - impact in human tumorigenesis. ICVS, Universidade do Minho (Supervision –
Reis RM). 2011-present.
4. Gustavo Berardinelli. Elucidação do impacto molecular e clínico da instabilidade de
microssatélite em pacientes com câncer colorretal esporádico do Hospital de Câncer de
Barretos. HCB (Supervision – Reis RM). 2013 – present.
5. Herlander Jose Resende Marques. Prevalência de vírus Herpes nos Linfomas Foliculares
Influência dos polimorfismos dos sistemas apresentadores de antigénio na infecção crónica.
ICVS, Universidade do Minho. (Supervision - Longatto Filho A). 2008 - 2013.
27 Molecular Oncology Research Center – Barretos Cancer Hospital
6. Julieta Alexandra Pereira Afonso. The Biology of Lymphatic Spread of Urothelial Bladder
Cancer. ICVS, Universidade do Minho. (Supervision - Longatto Filho A). 2008 - 2013.
7. Junea Caris de Oliveira. Correlação genotipo-fenotipo em pacientes portadores de Polipose
Adenomatosa Familial. HCB (Supervision – Rossi BM, Co-supervision- Palmero EI). 2012 –
present.
8. Leonado Gabeira Secco. Fatores Prognósticos em Carcinoma Bem Diferenciado da
Tireóide. FMUSP (Supervision – Carvalho AL). 2005-present.
9. Maria Teresa Roncaglia. O valor da captura híbrida para HPV no seguimento de pacientes
com neoplasia intra-epitelial de alto grau submetidas à conização do colo uterino por cirurgia
de alta freqüência. FMUSP (Supervision –Longatto Filho A). 2010- present.
10. Roberta Targa Stramandinoli. Avaliação da interface osso/implante em mandíbula de
miniporcos irradiados e o uso de biomateriais na osseointegração. FMUSP (Supervision –
Carvalho AL). 2010-present.
11. Sandra Fátima Fernandes Martins. Expression of Colorectal Cancer Metabolic and
Angiogenic Markers: Association with Clinicopathological Characteristics and Impact on
Prognosis. ICVS, Universidade do Minho. (Orientação Longatto Filho L). 2008 - 2013.
12. Thiago Buosi Silva. Desenvolvimento e validação de nomogramas para estimar os riscos
de câncer de próstata e de câncer de próstata de baixo e alto grau de malignidade. FMUSP
(Supervision – Carvalho AL). 2010-2013
13. Renato José da Silva Oliveira. Identificação de novos biomarcadores preditivos da
resposta à terapia anti-EGFR em tumores sólidos. HCB (Supervision – Reis RM, Co-
supervision- Carvalho AL). 2011 – present.
14. Flávio Mavignier Cárcano. Estudo da instabilidade de microssatélite, ADAMTSI e OCT-
3/4 nos tumores de células germinativas do testículo e suas associações prognósticas
preditivas nos pacientes submetidos à quimioterapia. Hospital de Câncer de Barretos
(Supervision: Lopes LF). 2012-present.
7.2) Master
1. Adriana Cruvinel. Caracterização Citogenética e Molecular de Linhagens Primárias de
Gliomas. Hospital de Câncer de Barretos (Supervision - Reis RM). 2011-2013.
2. Adriano Jander Ferreira. Catalogação dos pacientes com diagnostico de Sarcoma de Ewing
tratados no Hospital de Câncer de Barretos. Hospital de Câncer de Barretos (Supervision -
Lopes LF). 2011 - 2013
28 Molecular Oncology Research Center – Barretos Cancer Hospital
3. Ana Laura Bordinhão Rodrigues. Avaliação da expressão de microRNAs em linhagens
celulares de carcinoma mamário humano expostas a ação do fármaco Cediranib. Hospital de
Câncer de Barretos (Supervision- Marques, MMC). 2011-2013.
4. Augusto Ludvik Filip Marino. Análise do perfil de expressão diferencial de microRNAs
em carcinomas mamários por microarrays. Hospital de Câncer de Barretos (Supervision -
Marques, MMC). 2011-2013.
5. Camila Maria da Silva Martinelli. Avaliação do perfil de metilação de genes alvo
candidatos em tumores de células germinativas do testículo. Hospital de Câncer de Barretos
(Supervision- Lopes LF, Co-supervision- Vidal DO). 2013 – present.
6. Croider Franco Lacerda. Estudo do gene supressor tumoral, TP53, no carcinoma de células
escamosas do esôfago associado ao megaesôfago chagásico. Hospital de Câncer de Barretos
(Supervision - Reis RM, Co-supervision- Guimaraes DP). 2011-2013.
7. Flávia Coltri Eguchi. Avaliação da superexpressão das proteínas TMPRSS2 e ERG e a
fusão gênica TMPRSS2:ERG em portadores de câncer prostático. Hospital de Câncer de
Barretos (Supervision - Campos, SGP). 2011-2013.
8. Gabriela Carvalho Fernandes. Identificação de mulheres em risco para câncer de mama
hereditário por mutação nos genes BRCA1 e BRCA2: contribuição dos dados patológicos,
história familiar e modificadores genéticos do risco de câncer. Hospital de Câncer de Barretos
(Supervision - Palmero EI). 2013-2015.
9. Juliana Levy Daher. Aspectos funcionais e emocionais da deglutição e fonação no paciente
com câncer de cabeça e pescoço pré e pós tratamento oncológico Hospital de Câncer de
Barretos. (Supervision - Carvalho AL). 2011-2013.
10. Júlio Cesar Possati Resende. Detecção de lesão intraepitelial cervical de alto grau em
mulheres com citologia de ASC-US E LIEBG: Comparação entre a expressão
imunocitoquímica dos biomarcadores P16/Ki-67 e teste molecular de DNA-HPV de alto risco.
(Supervision – Scapulatempo-Neto, C). 2012-2014.
11. Letícia Rodrigues Cardoso. Síndrome de Dor Miofascial em pacientes portadores de
câncer de cabeça e pescoço. Hospital de Câncer de Barretos (Supervision - Carvalho AL).
2011-present.
12. Leticia dos Santos Yamane. Estudo mutacional dos oncogeneses KRAS e BRAF nas
lesões do cólon e reto. Hospital de Câncer de Barretos (Supervision – Guimaraes DG, Co-
supervision- Reis, RM). 2011 – 2013.
13. Luiz Cesar Záccaro da Silva. Análise crítica da discrepância entre achados
histopatológicos da biópsia prostática realizada em centros não oncológicos e sua revisão em
29 Molecular Oncology Research Center – Barretos Cancer Hospital
um centro oncológico. Hospital de Câncer de Barretos (Supervision - Scapualtempo-Neto C).
2011-2013.
14. Maira DeGiovani Stein. Desempenho diagnóstico da citologia manual versus a citologia
assistida por computador usando BD FocalPoint GS Imaging system em material preparado
em sistema BD SurePath de base líquida. Hospital de Câncer de Barretos (Supervision -
Adhemar Longatto Filho). 2011-2013.
15. Maicon Fernando Zanon da Silva. Avaliação da via de sinalização FGFR1/PI3K/AKT em
carcinomas adenóides císticos. Hospital de Câncer de Barretos (Supervision – Scapulatempo-
Neto C). 2012-2014.
16. Marcelo Simonsen. Comparação da correlação cito-histológica utilizando os diferentes
dispositivos Cytobrush™ e Cervex-Brush Combi™ na coleta de amostras uterinas para
confecção de citologias de base líquida. Hospital de Câncer de Barretos (Supervision
Scapulatempo- Neto C). 2013-2015.
17. Natalia Campacci. Rastreamento populacional de famílias com predisposição hereditária
de câncer de mama e/ou câncer colorretal. Hospital de Câncer de Barretos (Supervision -
Palmero EI). 2011-2013.
18. Nathália Cristina Campanella. Estudo da instabilidade de microssatélite e potenciais
genes alvos em GISTs. Hospital de Câncer de Barretos (Supervision - Reis RM). 2012-2013.
19. Taciane Macedo. Estudo funcional de microRNAs associados ao processo de metástase
em linhagens celulares de carcinoma mamário humano. Hospital de Câncer de Barretos
(Supervision - Marques, MMC) 2012- present.
20. Vanessa Regina Maciel Uzan. Perfil de expressão gênica dos RNAs não codificadores
HOTAIR, MALAT1, HULC e BCYRN1 (BC200) em Osteossarcoma. Hospital de Câncer de
Barretos (Supervision- Lopes LF, Co-supervision- Vidal DO). 2013 – present.
21. Marcelo Simonsen. Comparação do desempenho dos dispositivos de coleta de material
cervical Cervex brush e escova endocervical + espátula de Ayre na detecção de lesões
intraepiteliais (Supervision- Scapulatempo-Neto C). 2013- present.
22. Júlio César Possati Ribeiro. Comparação entre o teste molecular COBAS e a co-expressão
de ki-67/p16 na detecção de lesões intra epiteliais de alto grau em pacientes com diagnóstico
de ASC-US e LSIL na citologia cérvico vaginal (Supervision- Scapulatempo-Neto C). 2012-
present.
23. Thiago Rabelo da Cunha. Estudo comparativo entre diferentes parâmetros de coagulação
com plasma de argônio no tratamento da retite actínica. (Supervision- Guimarães DP). 2012-
present.
30 Molecular Oncology Research Center – Barretos Cancer Hospital
7.3) Trainee Fellows
1. André de Lima Mota. Avaliação da expressão de VEGF e do seu receptor VEGFR-1/Flt-1
e VEGFR-2/Flk-1 em linhagens celulares de carcinoma mamário humano expostas a ação do
fármaco Cediranib. Hospital de Câncer de Barretos (Supervision - Marques MMC).
2. Fernanda de Paula Cury. Análise do potencial risco de câncer na exposição dos
trabalhadores da construção civil a agentes carcinogênicos. HCB (Supervision – Silveira HC).
3. Graziela Sartori. Caracterização molecular em melanomas acrolentiginosos e das mucosas.
Hospital de Câncer de Barretos (Supervision - Vazquez VL).
4. Juliana Oliveira de Lima. Rastreamento populacional de famílias com predisposição
hereditária de câncer de mama e/ou câncer colorretal. Hospital de Câncer de Barretos, HCB.
(Supervision - Palmero EI).
5. Lamis Ramadan. Desenvolvimento de estrategias educativas para famílias com
predisposição hereditária ao câncer de mama e/ou câncer colorretal. Hospital de Câncer de
Barretos, HCB. (Supervision - Palmero EI).
6. Talitha Cezareti Blau Fonseca. Identificação de mulheres em risco para câncer de mama
hereditário por mutação nos genes BRCA1 e BRCA2: contribuição dos dados patológicos,
história familiar e modificadores genéticos do risco de câncer. Hospital de Câncer de Barretos
(Supervision - Palmero EI)
7. Verônica Rissati. Validação de novas estratégias para identificação de indivíduos em risco
para câncer hereditário.. Hospital de Câncer de Barretos (Supervision - Palmero EI).
8. Manuela Catarina Aguena souza Ramos. Análise comparativa para seleção de
Micronúcleos em células esfoliadas da mucosa bucal preparados por citologia de base liquida.
Hospital de Câncer de Barretos, HCB. (Supervision - Silveira HC).
8) Prizes
1. IV Octavio Frias de Oliveira Prize in the categorie of Research on Oncology with
Prognostic significance of TIMP3 hypermethylation in post-treatment salivary rinse from
head and neck squamous cell carcinoma patients. Rettori MM, de Carvalho AC, Bomfim
Longo AL, de Oliveira CZ, Kowalski LP, Carvalho AL, Vettore AL. 05 August 2013.
2. Best Scientific Research work at the III Simpósio em Oncologia Translacional do Hospital
de Câncer de Barretos, with The importance of molecular characterization of head and neck
31 Molecular Oncology Research Center – Barretos Cancer Hospital
cancer cell lines for the prediction of anti-EGFR therapies resistance.” Oliveira-Silva, RJ,
Martinho O, Berardinelli GN, Viana L, Carvalho AL, Reis RM. 29-30 August 2013.
3. Honour Mention at the III Congresso Luso-Brasileiro de Patologia Experimental.
Tiradentes, Minas Gerais, with “The semi-synthetic Ingenol C derived from Euphorbia
tirucalli induces cell death via autophagy but not apopotosis in human glioma cancer cells.
Silva, VAO, Rosa MN,Tansini A,Costa AM, Oliveira-Silva R, Martinho O, Pianowski LF.
Reis RM. 23- 25 October 2013.
4. Best Poster at XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, with
"HOXA9 Promotes Glioma Initiation and Sustains Human Glioblastoma Aggressiveness and
Resistance to Therapy."Pojo M, Gonçalves SC, Xavier-Magalhães A, Fernandes R, Gonçalves
T, Rodrigues AJ, Costa S;Pinto L, Reis RM, Rocha M, Costello, JF, Sousa N, Costa BM.
Portugal, 2013.
5. Best Poster at V Encontro Científico do Hospital de Câncer de Barretos, with The semi-
synthetic ingenol c derived from Euphorbia tirucalli induces cell death via autophagy but not
apoptosis in human glioma cancer cells. Silva VAO, Rosa MN, Tansini A, Costa AM,
Oliveira-Silva R, Martinho O, Pianowski LF, Reis RM. December, Barretos, Brazil, 2013.
6. Best Scientific Work (Gizele Rozone de Luca Award) at XXV Congresso Brasileiro de
Genética Médica, with “Utilização das unidades móveis e fixa de prevenção para
rastreamento populacional de famílias com predisposição hereditária de câncer de mama”.
Campacci N, Lima JO, Rossati V, Toledo EMP, Ramadan L, Palmero EI. Florianópolis, Brazil,
2013.
7. Honour Mention at the I Encontro de Jovens Talentos do Hospital de Câncer de Barretos,
with Assessment of genotoxic damages in civil construction workers using micronucleus
assay. Cury FP, Ramos MC, Scapulatempo-Neto C, Silveira HC. Barretos, Brazil, 2013.
9) Participation in Internacional Networks
1. Carvalho AL, Silveira HC, Reis RM. International Cancer Genome Consortium. 2012-
present.
2. Carvalho AL, Marques MMC, Reis RM, Scapulatempo-Neto C - US-Latin American
Cancer Research Network (USLACRN). 2010-present.
3. Carvalho AL, Mauad EC- WIN - World Innovative Networking, 2010-present.
4. Carvalho AL- INTERCHANGE – Head and Neck Study Group (IARC), 2010-present.
5. Carvalho AL, Silveira HC. The Cancer Genome Atlas (TCGA). 2013 – present.
32 Molecular Oncology Research Center – Barretos Cancer Hospital
6. Mauad EC, Carvalho AL, Reis RM, Scapulatempo-Neto C – GAP – Global Academic
Program – Sister Institution Network (MDANderson). 2011-present.
7. Reis RM - IMMEnSE (International Multiple Myeloma rESEarch) consortium – 2010-
present.
8. Reis RM - Société Internationale d'Oncologie Pédiatrique (SIOP) - Brain Tumour
Committee- High Grade Glioma Working Group. 2010-present.
10) Participation in National Networks
1. Carvalho AL, Scapulatempo-Neto C – GENCAPO – Projeto de Genoma Cabeça e Pescoço
Brasileiro, 2010-present.
2. Palmero EI, Reis RM. Rede Brasileira de Câncer Familiar
3. Silveira HC – INAIRA - Instituto Nacional de Análise Integrada do Risco Ambiental
(INCT)
11) Organization of Conferences and Meetings
1. Carvalho AL, Fregnani JH, Longatto Filho A, Scapulatempo Neto C, Vidal DO, Palmero E,
Silveira H, Marques MM, Viana L, Serrano SV, Reis RM. III Simpósio Internacional em
Oncologia Translacional do Hospital de Câncer de Barretos, August, 2013.
2. Lopes LF. II Encontro Internacional de Oncologia Pediátrica de Barretos, March, 2013.
12) Lectures / Seminars at Conferences and Meetings
1. Guimarães DP. XII Semana Brasileira do Aparelho Digestivo. Caracterização Endoscópica
de Adenomas Serrilhados Sésseis. 2013, Goiânia, Brazil.
2. Mariano VS. V Jornada de Integração das ligas de Biomedicina. O papilomavírus humano
como agente causador de câncer. 2013, Ribeirão Preto, São Paulo, Brazil.
3. Longatto AF. Patologia molecular en el diagnostico oncológico, Universidad de La
Republica Uruguaya, Screening en Cáncer Cervical: Nuevo Era Nuevos Paradigmas. 16-17
May 2013, Montevideo, Uruguai.
4. Longatto AF. 18th International Congress of Cytology. Cervical câncer prevention in
Barretos region, Brazil. 26-30 May 2013, Paris, France.
33 Molecular Oncology Research Center – Barretos Cancer Hospital
5. Longatto AF. The EUROGIN 2013. Screening: molecular-based strategies careHPV. 3-6
November 2013, Florence, Italy.
6. Longatto AF. VIII Congreso Latinoamericano de Patologia Del Tracto Genital Inferior y
Colposcopia. Prevención de cáncer cervical en Latinoamérica. 13-15 November 2013, Buenos
Aires, Argentina.
7. Longatto AF. VIII Congreso Latinoamericano de Patologia Del Tracto Genital Inferior y
Colposcopia. Diagnóstico citopatológico y molecular en El TGI - Diagnótico citológico y
anatomopatológico de la ZT. 13-15 November 2013, Buenos Aires, Argentina.
8. Longatto AF. VIII Congreso Latinoamericano de Patologia Del Tracto Genital Inferior y
Colposcopia. HPV. Biologia molecular y respuesta inmune’. Marcadores pronósticos de La
lesión inducida por HPV. 13-15 November 2013, Buenos Aires, Argentina.
9. Lopes LF. XI Congresso de Saúde e Qualidade de Vida do Cone Leste Paulista. Banco de
tumores pediátricos no auxílio a pesquisa tranlacional e a aplicação a prática clínica da
oncologia pediátrica. 2013. UNIVAP-São José dos Campos, São Paulo, Brazil.
10. Lopes LF. II Encontro do Comitê de Sindromes Mielodisplásticas da ABHH. Grupo
Brasileiro de SMD pediátrica: sucessos e dificuldades. 2013, São Paulo, São Paulo, Brazil.
11. Lopes LF. I Encontro Nacional dos Profissionais de Pesquisa Clínica em Oncopediatria no
XIV Encontro Nacional de Grupos Cooperativos. Tumores de células germinativas. 2013. São
Paulo, São Paulo, Brazil.
12. Lopes LF. II Encontro Internacional de Oncologia Pediátrica de Barretos. Tumor de
células germinativas: dados do grupo brasileiro. 2013, Barretos, São Paulo, Brazil.
13. Lopes LF. II Encontro Internacional de Oncologia Pediátrica de Barretos. SMD da
infância: histórico e dados epidemiológicos. 2013, Barretos, São Paulo, Brazil.
14. Lopes LF. 45° Congresso da Sociedade Internacional de Oncologia Pediátrica. 2013,
Hong Kong, China.
15. Lopes LF. III Jornada Latino Americana- Israelense de Hemantologia Pediátrica e 7ª
Renião Científica Anual do Grupo Galop. Tumores de Células Germinativas- Resultados de
TCG 2008. 2013. Montevideo, Uruguai.
16. Lopes LF. Congresso Brasileiro de Hematologia e Hemoterapia da ABHH. Avanços na
Patonense e tratamento da Leucemia Mielomonocitica Juvenil. Brasília, Brazil.
17. Lopes LF. GAP 2013 Meeting. The Brazilian cooperative Group on Pediatric
Myelodyplastic syndrome from 1997 to 2012: is it relevant to improve educational approach
and correct diagnosis. 2013 Houston, USA.
34 Molecular Oncology Research Center – Barretos Cancer Hospital
18. Pinheiro C. III International Symposium on Translational Oncology of the Barretos
Cancer Hospital. Therapeutic targeting of cancer metabolism: exploitation of
monocarboxylate transporters.29-30 August 2013, Barretos, Brazil.
19. Palmero EI. III International Symposium on Translational Oncology of the Barretos
Cancer Hospital. The interplay between research and clinics in hereditary cancer, 29-30
August 2013, Barretos, Brazil.
20. Palmero EI. XXV Congresso Brasileiro de Genética Médica. Importância do diagnóstico
molecular para a identificação dos indivíduos em risco. 2013, Florianopolis, Brazil.
21. Palmero EI. Ion World 2013 - Next Generation Sequencing: From Bench top to the
Clinic. Applications of Next-Generation Sequencing in Oncology. 2013, São Paulo, Brazil.
22. Reis RM. I Simpósio de Pesquisa Clínica do Hospital de Câncer de Barretos. Pesquisa
Translacional: o que esperar do future? 29 November 2013, Barretos, Brazil.
23. Reis RM. I Jornada de Cirurgia Hepatobiliopancreática do HUGG. Biologia Molecular no
tratamento Onco-Cirúrgico. 28-30 October 2013, Rio de Janeiro, Brazil.
24. Reis RM. Meeting de Gliomas, Universidade Federal da Bahia (UFBA), Instituto de
Ciências da Saúde (ICS). Biologia Molecular de Gliomas: Impacto Clínico. 23 October 2013,
Salvador, Brazil.
25. Reis RM. III Simpósio Internacional de Oncologia Translacional do Hospital de Câncer
de Barretos. The role of RTKs signaling in gliomas. 29-30 August 2013. Barretos, Brazil.
26. Reis RM. World Innovative Networking (WIN) 2013. Challenges and opportunities in the
implementation of personalized medicine in Brazil. July 2013, Paris, France.
27. Reis RM. XVI Pathology Meeting of A. C. Camargo Cancer Center and VI International
Meeting on Investigative Pathology. The role of RTKs and the downstream MAPK pathway
in glioma biology and therapy. 7-9 August 2013, São Paulo, Brazil.
28. Reis RM. 1er Curso en Patologia Molecular Diagnostica Terapêutica e Investigativa.
Centro de Pesquisa em Oncologia Molecular, Hospital de Câncer de Barretos. 16-17 May
2013, Montevideo, Uruguai.
29. Reis RM. 1er Curso en Patologia Molecular Diagnostica Terapeutica e Investigativa.
Bases Moleculares en el Diagnostico y Terapeutica en Cancer. 16-17 May 2013, Montevideo,
Uruguai.
30. Scapulatempo CN. III International Symposium on translational oncology of The Barretos
Cancer Hospital. Recent genomic discoveries with potential impact in personalized medicine.
29-30 August. Barretos, Brazil.
35 Molecular Oncology Research Center – Barretos Cancer Hospital
31. Scapulatempo CN. Practicas em Patología Molecular. Primeiro Curso em Patologia
Molecular Diagnóstica Terapêutica e Investigativa. 16-17 May 2013, Hospital de Clínicas de
Montevideo, Uruguai.
32. Scapulatempo CN. Discussão de Casos-Clinicos. Patología Molecular. Primeiro Curso em
Patologia Molecular Diagnóstica Terapêutica e Investigativa. 16-17 May 2013, Hospital de
Clínicas de Montevideo, Uruguai.
33. Scapulatempo CN. Seminário de Lâminas- Citologia. XXIX Congresso Brasileiro de
Patologia. 13-16 November 2013, Florianopolis, Brazil.
34. Scapulatempo CN. Como eu diagnóstico carcinoma escamocelular versus
adenocarcinoma em pequenas amostras de biópsia pulmonar. XXIX Congresso Brasileiro de
Patologia. 13-16 November 2013, Florianopolis, Brazil.
35. Scaputatempo CN. Seminário de Lâminas - Patologia cirúrgica: Armadilhas em patologia
cirúrgica. XXIX Congresso Brasileiro de Patologia. 13-16 November 2013, Florianopolis,
Brazil.
36. Silveira H. III International Symposium on Translacional Oncology. Risk assessment on
occupationally exposed populations. 29-30 August 2013, Barretos, Brazil.
37. Marques MCM. III International Symposium on Translational Oncology of the Barretos
Cancer Hospital. MicroRNAs as biomarkers in breast cancer. 29-30 August 2013, Barretos,
Brazil.
38. Marques MM. Controle pos-transcricional da expressão genica por microRNAs.
Universidade Federal de São Carlos. 21 November 2013, São Carlos, Brasil.
39. Vazquez VL. 10ª Conferencia Brasileira de Melanoma- linfadenectomia video assistida.
2-3 August 2013. Belo Horizonte, Brazil.
40. Vazquez VL. XI Congresso da Sociedade Brasileira de Cirurgia Oncológica-
linfadenectomia video assistida. 17-19 October 2013. São Paulo, Brazil.
41. Vidal DO. II Encontro Internacional de Oncologia Pediátrica de Barretos. Síndrome
Mielodisplásica da Infância: Estudos de Biologia Molecular: revisão da literatura e dados
brasileiros. 22-25 March 2013. Barretos, Brazil.
42. Vidal DO. II Curso Avançado em Citogenômica do Câncer: Abordagem teórico-prática
em Citogenétia e Biologia Molecular aplicada a onco-hematologia. Epigenética em onco-
hematologia. 20–23 November 2013, Fortaleza, Brazil.
43. Vidal DO. II Curso Avançado em Citogenômica do Câncer: Abordagem teórico-prática
em Citogenétia e Biologia Molecular aplicada a onco-hematologia. Epigenética e Câncer:
conceitos teóricos. 20–23 November2013, Fortaleza, Brazil.
36 Molecular Oncology Research Center – Barretos Cancer Hospital
13) Funding
13.1) Governmental Agencies
1. Análise de metilação em câncer de cabeça e pescoço
Funding Agency: FAPESP (R$ 350.000)
CPOM -Hospital de Câncer de Barretos (R$ 70.000)
Duration: 2010-2013
PI: Eloiza Tajara, Membros, André Lopes Carvalho, Matias Melendez
2. Avaliação do papel de microRNAs diferencialmente expressos no controle de invasão e
metástase do câncer de mama
Funding Agency: FAPESP (R$ 300.000,00)
CPOM -Hospital de Câncer de Barretos (R$ 300.000,00)
Duration: 2011-2013
PI: Márcia MC Marques
3. Chamada CNPq Nº 014/2011- Caracterização da instabilidade genômica em glioblastomas:
identificação e elucidação de novas vias moleculares em tumores e culturas primárias”
Funding Agency: CNPq Universal (R$113.356,00)
CPOM -Hospital de Câncer de Barretos (R$113.356,00)
Duration: 2012-2013
PI: Rui M Reis
4. Instituto Nacional de Ciência E Tecnologia para o estudo de papilomaviroses humanas
Agências de Fomento: CNPq - Auxílio financeiro / FAPESP - Auxílio financeiro
(R$7.000.000)
CPOM -Hospital de Câncer de Barretos (R$507.360,00)
Duration: 2009 – 2013
PI: Luisa Lina Villa, Membro - Adhemar Longatto Filho
5. Implantação do Centro de Prevenção - Edital FINEP - CT-INFRA - 01/2012
Funding Agency: FINEP (R$ 1.551.241,00)
CPOM -Hospital de Câncer de Barretos
Duration: 2012-2013
PI: André L. Carvalho; Adhemar Longatto-Filho
37 Molecular Oncology Research Center – Barretos Cancer Hospital
6. Decifrando o papel dos pyknons não-codificantes no câncer colorretal
Funding Agency: SINF-MDAnderson Cancer Center (USAdollars – 100.000,00)
CPOM -Hospital de Câncer de Barretos
Duration: 2012-2014
PI: George Calin, Membro; Rui M Reis
7. Avaliação do papel biológico e clínico de alterações nas vias moleculares RAS-MAPK e
PI3K-AKT , em melanomas cutâneos e de mucosa em população brasileira e comparação com
a população estadunidense
Funding Agency: FAPESP/fluxo contínuo – auxílio financeiro (R$ 209.186,00).
CPOM-Hospital de Câncer de Barretos
Duration: 2012-2014
PI: Vinicius de Lima Vazquez
8. Transportadores de monocarboxilatos como potenciais alvos terapêuticos em câncer:
estudos de expressão e de inibição em tumores de células germinativas
Funding Agency: CNPq- Universal 14/2013 (R$24.000,00)
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2017
PI: Céline Pinheiro
9. Nova abordagem para o tratamento de células de glioblastoma com deleção de MTAP
Funding Agency: CNPq- Universal 14/2013 (R$24.000,00)
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2017
PI: Lucas Bidinotto
10. Estudo do papel biológico e terapêutico da Raf kinase inhibitor protein (RKIP) em GISTs
e sua correlação com o fenótipo de instabilidade de microssatélites (MSI)
Funding Agency: CNPq- Universal 14/2013 (R$60.000,00)
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2017
PI: Rui Manuel Reis
11. Care HPVTM – Captura Híbrida em unidade móvel para melhoria do programa de rastreio
do câncer cervical em áreas restritas e remotas brasileiras
Funding Agency: PPSUS (R$365.374,40)
CPOM-Hospital de Câncer de Barretos
Duration: 2013-2015
38 Molecular Oncology Research Center – Barretos Cancer Hospital
PI: Adhemar Longatto-Filho
12. BIOPLAT – Plataforma Brasileira para Estudos de Bioprospecção de compostos naturias
com potencial anticâncer em fase pré-clínica
Agência de fomento: FINEP (MCTI/FINEP/MS/SCTIE/DECIT-1302/13) (R$1.384.000,00)
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2016
PI: Rui Manuel Reis
13. Perfil mutacional de linhagens primárias de glioblastomas
Funding Agency: FAPESP/fluxo contínuo – auxílio financeiro (R$ 350.110,00).
CPOM-Hospital de Câncer de Barretos
Duration: 2013-2015
PI: Rui Manuel Reis
14. Estudo funcional da modulação dos miRNAs, miR-451 e miR-720, em linhagens celulares
de tumores humanos
Funding Agency: FAPESP/ Projeto de Pesquisa – Regular (R$ 200.000,00)
CPOM – Hospital de Câncer de Barretos
Duration: 2013-2015
PI: Daniel Onofre Vidal
15. Estudo do efeito antineoplásico de extratos e derivados de Euphorbia tirucalli em tumores
cerebrais e células tronco tumorais cerebrais
Funding Agency: MCTI/CNPq (73/2013) (R$ 490.748,00)
CPOM-Hospital de Câncer de Barretos
Duration: 2013-2015
PI: Rui Manuel Reis
16. Avaliação do câncer ocupacional e do potencial risco em trabalhadores rurais expostos a
agentes carcinogênicos ambientais e ocupacionais na região de Barretos
Funding Agency: Ministério da Saúde – Chamamento Publico n°20 – Estudos e Pesquisas
Aplicadas em Vigilância em Saúde
Duration: 2013-2015 (R$ 140.000,00)
PI: Henrique Cesar Santejo Silveira
17. The Cancer Genome Atlas (TCGA)
Funding Agency: NIH
Duration: 2013-2014 (R$ 800.000,00)
PI: André Lopes Carvalho
39 Molecular Oncology Research Center – Barretos Cancer Hospital
13.2) Pharmaceutical / Biotechnology Industry
1. Estudo pré-clinico dos potenciais compostos anti-neoplásicos AM10 e AM11.
Industry: Fitomedicamentos Amazônica (R$1.455.963,00)
CPOM -Hospital de Câncer de Barretos (R$1.455.963,00)
Duration: 2012-2015
PI: Rui M Reis
2. Tumores de Origem Primária Desconhecida ou Incerta: Identificação através de um
Diagnóstico Molecular Inovador.
Industry: Laboratório Fleury (R$500.000,00)
Duration: 2012-2014
PI: André Carvalho Lopes
3. Métodos moleculares para rastreamente de lesões de colo uterino induzidas por
Papilomavírus humano.
Industry: Laboratório Fleury (R$500.000,00)
Duration: 2012-2014
PI: Adhemar Longatto Filho
13.3) Individual Grants
13.3.1) Technical Support / Research Initiation
1. Beneficiary: Aline Oliveira da Rocha (TT3)
Agency: FAPESP (R$ 21.650,00)
Duration: 2013-2015
Responsible: Daniel Onofre Vidal
2. Beneficiary: Anna Luiza Almeida (TT3)
Agency: FAPESP (R$ 21.650,00)
Duration: 2012-2014
Responsible: Vinicius Vazquez
3. Beneficiary: Weder Menezes (TT3)
Agency: FAPESP (R$ 21.650,00)
Duration: 2013-2015
Responsible: Rui Manuel Reis
4. Beneficiary: Fernanda Cury
40 Molecular Oncology Research Center – Barretos Cancer Hospital
Agency: CNPq (R$ 4.800,00)
Responsible: Henrique Cesar Santejo Silveira
13.3.2) Master
1. Beneficiary: Augusto Ludvik Filip Marino
Agency: FAPESP (R$ 18.516,00)
Duration: 2012-2013
Responsible: Márcia MC Marques Silveira
2. Beneficiary: Nathália Cristina Campanella
Agency: FAPESP (R$ 42.050,00)
Duration: 2012-2013
Responsible: Rui M Reis
3. Beneficiary: Flávia Coltri Eguchi
Agency: FAPESP (R$ 42.050,00)
Duration: 2012-2013
Responsible: Silvana Campos
4. Beneficiary: Taciane Macedo
Agency: FAPESP (R$ 18.516,00)
Duration: 2013-2014
Responsible: Márcia MC Marques Silveira
13.3.3) Post-Doc Fellowship
1. Beneficiary: Adriane Feijó Evangelista
Agency: FAPESP (R$ 133.891,20)
Local: CPOM -Hospital de Câncer de Barretos
Duration: 2012-2014
Responsible: Márcia MC Marques Silveira
2. Beneficiary: Matias Melendez
Agency: CNPq (R$ 103.000,00)
Duration: 2012-2014
Responsible: André Lopes Carvalho
13.3.4) Exchange Grants
1. Beneficiary: André van Helvoort Lengert
41 Molecular Oncology Research Center – Barretos Cancer Hospital
Agency: St. Jude Children’s Research Hospital (U$ 36.000,00)
Duration: July 2012 - June 2013
Country: U.S.A.
Responsible: Daniel Onofre Vidal and Luiz Fernando Lopes.
13.3.5) Excelentce in Research Grants
1. Bolsista de Produtividade em Pesquisa 1D
Funding Agency: CNPq
CPOM-Hospital de Câncer de Barretos
Duration: 2010-2013
PI: André Lopes Carvalho
2. Bolsista de Produtividade em Pesquisa 1D
Funding Agency: CNPq
CPOM -Hospital de Câncer de Barretos
Duration: 2011-2014
PI: Adhemar Longatto Filho
3. Bolsista de Produtividade em Pesquisa 1D
Funding Agency: CNPq
CPOM -Hospital de Câncer de Barretos
Duration: 2011-2014
PI: Rui M Reis
13.3.6) Visiting Professor Grant
1. Funding Agency: CNPq
CPOM - Hospital de Câncer de Barretos
Visiting Porfessor: Kari Juhani Syrianny
Duration: 2012-2014
Responsible: Adhemar Longatto-Filho
14) Patents
Title: Usos de pelo menos um miRNA, kit métodos de diagnóstico de câncer de mama e
métodos para avaliação de risco de metástase.
42 Molecular Oncology Research Center – Barretos Cancer Hospital
Identification number: PCT/BR2013/000357
Responsible: Márcia MC Silveira
15) Jury Participartion
15.1) PhD
1. Marques MMC. Danilo Jordão Xavier, Influencia da hiperglicemia sobre perfis de
expressão transcricional de mRNAs e microRNAs em linfócitos de pacientes com Diabetes
Mellitus tipo 2. Departamento de Genética Faculdade de Medicina de Ribeirão Preto, 2013.
2. Marques MMC: Danielle Calheiros Maia. Avaliação do perfil de expressão de microRNAs
como marcadores prognosticos em tumores iniciais de laringe tratados com radioterapia
exclusiva. Universidade Federal de São Paulo, 2013.
3. Lopes LF. Indhira Dias Oliveira. Estudo de expressão genica nos mecanismos de
manutenção de telomeros e de remodelação óssea em osteossarcoma.CUniversidade Federal
de São Paulo, 2013.
4. Reis RM. Rute Maria Ferreira Lima. Caracetrização Fenotípica de ESP12, uma nova
linhagem de células tumorais de glioblastomas humano, e desenvolvimento de um modelos in
vitro para avaliar a resistência de gliomas e quimioterápicos. Patologia Humana e Patologia
Experimental, Universidade Federal de Bahia, FioCruz, Salvador, 2013.
5. Reis RM. Israel Gomy. Análise da Suscetibilidade ao Câncer Colorretal em Indivíduos
Brasileiros por Genotipagem de Polimorfismos de Nucleotídeo Único Conhecidos. Fundação
Antônio Prudente, 2013.
6. Reis RM. Ana Ines Rebelo Crespo. Genetic imbalances and numerical chromosomal
alterations in glioblastomas as assessed by SNP-arrays and their impacto n gene expression.
Universidade de Coimbra, January, 2013.
7. Vidal DO. Lídia Maria Rebolho Batista Arantes. Metilação do DNA e Biomarcadores em
Câncer de Cabeça e Pescoço. Doutorado em Ciências da Saúde - Faculdade de Medicina de
São José do Rio Preto. 2013.
15.2) Master
1. Carvalho AL. Carlos Eduardo Goulart Silveira. HPV-16 Como fator preditivo de
recorrência para lesões intraepiteliais do colo do uterino tratadas cirurgicamente. Hospital de
Câncer de Barretos, 2013.
2. Evangelista AE. Fernanda Bueno Barbosa. CNVs em Lúpus Eritematoso Sistêmico.
Faculdade de Medicina de Ribeirão Preto/USP. 2013.
43 Molecular Oncology Research Center – Barretos Cancer Hospital
3. Fregnani JH. Maíra Degiovani Stein. Desempenho diagnóstico da citologia cervical
preparada em base líquida, lida manualmente versus a lida de forma automatizada e assistida
por computador. Hospital de Câncer de Barretos, 2013.
4. Fregnani JH. Letícia dos Santos Yamane. Caracterização mutacional dos oncogenes KRAS
e BRAF e análise de MSI nas lesões precursoras do câncer colorretal. Hospital de Câncer de
Barretos, 2013.
5. Fregnani JH. Emilze Mafra de Lima. Saúde oral como fator de risco para neutropenia febril
pós quimioterapia em pacientes com neoplasias hematológicas. Fundação Pio XII - Hospital
de Câncer de Barretos, 2013.
6. Fregnani JH. Fernando Luís Visoni Poliseli. Avaliação do número de cópias do gene
TOP2A e da expressão da sua proteína em leiomiossarcomas uterinos. Hospital A.C.
Camargo, 2013.
7. Garcia EA. Maíra Degiovani Stein. Desempenho diagnóstico da citologia cervical
preparada em base líquida, lida manualmente versus a lida de forma automatizada e assistida
por computador. Hospital de Câncer de Barretos, 2013.
8. Garcia EA. Luana Pimenta Gomes. Avaliação dos fatores de crescimento endotelial
vascular VEGF e de seus principais receptores VEGFR-1 e -2 no processo de cicatrização
com influência da radioterapia em ratos da linhagem Wistar. Faculdade de Medicina da
Universidade de São Paulo, 2013.
9. Guimarães DP. Ana Laura Rodrigue Bordinhão. Avaliação da expressão de micrornas em
linhagens celulares de carcinoma mamário humano expostas a ação do fármaco Cediranib.
Hospital de Câncer de Barretos, 2013.
10. Longatto AF. Carlos Eduardo Mattos da Cunha Andrade. HPV-16 Como fator preditivo
de recorrência para lesões intraepiteliais do colo uterino tratadas cirurgicamente, Hospital de
Câncer de Barretos, 2013.
11. Lopes LF. Juliana Levy Daher. Análise da qualidade de vida, voz e deglutição no paciente
com câncer de cabeça e pescoço pré e pós tratamento oncológico, Hospital de Câncer de
Barretos, 2013.
12. Palmero EI. Croider Franco Lacerda. Perfil multinacional do gene supressor tumoral TP53
no carcinoma de células escamosas de esôfago associado ao megaesôfogo chagásico, Hospital
de Câncer de Barretos, 2013.
13. Palmero EI. Henrique de Campos Reis Galvão. Caracterização de pacientes com Polipose
Adenomatosa Familial atendidos no Hospital de Clínicas de Porto Alegre: enfoque nos
achados extracolônicos. Universidade Federal do Rio Grande do Sul. 2013.
44 Molecular Oncology Research Center – Barretos Cancer Hospital
14. Pinheiro C. Ana Laura Rodrigues Bordinhão. Avaliação da expressão de mircroRNAs em
linhagem celulares de carcinoma mamário humano expostas a ação do fármaco Cediranib”,
Hospital de Câncer de Barretos, 2013.
15. Reis RM. Thalles Olivi de Almeida. Valor do spect mibi cerebrla na predição da
sobrevida em pacientes portadores de glioblastoma multiforme. Hospital de Câncer de
Barretos, 2013.
16. Scapulatempo CN. Augusto Ludvik Filip Marino. Análise do perfil de expressão
diferencial de micrornas em carcinomas mamários por microarrays, Hospital de Câncer de
Barretos, 2013.
17. Marques MMC. Flávia Coltri Eguchi. Avaliação da superexpressãoda proteina ERG e da
fusão gênica- TMPRSS2: ERG em portadores de câncer prostático, Hospital de Câncer de
Barretos, 2013.
18. Marques MM. Thais Cristine Arns. Identificação de cascatas gênicas com base na
modulação trasncricional de células sangüíneas mononucleares periféricas de pacientes com
diabete mellitus do tipo 1”, Dissertação Mestrado, Faculdade de Medicina de Ribeirão Preto-
USP, Ribeirão Preto, 2013.
19. Vazquez VL. Regina Célia da Silva. Qualidade de vida em pacientes com linfoma não
Hodgkin durante a quimioterapia em regime ambulatorial: Avaliação com o questionário
EORTC-QLQ-C30. Hospital de Câncer de Barretos, 2013.
20. Vidal DO. Bruna Rodrigues Muys. Caracterização da estrutura e regulação dos genes
MGC16121 e CR596471. 2013. Faculdade de Medicina de Ribeirão Preto – USP, 2013.
16) National and Internacional Collaborations:
16.1 National
- Centro Internacional de Pesquisa e Ensino (CIPE) - Hospital AC Camargo, S. Paulo.
- Faculdade de Medicina da Universidade de São Paulo, S. Paulo.
- INCT-HPV, S. Paulo.
- Instituto de Medicina Integral Professor Fernando Figueira/ Instituto Materno Infantil de
Pernambuco (IMIP), Recife, PE.
- Laboratório de Poluição Atmosférica da Faculdade de Medicina da USP.
- Universidade Federal de Goiás.
- Universidade Federal do Rio Grande do Sul, Porto Alegre
16.2 International
45 Molecular Oncology Research Center – Barretos Cancer Hospital
- Harvard School of Public Health - HSPH, Boston, USA.
- Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP),
Porto, Portugal.
- Life and Health Science Research Institute (ICVS), University of Minho, Braga, Portugal.
- MDAnderson Cancer Center, Houston, USA.
- The Institute of Cancer Research (ICR), Sutton, UK.
- St. Jude Children’s Research Hospital, Memphis, TN, USA.
17) Molecular Diagnostic Center
The Molecular Diagnostics Center (http://hcbdiagnostico.com.br/) is offering to the Barretos
Cancer Hospital patients and external Institutions a variety of tests currently used in the
clinical routine in the following áreas: Cytogenetics, Personalized Medicine and Oncogenetics.
18) Prespectives for 2014
- Increase the number of publications and projects by researcher;
- Consolidate and structure the research lines and increased the interaction among researchers;
- Fostering and increase adherence to Journals Club/Scientific Meetings and Meeting of
seniors/junior researchers;
- Animal house facility;
- Consolidate partnerships with national and international partners (academic/industry).
Molecular Oncology Research Center - BARRETOS CANCER HOSPITAL46
MOLECULAR ONCOLOGY RESEARCH CENTER TEAM
Molecular Oncology Research Center - BARRETOS CANCER HOSPITAL47