2009 h1n1 pandemic update for ems _________________________ alexander l. brzezny, md, mph grant...
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2009 H1N1 PANDEMIC UPDATE FOR EMS_________________________
Alexander L. Brzezny, MD, MPHGrant County Health Officer
____________Jackie Dawson, PhD
Public Health Epidemiologist
TOPICS What you may not know about influenza A Caring for patients: suspect, probable and
confirmed influenza EMS-specific guidance /recommendations Personal Protective Equipment (PPE) use Triage protocols for pandemic flu surge Vaccine and antiviral medications use Healthcare workers & 2009-10 flu season
H1N1 control: Four numbers
6 (feet of separation)100 (Fahrenheit)7 (days of exclusion)24 (hours w/o fever)
ILI=Influenza-Like IllnessInfluenza-like illness (ILI):
Fever>100F (37.8C) ANDCough AND/OR Sore Throat Absence of other obvious known cause
Influenza (flu) is caused by a virus that spreads easily by coughing and sneezing. Close contact within 6 feet. Can be transmitted by surfaces.
Influenza is a Respiratory Illness
Social DensitySocial Density
http://buildingsdatabook.eren.doe.gov/docs/7.4.4.xls
12 feet 3-4 feet
8 feet
Elementary Schools
Hospitals
Offices
16 feet
Residences
Swine Influenza A(H1N1) Transmission Through Species
Avian Virus
Human Virus
Swine Virus
Avian/HumanReassorted Virus
Reassortment in Pigs
Novel H1N1 Influenza The virus contains
gene segments from FOUR different influenza types: North American swine North American avian North American human Eurasian swine
Rate & number (in parentheses) of hospitalized or fatal cases of PanH1 influenza by county, 2009 (n=119)
Clallam (1)
Grays Harbor
(1)
Pacific
Cowlitz*
Clark (4)
Island (1)
King (60)
Lewis*
Mason (3)
Pierce (22)
Skagit*
Snohomish (11)
Thurston (5)
Whatcom (1)
Adams
Benton (1)
Chelan*
Columbia
Franklin Garfield
Grant (3) Kittitas*
Klickitat
Lincoln
Okanogan
Spokane*
Walla Walla
Whitman*
Yakima (1)
Douglas*
Ferry
Stevens
Pend Oreille
Asotin* Skamania
Wahkiakum
Jefferson* Kitsap
(7)
San Juan
*Reported non-hospitalized PanH1 influenza case(s)
Rate per 100,000:
0.1-1 1.1-2
2.1-3 3+
0
H1N1 SURVEILLANCE Infectious period for a confirmed case of 2009
H1N1 infection: 1 day prior to the case’s illness onset to 7 days after onset (or 24 hours after fever gone).
Close contact: within about 6 feet of an ill person who is a confirmed or suspected case of 2009 H1N1 (swine flu) virus infection during the case’s infectious period
H1N1 SURVEILLANCE Suspect H1N1 case: a person with an
influenza-like illness (ILI) Probable H1N1 case: a person who meets
the suspect case definition and who is positive for influenza A
Confirmed H1N1 case: a person with ILI and laboratory-confirmed novel influenza A (H1N1) infection by one or more of the following tests: Real-time RT-PCR Viral culture
H1N1 SURVEILLANCE MANDATORY REPORTING CHANGE Healthcare workers and hospitals should
IMMEDIATELY report the following patients to public health: Hospitalized patients with laboratory-confirmed*
(not “suspected”) influenza infection, Deceased patients with laboratory-confirmed*
influenza infection, and Deceased patients suspected to have influenza
infection.
*a positive rapid influenza test, PCR test, direct or indirect fluorescent antibody, or viral culture
H1N1 SURVEILLANCE If testing for 2009 H1N1 virus has not
been performed, laboratories should submit clinical specimens or viral isolates to PHL (public health lab) within 72 H of collection from: Deceased or critically ill patients (i.e., ICU
admission) suspected to have influenza. Hospitalized patients who have tested positive for
influenza. Option to submit specimens from non-hospitalized
pregnant women who have tested positive for influenza.
www.doh.wa.gov/ehsphl/Epidemiology/CD/swineflu/sflu-testalg.pdf
2009 H1N1- September, 2009Total WA 2009 H1N1 Flu Hospitalizations and
DeathsPosted September 11, 2009, 1:00 PM PT
Total WA Novel H1N1 Flu Hospitalizations
164Total U.S. Novel H1N1 Flu Deaths
16
Novel H1N1 vs. Seasonal Influenza Differences between the novel H1N1
and the seasonal flu variety: It is capable of multiplying deep within the lungs. High viral load in the upper airways. Attack rate of 35-40% in close contacts (vs. 5%) The immune system does not know it: lung
damage more severe in those severely ill. Most severe cases and deaths are occurring in
people below 50 years of age (88%). Projected to cause additional 30,000 - 90,000
deaths in 2009-2010.
Duration of hospital stay among hospitalized persons with 2009 H1N1 influenza* (Washington)
*Incomplete reports on 43 cases
1
13
30
97 7
5
0 0 0
4
0
5
10
15
20
25
30
35
0 1 2 3 4 5 6 7 8 9 10+
Length of stay (days)
Nu
mb
er o
f ca
ses
23.5 25.2
33.6
17.611.3
57.1
28.6
3.0
0
10
20
30
40
50
60
0-4 5-17 18-49 50+
Age group (years)
Per
cen
tag
e o
f P
anH
1 ca
ses
Hospitalized or fatal (n=119) Non-hospitalized (n=532)
p<0.001
All 2009 H1N1 cases by age group & hospitalization status
Symptoms of hospitalized/fatal cases of 2009 H1N1 influenza (Washington)
Hospitalized or Fatal
Symptoms (n*) Symptom Present %
Fever (111) 105 95
Cough (111) 105 95
Shortness of breath (70) 49 70
Sore throat (69) 35 51
Vomiting (90) 35 39
Diarrhea (90) 23 26
* Number of records where presence or absence of symptom specified
Pre-existing conditions in hospitalized or fatal 2009 H1N1 influenza (Washington)
Hospitalized or Fatal(N=111*)
Condition n %
Lung diseases/conditions 39 35 Asthma 24 22
Smoking 11 10
Chronic lung disease 9 8
Diabetes 16 14
Heart disease 14 13
Steroid therapy 8 7
Pregnancy 6 5
Chemotherapy/cancer in last year 5 5
*6 incomplete or missing case reports, 2 case investigations in progress
Clinical findings in hospitalized or fatal 2009 H1N1 influenza (Washington)
Hospitalized or Fatal
Clinical condition (n*) Present %
Pneumonia (95) 47 50
Hypoxia (77) 34 44
ICU admission (107) 33 31
Mechanical ventilation (32) 23
Adult respiratory distress syndrome (25) 17
Received antiviral medication (104) 81 78
* Number of records where presence or absence of condition specified
Washington 2009 H1N1 Summary 39% of hospitalized/fatal cases reported
vomiting compared to 25% of non-hospitalized cases.
74% of hospitalized cases had a pre-existing condition compared to 22% of non-hospitalized cases.
More hospitalized cases were pregnant or had asthma, chronic lung disease, diabetes, heart disease, steroid therapy, chronic kidney disease, cancer or chemotherapy in the preceding year.
H1N1 is now endemic in Grant County and is causing regional epidemics in WA
Influenza high-risk individuals Pregnant women, People with asthma and other lung disease, Diabetics, Morbidly obese person, People with blood disorders (sickle cell, etc.) People with compromised immune systems, People with heart disease, stroke or similar, Those with neuromuscular diseases (CP, etc.), Hemodialysis patients (and other ESRD), Infants, elderly, nursing home residents, Individuals with a recent illness.
Recommendations for EMS and Medical First Responder Personnel Including Firefighter and Law Enforcement First Responders
For purposes of this section, “EMS providers” means pre-hospital EMS, Law Enforcement and Fire Service First Responders.”
http://www.cdc.gov/h1n1flu/guidance_ems.htm
Recommendations for 9-1-1 Public Safety Answering Points (PSAP) PSAP to question callers and ascertain:
Is anyone at the incident location afflicted by the swine-origin influenza A (H1N1) virus:
to communicate the possible risk to EMS personnel prior to arrival, and
to assign the appropriate EMS resources. PSAPs should review existing medical dispatch
procedures and coordinate any modifications with their EMS medical director and in coordination with public health.
Recommendations for 9-1-1 Public Safety Answering Points (PSAP) PSAP should screen all callers for any
symptoms of acute febrile respiratory illness.
Callers should be asked if they, or someone at the incident location, has fever, cough, sore throat, shortness of breaht, nasal congestion, or other flu-like symptoms. If the PSAP suspects ILI, they should make sure
any first responders and EMS personnel are aware of the potential for “acute febrile respiratory illness” or “ILI” before the responders arrive on scene.
Scene Safety Address scene safety:
If PSAP advises potential for acute febrile respiratory illness symptoms on scene, EMS personnel should don PPE PRIOR TO ENTERING SCENE
If PSAP has not identified any ILI individuals, EMS personnel should stay more than 6 feet away from patient and bystanders with symptoms and exercise appropriate routine respiratory droplet precautions while assessing all patients for suspected cases of influenza.
All patients with acute febrile respiratory illness should wear a surgical mask, if tolerated by the patient.
Scene Safety Assess all patients for symptoms of
acute febrile respiratory illness (fever plus one or more of the following: sore throat, or cough, possibly rhinorrhea). If no symptoms of acute febrile respiratory
illness, provide routine EMS care. If symptoms of acute febrile respiratory illness,
don appropriate PPE for suspected case of swine-origin influenza if not already on.
Report information about any ILI patients to the patient transport destination
Current WA State recommendations for use of PPE for HCW and EMS EMS workers should put on a mask when
attending to a patient with influenza-like illness.
When splashing or contact with respiratory fluids is likely or when close contact is expected as when caring for an infant, EMS caring for patients with influenza-like illness should use gown, gloves, and face protection (mask and goggles or faceshield).
Before and after contact with the patient, clean hands thoroughly with soap and water or an alcohol-based hand gel.
Current WA State recommendations for use of PPE for HCW and EMS For cough-inducing or aerosol-generating
procedures in patients with influenza-like illness, healthcare personnel should use either a respirator (e.g. N95) and eye protection (or PAPR). Such procedures include: nebulizer treatments trachostomy care suctioning bronchoscopy intubation post-mortem examination
While collecting respiratory specimens, an N95 respirator would be preferred but, if not available, a tightly fitting mask with eye protection is acceptable.
Surgical masks Easily available and commonly used for routine surgical and
examination procedures High-filtration respiratory mask (i.e. N95)
The masks have numbers beside them that indicate their filtration efficiency. For example, a N95 mask has 95% efficiency in filtering out particles greater than 0.3 micron under normal rate of respiration.
The next generation of masks use Nano-technology which are capable of blocking particles as small as 0.027 micron.
Types of Protective Masks
Types of Protective Masks Small facemasks are available for children:
problematic to be worn correctly and consistently.
no facemasks (or respirators) have been cleared by the FDA for use by children.
PAPR (Powered Air Purifying Respirator)
Current WA State recommendations for use of PPE for HCW and EMS Healthcare facilities should plan for allocation of
personal protective equipment, including masks and N95 respirators.
Respirators should be used in accordance with Occupational Safety and Health Administration (OSHA) regulations. Staff should be checked for medical contraindications.
In addition, staff should be fit-tested and trained for respirator use (WAC 296-842, OSHA 1910.134) including proper fit-testing, use, safe removal, and disposal of respirators (www.fda.gov/cdrh/ppe/masksrespirators.html)
How to Reduce Respiratory Droplet Exposure? Standard droplet respiratory precautions will
significantly reduce the transmission of respiratory illness.
Consider Metered Dose Inhaler (MDI) rather than a nebulizer, supra-glottic adjunct airway devices verses intubation (Combitube or King Airways), and HEPA filters on bag-valve-mask devices or any Oxygen delivery systems (as available).
Encourage good patient compartment vehicle airflow/ventilation to reduce the concentration of aerosol accumulation when possible.
At The Receiving Facility Routinely assess all persons entering a receiving
facility and offer a mask to those with cough or respiratory symptoms if already not on.
Assess incoming patients in a location with negative pressure air handling if feasible.
Assure provisions for prompt isolation and assessment of symptomatic patients.
Place patients with influenza-like illness in a private room with a closed door, or cohort patients with influenza-like illnesses if private rooms are unavailable.
Have patients with influenza-like illness wear a mask when outside their hospital room, or use tissues to cover coughs and sneezes if mask use is not possible.
At The Receiving Facility Place patients with suspected or confirmed 2009
H1N1 infection, especially those who require frequent aerosol-generating procedures, in an airborne infection isolation hospital room (6-12 air changes per hour), if available.
Emphasize hand hygiene before and after patient care, after removing personal protective equipment (including gloves), and after any contact with respiratory secretions.
Limit healthcare workers entering the room of a patient in isolation to those performing direct patient care.
Healthcare workers should put on a mask when entering the room of a patient with influenza-like illness.
After Response /Transportation Perform a thorough cleaning of the stretcher and
all equipment that has come in contact with or been within 6 feet with an approved disinfectant, upon completion of the call.
Stretchers, railings, medical equipment control panels, adjacent flooring, walls, ceilings and work surfaces, door handles, radios, keyboards and cell phones, etc.
After the patient has been removed and prior to cleaning, the air within the vehicle may be exhausted by opening the doors and windows of the vehicle while the ventilation system is running (away from pedestrian traffic).
After Response /Transportation Large spills of bodily fluids (e.g., vomit) should first
be managed by removing visible organic matter with absorbent material.
Place contaminated reusable patient care devices and equipment in biohazard bags.
Clean and disinfect non-patient-care areas of the vehicle according to the vehicle manufacturer’s recommendations.
Cleaning should be done with detergent and water and then disinfected using an EPA-registered hospital disinfectant in accordance with the manufacturer's instructions.
www.flu.gov/professional/hospital/cleaning_ems.html
Source: Bean B, et al. JID 1982;146:47-51
Survival of Influenza Virus Surfaces and Affect of Humidity &
Temperature* Hard non-porous surfaces 24-48 hours
Plastic, stainless steel Recoverable for > 24 hours Transferable to hands up to 24 hours
Cloth, paper & tissue Recoverable for 8-12 hours Transferable to hands 15 minutes
Viable on hands <5 minutes only at high viral titers Potential for indirect contact transmission
*Humidity 35-40%, Temperature 28C (82F)
After Response /Transportation Health care personnel, public health workers, or
first responders who have had a recognized, unprotected close contact exposure to a person with confirmed, probable, or suspected 2009 H1N1 or seasonal influenza during that person’s infectious period should be considered for antiviral chemoprophylaxis with either oseltamivir or zanamivir. (www.cdc.gov/h1n1flu/recommendations.htm)
EMS and Healthcare Workers should be monitored daily for signs and symptoms of influenza-like illness.
Ill EMS and HCW’s should be excluded from work for 7 days, or until 24 hours after symptoms resolve, whichever is longer.
No further follow-up
Yes
No
Assessment Flow Chart
Temp is >100.4o F. and
you develop any of the first4 symptoms of diary
- Notify Employee Health Service- Fill out "Employee Incident Report"- Stay home & report illness to \ Staffing Office or supervisor
Note: The infectious period for H1N1 flu is one day before symptom onsetuntil seven days after the patient's
onset of illness. If close contact occurred with a case whose illness started more than 7 daysbefore contact, then prophylaxis is not necessary.
No
Yes
Limited Exposure
- Wore mask during patient care- Transported patient- Cared for patient but did not have close or prolonged contact with patient's aerosolized oral secretions
Less than 7 dayssince exposure
NoNo furtherfollow-up
Yes
* Receive Prophylaxis
Self-monitor for "Influenza-like Illness" symptoms for 7 days
after limited exposureusing "Symptom Diary" (page 3)
H1N1 Influenza Virus ExposureFor use with exposure to patients/individuals with suspected or confirmed H1N1 Influenza only.
* PAPR = purified air particulate respirator.
Complete Patient Information Profile (page 2 of this policy) and
Complete Employee Incident Report &see Emergency Department Physician
Close Contact Exposure(with no mask/PAPR* & within 6 feet of patient)
Directly exposed to patient's aerosolizedsecretions by endotracheal intubation,
suctioning, ET tube management, oral suctioning,or directly to patient's cough or sneeze.
Effect of Prehospital and other Community Interventions1. Delay disease transmission and outbreak peak
2. Decompress peak burden on healthcare infrastructure3. Diminish overall cases and health impacts
DailyCases
#1
#2
#3
Days since First Case
Pandemic outbreak:No intervention
Pandemic outbreak:With intervention
Summary of pre-hospital interventions Before moving closer than 6 feet, Use PPE for respiratory droplet precautions (a
mask, fit-tested N95 respirator when appropriate, disposable gloves, gown, and eye protection).
Place a mask on the patient. After contact with the patient clean hands
thoroughly with soap and water or an alcohol-based hand gel.
After caring for the patient cleanse the vehicle for respiratory droplet contamination.
Sample triage forms Employee exposure form SORT Adolescent-Adult triage Kaiser Permanente Colorado CDC triage forms still preparation
SORT triage evaluation (KPCO)
Risk GroupNumber of
Clinic Visits
Related Hospitalization
s Within 14 days
Rate of Hospitalizations within 14 Days
Elevated 573 30 5.2%Intermediate 645 8 1.2%Low 1540 2 0.1%
Unique people per risk group using the CDC definition of symptoms Fever ( by VS temp or complaint) + one Sore Throat or Cough.
Risk GroupNumber of Clinic
Visits
Related Hospitaliz
ations Within 14
daysRate of Hospitalizations
within 14 Days
Elevated 650 39 6.0%Intermediate 711 9 1.2%Low 1709 2 0.1%
Unique people per risk group using the Broader definition of symptoms Fever ( by VS temp or complaint) + one of the other sx (ST, cough, uri, flu sx, bronchitis etc).
Pandemics are unpredictable Epidemiology reveals waves of
infection Ages/areas not initially infected
vulnerable in subsequent waves 1918- virus mutated into more virulent form
1957 schoolchildren first wave, elderly died in second wave
Public health interventions delay, but do not stop pandemic spread Quarantine, travel restriction show little
effect Temporary banning of public gatherings,
closing schools potentially effective in case of severe disease and high mortality
Delaying spread is desirable Fewer people ill at one time improve
capacity to cope with sharp increase in need for medical care
Lessons Learned formPast Pandemics
Is it ethical to not vaccine EMS /HCW’s against influenza?
Influenza is NUMBER ONE vaccine preventable disease.
Influenza is NUMBER ONE killer when compared to any other vaccine preventable disease.
Influenza is very contagious (from patients to workers then from workers to unsuspecting victims elsewhere).
Flu shots are cheap and safe
Seasonal flu causes up to 36,000-50,000 deaths per year in the United States. These are often vaccine
preventable.
Ethics of EMS /HCW’s influenza vaccination
Vaccination of EMS and health care workers (HCW) results in indirect protection of patients who are at high-risk for influenza.
Institutions caring for children and elderly have the responsibility to implement voluntary programs for vaccination against influenza.
When uptake falls short a mandatory program may be justified.
The caregivers have a duty not to harm one's patient when one knows there is a significant risk of harm and the intervention to reduce this chance has a favorable balance of benefit over burdens and risks.
Van Delden et al. The ethics of mandatory vaccination against influenza. Vaccine. 2008 Oct 16;26(44):5562-6. Epub 2008 Aug 21
Healthcare Professional Excuses That Result in Very Low Vaccination Rates Fear of adverse effects: 8–54% “Vaccination can cause influenza" 10–45% “Not at risk” 6–58% The times/locations of vaccination were
unsuitable for 6–59% (usually students and inpatient staff)
Doubt that influenza is a serious disease: 2–32%
Inefficacy of the vaccine: 3–32% (44% non-allopathic
providers) Fear of injections: 4–26%
Hoffman, C. Infection 2006; 34: 142–147
Novel H1N1 Vaccine Information
Vaccine should be available BY mid-October (195mln doses ordered). FDA approved today.
Studies on children and adults are under way. Seasonal influenza and H1N1 vaccines can be
given together (most current assumption). Two doses are likely to be necessary for
children, one dose for adults. Limited cost to the individual vaccinated. The H1N1 vaccine will reach the county through
the Grant County Health District and your hospital in parallel.
On-site vaccination of EMS recommended.
Novel H1N1 Vaccine InformationRecommended Target Groups (from CDC) Children and young people between the ages
of 6 months and 24 years of age, Pregnant women, Household contacts and caregivers of
children who are younger than 6 months of age,
Healthcare workers and emergency medical services personnel,
Adults 25-64 years of age with underlying risk conditions or medical conditions that increase their risk for complications from influenza.
Who should get the seasonal flu vaccine? Healthcare workers and EMS All children, age 6 months up to the 19th
birthday, especially those with illnesses like asthma, diabetes, or heart disease.
Anyone living with or caring for children especially babies under 6 months (who are too young to get flu vaccine).
Pregnant women. People age 50 and older. People with certain chronic medical conditions. People living in long-term care facilities. Others near those at high risk for flu
complications.
Intranasal influenza vaccine LAIV:“live attenuated influenza vaccine”
Intramuscular influenza vaccineTIV:“trivalent inactivated influenza vaccine”
Virginia Mason Flu Clinic Drive, 2006
http://www.preventinfluenza.com/summits/2007/Session_Four/Hagar_2007.pdf last accessed 08/01/2009
THIMEROSAL (C9H9HgNaO2S), or sodium ethylmercurithiosalicylate Because thimerosal is half mercury (47% Hg),
a vaccine with 0.01% concentration of thimerosal (in 0.5ml) = 0.005% concentration
of HgThat equals 25 micrograms of mercury per
0.5 mL of vaccine.
Most commercial fish contain an average of 23 micrograms of mercury per 8 ounces
of fish (i.e., 0.1 micrograms of mercury per gram of fish).