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Technology Transfer and Intellectual Property Services 2005 Annual Report

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Page 1: 2005 - University of California, San Diego

Technology Transfer and Intellectual Property Services

2005A n n u a l R e p o r t

Page 2: 2005 - University of California, San Diego

The UCSD Technology Transfer Advisory Committee (TTAC)

is responsible for general oversight of the UCSD Technology

Transfer Program. This standing committee is appointed

by the chancellor and is chaired by the vice chancellor of

Research. It meets periodically to assess UCSD technology

transfer policy and guide the direction of the overall program.

COMMITTEE MEMBERS (FY2005)

RICHARD ATTIYEH (Chair )

Vice Chancellor, Research

ROGER BOHN

Professor, International Relations and Pacific Studies

MAARTEN CHRISPEELS

Professor, Division of Biological Sciences

FRED CUTLER

Executive Director, UCSD CONNECT

LINDA DALE

Director, Office of Contract and Grant Administration

GARY FIRESTEIN

Professor, Medicine

TOM JACKIEWICZ

Chief of Staff, School of Medicine

WILLIAM KUPERMAN

Professor, Scripps Institution of Oceanography,

Marine Physical Laboratory

JOE BEAR

Executive Director, William J. von Liebig Center,

Jacobs School of Engineering

LAWRENCE MILSTEIN

Professor, Electrical and Computer Engineering

ALAN PAAU (Secretary)

Assistant Vice Chancellor,

Technology Transfer and Intellectual Property Services

GEERT SCHMID-SCHOENBEIN

Professor, Bioengineering

ROBERT SULLIVAN

Dean, Rady School of Management

JOHN WOODS

Vice Chancellor, Resource Management and Planning

Page 3: 2005 - University of California, San Diego

Technology Transfer and Intellectual Property Services 2005 Annual Report

4 Top Five UCSD Innovations

6 Spotlight Start-ups

8 FY2005 Start-ups

12 Community Outreach

14 Results

15 Financials

16 Appendix

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Message from Technology Transfer and Intellectual Property Services

I am delighted to share with you the FY2005 activities of the UC San Diego Technology Transfer and Intellectual Property Services (TechTIPS). The campus reached all-time highs in several significant areas: 334 disclosures of invention and copyright work by UCSD researchers; 71 executed licenses granting industry partners intellectual prop-erty rights to develop UCSD innovations; 60 patents issued by the United States Patent and Trademark Office to protect novel UCSD inventions; and gross revenues of over $21 million. They reflected well on the excellent research of our academic programs at UCSD and the relationship we have built with industry through the years.

In the second half of FY2005, UCSD also began a concerted effort with the UC systemwide Office of Technology Transfer to complete the “decentralization” of invention management started by the UC Office of the President. By the end of FY2006, the

UCSD campus office will be fully responsible for the management of all UCSD inventions. We hope by consolidating the management responsibility, we can provide more consis-tent, uniform, and timely services to our re-searchers and our industry partners. Please read more about this subject on page 7.

We were again busy promoting UCSD and UCSD innovations both at home and far away. We hosted many visitors who came to UCSD to study our technology trans-fer program and to exchange technology management and economic development ideas. We welcomed and took advantage of the opportunities to learn from each other. Please read more about our outreach and partnering activities starting on page 12.

The entrepreneurial spirit was rekindled at UCSD as the economy slowly recovered from the technology “nuclear winter” of 2002–2003. UCSD innovations were the

Alan S. Paau, M.B.A., Ph.D.Assistant Vice ChancellorTechnology Transfer and Intellectual Property Services

basis of fifteen new businesses formed in FY2005, some of which are highlighted on pages 8–10. UCSD innovations continue to gain market success. In FY2005, five of the Top 25 revenue-generating innovations from the entire UC system came from UCSD. Please read more about them on page 4.

I hope you find this report informative. If you have questions or suggestions for future re-ports, please do not hesitate to contact us. UCSD TechTIPS welcomes your input.

TECHTIPS UC SAN DIEGO ANNUAL REPORT �

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Five UCSD Innovations Among the UC Top 25

In FY2005, five UCSD innovations made their way to the UC Top 25 list of revenue-generating inventions. Their presence reflected well on UCSD and included repeat honorees ELMIRON®, a therapeutic for interstitial cystitis; Ultravist® and Isovist®, two radiographic contrasting media for medical imaging; and the firefly Luciferase Assay System®, a ubiquitous life-science research tool. The two new honorees included Amplicor® and Ampliscreen®, for the diagnosis and detection of human cytomegalovirus; and Erbutix®, a biopharmaceutical for the treatment of colorectal and head and neck cancer.

Page 7: 2005 - University of California, San Diego

ELMIRON® ELMIRON (pentosan polysulfate) is indicated for the relief of bladder pain or discomfort associated with interstitial cystitis. It was the first and only oral medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of interstitial cystitis, also known as painful bladder syndrome. Interstitial cystitis patients struggle with symptoms of urinary frequency, urgency, pressure, and/or pain, as well as nocturia (frequent urination at night), dyspareunia (painful intercourse), pain, and/or discomfort while sitting in a car, while driving, and/or traveling. ELMIRON is sold by Ortho McNeil, a subsidiary of Johnson & Johnson, and resulted from pioneering work at UCSD by Professor C. Lowell Parsons (Surgery).

Ultravist® and Isovist®

Ultravist (iopromide) and Isovist (iotrolan, a dimer of triiodinated isophthalic acid derivatives) are two commercial radio- graphic contrasting agents. Isovist is useful in imaging spaces surrounding the central nervous system, such as the ventricles, after injection into the cerebrospinal fluid. It can also be used to image joint spaces and in endoscopic retrograde cholangiopancrea-tography. Ultravist is a nonionic, iodinated, low osmolar, injectable radiological con-trast agent for intravascular administration. Ultravist is being used today in over 100 countries worldwide with clinical experience in over 100 million patients. Sales for Ultrav-ist were over 248 million Euros in 2005, and it is sold by Berlex, a subsidiary of Schering Ag. These contrasting agents resulted from work by former UCSD researchers Drs. Milos Sovak and Ramachandran Ranganathan.

The Luciferase Assay System®

The Luciferase Assay System is an ex-tremely sensitive and rapid research tool for quantization of firefly luciferase that cata-lyzes a reaction with the substrate, luciferin, in the presence of ATP to produce light as a reporter gene. Linear results are seen over at least eight orders of magnitude of enzyme concentration, and patented technology incorporated in the formulation has allowed for less than 10–20 moles of luciferase to be measured under optimal conditions. Generally, 100-fold greater sensitivity can

be achieved over the competing chloram-phenicol acetyltransferase (CAT) assay. This reagent generates light that is nearly constant for at least one minute and is compatible with measuring firefly luciferase in a single-tube luminometer or in a multiwell plate luminometer with an auto-injector. In molecular biology, a reporter gene is a gene that researchers attach to another gene of interest in cell cultures, animals, or plants. Luciferase gene expression, because of its light-emitting reaction with luciferin, is easily identified and measured. The Luciferase Assay System line of products is sold by Promega Corporation. Other products, using this same cloned gene that resulted from work by Professors Donald Helinski and Marlene Deluca McElroy (Biological Sci-ences) at UCSD, are currently sold by other companies.

The Human CMV Monitoring KitThe human CMV monitoring kit is a diagnos-tic tool that resulted from work by Professor Deborah Spector (Cellular and Molecular Medicine) at UCSD and is widely used to test blood and blood products for the pres-ence of human cytomegalovirus, or hCMV. hCMV is a common virus that infects many people worldwide. An hCMV infection is usually harmless and rarely causes illness. A healthy immune system can hold the virus in check. However, if a person's immune sys-tem is seriously weakened in any way, the virus can become active and cause hCMV diseases. Cytomegalovirus is a member of the herpesvirus family and attacks the sali-vary glands. It may be devastating or even fatal to fetuses. An hCMV infection can be life threatening for patients who are immu-no-compromised (e.g., patients with HIV or organ transplant recipients). Other members of the herpesvirus family cause chickenpox, infectious mononucleosis, fever blisters, and genital herpes. These viruses all share the

ability to remain alive, but dormant, in the body for life. The human cytomegalovirus monitoring kits are sold by Roche Molecular Diagnostics as in vitro diagnostic kits under the trade name AMPLICOR®, and as kits for screening blood and blood products under the trade name AmpliScreen®.

Erbitux® Erbitux (cetuximab) is a new FDA-approved clinical product for the treatment of ad-vanced colorectal cancer that entered the market in 2004. In 2005, the FDA further approved its use for head and neck cancer. It can be used in combination with another approved colorectal drug, irinotecan, or alone if the patients cannot tolerate irinote-can. Erbitux is derived from a monoclonal antibody developed at UCSD by former pro-fessors Gordon Sato and John Mendelsohn and their associates. The antibody specifi-cally targets and blocks epidermal growth factor receptors on the surface of cancer cells and interferes with their growth and proliferation. UCSD granted license rights of this innovation to Imclone Systems, Inc. (IMCL–NasdaqNM) of New York to develop this cancer therapeutic. Imclone co-pro-motes Erbitux with its marketing partners, Bristol-Myers Squibb (BMY-NYSE), in the U.S. and in Canada, and with Merck KGaA in Europe. In 2005, sales of Erbitux were over $400 million in the U.S. alone.

TECHTIPS UC SAN DIEGO ANNUAL REPORT �

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In 2005, NetSift, Inc., a UCSD start-up, was acquired by Silicon Valley-based Cisco Systems for $30 million. NetSift was formed in 2004 to commercialize solutions for high-speed communications network security using technology developed by Professors George Varghese and Stefan Savage (Com-puter Science and Engineering), and gradu-ate scholars Sumeet Singh and Cristian Estan. Varghese and Singh were cofounders of the company.

CSE graduate student Sumeet Singh (left) and CSE professor George Varghese.

UCSD Start-up Acquired by Cisco Systems

TechTIPS provided the original technology license to establish the start-up and repre-sented the university’s interest in the acqui-sition negotiation. NetSift originally received venture backing from a local venture capital firm, Enterprise Partners Venture Capital, and employed several alumni from UCSD. Upon acquisition, the company and its employees became part of Cisco’s Internet Systems business unit.

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UCSD Start-up Acquired by Cisco Systems

Decentralization

The technology transfer program at the University of California system is moving towards a decentralization scheme, which will distribute responsibilities to its vari-ous campuses. During the second half of FY2005, about fifty inventions previously disclosed to and managed by the system-wide Office of Technology Transfer (OTT) in Oakland were transferred to UCSD’s Technology Transfer and Intellectual Prop-erty Services (TechTIPS) office. Over the course of FY2006, all inventions previously disclosed to and managed by OTT will be transferred to the campus office.

With the consolidation of the entire UCSD portfolio of innovations to the campus, we hope to realize several advantages of local management of these innovations, including:

• Improved responsiveness to faculty and the San Diego industry community

• Local access to UCSD researchers for services provided by the local office

• A “one-stop shop” for industry or other third parties interested in licensing UCSD innovations

• Simplified financial accounting and control of licensing, legal expenses, and income

RedXDefense, LLC, a start-up company based in Rockville, Maryland, licensed tech-nologies from the research of Professors William Trogler and Michael Sailor, both of the Department of Chemistry and Biochem-istry at UCSD. The licensed technologies, together with technologies licensed from the Wisconsin Alumni Research Founda-tion, provide a simple, fast, and inexpensive method to detect trace amounts of explo-sives using fluorescent detection inks and silicon “nanowires” that are 2,000 times thinner than a human hair. The company’s Explosives Particulates Analysis Kit (XPAK) product can detect fingerprints left by some-

one who has handled explosives, such as TNT, DNT, RDX, HMX, PETN, Tetryl, C4, PE-4, Semtex, Composition B, and others, even in a heavy background of other fingerprints.

RedXDefense recently partnered with Smiths Detection, the world’s leading pro-vider of trace and x-ray detection systems, to jointly develop for the mass transit envi-ronment an advanced explosives screening system capable of screening 100 percent of passengers. The two companies will partner to adapt advanced RedXDefense detection technology into an explosives screening system that can meet the high throughput demands of subway stations.

The target market for this new explo-sives screening system is every turnstile in America’s subways. In New York City alone, there are 468 subways stations that accommodate 4.7 million passengers daily. If deployed in New York City, this advanced explosives detection system would screen 1.45 billion trips per year.

Start-up RedXDefense Teams with Smiths Detection to Improve Subway Security

TECHTIPS UC SAN DIEGO ANNUAL REPORT �

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in October 2005. This spring, a customer obtained its first product silicon optimized with Blaze’s software tools.

“Results so far with our first product have exceeded our customers’ most optimistic expectations,” says Professor Andrew Kahng (Blaze co-founder and UCSD faculty member in Computer Science Engineering). “Now we want as many chip designers as possible to benefit from it.”

The “DFM” in the company’s name means “design for manufacturing” and refers to a concept of designing integrated circuits in a way that improves the percentage of chips on a wafer to meet product specifications and therefore can be shipped. But as chip sizes drop and densities increase, improving yields on sub-100-nanometer (nm) pro-cesses becomes an even bigger problem because of power leakage and manufactur-ing variability.

“DFM is the semiconductor industry’s only hope for a cost-effective continuation of Moore’s Law,” says Kahng. “It’s been my research focus since 1997. I felt I had to do something to help solve critical challenges of

variability, power and cost—if only as a safe-ty net for the industry. I am grateful to UCSD for having provided me with this opportunity to translate university research into practical impact. The strong interest, support, and follow-through from the technology transfer staff at UCSD has been very gratifying, as has been the sight of my research turning into commercial products.”

Kahng's new technology does DFM with a twist. He calls it “Electrical” DFM. Most of the DFM tools used today have a geometric mindset: they focus on whether the shapes of circuit features in silicon exactly match the layout as designed. But, argues Kahng, shape fidelity is not the same as maximizing the number of sellable chips per wafer (and therefore revenue per wafer). To optimize the yield of chips on a wafer, he says, designers must take into account electrical require-ments, notably power and timing.

“Leakage power is a big part of the prob-lem at the sub-100nm level,” notes Kahng. “Because of leakage currents, a fast chip may burn too much power and be unusable in, say, a mobile application, and a slow chip may not be usable either. Electrical DFM

ARS Holding Corp. Cupertino, CA ARS is commercializing advanced RF transceivers for wireless handsets using technologies developed by Professor Larry Larson (Electrical and Computer Engineering).

Bettles Gates LLC Las Vegas, NVBettles Gates was formed to bundle, develop, and commercialize a portfolio of teleconferencing technologies from patents donated to UCSD with technologies from other sources. The company has been suc-cessful in licensing the bundled technologies to other companies for commercial uses.

Blaze DFM, Inc. Sunnyvale, CA Blaze DFM, Inc., which now comprises twenty employees, has attained all of its benchmarks since closing a $6 million initial round of venture capital financing in late 2004. Alpha testing of its first product, Blaze MO, began in March 2005, and the product was first installed at a beta customer site

FY2005 Start-upsFY2005 was a prolific year for UCSD start-ups with fifteen newly formed companies entering the business world. Of the fifteen companies, five were biotechnology/biomedical companies and the rest were engineering/software development companies. Twelve of the fifteen companies are in California, and ten of those are in the San Diego area.

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looks at these electrical requirements and optimizes the chip design so that manufac-tured silicon meets parametric specifications while burning as little power as possible. Our products also directly mitigate the manufacturing variation that is so challeng-ing at leading-edge process nodes.”

Digital Media Research, Inc.dba Immersive Media Research, Inc. Del Mar, CADigital Media Research was formed with vortex surround technology developed by Professor Peter Otto (Music). Vortex sur-round facilitates the creative and expressive manipulation of individual sounds in space as well as the combining of these sounds into multichannel sound cues and fully im-mersive soundscapes. Three applications (Vortex Surround Designer, Vortex Surround Mixer, and Vortex Surround Encoder) form a surround authoring system, and may be used individually or together as elements of a complete production chain. They also work transparently with other audio applica-tions and can be used to provide multichan-

nel sound capabilities for authoring environ-ments that are otherwise less capable.

Eilean Technologies, LLC Las Vegas, NVEilean, a holding company, was formed to explore bundled communications-related technologies developed by university researchers, including UCSD Professors Pa-mela Cosman, Larry Larson, Peter Asbeck, and Ian Galton (Electrical and Computer Engineering); and Mark Zumberge (Institute for Geophysics and Planetary Physics). The technologies utilize advanced signal pro-cessing techniques that will prove invaluable in tomorrow’s mixed-signal and portable power applications.

HiGene Therapeutics, Inc.San Diego, CAHiGene was formed with technology developed by Professor Yang Xu (Biologi-cal Sciences) that allows the production of humanized antibodies using a specialized transgenic mouse. Human or humanized monoclonal antibodies have proven to be

very effective therapeutics against a variety of cancers, autoimmune diseases, and inflammatory diseases. This new technology will allow a more cost-effective production of future antibody therapeutics in a less labor-intensive and time-consuming manner.

HypoxyGen La Jolla, CAHypoxyGen was formed with technology developed by Professor Randall Johnson (Biological Sciences) and his associates that enhances bacterial killing by the im-mune system. The UCSD inventors have shown that use of hypoxia mimetics, iron chelators, and other compounds that up-regulate the HIF-1 hypoxia responsive transcription factor—or inhibit hydroxylase action—accelerate the killing of bacteria by white blood cells. The potential of pharma-cologically increasing the killing capacity of white blood cells, alone or in conjunction with antibiotics, holds significant clinical and market promise.

Clockwise from top left: Yu-Hwa Lo co-founder of Rhevision; ARS founder and Eilean collaborator, Larry Larson; Geert Schmid-Schoenbein, whose patented discoveries contributed to the founding of InflammaGen; Blaze co-founder and UCSD faculty member Andrew Kahng; Ortiva technology developer Sujit Dey.

TECHTIPS UC SAN DIEGO ANNUAL REPORT �

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InflammaGen, Inc. La Jolla, CAInflammaGen was founded to commercialize specific patented discoveries of Professor Geert Schmid-Schoenbein (Bioengineer-ing). UCSD researchers have discovered that blocking the action of inflammatory mediators dramatically increases survival rates among laboratory animals. In humans, obstructing the chain of biochemical events involved in shock may be able to save tens of thousands of lives annually in the United States and an even greater number on a global scale. Additionally, there is mounting evidence that suggests that inflammation is the underlying cause of degenerative diseases including arthritis, Alzheimer’s, coronary artery disease, diabetes, and even some cancers. The company is committed to testing and commercializing technologies to reduce severe inflammation in order to ameliorate disease and preserve human life.

IQ Analog San Diego, CAIQ Analog is a semiconductor design com-pany providing improved mixed-signal data converter technology for Radio Frequency (RF) systems.

Partnering with researchers at the university, the company is developing the latest digi-tally calibrated analog interface technology to provide practical, cost-effective commer-cial applications. The technologies include a digital-analog converter technology devel-oped by Professor Ian Galton (Electrical and Computer Engineering).

Mushroom Networks, Inc. La Jolla, CAMushroom Networks was formed to com-mercialize a smart network-sharing technol-ogy for broadband Internet access devel-oped by Professor Rene Cruz (Electrical and Computer Engineering).

Ortiva Wireless, Inc. San Diego, CAOrtiva Wireless provides enhanced wireless content delivery. The company’s technology compensates for real-time wireless channel fluctuations to ensure the highest quality mobile user experience by expanding both capacity and reach of wireless networks. Professor Sujit Dey (Electrical and Computer Engineering) is the developer of the technol-ogy and co-founder of the company.

Proveri, Inc. San Diego, CAProveri focuses on improving the diagnosis and prognosis of prostate cancer by devel-oping tests that distinguish aggressive and indolent prostate cancer. The company’s technology was jointly developed by re-searchers at UCSD and the Sydney Kimmel Cancer Center (La Jolla, CA), and utilizes biomarkers that are statistically indicative of aggressive prostate cancer. These bio-markers were identified in a large clinical trial that was funded by a $4.7 million grant from the National Institutes of Health.

Rhevision Technology, Inc. San Diego, CARhevision was founded to commercialize revolutionary technologies on tunable smart optics for mobile and miniature imaging. Licensed technology was developed by Professor Yu-Hwa Lo (Electrical and Com-puter Engineering), and the company was founded by UCSD faculty and scientists.

StemTech, Inc. San Diego, CAStem Tech was formed with licensed technology developed by Professor Alberto Hayek (Pediatrics) that allows the main-tenance of pluripotency and propagation of human stem cell in culture without the use of a mouse embryonic fibroblast (mEF) feeder cell layer or a conditioned medium using mEF. This technology holds prom-ise as a stem cell research tool as well as a preferred production tool as stem cell research advances ever closer to practical therapeutic applications.

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TECHTIPS UC SAN DIEGO ANNUAL REPORT 11

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INVENT.UCSD.EDU

AUG 2004 Presentation at the Amylin “Friend Raising” Evening (sponsored by UCSD External Relations)

Life Science Innovators Roundtable with presetations by Professors Virgil Woods, Jr., Nicholas Spitzer, Laura Borodinsky, and Wolfgang Dillmann

SEPT 2004 Life Science Innovators Roundtable with presentation by Professor Michael Sailor CONNECT Springboard Event for Hekko

OCT 2004 Life Science Innovators Roundtable with presentation by Professor Ajit Varki

Presentation at the meeting of the Control and Accountability Committee on Relationship Risks

Presentation at the Oceanids Annual Conference

Breakfast with TechTIPS with presentation by Professor Sujit Dey

Licensing Executive Society Annual Meeting

UCSD Technology Road Show to Boston (hosted by PureTech)

UCSD Technology Road Show to Shanghai, China (co-hosted by Crimson Pharmaceuticals, Paul Hastings, and the BayHelix Group)

AgBio Annual Conference (co-hosted by TechTIPS and the San Diego Center for Molecular Agriculture)

NOV 2004 Life Science Innovators Roundtable with presentation by Professor Juan Lama

UCSD Technology Road Show to Weihai, China (hosted by the International Biotechnology Center of the Shantung University)

Presentations and technology exhibition at the Taiwan Invention Exposition and TechnoMart Convention, Taipei, Taiwan

UCSD Technology Road Show to Hsinchu, Taiwan (hosted by the Industry Technology Research Institute)

Intellectual Property Seminar at Scripps Institution of Oceanography

TransMed program presentations at CONNECT Frontiers in Science

Innovators Showcase and TechTIPS Tenth Anniversary Celebration

CONNECT Most Innovative Product Awards Judging Presentation

Technology exhibition at the LARTA T2 Conference (Los Angeles) SABPA Company Profile 2 (co-hosted by TechTIPS and SABPA)

DEC 2004 CONNECT Most Innovative Product Awards Banquet Life Science Innovators Roundtable with presentation by Professor Yitzhak Tor

Community Outreach and Partnering

JAN 2005 Physical Science Innovators Roundtable with presentations by Professors Edward Yu, Kenneth Vecchio, Raymond de Callafon, and Yu-Hwa Lo

FEB 2005 AUTM Annual Meeting Start-up Seminar: Forming a New Company —Legal Issues to Consider

MAR 2005 PharmaSTART Drug Development Seminar

UCSD Technology Road Show to Industry Technology Research Institute (Hsinchu, Taiwan)

SABPA Second Annual Career Development Conference at UCSD

Life Science Innovators Roundtable with presentation by Professor Robert Mattrey

APR 2005 CONNECT Springboard for TheraPei

Intellectual Property Seminar (co-sponsored with Center for Wireless Communications)

MAY 2005 Plant Intellectual Property Seminar (co-spon- sored with San Diego Center for Molecular Agriculture)

JUN 2005 San Diego BioPharma Conference 2005 (co-sponsored with SABPA)

Presentation at the National Roundtable on Technology Transfer, Science and Trade (co-hosted by TAMU and University of Hawaii with support from the U.S. State Department)

Mentoring services to the Rady School of Management: Lab2Market class

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JUL 2004 Representatives from University of Wollongong, New South Wales, Australia

AUG 2004 Technion University, Israel–Dr. Eizenberg

SEP 2004 Kyoto Trade Mission/Kyoto Research Park Corp./JETRO of Japan

A*STAR, Singapore–Sze Tiam Lin

EMD Biosciences and Merck KgaA

OCT 2004 Domain Associates, LLC–Dr. Brian Halak

NOV 2004 Polaris Delegation of Science and Technology Park of Sardinia, Italy

Hsinchu Biomed Park Delegation of Taiwan

Institute for Information Industry (Taiwan/UCSD Extension hosted)

Technion R&D Foundation, Ltd., Israel –Ami Lowenstein

Tokuyama College of Technology, Japan –Professor Takashi Hara

DEC 2004 Hong Kong Science and Technology Park –Dr. Joseph Liu and Mr. Jim Huang

BioRiver ABCD Regional Consortium of Germany–Annette Traude and Josef Steffinn

JAN 2005 BioVentures–Mr. Micky Kim

Merck & Co.–Dr. James Schaeffer

FEB 2005 Steve Tomlin of Avalon Ventures

Northwestern University–Professor Burton Weisbrod

San Diego Union-Tribune –Teri Somers (biotech reporter) New Zealand Government Science Council –Counselor Brian Young and Tim Blackmore

MAR 2005 University of New England, Armidale, NSW, Australia–Professor Grant Harman

APR 2005 Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil–Professor Jose Antonio Martinelli

Dr. Dale Cooper, Head of Bioscience, BD–Americas, Procter & Gamble

Changchun Botai Biotech–Dr. Xun Zhu

MAY 2005 Université de Montréal Vice Recteur a la Récherche–Alain Caille

Invest New Zealand–Gabriella Riera, Bret Morris, and Adam Podmore

Swedish Office of Science and Technology –Mr. Anders Asperen

University of Hong Kong –Professor Paul Tam

JUN 2005 University of Hong Kong –Professor Wong Kam Fai Hong Kong Science and Technology Park –Dr. Joseph Liu

China State Intellectual Property Office Delegation

Texas A&M University Delegation

Beijing University Delegation

Yunnan University Delegation

China Ministry of Science and Technology

Welcome

Sharing Experience

AUG 2004 SRI BioAsia Licensing and Deal-Making Summit

SEPT 2004 UC Technology Transfer Managers Dialog with Science and Engineering Deans

UC Systemwide Intellectual Property Managers Conference

Kansas City/San Diego Leadership Exchange

OCT 2004 China Beijing Bioengineering and Pharma Industrial Park Delegates (co-hosted by TechTIPS and SABPA)

NOV 2004 Presentation at the National Association of University Attorneys Meeting

Presentation at the National Association of State Universities and Land-Grant Colleges (NASULGC) Annual Meeting

Presentation at “Invention to Ventures” Conference (hosted by UCSD von Liebig Center)

JAN 2005 Presentation at the Rady School FlexMBA Seminar Finnish Delegation (co-hosted by TechTIPS, IR/PS, and Global CONNECT)

Ontario Delegation of University Vice Presidents for Research (hosted by Global CONNECT)

FEB 2005 Presentation at the ENG100L (Teams in Engineering Service Program)

MAR 2005 UC Riverside Technology Transfer and Economic Development Advisory

UC Systemwide Independent Substantive Review Committee Seminar

Hong Kong Science and Technology Park International Technology Conference Chinese Medicine CEO Business Round- table (co-hosted by the Hong Kong Jockey Club, Institute for Chinese Medicine, and the Hong Kong Science and Technology Park)

Presentation at the SRI Biotech/Pharma Licensing Summit

Presentation at the California Western School of Law Intellectual Property Conference

APR 2005 Presentation at the University of South Florida Moffett Cancer Center Seminar

Presentation at the UCSD BioBusiness Extension Class

Presentation at the SDSIC Entrepreneur Forum: Technology—Acquire or Develop?

MAY 2005 MultiLaw IP Special Interest Group

VentureForth Biotechnology Conference

JUN 2005 Presentation at the Carmel Valley Section of IPLA

Presentation at the Fish & Richardson Video Seminar

TECHTIPS UC SAN DIEGO ANNUAL REPORT 1�

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IP DisclosuresThe basis of UCSD’s intellectual property portfolio starts with an invention or copyright disclosure from our researchers. These disclosures are the foundation for seeking statutory protection and licensing of protected rights for commercialization to serve the university’s mis-sions. In FY2005, we reached 334 disclosures—another all-time high for the campus.

AgreementsTechTIPS agreement activity increased to over 700 agreements in FY2005, a new high for the campus. This number included licenses, options, letters of intent (LOI), material transfer agreements (MTA), and other adminis-trative agreements.

IP ProtectionUCSD’s technology transfer program continues to achieve high numbers for patent prosecution and protection, ranking second to UCSF in the UC system. In FY2005, 239 patents were filed of which 172 were U.S. provisional or secondary filings and the remain-ing 67 were foreign applications. An all-time high was achieved with 147 issued patents, 60 U.S. and 87 foreign patents.

Results

0504030201009998979695

250

187 23

4

236

242

489

576

592 62

6

699

713

0504030201009998979695

Copyrights

Inventions

2628

56

16

41

16

15

11213

7

476

139 16

1

200

194

265

255

294

288

4429

0

Tech Transfer Agreements Licenses of Inventions and Copyrights Intellectual Property Disclosures

1995

107

0

107

1996

70

4

74

1997

94

11

105

1998

96

40

136

1999

60

87

37

184

2000

55

87

22

164

2001

74

76

40

190

2002

75

86

41

202

2003

127

45

69

241

2004

144

44

94

282

14

1

15

27

1

28

30

3

33

36

41

77

40

51

91

58

33

91

59

36

95

42

39

81

51

69

120

50

79

129

Filings

U.S. Provisional

Non-Provisional

International

TOTAL FILED

Patents Issued

U.S. Issued

International Issued

TOTAL ISSUED

2005

133

39

67

239

60

87

147

Inventions

6

1995

Copyrights

5

Inventions

21

1996

Copyrights

1

Inventions

23

1997

Copyrights

3

Inventions

41

2000

Copyrights

6

Inventions

34

2001

Copyrights

12

1999

Inventions

24Copyrights

19

Inventions

25

1998

Copyrights

2

Inventions

28

2002

Copyrights

23

Inventions

41

2004

Copyrights

15

Inventions

23

2003

Copyrights

18

Inventions

50

2005

Copyrights

22

Table 1 Patent Activities

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IncomeUCSD intellectual property income in FY2005 was ap-proximately $21.6 million. Income included over $15.5 million in license fees and royalties from inventions, over $214,000 in license fees and royalties from copyrights, over $578,000 in fees from the transfer of tangible research materials, and over $5.3 million in patent cost reimbursement. For a categorical breakdown of total income, please refer to the appendix.

Mandatory DistributionsIn FY2005, TechTIPS distributed over $8.5 million. Distributions were made to inventors, joint titleholders, participating academic units for research support, and the California State General Fund Pool in accordance with the UC systemwide patent policy and UCSD cam-pus guidelines. Invention income distributed is based on income received in the prior fiscal year. Copyright income and tangible research materials income distributed is based on income received in the same fiscal year.

Financials

ExpensesUCSD’s technology transfer program incurred total expenditures of $12.1 million. Expenditures included approximately $2.3 million for UCSD office operations, $890,000 for systemwide office operations and assess-ments, and $6 million in patent prosecution costs. A detailed categorical breakdown of total expenses is in the appendix.

Research ImpactUCSD’s technology transfer program continued to have a positive impact on UCSD research programs. TechTIPS distributed license income to support research by provid-ing incentives in the form of research support share and inventor/author share of the net income for faculty reten-tion and recruitment. In addition to the mandatory dis-tributions of income under UC Patent Policy and UCSD campus guidelines, TechTIPS negotiated additional funding for research in its license agreements whenever appropriate. In FY2005, the total research impact was estimated to be $5.9 million. These estimates include

distributions to researchers and authors, research laboratories, academic departments, copyrights, tangible research materials, and sponsored research pledges as a result of licenses and matching grants from the UC Discovery Grant Program.

In addition to distributing license income to encourage and support research, TechTIPS assisted in finalizing agreements for several research initiatives including the establishment of the Center for Networked Systems, a collaboration between the Department of Radiology and GE Healthcare, a gift from Sammy Studios of gaming software to the Center for Research in Computing and the Arts, and a gift from the William K. Warren Founda-tion to support the Celiac Disease Program. These gifts totaled almost $25 million.

0504030201009998979695

21.6

15.0

10.7

17.0

8.49.

1

6.1

5.3

4.3

3.7

3.0

Dollars in Millions

Estimated Research Impact Total Income from Intellectual Property Management

1995*

$643,705

13,178

252,930

$909,813

1996*

$848,778

11,413

243,952

$1,104,143

1997*

$907,112

46,882

299,023

$1,253,017

1998

$1,171,430

38,359

451,008

1,081,503

$2,742,300

1999

$2,512,878

94,221

345,741

235,872

$3,188,712

2000

$1,597,695

59,635

980,352

730,140

$3,367,822

2001

$2,154,601

196,770

928,614

$2,868,364

2002

$2,097,659

633,082

1,990,384

1,519,149

$6,240,274

2003

$4,055,993

303,719

1,003,550

$4,144,715

2004

$2,666,558

295,219

1,267,438

1,007,431

$5,236,646

Inventor/Author Share

Joint Titleholders Share

Research Labs/HAU#/Department Share State General Fund Share†

Total Distributions

2005

$3,716,953

190,694

1,987,232

2,658,331

$8,553,210

* Inventions Only # Home Academic Unit † FY01 and FY03 show credit

TOTALS

$22,373,358

1,883,173

8,954,320

6,398,163

$39,609,013

Table 2 Mandatory Distributions of IP Management Income

$.91million

$.64million

$.85million

$5.9million

$6.4million

$6.3million

$4.9million

$1.6million

$4.3million

$8.3million

$6.6million

1995 1996 1997

2001200019991998

2005200420032002

(411,621) (1,218,547)

TECHTIPS UC SAN DIEGO ANNUAL REPORT 1�

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INVENT.UCSD.EDU

Appendix

Invention

Copyright

Tangible Research Materials

Legal Cost Reimbursement

Extraordinary Income†

Total Income

1995

$2,204,002

761,687

$2,965,689

1996

$2,389,128

1,287,424

$3,676,552

1997

$2,901,369

1,377,230

$4,278,599

1998

$3,057,487

11,649

2,259,994

3,000,000

$8,329,130

1999

$4,042,919

74,223

2,028,760

$6,145,902

2000

$5,476,522

83,581

647,401

2,848,046

$9,055,550

2001

$5,627,139

46,083

595,253

2,032,033

55,779

$8,356,287

2002

$7,240,086

202,503

1,122,889

2,898,996

5,552,353

$17,016,827

2003

$6,367,907

156,608

474,311

3,677,680

$10,676,506

2004

$11,472,540

314,268

405,074

2,896,168

$15,088,050

2005

$15,506,214

214,418

578,315

5,336,046

$21,634,993

Income

† Extraordinary income includes nonrecurring items such as legal settlements.

TOTALS

$66,285,313

1,103,333

3,823,243

27,404,064

8,608,132

$107,224,085

Patent Prosecution

Copyright

Campus Operations UCOP & OTT Assessment

Extraordinary Expenses*

State General Fund

Total Expense

Net Income

1995

$1,297,086

380,773

473,215

252,930

$2,404,004

$561,685

1996

$1,679,763

519,248

426,701

163,795

243,952

$3,033,459

$643,093

1997

$2,092,643

699,279

513,131

35,924

299,023

$3,640,000

$638,599

1998

$2,750,577

5,000

689,296

650,648

40,865

1,081,503

$5,217,889

$3,111,241

1999

$2,154,597

2,500

892,006

472,203

397,190

235,872

$4,154,368

$1,991,534

2000

$3,503,079

7,500

1,213,967

438,171

220,594

730,140

$ 6,113,451

$2,942,099

2001

$3,104,498

5,000

1,386,222

602,743

3,915,960

$8,602,802

2002

$3,832,578

937

1,696,395

862,383

2,992,514

1,519,149

$10,903,956

$6,112,871

2003

$4,026,056

2,901

1,981,436

901,692

6,566,816

$12,260,354

2004

$4,645,062

60

2,263,301

877,272

2,789,449

1,007,246

$11,582,390

$ 3,505,660

2005

$6,054,754

3,630

2,272,051

892,459

257,504

2,658,331

$12,138,729

$9,496,264

* Extraordinary expense includes unbudgeted legal expenses for litigation and settlement.

Expense

(411,621) (1,218,547)

$(246,515) $(1,583,848)

TOTALS

$35,140,693

27,528

13,993,974

7,110,618

17,380,611

6,397,978

$80,051,402

$27,172,683

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Technology Transfer and Intellectual Property Services University of California, San Diego9500 Gilman Drive, Dept # 0910 / La Jolla, California 92093-0910 / (858) 534-5815 / invent.ucsd.edu

0607-007