2010/2011sereno/596/readings2/lecture3.pdf · discontinuities: somatosensory system versus visual...
TRANSCRIPT
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2010/2011
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Somatosensory System
Lecture 3
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Topics
• Visual attention
• Arm diagram
• Somatosensory pathway
• Somatosensory cortial areas
• Somatosensory cortical plasticity
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How do we filter out irrelevant stimuli?
• our retinas are bombarded by constant
stimulation
• yet we are aware of only small subset of
visual stimuli
• How do we pay attention to some and not
other visual stimuli?
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Types of attention
• overt vs covert (w/ or w/out saccades)
• spatial attention vs. object-based attention
• endogenous vs. exogenous
• usually, these operate together
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Visual pathways from V1
dorsal:
magno (dLGN) ! V1 (4C") ! (4B, etc) ! V2 (thick stripes) ! MT ! MSTd, etc.
ventral:
parvo (dLGN) ! V1 (4C#) ! (layer 2/3) ! V2 (thin stripes) ! V4 ! inferotemporal cortex
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Visual pathways
Squire et al., 2003
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Network of brain areas mediating spatial attention
• evidence from neuropsychology (neglect),
neurophysiology, functional imaging: parietal, frontal,
cingulate areas control spatial attention
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Squire et al., 2003
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Attentional modulation of neuronal responses
• top-down signals from parietal and frontal cortex increase or suppress responses in visual areas that process specific stimulus attributes
(e.g. color, shape, etc.).
• attentional modulation: at almost all levels of the visual system
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Training monkeys
• why fixation cross is important: need to
control visual stimulation inside a neuron!s
RF.
• macaque monkeys are good
at covert attention (peripheral
monitoring)
• reward
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Single-unit recordings in V4
Squire et al., 2003
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Procedure
1) isolate a V4 cell & its receptive field location
2) identify preferred (good) stimulus of cell
3) present both preferred (good) and non-
preferred (bad) stimuli inside the RF
4) train monkey to attend to one or the other
stimulus
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Moran and Desimone (1985) V4 experiment
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+
Passive response to good stimulus
receptive field
fixation
Flavia Filimon, Systems Neuroscience 2008
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+
Passive response to good stimulus
receptive field
fixation
cell’s response
Flavia Filimon, Systems Neuroscience 2008
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+
Passive response to bad stimulus
fixation
receptive field
Flavia Filimon, Systems Neuroscience 2008
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+
Passive response to bad stimulus
fixation
receptive field cell’s response
Flavia Filimon, Systems Neuroscience 2008
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+
Both stimuli present, attend good
fixation
receptive field
Flavia Filimon, Systems Neuroscience 2008
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+
Both stimuli present, attend good
fixation
receptive field cell’s response
Flavia Filimon, Systems Neuroscience 2008
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Both stimuli present, attend bad
+
fixation
receptive field
Flavia Filimon, Systems Neuroscience 2008
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Both stimuli present, attend bad
+
fixation
receptive field cell’s response
Flavia Filimon, Systems Neuroscience 2008
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average firing rate
Results: Attention suppresses irrelevant stimuli in V4
Flavia Filimon, Systems Neuroscience 2008
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Results: Attention suppresses irrelevant stimuli in V4
• response onset ~ 40 ms
after stimulus onset
• attention takes an
additional 40 ms to
kick in
• even though good
stim. is also presented
in RF, attention to bad
stimulus suppresses
response to good stim.
average firing rate
Flavia Filimon, Systems Neuroscience 2008
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Possible mechanisms
• competition between stimuli
• top-down bias toward attended location/
feature (via feedback from fronto-parietal
attentional network)
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Discontinuities in the somatosensory system
• in V1 (visual system): 2 points close together on retina are close together in cortex
• in SI (somatosensory system), you can move a small distance on cortex and end up far away on skin (e.g. from thumb to eye)
finger representation
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Discontinuities: somatosensory system versus visual system
• in V1 (visual system): 2 points close together in cortex are close together in the visual field
• i.e. moving a short distance in cortex = moving a short distance in visual field
• BUT: can move short distance in visual field and end up far away in cortex: e.g. V2 horizontal meridian (upper and lower vis. fields); Left vs. Right vis. field representations.
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Discontinuities: somatosensory system versus visual system
• in S1 (somatosensory system): moving a short distance in cortex can mean a big jump on the skin
• e.g. from face to hand
• S1 has many discontinuous patches: e.g. tops and undersides are represented separately
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Flavia Filimon, Systems Neuroscience 2008
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Other differences between somatosensory and visual systems
• retina is a continuous receptor surface
• skin is discontinuous: separate fingers, can stimulate each finger in isolation
• RFs from different fingers are discontinuous
Flavia Filimon, Systems Neuroscience 2008
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Somatosensory receptors
• in visual system, receptor does not spike
• in somatosensory system, dorsal root ganglion forms receptor ! spike
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(receptor and sensory neuron are the same)
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Dorsal root ganglion
•
4
spinal cord
dorsal horn: sensory
ventral horn: motor
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Dorsal root ganglion cells form specialized peripheral receptors
• somatosensory stimuli are broken down into multiple modalities, e.g. pain, touch, temperature ! separate pathways
• exteroceptive: mechanoreception, thermoreception, nociception
• proprioceptive: kinesthesia: position + movement
• interoceptive: internal viscera
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II. Proprioception - muscle spindles
• muscle spindles: detect
stretch (sustained or
transient)
• encapsulated receptors
• innervated by !
motoneurons
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II. Proprioception - Golgi tendon organs
• Golgi tendon organs:
inside fibrous tendons of
muscle
• encapsulated
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Proprioceptive receptors
• muscle spindle Ia:
RA, detects
stretch
• muscle spindle II:
SA, detects
position
• Golgi Ib: tendon
stretch, force
exerted on
muscle
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!
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Why do muscle spindles innervate muscle spindle muscles?
• contraction of extrafusal muscle fibers ! if intrafusal (muscle spindle muscle) fibers were to go slack, could not detect stretch during every extension
• ! intrafusal fibers do not contract; only respond to elongation
• Examples of what activates which receptors
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Pathways to the brain:II: Anterolateral (spinothalamic) pathway
• VPL = ventro-
posterolateral
• CL = central lateral
nucleus (part of
intralaminar nuclei)
• POm = medial
nucleus of posterior
complex
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Pain+TemperatureInformation
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Pathways to the brain:II: Anterolateral (spinothalamic) pathway
• What happens when spinal cord is cut/injured just below 4th ventricle?
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Somatosensorycortex
• primary somatosensory cortex (SI): postcentral gyrus + posterior bank of central sulcus
• contains 4 sub-regions: 3a, 3b, 1, 2
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Each of the 4 areas in SI contains a homunculus
• regions of skin with greater number of receptors are enlarged on cortical surface
• NOTE: hand and face are close together in cortex, but far apart in terms of skin distance ! functional grouping
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Somatosensory Plasticity Experiments (S1)
1) Deafferentation of body part: small scale (mm - finger)
2) Deafferentation of body part: large scale (cm - arm)
3) Transferring skin patch to a different finger
4) Syndactily
5) Repetitive use of body part
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1) Deafferentation of finger
•
cortical representations for fingers 2 and 4 invade cortical area formerly representing #3
Flavia Filimon, Systems Neuroscience 2008
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2) Deafferentation of monkey arm
Pons et al., Science, 1991
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Face representation invades former arm representation
•
Pons et al., Science, 1991
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•
Pons et al., Science, 1991
> 12 years later:Stimulating parts of
the face will activate neurons in arm area (see II - V)
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3) Skin transplant from little finger to thumb
•
Initially, stimulating thumb will activate pinkie representation
(and will feel like pinkie)
Later, thumb will activate thumb representation
(and will feel like thumb)
Flavia Filimon, Systems Neuroscience 200818
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4) Syndactily
normally:sharp boundary between finger representations
due to correlation
Flavia Filimon, Systems Neuroscience 200819
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4) Syndactily
normally:sharp boundary between finger representations
due to correlation
syndactily:RFs cross over
between 3 and 4 - representations for 3 and 4 are
now continuous, due to correlated
input
Flavia Filimon, Systems Neuroscience 200820
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5) Repetitive somatosensory stimulation
•
Repetitive stimulation (monkey trained to touch spinning disk)
Cortical representation for that finger expands in ~2 weeks
Flavia Filimon, Systems Neuroscience 200821
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Possible mechanisms for plasticity in adult somatosensory cortex
1) for small-scale (2-3 mm) shift: rearrangement of existing synapses in S1
2) for large-scale (cm) rearrangements: growth of new axons? (including
dorsal column nuclei, VB)
Flavia Filimon, Systems Neuroscience 2008
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tuning synapsesup or down;
activating “silent” synapses
synaptic spread
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Summary
• adult somatosensory cortex is PLASTIC (to some extent).
• 2 possible mechanisms for plasticity: synaptic vs. larger-scale, axonal
• somatosensory cortex (SI, SII, and other areas) is organized somatotopically, with body part representations also grouped by functional correlation/co-activation (activity-dependent)
• (e.g. tops of fingers are not frequently co-stimulated with undersides, so ! separate; mouth is frequently co-stimulated with hand, e.g. during feeding
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