20 aznaurova
TRANSCRIPT
![Page 1: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/1.jpg)
Personalized approach to treatment of endometriosis
Yana Aznaurova,CIEP «Medicine of the Future»
![Page 2: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/2.jpg)
![Page 3: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/3.jpg)
Endometriosis
• Endometriosis is a common and painful condition characterized by the existence of endometrial glands and stroma outside the uterine cavity (endometrial implant).
• Endometriosis present with severe symptoms such as chronic pelvic pain, pain with menstruation, pain during intercourse (dyspareunia) and dysmenorrhea
![Page 4: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/4.jpg)
Significance
Endometriosis is one of the most enigmatic diseases:• the etiology and underlying pathophysiology is
still largely unknown• endometriosis impairs the quality of life of
women of reproductive age• in 30% leads to infertility
![Page 5: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/5.jpg)
![Page 6: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/6.jpg)
AnalogsHormone therapy Surgery Symptomatic
treatmentPersonalized
approach
Non-specific,
long-term, often lifetime
has many side effects
Does not eliminate the cause of the disease,
high probability of recurrence
"Operation of despair"
Short-term relief of symptoms,
does not cure the disease,
has side effects
Specificity
correction of intracellular damage,
low probability of recurrence
less side-effects
1 course of therapy+ IVF= $ 5500
1 operation + hormone therapy + IVF = $ 6700
1 course of therapy + IVF = $ 5250
1 biopsy + 1 genetic analysis + the cost of drugs = $ 760
![Page 7: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/7.jpg)
Competitive advantages
• individual approach to treatment • effective targeted selection of drugs• lower economic cost of treatment • optimization of the making decision on the
treatment option for each patient
![Page 8: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/8.jpg)
Scientific novelty
• Drug's prescribing is based on the genetic analysis of each patient
![Page 9: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/9.jpg)
Current state
• Bioinformatic analysis of the main signaling pathways involved in pathogenesis of endometriosis in the article «Molecular aspects of development and regulation of endometriosis» in Reproductive Biology and Endocrinology Journal
• Perspective article about possibility of using Oncofinder software to implement the idea
![Page 10: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/10.jpg)
![Page 11: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/11.jpg)
Planned
• Creating a database of intracellular changes that underlie endometriosis
• Creating the medical protocol of personalized approach to diagnosis and treatment of endometriosis
• Obtaining a patent on intellectual property
![Page 12: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/12.jpg)
Implementation stages
Biopsy
Microchipping
Targeting drugs selection
In-vitro validation
![Page 13: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/13.jpg)
Resources
• The required sum of money (grant funds) - $ 220,000
• Scientific collaboration
![Page 14: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/14.jpg)
Business model
Counseling CenterPotential customers
• Department of Obstetrics and Gynecology in Hospitals
• Reproductive centers• Fertility clinics
Genetic Testing
Personalized treatment
![Page 15: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/15.jpg)
КомандаАзнаурова Я.Б.
ПМГМУ им. И.М.Сеченова
Румянцев С.А.
ФНКЦ ДГОИ им. Димы Рогачёва
Жуматаев М.Б.
ПМГМУ им. И.М.Сеченова
Гаража А.В.
ЦБРМ
Буздин А.А.
ИБХ РАН
![Page 16: 20 aznaurova](https://reader033.vdocuments.us/reader033/viewer/2022052900/55599301d8b42a14638b5153/html5/thumbnails/16.jpg)
Thank you for your attention!
Yana [email protected]
www.ScientistDoctor.com
Федеральный научно-клинический центр детской гематологии,
онкологии и иммунологии им. Димы Рогачёва