2006 compiled electrotherapy references reference list.pdf · a case report and review of the...

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Electrotherapy and Tissue Repair Compiled Reference List 2006 2006 Compiled Electrotherapy and Tissue Repair References This list is not claimed to be a ‘complete’ list of references in these topic areas, but may provide a useful resource for those working with the research and other published literature. There are many more references than are listed here for many of the topic areas, and I have therefore tried to identify those that are most likely to be of relevance (as I see it) rather than include all the ‘peripheral’ material that I find fascinating, but the reader might find is simply a form of clutter! My apologies to any and all authors of papers that have not been included. Tim Watson February 2007 Biofeedback Eogan, M. and C. O'Herlihy (2006). "Diagnosis and management of obstetric anal sphincter injury." Curr Opin Obstet Gynecol 18(2): 141-146. Leung, M. W. et al. (2006). "Electrical stimulation and biofeedback exercise of pelvic floor muscle for children with faecal incontinence after surgery for anorectal malformation." Pediatr Surg Int 22(12): 975-8. Ng, G. Y. et al. (2006). "Biofeedback exercise improved the EMG activity ratio of the medial and lateral vasti muscles in subjects with patellofemoral pain syndrome." J Electromyogr Kinesiol . Shafshak, T. F. (2006). "The treatment of facial palsy from the point of view of physical and rehabilitation medicine." Eura Medicophys 42(1): 41-7. Thompson, J. A. et al. (2006). "Assessment of voluntary pelvic floor muscle contraction in continent and incontinent women using transperineal ultrasound, manual muscle testing and vaginal squeeze pressure measurements." Int Urogynecol J Pelvic Floor Dysfunct 17(6): 624-30. van Ettekoven, H. and C. Lucas (2006). "Efficacy of physiotherapy including a craniocervical training programme for tension-type headache; a randomized clinical trial." Cephalalgia 26(8): 983- 91. Van, K. et al. (2006). "The use of real-time ultrasound imaging for biofeedback of lumbar multifidus muscle contraction in healthy subjects." J Orthop Sports Phys Ther 36(12): 920-5. Van Peppen, R. P. et al. (2006). "Effects of visual feedback therapy on postural control in bilateral standing after stroke: a systematic review." J Rehabil Med 38(1): 3-9. Verhagen, A. P. et al. (2006). "Ergonomic and physiotherapeutic interventions for treating work- related complaints of the arm, neck or shoulder in adults." Cochrane Database Syst Rev 3: CD003471. Voorham-van der Zalm, P. J. et al. (2006). "Placement of probes in electrostimulation and biofeedback training in pelvic floor dysfunction." Acta Obstet Gynecol Scand 85(7): 850-5. Yip, S. L. and G. Y. Ng (2006). "Biofeedback supplementation to physiotherapy exercise programme for rehabilitation of patellofemoral pain syndrome: a randomized controlled pilot study." Clin Rehabil 20(12): 1050-7. © Tim Watson (2007) Page 1

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Page 1: 2006 Compiled Electrotherapy References reference list.pdf · A case report and review of the literature." Acta Neurol Belg 106(1): 26-30. Ansari, A. et al. (2006). "Rupture of a

Electrotherapy and Tissue Repair Compiled Reference List 2006

2006 Compiled Electrotherapy and Tissue Repair References This list is not claimed to be a ‘complete’ list of references in these topic areas, but may provide a useful resource for those working with the research and other published literature. There are many more references than are listed here for many of the topic areas, and I have therefore tried to identify those that are most likely to be of relevance (as I see it) rather than include all the ‘peripheral’ material that I find fascinating, but the reader might find is simply a form of clutter! My apologies to any and all authors of papers that have not been included. Tim Watson February 2007

Biofeedback Eogan, M. and C. O'Herlihy (2006). "Diagnosis and management of obstetric anal sphincter injury." Curr Opin Obstet Gynecol 18(2): 141-146. Leung, M. W. et al. (2006). "Electrical stimulation and biofeedback exercise of pelvic floor muscle for children with faecal incontinence after surgery for anorectal malformation." Pediatr Surg Int 22(12): 975-8. Ng, G. Y. et al. (2006). "Biofeedback exercise improved the EMG activity ratio of the medial and lateral vasti muscles in subjects with patellofemoral pain syndrome." J Electromyogr Kinesiol. Shafshak, T. F. (2006). "The treatment of facial palsy from the point of view of physical and rehabilitation medicine." Eura Medicophys 42(1): 41-7. Thompson, J. A. et al. (2006). "Assessment of voluntary pelvic floor muscle contraction in continent and incontinent women using transperineal ultrasound, manual muscle testing and vaginal squeeze pressure measurements." Int Urogynecol J Pelvic Floor Dysfunct 17(6): 624-30. van Ettekoven, H. and C. Lucas (2006). "Efficacy of physiotherapy including a craniocervical training programme for tension-type headache; a randomized clinical trial." Cephalalgia 26(8): 983-91. Van, K. et al. (2006). "The use of real-time ultrasound imaging for biofeedback of lumbar multifidus muscle contraction in healthy subjects." J Orthop Sports Phys Ther 36(12): 920-5. Van Peppen, R. P. et al. (2006). "Effects of visual feedback therapy on postural control in bilateral standing after stroke: a systematic review." J Rehabil Med 38(1): 3-9. Verhagen, A. P. et al. (2006). "Ergonomic and physiotherapeutic interventions for treating work-related complaints of the arm, neck or shoulder in adults." Cochrane Database Syst Rev 3: CD003471. Voorham-van der Zalm, P. J. et al. (2006). "Placement of probes in electrostimulation and biofeedback training in pelvic floor dysfunction." Acta Obstet Gynecol Scand 85(7): 850-5. Yip, S. L. and G. Y. Ng (2006). "Biofeedback supplementation to physiotherapy exercise programme for rehabilitation of patellofemoral pain syndrome: a randomized controlled pilot study." Clin Rehabil 20(12): 1050-7.

© Tim Watson (2007) Page 1

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Electrotherapy and Tissue Repair Compiled Reference List 2006

General Papers that include Electrotherapy Cederwall, E. et al. (2006). "Evaluation of a physiotherapeutic treatment intervention in "Bell's" facial palsy." Physiotherapy Theory and Practice 22(1): 43-52. Coldham, F. (2006). "The Use of Splinting in the Non-Surgical Treatment of De Quervains Disease: a Review of the Literature." Br-J-Hand-Ther. 11(2): 48-55. Gur, A. (2006). "Physical therapy modalities in management of fibromyalgia." Curr-Pharm-Des. 12(1): 29-35. Mangold, S. and T. Keller (2006). "Applications of electrotherapy in occupational therapy." Ergotherapie-Rehab. 45(2): 19-24. Medlicott, M. S. and S. R. Harris (2006). "A systematic review of the effectiveness of exercise, manual therapy, electrotherapy, relaxation training, and biofeedback in the management of temporomandibular disorder." Phys Ther 86(7): 955-73.

Electroacupuncture Barlas, P. et al. (2006). "Effects of intensity of electroacupuncture upon experimental pain in healthy human volunteers: a randomized, double-blind, placebo-controlled study." Pain 122(1-2): 81-9. Ezzo, J. et al. (2006). "Cochrane systematic reviews examine P6 acupuncture-point stimulation for nausea and vomiting." J Altern Complement Med 12(5): 489-95. Ezzo, J. M. et al. (2006). "Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting." Cochrane Database Syst Rev(2): CD002285. Habib, A. S. et al. (2006). "Transcutaneous acupoint electrical stimulation with the ReliefBand for the prevention of nausea and vomiting during and after cesarean delivery under spinal anesthesia." Anesth Analg 102(2): 581-4. Hsu, C. C. et al. (2006). "Effects of electrical acupuncture on acupoint BL15 evaluated in terms of heart rate variability, pulse rate variability and skin conductance response." Am J Chin Med 34(1): 23-36. Kim, H. W. et al. (2006). "The anti-inflammatory effects of low- and high-frequency electroacupuncture are mediated by peripheral opioids in a mouse air pouch inflammation model." J Altern Complement Med 12(1): 39-44. Lee, J. H. et al. (2006). "Electroacupuncture inhibits inflammatory edema and hyperalgesia through regulation of cyclooxygenase synthesis in both peripheral and central nociceptive sites." Am J Chin Med 34(6): 981-8. Lee, M. S. et al. (2006). "Effects of abdominal electroacupuncture on parameters related to obesity in obese women: a pilot study." Complement Ther Clin Pract 12(2): 97-100. Lu, L. et al. (2006). "Clinical study on effect of electro-acupuncture combined with different anesthetics on auditory-evoked potential index." Chin J Integr Med 12(1): 1-5.

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Electrotherapy and Tissue Repair Compiled Reference List 2006

Millan-Guerrero, R. O. and S. Isais-Millan (2006). "Acupuncture in trigeminal neuralgia management." Headache 46(3): 532. Oh, J. H. et al. (2006). "Pain-relieving effects of acupuncture and electroacupuncture in an animal model of arthritic pain." Int J Neurosci 116(10): 1139-56. Rorsman, I. and B. Johansson (2006). "Can electroacupuncture or transcutaneous nerve stimulation influence cognitive and emotional outcome after stroke?" J Rehabil Med 38(1): 13-9. Sator-Katzenschlager, S. M. et al. (2006). "Auricular electro-acupuncture as an additional perioperative analgesic method during oocyte aspiration in IVF treatment." Hum Reprod 21(8): 2114-20. Somers, D. L. and F. R. Clemente (2006). "Transcutaneous electrical nerve stimulation for the management of neuropathic pain: the effects of frequency and electrode position on prevention of allodynia in a rat model of complex regional pain syndrome type II." Phys Ther 86(5): 698-709. Streitberger, K. et al. (2006). "Acupuncture for nausea and vomiting: an update of clinical and experimental studies." Auton Neurosci 129(1-2): 107-17. Tekeoglu, I. and A. Dogan (2006). "Electroacupuncture in the treatment of a ganglion of the wrist--a case report." Acupunct Med 24(1): 29-32. Wong, R. H. et al. (2006). "Analgesic effect of electroacupuncture in postthoracotomy pain: a prospective randomized trial." Ann Thorac Surg 81(6): 2031-6. Woo, Y. M. et al. (2006). "Effects of contralateral electroacupuncture on brain function: a double-blind, randomized, pilot clinical trial." J Altern Complement Med 12(8): 813-5. Xie, J. et al. (2006). "Effect of electroacupuncture at acupoints of the governor vessel on aquaporin-4 in rat with experimental spinal cord injury." J Tradit Chin Med 26(2): 148-52. Zeng, Y. et al. (2006). "Electroacupuncture modulates cortical activities evoked by noxious somatosensory stimulations in human." Brain Res 1097(1): 90-100. Zou, R. et al. (2006). "Comparative study on treatment of acute gouty arthritis by electroacupuncture with different frequency." Chin J Integr Med 12(3): 212-4.

Electrotherapy for Wound healing Gan, J. C. and P. A. Glazer (2006). "Electrical stimulation therapies for spinal fusions: current concepts." Eur Spine J 15(9): 1301-11. Hampton, S. and F. Collins (2006). "Treating a pressure ulcer with bio-electric stimulation therapy." British Journal of Nursing 15(6): s14-s18. Karamitros, A. E. et al. (2006). "Electric stimulation and hyperbaric oxygen therapy in the treatment of nonunions." Injury 37 Suppl 1: S63-73. Kesani, A. K. et al. (2006). "Electrical bone stimulation devices in foot and ankle surgery: types of devices, scientific basis, and clinical indications for their use." Foot Ankle Int 27(2): 148-56.

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Maimoun, L. et al. (2006). "Bone loss in spinal cord-injured patients: from physiopathology to therapy." Spinal Cord 44(4): 203-10. Olyaee Manesh, A. et al. (2006). "Electromagnetic therapy for treating pressure ulcers." Cochrane Database Syst Rev(2): CD002930. Owegi, R. and M. T. Johnson (2006). "Localized pulsed magnetic fields for tendonitis therapy." Biomed Sci Instrum 42: 428-33. Ravaghi, H. et al. (2006). "Electromagnetic therapy for treating venous leg ulcers." Cochrane Database Syst Rev(2): CD002933. Zhao, M. et al. (2006). "Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN." Nature 442(7101): 457-60.

Electrical Stimulation (General) [There are several thousand 2006 references related to electrical stimulation. This is a sample of what is out there rather than anything that claims to be a comprehensive listing] Abell, T. L. et al. (2006). "Looking to the future: electrical stimulation for obesity." Am J Med Sci 331(4): 226-32. Ainsworth, L. et al. (2006). "Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation." Pain 120(1-2): 182-7. Allen, R. J. (2006). "Physical agents used in the management of chronic pain by physical therapists." Phys Med Rehabil Clin N Am 17(2): 315-45. Amaro, J. L. et al. (2006). "Intravaginal electrical stimulation: a randomized, double-blind study on the treatment of mixed urinary incontinence." Acta Obstet Gynecol Scand 85(5): 619-22. Andersson, G. B. et al. (2006). "Treatment of intractable discogenic low back pain. A systematic review of spinal fusion and intradiscal electrothermal therapy (IDET)." Pain Physician 9(3): 237-48. Anninos, P. et al. (2006). "Transcranial magnetic stimulation. A case report and review of the literature." Acta Neurol Belg 106(1): 26-30. Ansari, A. et al. (2006). "Rupture of a flexor pollicis longus repair in a body builder through the use of an electronic muscle stimulator." Br J Sports Med 40(12): 1009-10. Aydemir, E. H. et al. (2006). "Quantitative effect of anodal current in the treatment of primary hyperhidrosis by direct electrical current." Int J Dermatol 45(7): 862-4. Aydemir, G. et al. (2006). "Treatment of tinnitus with transcutaneous electrical nerve stimulation improves patients' quality of life." J Laryngol Otol 120(6): 442-5. Baghai, T. C. et al. (2006). "Recent progress in pharmacological and non-pharmacological treatment options of major depression." Curr Pharm Des 12(4): 503-15. Bhadra, N. et al. (2006). "High frequency electrical conduction block of the pudendal nerve." J Neural Eng 3(2): 180-7. Bittar, R. G. (2006). "Neuromodulation for movement disorders." J Clin Neurosci 13(3): 315-8.

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Blum, A. S. and B. Morvarid (2006). "Neurostimulation for epilepsy." Med Health R I 89(4): 127-9. Blum, K. et al. (2006). "H-Wave, a nonpharmacologic alternative for the treatment of patients with chronic soft tissue inflammation and neuropathic pain: a preliminary statistical outcome study." Adv Ther 23(3): 446-55. Bosch, J. L. (2006). "Electrical neuromodulatory therapy in female voiding dysfunction." BJU Int 98 Suppl 1: 43-8; discussion 49. Brazzelli, M. et al. (2006). "Efficacy and safety of sacral nerve stimulation for urinary urge incontinence: a systematic review." J Urol 175(3 Pt 1): 835-41. Breen, P. P. et al. (2006). "A system for the delivery of programmable, adaptive stimulation intensity envelopes for drop foot correction applications." Med Eng Phys 28(2): 177-86. Buchser, E. et al. (2006). "Spinal cord stimulation for the management of refractory angina pectoris." J Pain Symptom Manage 31(4 Suppl): S36-42. Carey, B. (2006). "Doctors say electric pulses aided brain-damaged man." NY Times (Print): A14. Cheng, P. T. et al. (2006). "Effect of neuromuscular electrical stimulation on cough capacity and pulmonary function in patients with acute cervical cord injury." J Rehabil Med 38(1): 32-6. Chevrier, E. et al. (2006). "Is there a role for physiotherapy during deep brain stimulation surgery in patients with Parkinson's disease?" Eur J Neurol 13(5): 496-8. Conti, C. R. (2006). "Treatment options for refractory angina in patients who are not candidates for revascularization." Curr Cardiol Rep 8(4): 272-6. Cornwell, L. et al. (2006). "Problems with the use of self-adhesive electrode pads in neonates." Resuscitation 68(3): 425-8. Dahlin, L. et al. (2006). "Vibratory stimulation increase the electro-cutaneous sensory detection and pain thresholds in women but not in men." BMC Complement Altern Med 6(1): 20. Daly, J. J. et al. (2006). "A randomized controlled trial of functional neuromuscular stimulation in chronic stroke subjects." Stroke 37(1): 172-8. De Pinto, M. et al. (2006). "Pain management." Anesthesiol Clin 24(1): 19-37, vii. DeGiorgio, C. M. et al. (2006). "Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial." Epilepsia 47(7): 1213-5. Dickstein, R. et al. (2006). "TENS to the posterior aspect of the legs decreases postural sway during stance." Neurosci Lett 393(1): 51-5. DiMarco, A. F. et al. (2006). "Spinal cord stimulation: a new method to produce an effective cough in patients with spinal cord injury." Am J Respir Crit Care Med 173(12): 1386-9. Dobsak, P. et al. (2006). "Electrical stimulation of skeletal muscles. An alternative to aerobic exercise training in patients with chronic heart failure?" Int Heart J 47(3): 441-53. Doro, C. et al. (2006). "Complex regional pain syndrome type I in the upper extremity." Clin Occup Environ Med 5(2): 445-54, x.

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Electrotherapy and Tissue Repair Compiled Reference List 2006

Dortch, A. B. and M. T. Johnson (2006). "Characterization of pulsed magnetic field therapy in a rat model for rheumatoid arthritis." Biomed Sci Instrum 42: 302-7. Ezzo, J. M. et al. (2006). "Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting." Cochrane Database Syst Rev(2): CD002285. Fleischhackl, R. et al. (2006). "Influence of electromagnetic fields on function of automated external defibrillators." Acad Emerg Med 13(1): 1-6. Fregni, F. et al. (2006). "A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury." Pain 122(1-2): 197-209. Fregni, F. and A. Pascual-Leone (2006). "Hand motor recovery after stroke: tuning the orchestra to improve hand motor function." Cogn Behav Neurol 19(1): 21-33. Fregni, F. et al. (2006). "A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy." Epilepsia 47(2): 335-42. Gan, J. C. and P. A. Glazer (2006). "Electrical stimulation therapies for spinal fusions: current concepts." Eur Spine J 15(9): 1301-11. Ghacibeh, G. A. et al. (2006). "Effect of vagus nerve stimulation on creativity and cognitive flexibility." Epilepsy Behav 8(4): 720-5. Godbout, C. and J. Frenette (2006). "Periodic direct current does not promote wound closure in an in vitro dynamic model of cell migration." Phys Ther 86(1): 50-9; discussion 59-65. Goroszeniuk, T. et al. (2006). "Subcutaneous neuromodulating implant targeted at the site of pain." Reg Anesth Pain Med 31(2): 168-71. Gur, A. (2006). "Physical therapy modalities in management of fibromyalgia." Curr Pharm Des 12(1): 29-35. Hampton, S. and F. Collins (2006). "Treating a pressure ulcer with bio-electric stimulation therapy." Br J Nurs 15(6): S14-8. Han, T. R. et al. (2006). "Magnetic stimulation of the quadriceps femoris muscle: comparison of pain with electrical stimulation." Am J Phys Med Rehabil 85(7): 593-9. Hinze, J. and J. Junkin (2006). "The latest in treatments for incontinence in women." Nebr Nurse 39(2): 22-6; quiz 27-8. Hlustik, P. and M. Mayer (2006). "Paretic hand in stroke: from motor cortical plasticity research to rehabilitation." Cogn Behav Neurol 19(1): 34-40. Ho, C. L. et al. (2006). "Functional electrical stimulation changes dynamic resources in children with spastic cerebral palsy." Phys Ther 86(7): 987-1000. Hruby, G. et al. (2006). "Assessment of efficacy of transcutaneous electrical nerve stimulation for pain management during office-based flexible cystoscopy." Urology 67(5): 914-7. Humaidan, P. et al. (2006). "Pain relief during oocyte retrieval--exploring the role of different frequencies of electro-acupuncture." Reprod Biomed Online 13(1): 120-5.

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Hunt, K. J. et al. (2006). "Comparison of stimulation patterns for FES-cycling using measures of oxygen cost and stimulation cost." Med Eng Phys 28(7): 710-8. Hush, J. (2006). "TENS of unknown value in the treatment of chronic low back pain." Aust J Physiother 52(1): 64. Innis, J. (2006). "Pain assessment and management for a dialysis patient with diabetic peripheral neuropathy." Cannt J 16(2): 12-7, 20-6; quiz 18-9, 27-8. Iovino, P. et al. (2006). "Perception of electrocutaneous stimuli in irritable bowel syndrome." Am J Gastroenterol 101(3): 596-603. Iwasa, J. et al. (2006). "Decrease in anterior knee laxity by electrical stimulation of normal and reconstructed anterior cruciate ligaments." J Bone Joint Surg Br 88(4): 477-83. Jorge, S. et al. (2006). "Interferential therapy produces antinociception during application in various models of inflammatory pain." Phys Ther 86(6): 800-8. Joseph, A. C. (2006). "Noninvasive therapies for treating post-prostatectomy urinary incontinence." Urol Nurs 26(4): 271-5, 269; quiz 276. Kamper, D. G. et al. (2006). "Effects of neuromuscular electrical stimulation treatment of cerebral palsy on potential impairment mechanisms: a pilot study." Pediatr Phys Ther 18(1): 31-8. Kapatkin, A. S. et al. (2006). "Effects of electrostimulated acupuncture on ground reaction forces and pain scores in dogs with chronic elbow joint arthritis." J Am Vet Med Assoc 228(9): 1350-4. Karamitros, A. E. et al. (2006). "Electric stimulation and hyperbaric oxygen therapy in the treatment of nonunions." Injury 37 Suppl 1: S63-73. Kesani, A. K. et al. (2006). "Electrical bone stimulation devices in foot and ankle surgery: types of devices, scientific basis, and clinical indications for their use." Foot Ankle Int 27(2): 148-56. Khadilkar, A. et al. (2006). "Ottawa panel evidence-based clinical practice guidelines for post-stroke rehabilitation." Top Stroke Rehabil 13(2): 1-269. Kim, H. W. et al. (2006). "The anti-inflammatory effects of low- and high-frequency electroacupuncture are mediated by peripheral opioids in a mouse air pouch inflammation model." J Altern Complement Med 12(1): 39-44. Kopman, A. F. (2006). "Can conventional peripheral nerve stimulators induce direct muscle depolarization?" Anesth Analg 102(6): 1905; author reply 1905-6. Latini, J. M. et al. (2006). "Efficacy of sacral neuromodulation for symptomatic treatment of refractory urinary urge incontinence." Urology 67(3): 550-3; discussion 553-4. Lee, M. S. et al. (2006). "Effects of abdominal electroacupuncture on parameters related to obesity in obese women: a pilot study." Complement Ther Clin Pract 12(2): 97-100. Loeb, G. E. et al. (2006). "The BION devices: injectable interfaces with peripheral nerves and muscles." Neurosurg Focus 20(5): E2. Maffiuletti, N. A. et al. (2006). "Neuromuscular adaptations to electrostimulation resistance training." Am J Phys Med Rehabil 85(2): 167-75.

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Electrotherapy and Tissue Repair Compiled Reference List 2006

Maimoun, L. et al. (2006). "Bone loss in spinal cord-injured patients: from physiopathology to therapy." Spinal Cord 44(4): 203-10. McCarthy, C. J. et al. (2006). "Pulsed electromagnetic energy treatment offers no clinical benefit in reducing the pain of knee osteoarthritis: a systematic review." BMC Musculoskelet Disord 7: 51. McNeely, M. L. et al. (2006). "A systematic review of the effectiveness of physical therapy interventions for temporomandibular disorders." Phys Ther 86(5): 710-25. Medlicott, M. S. and S. R. Harris (2006). "A systematic review of the effectiveness of exercise, manual therapy, electrotherapy, relaxation training, and biofeedback in the management of temporomandibular disorder." Phys Ther 86(7): 955-73. Mehta, M. P. et al. (2006). "Management of intractable angina pectoris with spinal cord stimulation." J Ky Med Assoc 104(3): 98-101. Mora, B. et al. (2006). "Transcutaneous electrical nerve stimulation: an effective treatment for pain caused by renal colic in emergency care." J Urol 175(5): 1737-41; discussion 1741. Nelson, D. V. and B. R. Stacey (2006). "Interventional therapies in the management of complex regional pain syndrome." Clin J Pain 22(5): 438-42. Norton, C. et al. (2006). "Randomized, controlled trial of anal electrical stimulation for fecal incontinence." Dis Colon Rectum 49(2): 190-6. Nowak, D. A. et al. (2006). "Sensory timing cues improve akinesia of grasping movements in Parkinson's disease: a comparison to the effects of subthalamic nucleus stimulation." Mov Disord 21(2): 166-72. Nuccitelli, R. et al. (2006). "Nanosecond pulsed electric fields cause melanomas to self-destruct." Biochem Biophys Res Commun 343(2): 351-60. Nunez, S. C. et al. (2006). "Management of mouth opening in patients with temporomandibular disorders through low-level laser therapy and transcutaneous electrical neural stimulation." Photomed Laser Surg 24(1): 45-9. O'Dwyer, S. B. et al. (2006). "An electrode configuration technique using an electrode matrix arrangement for FES-based upper arm rehabilitation systems." Med Eng Phys 28(2): 166-76. Ohtake, P. J. et al. (2006). "Does electrical stimulation improve motor recovery in patients with idiopathic facial (Bell) palsy?" Phys Ther 86(11): 1558-64. Olyaee Manesh, A. et al. (2006). "Electromagnetic therapy for treating pressure ulcers." Cochrane Database Syst Rev(2): CD002930. Owegi, R. and M. T. Johnson (2006). "Localized pulsed magnetic fields for tendonitis therapy." Biomed Sci Instrum 42: 428-33. Ozer, K. et al. (2006). "Neuromuscular electrical stimulation and dynamic bracing for the management of upper-extremity spasticity in children with cerebral palsy." Dev Med Child Neurol 48(7): 559-63. Paicius, R. M. et al. (2006). "Peripheral nerve field stimulation in chronic abdominal pain." Pain Physician 9(3): 261-6.

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Petterson, S. and L. Snyder-Mackler (2006). "The use of neuromuscular electrical stimulation to improve activation deficits in a patient with chronic quadriceps strength impairments following total knee arthroplasty." J Orthop Sports Phys Ther 36(9): 678-85. Pomeroy, V. M. et al. (2006). "Electrostimulation for promoting recovery of movement or functional ability after stroke." Cochrane Database Syst Rev(2): CD003241. Popovic, M. R. et al. (2006). "Functional electrical therapy: retraining grasping in spinal cord injury." Spinal-Cord. 44(3): 143-51. Ravaghi, H. et al. (2006). "Electromagnetic therapy for treating venous leg ulcers." Cochrane Database Syst Rev(2): CD002933. Robbins, S. M. et al. (2006). "The therapeutic effect of functional and transcutaneous electric stimulation on improving gait speed in stroke patients: a meta-analysis." Arch Phys Med Rehabil 87(6): 853-9. Sabatier, M. J. et al. (2006). "Electrically stimulated resistance training in SCI individuals increases muscle fatigue resistance but not femoral artery size or blood flow." Spinal Cord 44(4): 227-33. Sabbah, H. N. et al. (2006). "Treating heart failure with cardiac contractility modulation electrical signals." Curr Heart Fail Rep 3(1): 21-4. Sawaki, L. et al. (2006). "Effects of somatosensory stimulation on use-dependent plasticity in chronic stroke." Stroke 37(1): 246-7. Scott, W. B. et al. (2006). "Contractile properties and the force-frequency relationship of the paralyzed human quadriceps femoris muscle." Phys Ther 86(6): 788-99. Sheffler, L. R. et al. (2006). "Peroneal nerve stimulation versus an ankle foot orthosis for correction of footdrop in stroke: impact on functional ambulation." Neurorehabil Neural Repair 20(3): 355-60. Shields, R. K. and S. Dudley-Javoroski (2006). "Musculoskeletal plasticity after acute spinal cord injury: effects of long-term neuromuscular electrical stimulation training." J Neurophysiol 95(4): 2380-90. Shields, R. K. et al. (2006). "Electrically induced muscle contractions influence bone density decline after spinal cord injury." Spine 31(5): 548-53. Somers, D. L. and F. R. Clemente (2006). "Transcutaneous electrical nerve stimulation for the management of neuropathic pain: the effects of frequency and electrode position on prevention of allodynia in a rat model of complex regional pain syndrome type II." Phys Ther 86(5): 698-709. Sprick, C. (2006). "Neuro-muscular junction block stimulator simulator." Australas Phys Eng Sci Med 29(1): 101-6. Sutbeyaz, S. T. et al. (2006). "The effect of pulsed electromagnetic fields in the treatment of cervical osteoarthritis: a randomized, double-blind, sham-controlled trial." Rheumatol Int 26(4): 320-4. Tan, G. et al. (2006). "Complementary and alternative medicine approaches to pain management." J Clin Psychol 62(11): 1419-1431. Taylor, R. S. (2006). "Spinal cord stimulation in complex regional pain syndrome and refractory neuropathic back and leg pain/failed back surgery syndrome: results of a systematic review and meta-analysis." J Pain Symptom Manage 31(4 Suppl): S13-9.

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Thrasher, T. A. et al. (2006). "Gait training regimen for incomplete spinal cord injury using functional electrical stimulation." Spinal Cord 44(6): 357-61. Tong, R. K. et al. (2006). "Gait training of patients after stroke using an electromechanical gait trainer combined with simultaneous functional electrical stimulation." Phys Ther 86(9): 1282-94. Urmey, W. F. (2006). "Using the nerve stimulator for peripheral or plexus nerve blocks." Minerva Anestesiol 72(6): 467-71. Van Buyten, J. P. (2006). "Neurostimulation for chronic neuropathic back pain in failed back surgery syndrome." J Pain Symptom Manage 31(4 Suppl): S25-9. van der Salm, A. et al. (2006). "Comparison of electric stimulation methods for reduction of triceps surae spasticity in spinal cord injury." Arch Phys Med Rehabil 87(2): 222-8. van Tulder, M. W. et al. (2006). "Outcome of non-invasive treatment modalities on back pain: an evidence-based review." Eur Spine J 15 Suppl 1: S64-81. Verhoeven, K. and J. G. van Dijk (2006). "Decreasing pain in electrical nerve stimulation." Clin Neurophysiol 117(5): 972-8. Vivodtzev, I. et al. (2006). "Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD." Chest 129(6): 1540-8. Ward, A. R. et al. (2006). "Wrist extensor torque production and discomfort associated with low-frequency and burst-modulated kilohertz-frequency currents." Phys Ther 86(10): 1360-7. Wenzel, B. J. et al. (2006). "Closed loop electrical control of urinary continence." J Urol 175(4): 1559-63. Williams, J. et al. (2006). "10 Hz flicker improves recognition memory in older people." BMC Neurosci 7: 21. Wood, M. and R. K. Willits (2006). "Short-duration, DC electrical stimulation increases chick embryo DRG neurite outgrowth." Bioelectromagnetics 27(4): 328-31. Wu, C. W. et al. (2006). "Influence of electric somatosensory stimulation on paretic-hand function in chronic stroke." Arch Phys Med Rehabil 87(3): 351-7. Yarrobino, T. E. et al. (2006). "Lidocaine iontophoresis mediates analgesia in lateral epicondylalgia treatment." Physiother Res Int 11(3): 152-60. Yavuzer, G. et al. (2006). "Neuromuscular electric stimulation effect on lower-extremity motor recovery and gait kinematics of patients with stroke: a randomized controlled trial." Arch Phys Med Rehabil 87(4): 536-40. Yozbatiran, N. et al. (2006). "Electrical stimulation of wrist and fingers for sensory and functional recovery in acute hemiplegia." Clin Rehabil 20(1): 4-11.

Heat Therapy

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Akasaki, Y. et al. (2006). "Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia." Circ J 70(4): 463-70. Allen, R. J. (2006). "Physical agents used in the management of chronic pain by physical therapists." Phys Med Rehabil Clin N Am 17(2): 315-45. Badke, M. B. and W. G. Boissonnault (2006). "Changes in disability following physical therapy intervention for patients with low back pain: dependence on symptom duration." Arch Phys Med Rehabil 87(6): 749-56. Beyerman, K. L. et al. (2006). "Efficacy of treating low back pain and dysfunction secondary to osteoarthritis: chiropractic care compared with moist heat alone." J Manipulative Physiol Ther 29(2): 107-14. Chambers, C. D. (2006). "Risks of hyperthermia associated with hot tub or spa use by pregnant women." Birth Defects Res A Clin Mol Teratol 76(8): 569-73. Davila, S. A. and K. Johnston-Jones (2006). "Managing the stiff elbow: operative, nonoperative, and postoperative techniques." J Hand Ther 19(2): 268-81. Demir, E. et al. (2006). "[Heated car seats--a potential burn risk for paraplegics]." Nervenarzt 77(2): 201-3. French, S. D. et al. (2006). "A Cochrane review of superficial heat or cold for low back pain." Spine 31(9): 998-1006. French, S. D. et al. (2006). "Superficial heat or cold for low back pain." Cochrane Database Syst Rev(1): CD004750. George, S. Z. et al. (2006). "Immediate effects of spinal manipulation on thermal pain sensitivity: an experimental study." BMC Musculoskelet Disord 7: 68. Giombini, A. et al. (2006). "Short-term Effectiveness of Hyperthermia for Supraspinatus Tendinopathy in Athletes: A Short-term Randomized Controlled Study." Am J Sports Med. Gusi, N. et al. (2006). "Exercise in waist-high warm water decreases pain and improves health-related quality of life and strength in the lower extremities in women with fibromyalgia." Arthritis Rheum 55(1): 66-73. Horsman, M. R. (2006). "Tissue physiology and the response to heat." Int J Hyperthermia 22(3): 197-203. Hume, P. A. et al. (2006). "Epicondylar injury in sport: epidemiology, type, mechanisms, assessment, management and prevention." Sports Med 36(2): 151-70. Kent, P. (2006). "Heat wrap therapy reduces pain and disability in early stage low back pain." Aust J Physiother 52(3): 227. Mayer, J. M. et al. (2006). "Continuous low-level heat wrap therapy for the prevention and early phase treatment of delayed-onset muscle soreness of the low back: a randomized controlled trial." Arch Phys Med Rehabil 87(10): 1310-7. Meakins, A. and T. Watson (2006). "Longwave ultrasound and conductive heating increase functional ankle mobility in asymptomatic subjects." Physical Therapy in Sport 7.

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Melling, A. C. and D. J. Leaper (2006). "The impact of warming on pain and wound healing after hernia surgery: a preliminary study." J Wound Care 15(3): 104-8. Perret, D. M. et al. (2006). "A geriatrician's guide to the use of the physical modalities in the treatment of pain and dysfunction." Clin Geriatr Med 22(2): 331-54; ix. Seiger, C. and D. O. Draper (2006). "Use of pulsed shortwave diathermy and joint mobilization to increase ankle range of motion in the presence of surgical implanted metal: A case series." J Orthop Sports Phys Ther 36(9): 669-77. Shafshak, T. F. (2006). "The treatment of facial palsy from the point of view of physical and rehabilitation medicine." Eura Medicophys 42(1): 41-7. Usuba, M. et al. (2006). "Effect of heat in increasing the range of knee motion after the development of a joint contracture: an experiment with an animal model." Arch Phys Med Rehabil 87(2): 247-53.

Ice and Cold Therapy Allen, R. J. (2006). "Physical agents used in the management of chronic pain by physical therapists." Phys Med Rehabil Clin N Am 17(2): 315-45. Bleakley, C. M. et al. (2006). "Cryotherapy for acute ankle sprains: a randomised controlled study of two different icing protocols." Br J Sports Med 40(8): 700-5; discussion 705. Cuthilla, J. A. and G. S. Cuthillb (2006). "Partial-thickness burn to the leg following application of a cold pack: Case report and results of a questionnaire survey of Scottish physiotherapists in private practice." Physiotherapy 92(1): 62-65. Datrice, N. et al. (2006). "Cutaneous effects of cryogen spray cooling on in vivo human skin." Dermatol Surg 32(8): 1007-12. French, S. D. et al. (2006). "Superficial heat or cold for low back pain." Cochrane Database Syst Rev(1): CD004750. Hirvonen, H. E. et al. (2006). "Effectiveness of different cryotherapies on pain and disease activity in active rheumatoid arthritis. A randomised single blinded controlled trial." Clin Exp Rheumatol 24(3): 295-301. Hodges, G. J. et al. (2006). "The involvement of nitric oxide in the cutaneous vasoconstrictor response to local cooling in humans." J Physiol 574(Pt 3): 849-57. Knobloch, K. et al. (2006). "Changes of Achilles Midportion Tendon Microcirculation After Repetitive Simultaneous Cryotherapy and Compression Using a Cryo/Cuff." Am J Sports Med 34(12): 1953-1959. Knobloch, K. et al. (2006). "Microcirculation of the ankle after Cryo/Cuff application in healthy volunteers." Int J Sports Med 27(3): 250-5. Loten, C. et al. (2006). "A randomised controlled trial of hot water (45 degrees C) immersion versus ice packs for pain relief in bluebottle stings." Med J Aust 184(7): 329-33.

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Manias, P. and D. Stasinopoulos (2006). "A controlled clinical pilot trial to study the effectiveness of ice as a supplement to the exercise programme for the management of lateral elbow tendinopathy." Br J Sports Med 40(1): 81-5. Muldoon, J. (2006). "Skin cooling, pain and chronic wound healing progression." Br J Community Nurs 11(3): S21, S24-5. Tuncel, A. (2006). "Apply peas as an ice pack." Ann Plast Surg 56(3): 347-8.

Interferential Therapy Al Abdulwahab, S. S. and A. M. Beatti (2006). "The effect of prone position and interferential therapy on lumbosacral radiculopathy." Advances in Physiotherapy 8: 82-87. Atamaz, F. et al. (2006). "A comparison of two different intra-articular hyaluronan drugs and physical therapy in the management of knee osteoarthritis." Rheumatol Int: 1-6. Jorge, S. et al. (2006). "Interferential therapy produces antinociception during application in various models of inflammatory pain." Phys Ther 86(6): 800-8. Kocic, M. et al. (2006). "[Methods of the physical medicine therapy in prevention of heterotopic ossification after total hip arthroplasty]." Vojnosanit Pregl 63(9): 807-11. McManus, F. J. et al. (2006). "The analgesic effects of interferential therapy on two experimental pain models: cold and mechanically induced pain." Physiotherapy 92(2): 95-102. Walker, U. A. et al. (2006). "Analgesic and disease modifying effects of interferential current in psoriatic arthritis." Rheumatol Int: 1-4.

Laser Therapy Aimbire, F. et al. (2006). "Low-level laser therapy induces dose-dependent reduction of TNFalpha levels in acute inflammation." Photomed Laser Surg 24(1): 33-7. Bayat, M. et al. (2006). "Effect of low-level helium-neon laser therapy on the healing of third-degree burns in rats." J Photochem Photobiol B 83(2): 87-93. Bjordal, J. M. et al. (2006). "Photoradiation in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials." Photomed Laser Surg 24(2): 158-68. Bjordal, J. M. et al. (2006). "A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations." Br J Sports Med 40(1): 76-80; discussion 76-80. Bot, S. D. and L. M. Bouter (2006). "The efficacy of low level laser therapy for chronic neck pain." Pain 124(1-2): 5-6. Chow, R. (2006). "Laser acupuncture studies should not be included in systematic reviews of phototherapy." Photomed Laser Surg 24(1): 69.

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Chow, R. T. et al. (2006). "The effect of 300 mW, 830 nm laser on chronic neck pain: a double-blind, randomized, placebo-controlled study." Pain 124(1-2): 201-10. da Silva, R. V. and J. A. Camilli (2006). "Repair of bone defects treated with autogenous bone graft and low-power laser." J Craniofac Surg 17(2): 297-301. Glushkov, O. V. et al. (2006). "[Effects of exposure of different skin areas to low-power laser light]." Biofizika 51(1): 123-35. Gur, A. (2006). "Physical therapy modalities in management of fibromyalgia." Curr Pharm Des 12(1): 29-35. Lopes-Martins, R. A. et al. (2006). "Effect of low-level laser (Ga-Al-As 655 nm) on skeletal muscle fatigue induced by electrical stimulation in rats." J Appl Physiol 101(1): 283-8. Maher, S. (2006). "Low-level laser therapy and lateral epicondylitis." Phys Ther 86(8): 1161-7. McNeely, M. L. et al. (2006). "A systematic review of the effectiveness of physical therapy interventions for temporomandibular disorders." Phys Ther 86(5): 710-25. Medlicott, M. S. and S. R. Harris (2006). "A systematic review of the effectiveness of exercise, manual therapy, electrotherapy, relaxation training, and biofeedback in the management of temporomandibular disorder." Phys Ther 86(7): 955-73. Naeser, M. A. (2006). "Photobiomodulation of pain in carpal tunnel syndrome: review of seven laser therapy studies." Photomed Laser Surg 24(2): 101-10. Novoselova, E. G. et al. (2006). "Effects of low-power laser radiation on mice immunity." Photodermatol Photoimmunol Photomed 22(1): 33-8. Nunez, S. C. et al. (2006). "Management of mouth opening in patients with temporomandibular disorders through low-level laser therapy and transcutaneous electrical neural stimulation." Photomed Laser Surg 24(1): 45-9. Weber, J. B. et al. (2006). "Laser therapy improves healing of bone defects submitted to autologous bone graft." Photomed Laser Surg 24(1): 38-44.

Magnetic Therapies [These represent a small proportion of the articles in the database, but I have not included the papers relating to occupational exposure, the work on mobile phones and almost all the cancer related studies. The included papers are predominantly those related to therapy] Blechman, A. (2006). "Magnetic insoles." Mayo Clin Proc 81(2): 264, 266; author reply 266-7. Calleja, G. et al. (2006). "Potential use of therapies for osteoporosis to treat neurological diseases of elderly people." Med Hypotheses 66(4): 858-9. Chang, K. et al. (2006). "Pulsed electromagnetic fields accelerate apoptotic rate in osteoclasts." Connect Tissue Res 47(4): 222-8. Eccles, N. (2006). "Static magnets prevent leg ulcer recurrence: savings for the NHS?" Br J Community Nurs 11(3): S26, S28-30.

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Ernst, E. (2006). "Complementary or alternative therapies for osteoarthritis." Nat Clin Pract Rheumatol 2(2): 74-80. Finegold, L. and B. L. Flamm (2006). "Magnet therapy." Bmj 332(7532): 4. Gwechenberger, M. et al. (2006). "Interference of programmed electromagnetic stimulation with pacemakers and automatic implantable cardioverter defibrillators." Bioelectromagnetics 27(5): 365-77. Han, T. R. et al. (2006). "Magnetic stimulation of the quadriceps femoris muscle: comparison of pain with electrical stimulation." Am J Phys Med Rehabil 85(7): 593-9. Huang, H. M. et al. (2006). "Static magnetic fields up-regulate osteoblast maturity by affecting local differentiation factors." Clin Orthop Relat Res 447: 201-8. Jeong, J. H. et al. (2006). "Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis." Life Sci 78(13): 1407-12. Kelleher, M. O. et al. (2006). "Use of a static magnetic field to promote recovery after peripheral nerve injury." J Neurosurg 105(4): 610-5. Leszczynski, D. (2006). "The need for a new approach in studies of the biological effects of electromagnetic fields." Proteomics 6(17): 4671-3. Shimada, Y. et al. (2006). "Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension." Biomed Res 27(1): 23-7. Singh, P. et al. (2006). "Augmented bone-matrix formation and osteogenesis under magnetic field stimulation in vivo XRD, TEM and SEM investigations." Indian J Biochem Biophys 43(3): 167-72. Virtanen, H. et al. (2006). "Interaction of radio frequency electromagnetic fields and passive metallic implants--a brief review." Bioelectromagnetics 27(6): 431-9.

Microcurrent Therapy El-Husseini, T. et al. (2006). "Microcurrent skin patches for postoperative pain control in total knee arthroplasty: a pilot study : A pilot study." Int Orthop. Labotz, M. et al. (2006). "Selective serotonin reuptake inhibitors and rhabdomyolysis after eccentric exercise." Med Sci Sports Exerc 38(9): 1539-42. Lin, Y. L. et al. (2006). "Effect of microcurrent electrical tissue stimulation on equine tenocytes in culture." Am J Vet Res 67(2): 271-6. Lin, Y. L. et al. (2006). "Influence of electrode placement on effective field strength in the superficial digital flexor tendon of horses." Am J Vet Res 67(5): 845-9. Tan, G. et al. (2006). "Using cranial electrotherapy stimulation to treat pain associated with spinal cord injury." J Rehabil Res Dev 43(4): 461-74.

Shock Wave Therapy

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Borchers, J. R. and T. M. Best (2006). "Corticosteroid injection compared with extracorporeal shock wave therapy for plantar fasciopathy." Clin J Sport Med 16(5): 452-3. Buchbinder, R. et al. (2006). "Systematic review of the efficacy and safety of shock wave therapy for lateral elbow pain." J Rheumatol 33(7): 1351-63. Cacchio, A. et al. (2006). "Effectiveness of Radial Shock-Wave Therapy for Calcific Tendinitis of the Shoulder: Single-Blind, Randomized Clinical Study." Phys Ther 86(5): 672-682. Cacchio, A. et al. (2006). "Effectiveness of radial shock-wave therapy for calcific tendinitis of the shoulder: single-blind, randomized clinical study." Phys Ther 86(5): 672-82. Durst, H. B. and M. S. Kuster (2006). "[Extracorporeal shock-wave lithotripsy for the treatment of calcific tendonitis of the glutaeus maximus tendon]." Z Orthop Ihre Grenzgeb 144(5): 516-8. Furia, J. P. (2006). "High-energy extracorporeal shock wave therapy as a treatment for insertional achilles tendinopathy." Am J Sports Med 34(5): 733-40. Hosseini, S. H. et al. (2006). "Development of shock wave assisted therapeutic devices and establishment of shock wave therapy." Minim Invasive Ther Allied Technol 15(4): 230-40. Iserentant, C. and J. M. Crielaard (2006). "[Extracorporeal shock wave therapy value in calcific soft tissue pathologies]." Rev Med Liege 61(5-6): 341-4. Jang, Y. B. et al. (2006). "Treatment of subcapsular haematoma, a complication of extracorporeal shock wave lithotripsy (ESWL), by percutaneous drainage." Nephrol Dial Transplant 21(4): 1117-8. Kersh, K. D. et al. (2006). "The evaluation of extracorporeal shock wave therapy on collagenase induced superficial digital flexor tendonitis." Vet Comp Orthop Traumatol 19(2): 99-105. Kudo, P. et al. (2006). "Randomized, placebo-controlled, double-blind clinical trial evaluating the treatment of plantar fasciitis with an extracoporeal shockwave therapy (ESWT) device: A North American confirmatory study." J Orthop Res 24(2): 115-123. Liu, H. M. et al. (2006). "Humeral head osteonecrosis after extracorporeal shock-wave treatment for rotator cuff tendinopathy. A case report." J Bone Joint Surg Am 88(6): 1353-6. Moretti, B. et al. (2006). "Extracorporeal shock wave therapy in runners with a symptomatic heel spur." Knee Surg Sports Traumatol Arthrosc 14(10): 1029-32. Rompe, J. D. (2006). "Shock wave therapy for chronic Achilles tendon pain: a randomized placebo-controlled trial." Clin Orthop Relat Res 445: 276-7; author reply 277. Seil, R. et al. (2006). "Extracorporeal shock wave therapy for tendinopathies." Expert Rev Med Devices 3(4): 463-70. Sems, A. et al. (2006). "Extracorporeal shock wave therapy in the treatment of chronic tendinopathies." J Am Acad Orthop Surg 14(4): 195-204. Takahashi, N. et al. (2006). "Second application of low-energy shock waves has a cumulative effect on free nerve endings." Clin Orthop Relat Res 443: 315-9. Wang, C. J. et al. (2006). "Long-term results of extracorporeal shockwave treatment for plantar fasciitis." Am J Sports Med 34(4): 592-6.

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Shortwave, Pulsed Shortwave and Radiofrequency Therapies (2006). "Effects of repetitive shortwave diathermy for reducing synovitis in patients with knee osteoarthritis: an ultrasonographic study." Ultrasound Q 22(2): 113-4. Al Mandeel, M. and T. Watson (2006). "An Evaluative Audit of Patient Records in Electrotherapy with Specific Reference to Pulsed Short Wave Therapy (PSWT)." International Journal of Therapy and Rehabilitation 13(9): 414-419. Gwechenberger, M. et al. (2006). "Interference of programmed electromagnetic stimulation with pacemakers and automatic implantable cardioverter defibrillators." Bioelectromagnetics 27(5): 365-77. Jan, M. H. et al. (2006). "Effects of repetitive shortwave diathermy for reducing synovitis in patients with knee osteoarthritis: an ultrasonographic study." Phys Ther 86(2): 236-44. Li, J. K. et al. (2006). "Comparison of ultrasound and electromagnetic field effects on osteoblast growth." Ultrasound Med Biol 32(5): 769-75. McCarthy, C. J. et al. (2006). "Pulsed electromagnetic energy treatment offers no clinical benefit in reducing the pain of knee osteoarthritis: a systematic review." BMC Musculoskelet Disord 7: 51. Sakai, Y. et al. (2006). "Exposure of mouse preosteoblasts to pulsed electromagnetic fields reduces the amount of mature, type I collagen in the extracellular matrix." J Orthop Res 24(2): 242-53. Seiger, C. and D. O. Draper (2006). "Use of pulsed shortwave diathermy and joint mobilization to increase ankle range of motion in the presence of surgical implanted metal: A case series." J Orthop Sports Phys Ther 36(9): 669-77. Takashima, Y. et al. (2006). "Effects of continuous and intermittent exposure to RF fields with a wide range of SARs on cell growth, survival, and cell cycle distribution." Bioelectromagnetics 27(5): 392-400. Usichenko, T. I. et al. (2006). "Low-intensity electromagnetic millimeter waves for pain therapy." Evid Based Complement Alternat Med 3(2): 201-7. Virtanen, H. et al. (2006). "Interaction of radio frequency electromagnetic fields and passive metallic implants--a brief review." Bioelectromagnetics 27(6): 431-9. Yasura, K. et al. (2006). "Mechanical and Biochemical Effect of Monopolar Radiofrequency Energy on Human Articular Cartilage: An In Vitro Study." Am J Sports Med.

TENS [This list excludes many of the electroacupuncture studies and those forms of electrical stimulation that are technically TENS but not in the clinical sense of the modality] Ainsworth, L. et al. (2006). "Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation." Pain 120(1-2): 182-7. Allen, R. J. (2006). "Physical agents used in the management of chronic pain by physical therapists." Phys Med Rehabil Clin N Am 17(2): 315-45.

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Aydemir, G. et al. (2006). "Treatment of tinnitus with transcutaneous electrical nerve stimulation improves patients' quality of life." J Laryngol Otol 120(6): 442-5. Barlas, P. et al. (2006). "Effects of intensity of electroacupuncture upon experimental pain in healthy human volunteers: a randomized, double-blind, placebo-controlled study." Pain 122(1-2): 81-9. Bjordal, J. M. et al. (2006). "Physical treatments have valuable role in osteoarthritis." Bmj 332(7545): 853. Bosch, J. L. (2006). "Electrical neuromodulatory therapy in female voiding dysfunction." BJU Int 98 Suppl 1: 43-8; discussion 49. Cabioglu, M. T. and N. Ergene (2006). "Changes in serum leptin and beta endorphin levels with weight loss by electroacupuncture and diet restriction in obesity treatment." Am J Chin Med 34(1): 1-11. Dean, J. et al. (2006). "The effects of unilateral transcutaneous electrical nerve stimulation of the median nerve on bilateral somatosensory thresholds." Clin Physiol Funct Imaging 26(5): 314-8. Dickstein, R. et al. (2006). "TENS to the posterior aspect of the legs decreases postural sway during stance." Neurosci Lett 393(1): 51-5. Ezzo, J. M. et al. (2006). "Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting." Cochrane Database Syst Rev(2): CD002285. Gur, A. (2006). "Physical therapy modalities in management of fibromyalgia." Curr Pharm Des 12(1): 29-35. Habib, A. S. et al. (2006). "Transcutaneous acupoint electrical stimulation with the ReliefBand for the prevention of nausea and vomiting during and after cesarean delivery under spinal anesthesia." Anesth Analg 102(2): 581-4. Hruby, G. et al. (2006). "Assessment of efficacy of transcutaneous electrical nerve stimulation for pain management during office-based flexible cystoscopy." Urology 67(5): 914-7. Hush, J. (2006). "TENS of unknown value in the treatment of chronic low back pain." Aust J Physiother 52(1): 64. Innis, J. (2006). "Pain assessment and management for a dialysis patient with diabetic peripheral neuropathy." Cannt J 16(2): 12-7, 20-6; quiz 18-9, 27-8. Iovino, P. et al. (2006). "Perception of electrocutaneous stimuli in irritable bowel syndrome." Am J Gastroenterol 101(3): 596-603. Kim, H. W. et al. (2006). "The anti-inflammatory effects of low- and high-frequency electroacupuncture are mediated by peripheral opioids in a mouse air pouch inflammation model." J Altern Complement Med 12(1): 39-44. Kopman, A. F. (2006). "Can conventional peripheral nerve stimulators induce direct muscle depolarization?" Anesth Analg 102(6): 1905; author reply 1905-6. McNeely, M. L. et al. (2006). "A systematic review of the effectiveness of physical therapy interventions for temporomandibular disorders." Phys Ther 86(5): 710-25.

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Mora, B. et al. (2006). "Transcutaneous electrical nerve stimulation: an effective treatment for pain caused by renal colic in emergency care." J Urol 175(5): 1737-41; discussion 1741. Paker, N. et al. (2006). "Comparison of the therapeutic efficacy of TENS versus intra-articular hyaluronic acid injection in patients with knee osteoarthritis: a prospective randomized study." Adv Ther 23(2): 342-53. Perret, D. M. et al. (2006). "A geriatrician's guide to the use of the physical modalities in the treatment of pain and dysfunction." Clin Geriatr Med 22(2): 331-54; ix. Robbins, S. M. et al. (2006). "The therapeutic effect of functional and transcutaneous electric stimulation on improving gait speed in stroke patients: a meta-analysis." Arch Phys Med Rehabil 87(6): 853-9. Rorsman, I. and B. Johansson (2006). "Can electroacupuncture or transcutaneous nerve stimulation influence cognitive and emotional outcome after stroke?" J Rehabil Med 38(1): 13-9. Shiao, S. Y. and S. L. Dibble (2006). "Metaanalyses of acustimulation effects on nausea and vomiting across different patient populations: a brief overview of existing evidence." Explore (NY) 2(3): 200-1. Shiao, S. Y. and L. S. Dune (2006). "Metaanalyses of acustimulations: effects on nausea and vomiting in postoperative adult patients." Explore (NY) 2(3): 202-15. Sluka, K. A. et al. (2006). "Increased release of serotonin in the spinal cord during low, but not high, frequency transcutaneous electric nerve stimulation in rats with joint inflammation." Arch Phys Med Rehabil 87(8): 1137-40. Somers, D. L. and F. R. Clemente (2006). "Transcutaneous Electrical Nerve Stimulation for the Management of Neuropathic Pain: The Effects of Frequency and Electrode Position on Prevention of Allodynia in a Rat Model of Complex Regional Pain Syndrome Type II." Phys Ther 86(5): 698-709. Su, H. P. et al. (2006). "Paravertebral transcutaneous electrical nerve stimulation reduces movement during general anesthesia with isoflurane." Anesth Analg 102(6): 1765-7. Urmey, W. F. (2006). "Using the nerve stimulator for peripheral or plexus nerve blocks." Minerva Anestesiol 72(6): 467-71. Uthaman, U. S. and P. L. LeRoy (2006). "Pain treatment in ambulatory medical practice." Del Med J 78(2): 61-9. van Tulder, M. W. et al. (2006). "Outcome of non-invasive treatment modalities on back pain: an evidence-based review." Eur Spine J 15 Suppl 1: S64-81. Verhoeven, K. and J. G. van Dijk (2006). "Decreasing pain in electrical nerve stimulation." Clin Neurophysiol 117(5): 972-8. Warke, K. et al. (2006). "Efficacy of transcutaneous electrical nerve stimulation (tens) for chronic low-back pain in a multiple sclerosis population: a randomized, placebo-controlled clinical trial." Clin J Pain 22(9): 812-9. Yozbatiran, N. et al. (2006). "Electrical stimulation of wrist and fingers for sensory and functional recovery in acute hemiplegia." Clin Rehabil 20(1): 4-11.

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Ultrasound Therapy Allen, R. J. (2006). "Physical agents used in the management of chronic pain by physical therapists." Phys Med Rehabil Clin N Am 17(2): 315-45. Ansari, N. N. et al. (2006). "The effect of physiotherapeutic ultrasound on muscle spasticity in patients with hemiplegia: a pilot study." Electromyogr Clin Neurophysiol 46(4): 247-52. Baba-Akbari Sari, A. et al. (2006). "Therapeutic ultrasound for pressure ulcers." Cochrane Database Syst Rev 3: CD001275. Chan, C. W. et al. (2006). "Low intensity pulsed ultrasound accelerated bone remodeling during consolidation stage of distraction osteogenesis." J Orthop Res 24(2): 263-70. Citak-Karakaya, I. et al. (2006). "Short and long-term results of connective tissue manipulation and combined ultrasound therapy in patients with fibromyalgia." J Manipulative Physiol Ther 29(7): 524-8. Dalla-Bona, D. A. et al. (2006). "Effects of ultrasound on cementoblast metabolism in vitro." Ultrasound Med Biol 32(6): 943-8. D'Vaz, A. P. et al. (2006). "Pulsed low-intensity ultrasound therapy for chronic lateral epicondylitis: a randomized controlled trial." Rheumatology (Oxford) 45(5): 566-70. Ennis, W. J. et al. (2006). "Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds." Adv Skin Wound Care 19(8): 437-46. Erdogan, O. et al. (2006). "Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: an experimental study in rabbits." J Oral Maxillofac Surg 64(2): 180-8. Hoppenrath, T. and C. D. Ciccone (2006). "Is there evidence that phonophoresis is more effective than ultrasound in treating pain associated with lateral epicondylitis?" Phys Ther 86(1): 136-40. Hsieh, Y. L. (2006). "Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthase in arthritic rats." Phys Ther 86(1): 39-49. Koel, G. (2006). "Anti-impingement therapy?" Phys Ther 86(1): 143-4; author reply 144-5. Kopakkala-Tani, M. et al. (2006). "Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes." Biorheology 43(3-4): 271-82. Leung, M. C. et al. (2006). "Therapeutic ultrasound enhances medial collateral ligament repair in rats." Ultrasound Med Biol 32(3): 449-52. Li, J. K. et al. (2006). "Comparison of ultrasound and electromagnetic field effects on osteoblast growth." Ultrasound Med Biol 32(5): 769-75. Liu, H. L. et al. (2006). "Cavitation-enhanced ultrasound thermal therapy by combined low- and high-frequency ultrasound exposure." Ultrasound Med Biol 32(5): 759-67. Lu, H. et al. (2006). "Low-Intensity Pulsed Ultrasound Accelerates Bone-Tendon Junction Healing: A Partial Patellectomy Model in Rabbits." Am J Sports Med 34(8): 1287-1296.

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Maddi, A. et al. (2006). "Long wave ultrasound may enhance bone regeneration by altering OPG/RANKL ratio in human osteoblast-like cells." Bone 39(2): 283-8. Maiti, S. K. et al. (2006). "Ultrasound therapy in tendinous injury healing in goats." J Vet Med A Physiol Pathol Clin Med 53(5): 249-58. Malizos, K. N. et al. (2006). "Low-intensity pulsed ultrasound for bone healing: An overview." Injury 37(Suppl 1): S56-62. Malizos, K. N. et al. (2006). "Transosseous application of low-intensity ultrasound for the enhancement and monitoring of fracture healing process in a sheep osteotomy model." Bone 38(4): 530-9. Meakins, A. and T. Watson (2006). "Longwave ultrasound and conductive heating increase functional ankle mobility in asymptomatic subjects." Physical Therapy in Sport 7. Mohseni-Bandpeia, M. A. et al. (2006). "A prospective randomised controlled trial of spinal manipulation and ultrasound in the treatment of chronic low back pain." Physiotherapy 92(1): 34-42. Qin, L. et al. (2006). "Low intensity pulsed ultrasound increases the matrix hardness of the healing tissues at bone-tendon insertion-a partial patellectomy model in rabbits." Clin Biomech (Bristol, Avon) 21(4): 387-94. Ricardo, M. (2006). "The effect of ultrasound on the healing of muscle-pediculated bone graft in scaphoid non-union." Int Orthop 30(2): 123-7. Schabrun, S. et al. (2006). "Are therapeutic ultrasound units a potential vector for nosocomial infection?" Physiother Res Int 11(2): 61-71. Tsai, W. C. et al. (2006). "Ultrasound stimulation of types I and III collagen expression of tendon cell and upregulation of transforming growth factor beta." J Orthop Res 24(6): 1310-6. Warden, S. J. et al. (2006). "Low-Intensity Pulsed Ultrasound Accelerates and a Nonsteroidal Anti-inflammatory Drug Delays Knee Ligament Healing." Am J Sports Med 34(7): 1094-102. Warden, S. J. et al. (2006). "Ultrasound produced by a conventional therapeutic ultrasound unit accelerates fracture repair." Phys Ther 86(8): 1118-27. Watson, J. and E. A. Nelson (2006). "An exploration of the use of ultrasound in the treatment of chronic venous leg ulcers." J Wound Care 15(1): 39-41. Weaver, S. L. et al. (2006). "Effect of transducer velocity on intramuscular temperature during a 1-MHz ultrasound treatment." J Orthop Sports Phys Ther 36(5): 320-5. Yeung, C. K. et al. (2006). "Pulsed ultrasound treatment accelerates the repair of Achilles tendon rupture in rats." J Orthop Res 24(2): 193-201.

NSAID’s and Tissue Repair Arasapam, G. et al. (2006). "Roles of COX-2 and iNOS in the bony repair of the injured growth plate cartilage." J Cell Biochem 99(2): 450-61.

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Cohen, D. B. et al. (2006). "Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing." Am J Sports Med 34(3): 362-9. Daluiski, A. et al. (2006). "Cyclooxygenase-2 inhibitors in human skeletal fracture healing." Orthopedics 29(3): 259-61. Hofmann, A. A. et al. (2006). "Does celecoxib have an adverse effect on bone remodeling and ingrowth in humans?" Clin Orthop Relat Res 452: 200-4. Koester, M. C. and K. P. Spindler (2006). "Pharmacologic agents in fracture healing." Clin Sports Med 25(1): 63-73, viii. Komatsubara, S. et al. (2006). "High-grade slippage of the lumbar spine in a rat model of spondylolisthesis: effects of cyclooxygenase-2 inhibitor on its deformity." Spine 31(16): E528-34. Leonelli, S. M. et al. (2006). "Effects of a cyclooxygenase-2 inhibitor (rofecoxib) on bone healing." Am J Orthop 35(2): 79-84. Mehallo, C. J. et al. (2006). "Practical management: nonsteroidal antiinflammatory drug (NSAID) use in athletic injuries." Clin J Sport Med 16(2): 170-4. Murnaghan, M. et al. (2006). "Nonsteroidal anti-inflammatory drug-induced fracture nonunion: an inhibition of angiogenesis?" J Bone Joint Surg Am 88 Suppl 3: 140-7. Tsai, W. C. et al. (2006). "Ibuprofen inhibition of tendon cell migration and down-regulation of paxillin expression." J Orthop Res 24(3): 551-8. Vestergaard, P. et al. (2006). "Fracture risk associated with the use of morphine and opiates." J Intern Med 260(1): 76-87. Vestergaard, P. et al. (2006). "Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis." Calcif Tissue Int 79(2): 84-94. Warden, S. J. et al. (2006). "Low-intensity pulsed ultrasound accelerates and a nonsteroidal anti-inflammatory drug delays knee ligament healing." Am J Sports Med 34(7): 1094-102.

Tissue Repair & Wound Healing [There have been hundreds of papers published during 2006 on these topics. Those identified below are a VERY small selection] (2006). "Exercise speeds wound healing." Health News 12(3): 9. Arnold, M. and A. Barbul (2006). "Nutrition and wound healing." Plast Reconstr Surg 117(7 Suppl): 42S-58S. Aslan, M. et al. (2006). "The effect of hyaluronic acid-supplemented bone graft in bone healing: experimental study in rabbits." J Biomater Appl 20(3): 209-20. Bishop, N. E. et al. (2006). "Shear does not necessarily inhibit bone healing." Clin Orthop Relat Res 443: 307-14.

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Brochhausen, C. et al. (2006). "Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ - prostaglandin E2 dependent proliferation of growth plate chondrocytes." Arthritis Res Ther 8(3): R78. Broughton, G. et al. (2006). "The basic science of wound healing." Plast Reconstr Surg 117(7 Suppl): 12S-34S. Broughton, G. et al. (2006). "Wound healing: an overview." Plast Reconstr Surg 117(7 Suppl): 1e-S-32e-S. Claes, L. et al. (2006). "Moderate soft tissue trauma delays new bone formation only in the early phase of fracture healing." J Orthop Res 24(6): 1178-85. Dimitriou, R. et al. (2006). "The role of inhibitory molecules in fracture healing." Injury 37 Suppl 1: S20-9. Donahue, S. W. and S. A. Galley (2006). "Microdamage in bone: implications for fracture, repair, remodeling, and adaptation." Crit Rev Biomed Eng 34(3): 215-71. Drosos, G. I. et al. (2006). "Factors affecting fracture healing after intramedullary nailing of the tibial diaphysis for closed and grade I open fractures." J Bone Joint Surg Br 88(2): 227-31. Efthimiadou, A. et al. (2006). "Angiogenic effect of intramuscular administration of basic and acidic fibroblast growth factor on skeletal muscles and influence of exercise on muscle angiogenesis." Br J Sports Med 40(1): 35-9; discussion 35-9. Efthimiadou, A. et al. (2006). "Angiogenic effect of intramuscular administration of basic fibroblast growth factor in atrophied muscles: an experimental study in the rat." Br J Sports Med 40(4): 355-8; discussion 358. Epari, D. R. et al. (2006). "Mechanical conditions in the initial phase of bone healing." Clin Biomech (Bristol, Avon) 21(6): 646-55. Erdogan, O. et al. (2006). "Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: an experimental study in rabbits." J Oral Maxillofac Surg 64(2): 180-8. Faler, B. J. et al. (2006). "Transforming growth factor-beta and wound healing." Perspect Vasc Surg Endovasc Ther 18(1): 55-62. Fowble, V. A. et al. (2006). "Neovascularity in chronic posterior tibial tendon insufficiency." Clin Orthop Relat Res 450: 225-30. Godbout, C. and J. Frenette (2006). "Periodic direct current does not promote wound closure in an in vitro dynamic model of cell migration." Phys Ther 86(1): 50-9; discussion 59-65. Haraldsson, B. T. et al. (2006). "Corticosteroids Reduce the Tensile Strength of Isolated Collagen Fascicles." Am J Sports Med 34(12): 1992-1997. Hosgood, G. (2006). "Stages of wound healing and their clinical relevance." Vet Clin North Am Small Anim Pract 36(4): 667-85. Inbal, A. and R. Dardik (2006). "Role of coagulation factor XIII (FXIII) in angiogenesis and tissue repair." Pathophysiol Haemost Thromb 35(1-2): 162-5.

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Itoh, S. et al. (2006). "Effect of electrical polarization of hydroxyapatite ceramics on new bone formation." Calcif Tissue Int 78(3): 133-42. Karim, A. et al. (2006). "Smoking and reconstruction of the anterior cruciate ligament." J Bone Joint Surg Br 88(8): 1027-31. Knobloch, K. et al. (2006). "Achilles tendon and paratendon microcirculation in midportion and insertional tendinopathy in athletes." Am J Sports Med 34(1): 92-7. Lin, T. W. et al. (2006). "Tendon healing in interleukin-4 and interleukin-6 knockout mice." J Biomech 39(1): 61-9. McDougall, S. et al. (2006). "Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications." Philos Transact A Math Phys Eng Sci 364(1843): 1385-405. Melling, A. C. and D. J. Leaper (2006). "The impact of warming on pain and wound healing after hernia surgery: a preliminary study." J Wound Care 15(3): 104-8. Muldoon, J. (2006). "Skin cooling, pain and chronic wound healing progression." Br J Community Nurs 11(3): S21, S24-5. Phieffer, L. S. and J. A. Goulet (2006). "Delayed unions of the tibia." J Bone Joint Surg Am 88(1): 206-16. Polyzois, V. D. et al. (2006). "Current concepts in delayed bone union and non-union." Clin Podiatr Med Surg 23(2): 445-53, viii. Posthauer, M. E. (2006). "Hydration: does it play a role in wound healing?" Adv Skin Wound Care 19(2): 74-6. Posthauer, M. E. (2006). "The role of nutrition in wound care." Adv Skin Wound Care 19(1): 43-52; quiz 53-4. Qin, L. et al. (2006). "Low intensity pulsed ultrasound increases the matrix hardness of the healing tissues at bone-tendon insertion-a partial patellectomy model in rabbits." Clin Biomech (Bristol, Avon) 21(4): 387-94. Ricardo, M. (2006). "The effect of ultrasound on the healing of muscle-pediculated bone graft in scaphoid non-union." Int Orthop 30(2): 123-7. Roy, H. et al. (2006). "Biology of vascular endothelial growth factors." FEBS Lett 580(12): 2879-87. Salvi, A. E. et al. (2006). "Spontaneous healing of an avulsed ischial tuberosity in a young football player. A case report." Acta Orthop Belg 72(2): 223-5. Schulz, G. and J. Stechmiller (2006). "Wound healing and nitric oxide production: too little or too much may impair healing and cause chronic wounds." Int J Low Extrem Wounds 5(1): 6-8. Shen, W. et al. (2006). "Inhibited skeletal muscle healing in cyclooxygenase-2 gene-deficient mice: the role of PGE2 and PGF2alpha." J Appl Physiol 101(4): 1215-21. Simpson, A. H. et al. (2006). "The role of growth factors and related agents in accelerating fracture healing." J Bone Joint Surg Br 88(6): 701-5.

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Steyaert, A. E. et al. (2006). "The effects of substance P on the biomechanic properties of ruptured rat Achilles' tendon." Arch Phys Med Rehabil 87(2): 254-8. Toumi, H. et al. (2006). "The role of neutrophils in injury and repair following muscle stretch." J Anat 208(4): 459-70. Vijayakumar, V. et al. (2006). "Load transmission through a healing tibial fracture." Clin Biomech (Bristol, Avon) 21(1): 49-53. Wang, H. Q. and L. Zhao (2006). "Impact of mechanical stress and tension-stress on angiogenesis in wound healing." Chin J Traumatol 9(2): 118-24. Wang, J. H. et al. (2006). "Biomechanical basis for tendinopathy." Clin Orthop Relat Res 443: 320-32. Warden, S. J. et al. (2006). "Ultrasound produced by a conventional therapeutic ultrasound unit accelerates fracture repair." Phys Ther 86(8): 1118-27. Watson, T. (2006). "Electrotherapy and tissue repair." Sportex-Medicine. 29: 7-13. Watson, T. (2006). "Tissue repair: The current state of the art." Sportex-Medicine. 28: 8-12. Winter, G. D. (2006). "Some factors affecting skin and wound healing." J Tissue Viability 16(2): 20-3. Woo, S. L. et al. (2006). "Biomechanics of knee ligaments: injury, healing, and repair." J Biomech 39(1): 1-20. Yeung, C. K. et al. (2006). "Pulsed ultrasound treatment accelerates the repair of Achilles tendon rupture in rats." J Orthop Res 24(2): 193-201. Zhao, M. et al. (2006). "Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN." Nature 442(7101): 457-60.