Ada Doisy Lecturers

1970-1971 Charles Huggins* and Elwood V. Jensen1972-1973 Paul Berg* and Walter Gilbert*1973-1974 Saul Roseman and Bruce Ames 1974-1975 Arthur Kornberg* and Osamu Hayaishi1976-1977 Luis F. Leloir*1977-1978 Albert L. Lehninger and Efraim Racker1978-1979 Donald D. Brown and Herbert Boyer1979-1980 Charles Yanofsky1980-1981 Leroy E. Hood1983-1984 Joseph L. Goldstein* and Michael S. Brown*1984-1985 Joan Steitz and Phillip Sharp*1985-1986 Stephen J. Benkovic and Jeremy R. Knowles1986-1987 Tom Maniatis and Mark Ptashne1988-1989 J. Michael Bishop* and Harold E. Varmus*1989-1990 Kurt Wüthrich*1990-1991 Edmond H. Fischer* and Edwin G. Krebs*1993-1994 Bert W. O’Malley1994-1995 Earl W. Davie and John W. Suttie1995-1996 Richard J. Roberts*1996-1997 Ronald M. Evans1998-1999 Elizabeth H. Blackburn*1999-2000 Carl R. Woese† and Norman R. Pace2000-2001 Willem P. C. Stemmer and Ronald W. Davis2001-2002 Janos K. Lanyi and Sir John E. Walker* 2002-2003 Peter B. Moore and Harry F. Noller2003-2004 Elizabeth A. Craig and Susan L. Lindquist2004-2005 Peter C. Agre* and Douglas C. Rees2005-2006 Robert J. Lefkowitz and Brian K. Kobilka2006-2007 Roger Kornberg* and C. David Allis2007-2008 Christopher M. Dobson and David A. Baker2008-2009 Mark Krasnow and Gail Martin2009-2010 Jack Szostak* and Jennifer Doudna

* Nobel Laureate† Crafoord Prize

Engineering Cells to Death

Ada Doisy Lectures in BIOCHEMISTRY

4:00 p.m.Wednesday, May 4, 2011Medical Sciences Auditorium

12:00 noonThursday, May 5, 2011Medical Sciences Auditorium

Sponsored by the Department of Biochemistry • University of Illinois at Urbana-Champaign

20102011

WellsDr. James

Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology

University of California at San FranciscoSan Francisco, California

Relating the GeneticFeatures of HumanCancers to Small-Molecule Sensitivities

Dr. Stuart

Howard Hughes Medical Institute

Department of Chemistry & Chemical Biology

Harvard UniversityCambridge, Massachusetts

Schreiber

o

relationships betweensmall molecules

relationships betweencell measurements

timedose

1,000 CCLs(genetic features)

roles of quantitative variables

CTD2

probe kit (high

specificity)

cancer cell measurement

relationships between genetic features

8 (in duplicate) concentrations

apoptoticstimulus

Professor Stuart Schreiber received his B.A. in Chemistry from the University of Virginia in 1977 and his Ph.D. in Organic Chemistry from Harvard University in 1981. He then joined the faculty at Yale University, where he was promoted quickly through the ranks to Professor within 5 years. In 1988 he moved back to Harvard University and has held the Morris Loeb Professorship since 1998 in the Department of Chemistry and Chemical Biology. Dr. Schreiber has been an Investigator of the Howard Hughes Medical Institute since 1994 and was elected to the National Academy of Sciences and the American Academy of Arts and Sciences in 1995. Amongst his numerous awards, the American Chemical Society has recognized Dr. Schreiber with the Arthur C. Cope Scholar Award (1986), Eli Lilly Award in Biological Chemistry (1993), and Alfred Bader Award in Bioorganic and Bioinorganic Chemistry (2000). In 2001, he received the William H. Nichols Medal for his outstanding contribution to understanding signal transduction pathways by merging synthetic organic chemistry and molecular and cell biology approaches. Translational biomedical research from Dr. Schreiber's lab has produced torisel, which targets mTOR to treat renal cell carcinoma. His multi-disciplinary research program has also yielded vorinostat, which targets HDAC1 to treat cutaneous T-cell lymphoma. In 2003, Dr. Schreiber received NIH Director’s recognition for his role in founding ChemBank, the first public small molecule screening database. He has also founded Vertex Pharmaceuticals, Ariad Pharmaceuticals, and Infinity Pharamaceuticals. His life-saving work was recognized by the 2010 AACR Award for Outstanding Achievement in Chemistry in Cancer Research.

Professor James Wells obtained a B.A. in Biochemistry from the University of California-Berkeley in 1973. His Ph.D. studies in Biochemistry (1979) were carried out at Washington State University, followed by postdoctoral work at Stanford University Medical School. Subsequently in 1982, Dr. Wells joined Genentech where he was the founding member of its Protein Engineering Department. His groundbreaking industrial work that centered on engineering new functions into enzymes and hormones and their applications was recognized in 1990 by the American Chemical Society’s Pfizer Award and in 1998 by The Protein Society’s Christian B. Anfinson Award and the American Peptide Society’s Vincent du Vignead Award. In 1999, Dr. Wells was elected to the National Academy of Sciences. Dr. Wells founded Sunesis Pharmaceuticals in 1998 serving as President and Chief Scientific Officer to develop a novel fragment discovery technology called Tethering that is based on disulfide trapping. In 2005, Professor Wells moved to the University of California–San Francisco as the Harry W. and Diana Hind Distinguished Professor and Chair of Pharmaceutical Sciences, where he continues to work at the technological and medicinal interfaces of translational biochemistry to develop therapeutics to treat inflammation and cancer. He is also a joint member of the Department of Cellular & Molecular Pharmacology as well as the Director of the Small Molecule Discovery Center at UCSF. Professor Wells has been recognized for his outstanding contributions in biomedical research by the Hans Neurath Award from The Protein Society (2003) and received the Paul Janssen Prize in Advanced Biotechnology and Medicine (2006).

The Ada Doisy Memorial Lectures were established by the late Dr. Edward A. Doisy in honor of his mother Ada Doisy, whom he credited with instilling his love and reverence for learning and inquiry. Dr. Doisy received his Bachelor's degree in 1914 and his Master's degree in 1916 from the University of Illinois. He received his Ph.D. from Harvard University in 1920 and immediately joined the faculty at Washington University School of Medicine. In 1924 Dr. Doisy moved to the St. Louis University School of Medicine, to found the Department of Biochemistry and assume its headship. He remained Head until his retirement in 1965. Among many contributions to natural products and nutritional chemistry, Dr. Doisy isolated and synthesized vitamin K. For this work, he shared the Nobel

Prize in Physiology or Medicine in 1943 with Henrik Dam of Denmark. Dr. Doisy was awarded the Illinois Achievement Award by the University of Illinois Alumni Association in 1958, and received an honorary degree from the University of Illinois in 1960.

The Ada Doisy Lectures are among the most distinguished lectureships in the Chemical and Life Sciences. Doisy Lecturers have been recognized by nineteen Nobel Prizes and one Crafoord Prize, an equivalent to the Nobel Prize for areas not covered by it. Fifteen of these awards were announced after invitation as Doisy Lecturers.