2 | annual report 2012-2013

2 | Annual Report 2012-2013

It seems like only a few moments ago when Founding Chair, Jerome S. Schultz, recruited the first four Bioengineering faculty members in 2006. Our initial program had only five graduate students and 14 undergraduates. Today the Department of Bioengineering has 12 core faculty members, 46 affiliated faculty members through BIG (Bioengineering Interdepartmental Graduate Program), over 350 undergraduates and 90 graduate students. Throughout the last few years, the growth has been rewarding and we are proud to be producing some of the most extraordinary graduates. In the last year, we have achieved several milestones. Perhaps the most notable achievement was our program becoming fully ABET accredited. ABET also recognized our program for its extraordinary undergraduate

research program and our success with preparing students for NSF Fellowships. In addition, Dr. Schultz was elevated to Fellow for both ACS and AIChE and Dr. Anvari was elevated to Fellow for SPIE. We also established a new lower-division design initiative for undergraduate majors. Our efforts with the new School of Medicine also continued to develop, and we are pleased to announce that the collaboration between Dr. Hyle Park and Dr. Binder has resulted in an NIH-funded grant. We are excited about what the new prospects this year will bring and we wish you a wonderful year as well.

Dr. Victor RodgersProfessor and Chair of BioengineeringBourns College of Engineering

Bioengineering - Bourns College of Engineering · UC Riverside | 3

BIG combines a solid fundamental foundation in biological science and engineering, and aims to equip the students with diverse communication skills and training in the most advanced quantitative bioengineering research so that they can become leaders in their respective fields. Students have the opportunity to interact with, not only their advisors, but continuously with the BIG Faculty in a host of academic settings. The result is a rigorous, but exceptionally interactive and welcoming educational training for BIG students.

UCR is among the few

research intensive

institutions that is certified

as a Hispanic Serving

Institution (HSI).

ACCREDITATION The Department of Bioengineering is proud to announce that it has been approved for the maximum (six years) accreditation from ABET. ABET accreditation provides

assurance that a college or university program meets the quality standards established by the profession for which the program prepares its students.

The Engineering Accreditation Commission (EAC) of ABET has

identified that our program offers students extraordinary access to undergraduate research opportunities. Their success is documented through inclusion in the university Undergraduate Research Journal, presentations at regional and nation research conferences, and successful competition for National Science Foundation fellowships for undergraduates continuing tograduate study.

DR. JEROME S. SCHULTZ


DR. BAHMAN ANVARI

The Department of Bioengineering is proud to announce that Dr. Jerome S. Schultz has been elected as Fellow of American Chemical Society (ACS) & American Institute of Chemical Engineers (AIChE) and Dr. Bahman Anvari has been elevated to Fellow of the International Society for Optics and Photonics (SPIE). To become a fellow in these organizations one must make exceptional contributions to the science or profession in their specific discipline.

BRIEF HISTORY

The Department of Bio-

engineering was formed

in the fall of 2006

and has produced 180

graduates

with 59 graduating

in the 2012-2013

academic year.

Undergraduate and

graduate enrollment

in the 2013-2014

academic year totals

over 400 students.

Professor Schultz is recognized by ACS and AIChE for his research initiatives in the areas of biosensors and synthetic membranes. His study of biosensors involves the utilization of biomolecules that have recognition functions - e.g., antibodies, membrane proteins, bioreceptors - to provide the selectivity capability of sensor probe devices.

The purpose of the ACS Fellows Program, one component of the broader ACS Awards Program, is to recognize and honor members of the American Chemical Society for their outstanding achievements in and contributions to the science and the profession and for their equally exemplary service to the Society.

Fellows of AIChE are elite members of who have been practicing chemical engineering for normally 25 years or more, and have been a Member for at least ten years.

Dr. Anvari is recognized by SPIE as one of the pioneers in engineering and development of optical nano-structures derived from biological and organic materials for imaging and phototherapeutic applications.

SPIE is a not-for-profit international society advancing an interdisciplinary approach to the science and application of light since 1955, and has approximately 17,000 members. SPIE is responsible for organizing conferences and publication of journals, trade exhibitions, as well as research and education programs in optics and photonics.

DR. HUINAN LIU


FACULTY HIGHLIGHTS

Dr. Liao and Dr. Vullev have received

promotions to Associate Professor.

Dr. Liao’s research includes studies on signal transduction

pathways, small ubiquitin-like

modifier ligase, G protein-

coupled receptors, and lipid receptors.

Dr. Vullev’s research involves fundamental

and advanced concepts of

physical organic chemistry and

biophysics.

DR. HUINAN LIUReceives MSEC Young Researcher AwardProfessor Liu was presented with the Materials Science and Engineering C Young Researcher Award by Elsevier. The Young Researcher Award recognizes research excellence in experimental and theoretical topics at the interface of the biological sciences and materials engineering by individuals who are 35 years

old or younger. The award was presented at TMS 2013 Annual Meeting in San Antonio, TX on March 4th, 2013.

Dr. Liu directs the Liu Research Group which focuses on the design, fabrication, and evalu-ation of novel biodegradable materials for tissue regeneration, controlled drug delivery, medical implants, and devices. The Liu group actively explores medical applications of nanomaterials and nanotechnology. Their interest lies in both fundamental studies and research as they pertain to the world of biomaterials.

Controlled drug delivery concept

BRIGHTFOCUS FOUNDATION

Macular Degeneration

Research (MDR)

is the newest

BrightFocus program.

Since 1999, BrightFocus

has awarded over $12.5

million to support basic

research into the causes

and potential treatments

of this disease. MDR is

currently supporting

31 biomedical

research projects.


DR. DIMITRIOS MORIKIS

DR. DIMITRIOS MORIKISHonored with Grant and Award for Macular Degeneration ResearchWe are proud to announce that Dr. Morikis has received the Carolyn K. McGillvray Memorial Award for Macular Degeneration Research, administered by the BrightFocus Foundation (www.brightfocus.org). Dr. Morikis has published extensively on the development

of immune system inhibitors that are candidates for the treat-ment of age-related macular degeneration. Mrs. McGillvray was a successful businesswoman, savvy investor, and much-loved wife, mother and grandmother. She died at the age of 99 in 2008. Her son made a generous gift to MDR to the BrightFocus Foundation to honor her memory and her fighting spirit as she battled macular degeneration.

Dr. Morikis has also received a $120,000 Macular Degeneration grant from the BrightFocus Foundation for his research project entitled “Drug Discovery for Macular Disease.” This grant will enable Dr. Morikis and his research group to perform virtual screening studies to identify chemical compounds that have the potential to become therapeutics for age-related macular degeneration. Dr. Morikis and collaborator Dr. Monte Radeke of University of California, Santa Barbara, will complement the computational studies with biochemical and cell-based functional assays.

Macular Degeneration

Iris

Pupil

Cornea

Lens

Sclera

Choroid

Retina

Macula

Optic disk(blind spot)

Blood vessels

Optic nerve

Normal “Wet” Macular Degeneration

“Dry” Macular Degeneration


DR. WILLIAM GROVER

DR. WILLIAM GROVERAssistant Professor The Department of Bioengineering is pleased to welcome their newest faculty member, Assistant Profes-sor William Grover. Dr. Grover brings a diverse expertise in sensors, diagnostics, biomaterials, biophysics, pharmacology, and microfluidics.

Dr. Grover’s lab develops precision tools for measuring and exploiting the fundamental physical properties of micron-scale objects like cells, microorgan-isms, and particles. For example, the density of a cell (its mass-to-volume ratio) changes during important processes like growth, apoptosis, and malignant transformation. Using a microfluidic mass sensor with femtogram resolution, Dr. Grover made the first precision measurements of the density of single living cells. His lab is now adapting this technique to study microorganism develop-ment, characterize biomaterials, monitor blood products, screen drug compounds, and identify environmental pollutants. In another project, Dr. Grover’s lab is developing microfluidic devices capable

of separating mixtures of cells or particles based on their different densities and other physical properties. Since all objects have these fundamental physical properties, Dr. Grover’s research has applications in fields as diverse as cell biology, materials science, forensics, environmental science, and pharmacology.

Dr. Grover joins UCR from the Biological Engineering Division at the Massachusetts Institute of Technology, where he received his post-doctoral training. He received his Ph.D. in Chemistry from the University of California, Berkeley and his B.S. in Chemistry from the University of Tennessee, Knoxville.

Microfluidic Mass SensorWe measure the density of single living cells.

Blue fluid contains cells

Cell passes through resonator, where weight is measured.

Resonator(size of a human hair)

Cell enters yellow fluid.

Yellow fluid has different density Fluid is reversed

and cell is measured a second time.

From these two weight measurements, we can calculate the mass, density, and volume of a cell every5 seconds.

1

2

3 4

BIOENGINEERINGFACULTY

Bioengineering faculty

is composed

of 1 member of NAE,

4 Fellows of AAAS,

4 Fellows of AIMBE,

and 1 Fellow

from each of the

following: ACS,

AIChE, AIMBE

BMES, and SPIE.


VICTOR G. J. RODGERSProfessor and ChairBiotransport and bioreaction kinetics

JEROME S. SCHULTZDistinguished Professor and Founding ChairIntracellular sensors and metabolic controls

BAHMAN ANVARIProfessorBiophotonics, cell membrane electromechanics

KAUSTABH GHOSHAssistant ProfessorCellular mechanobiology, vascular physiology, nanomedicine

WILLIAM H. GROVERAssistant ProfessorSensors, diagnostics, biomaterials, biophysics, pharmacology, microfluidics

JIAYU LIAOAssociate ProfessorHigh-throughput screening, signal transduction

HUINAN LIUAssistant ProfessorBiomaterials for tissue regeneration and controlled drug delivery

JULIA LYUBOVITSKYAssistant ProfessorBiomedical imaging and non-destructive optical techniques

FACULTY


DIMITRIOS MORIKISProfessorImmunophysics, immunoengineering, and drug discovery

JIN NAMAssistant ProfessorOrthopaedic tissue engineering, polymeric scaffolding, mechanobiology in stem cells and skeletal cells

B. HYLE PARKAssistant ProfessorOptical coherence tomography

SHU-WEI SUNAdjunct Assistant Professor (Loma Linda University)Developing MRI techniques for understanding neural diseases

VALENTINE VULLEVAssociate ProfessorBiophysics, microfluidics and charge transfer

BIG PROGRAM OVERVIEW

BIG (Bioengineering

Interdepartmental

Graduate) Program

is the umbrella for

graduate level research

effort associated with

the faculty in the

Department of

Bioengineering as well

as BIG Faculty at UCR

who have a passion for

training graduate

students in bioengineering.

DR. AGUILAR DR. DAHANUKAR

DR. MARTINS-GREEN

DR. LO

BIG combines a solid fundamental foundation in biological science and engineering, and aims to equip the students with diverse communication skills and training in the most advanced quantitative bioengineering research so that they can become leaders in their respective fields. Students have the opportunity to interact with not only their advisors, but continuously with the BIG Faculty in a host of academic settings. The result is a rigorous, but exceptionally interactive and welcoming educational training for BIG students.

BIG Faculty Highlights

DR. AGUILAR and student research assistant Yasaman Damestani conducted research on “windows to the brain” which has been featured on UCR Today and the LA Times. This research has led

to them receiving an American Society for Laser Medicine and Surgery, Inc research grant.

DR. DAHANUKAR is currently researching the vinegar fly, Drosophila melanogaster, which offers a powerful model to investigate the molecular and cellular mechanisms that underlie behavior. Flies taste compounds in the environment and

make informed decisions that are critical to sur-vival such as to consume nutritious foods, avoid toxins, and select appropriate sites to lay eggs. Ongoing research in the lab is focused on three related areas: the mechanism by which the fly tastes and identifies various chemicals, the neural circuits that drive feeding behaviors, and the regulation of food choice by changes in nutrient demand.

DR. DAVID LOand his BIG students are focusing on the biology of mucosal surfaces such as the intestine and airways, and the immune surveillance at these surfaces: how the immune system becomes aware of pathogens and how protective immunity is triggered. His group has identified many genes responsible for the development and function of M cells, and is also focusing on the mechanisms by which M cells efficiently capture bacteria.

DR. MARTINS-GREEN’S research program focuses on understanding the cell and molecu-lar mechanisms involved in normal and abnormal healing, the effects of natural products on prostate cancer metastasis and engineering of

tissues which primary human cells to answer mechanistic questions.


BIG Faculty ListBCOE (Bourns College of Engineering)Chemical and Environmental Engineering• Ashok Mulchandani, Biosensors and biodetoxification• Nosang Myung, Nano-devices• Sharon Walker, Biofilms, bioremediation• Ian Wheeldon, Protein engineering, synthetic biology• Jianzhong Wu, Biothermodynamics and enzymatic processes• Charles Wyman, Biological conversion of abundant, non-food sources

Computer Science and Engineering• Tao Jiang, Bioinformatics, design and analysis of algorithms, computational molecular biology• Stefano Lonardi, Computational molecular biology, data compression, data mining, information hidingElectrical Engineering• Bir Bhanu, Computer vision, machine learning• Elaine Haberer, Bio-templated materials for electronics• Mihri Ozkan, Integrating quantum dots with cells

Mechanical Engineering• Guillermo Aguilar, Medical lasers• Elisa Franco, Biological feedback systems• Cengiz S. Ozkan, Self-assembly of structures and nanofabrication• Masaru P. Rao, Novel micro/nanofabrication methods for biomedical devices• Thomas F. Stahovich, Computational design tools• Hideaki Tsutsui, Biomedical microdevices, stem cell engineering

• Kambiz Vafai, Microcantilever arrays for bioanalysis

School of MedicineBiomedical Sciences• Devin K. Binder, Neurosurgery• Iryna Ethell, Molecular and cellular mechanisms of synapse development and plasticity• David Johnson, Enzyme mechanism analysis• David Lo, Mucosal vaccines

CNAS (College of Natural and Agricultural Sciences)Botany and Plant Sciences• Sean Cutler, Chemical Genomics; Analysis and exploitation of natural variation using small molecules

• Thomas Girke, Comparative genomics, data mining, cellular network analysis• Eugene Nothnagel, Control of biosynthesis in the golgi apparatus• Natasha Raikhel, Vacuolar trafficking through the secretory system, biosynthesis of cell wall polysaccharides in plantsCell Biology and Neuroscience• Richard Cardullo, Biochemical and biophysical methodologies determining molecules involved in fertilzation• Sarjeet Gill, Neuroscience cell membrane transport• Manuela Martins-Green, Wound healing and tumor development• Prue Talbot, Effects of cigarette smoke on cellular processes in stem cells• Nicole I. zur Nieden, Differentiation of osteocytesChemistry• Christopher J. Bardeen, Transport processes occur in complex systems• David Bocian, Energy-transducing systems, molecular photonic devices• Quan Cheng, Biosensing and imaging arrays• Robert C. Haddon, Electronic structure and properties of molecules and materials• Cynthia K. Larive, Ligand-protein interactions, tissue-targeted metabonomics• Thomas H. Morton, Mechanisms of receptor-ligand interactions• Michael Pirrung, Chemical biology, synthesis, and nucleic acidsEntomology• Michael E. Adams, Signaling in the nervous system• Anupama Dahanukar, Insect sensory neuronsPhysics & Astronomy• Umar Mohideen, Signal transmission in the human brain• Harry W. K. Tom, Nonlinear optics, surface science, ultra-fast phenomena

CHASS (College of Humanities, Arts, and Social Sciences)Psychology• G. John Andersen, Computational models of high level visual processing• Khaleel A. Razak, Development of sensory processing• Aaron Seitz, Cognitive-neuroscience; vision, perception, brain plasticity


AT A GLANCE

The University

of California, Riverside

Bioengineering program

provides students

with a broad

but rigorous education

that will allow them to

rapidly develop

into leadership roles

in the biotechnology/

biomedical device

industry. It will also

meet the requirements

of medical schools

or advanced

degree programs.


Lower Division Undergraduate Design Projects Debut In BioengineeringOn December 13, 2013, 105 undergraduate bioengineering students impressed the audience with their passion and acumen while demonstrating their dream bioengineering projects. This is the first time engineering design was incorporated into a lower division course – Overview of Bioengineering (BIEN 010).

Led by Dr. Prashanthi Vandrangi and her teaching assistants Doug Hill, Shirin Mesbah Oskouei and Carla De Los Santos, the students developed and proposed design topics in groups that spanned the many areas of biomedical engineering. The students chose topics ranging from the design of a low-resource economical hearing-aid to the

development of a wireless recharger for a defibrillator. The entire Bourns College of Engineering community joined to support the students in learning to use the machine shop, Comsol©, Matlab©, Solidworks©, Arduinos©, RasberryPi©, and many more tools. The experience embedded in the students a sense of teamwork and urgency in getting the project done right, and also showed them the importance of accountability and commitment. “Not only were the students projects extremely creative and complete, the students also appreciate how the bioengineering curriculum and experience at UCR will allow them to develop an advanced understanding of these related engineering concepts.” said Professor Victor G. J. Rodgers, Department Chair. He went on to say, “We always knew

DR. VANDRANGI

that our students were gifted, and this experience allowed us to see this at a much earlier stage in the curriculum.”

The Department of Bioengineering now plans to interweave design throughout the undergraduate curriculum with the senior design course, supervised by Professor Hyle Park, being the capstone for the students to demonstrate their most advanced efforts. On Friday, May 9, 2014, the department kicked off their Senior Design Day where industrial and academic leaders were invited to review all projects.


Bioengineering Senior Design Projects Are UnderwayOne of the requirements for undergraduates to graduate is to complete a senior design project. In bioengineering this consists of a two-quarter length course where students design, develop, and present a prototype for their projects. Eighty bioengineering students are currently hard at work on their senior design projects. In total, 14 different groups are working on separate projects. Students work directly with faculty who will supervise their work over the course of the project. These faculty encompass all areas of engineering and we soon hope to incorporate faculty from the newly opened School of Medicine. Students are also working closely with other senior undergraduate students from the School of Business Administration (SOBA) in order to formulate business plans for their products. The business students act as student consultants for the bioengineers. Designs bioengineering students come up with, must not only be practical, but also plausible for a business to develop and support.

Some of the projects student groups are currently working on are a non-invasive monitor that will be used to detect excess amounts of

bilirubin. Abnormally high amounts of bilirubin can be an indicator for diseases. Another project is a Google Glass-like product that will be able to see under skin. It can be worn similar to glasses and is meant to aid doctors during surgery especially when they are making incisions. We look forward to seeing all the projects presented at the end of the spring quarter.


Center for Bioengineering Research at UCRThe new Center for Bioengineering Research (CBR) is the focus of research activities of the Department of Bioengineering in cooperation with biomedical research units at other regional and co-operating institutions. CBR is being organized in technical divisions, the first of which is the Biomolecular Imaging Research and Technology (BIRT). The focus of the team is on developing new cutting-edge biophotonic technologies, utilizing a large array of advanced optical tools. Some current projects include the development of nanoparticles for laser treatment of cancer, mechanism of hearing, mechanism of charge transfer in biological systems, non-invasive monitoring of neurological systems and microfluidic devices for detection of infectious agents.

One of the more recent CBR projects is a collaborative effort between Haider Biologics and the Neurosci-ence and Optical Imaging Research (NOIR) lab directed by Dr. Hyle Park to develop a lightweight forward-viewing imaging needle. Park and his group have extensive experience with an optical imaging modality known as optical coherence tomography (OCT), which allows for high-resolution (2-10micron) minimally-invasive and label-free imaging but limited to visualization

of the first 2-3mm under the surface of biological tissue. Together with Haider Biologics, they are working to integrate this imaging technology into a forward-viewing needle with a diameter less than 1mm, which would allow for high-resolution and label-free imaging of deeper structures in a minimally-invasive manner.

DR. PARK

Intensity cross-sectional image from a developing tadpole where the two chambers of the heart are visible.

Doppler reconstruction of the flow profile in the heart.

Velocity of blood flow in the heart.

Sample work from Center for Bioengineering Research at UCR

Subsurface (500um below the surface) collagen in human skin. (5x5mm).

Differences between the backreflected intensity in the brain in a region that was impacted versus not (in a mouse brain).

Human Skin

Mouse Brain

Tadpole Heart


FELLOWSHIP AWARDS

The National Science

Foundation’s Graduate

Research Fellowship is

in recognition

and support of

outstanding graduate

students in

NSF-supported

science, technology,

engineering, and math-

ematics disciplines. Each

year 2,000 awards are

given throughout the

nation across all

appropriate disciplines.

Both the undergraduate and the BIG programs have had

tremendous success in attracting students of the quality worthy of

the NSF Graduate Research Fellowship. Currently of the eligible students, 24% are

NSF Graduate Research Fellows.

Bioengineering Students Honored with NSF Graduate Research Fellowship Award in 2013 – 2014 Year

The 2014 students are:• Jacklyn Whitehead (BIG student advised by Professor Prue Talbot)• Thien-Toan Tran (honorable mention, BIG student advised by Professor Ashok Mulchandani)• Brittney McKenzie (honorable mention, BIG student advised by Professor William Grover)

The prestigious National Science Foundation Graduate Research Fellowship Program recognized our Bioengineering students in the 2013-2014 year.

The 2013 students were:• Thanh Yen Nguygen (BIG student advised by Professor Huinan Liu)• Maricela Maldorado (BIG student advised by Professor Jin Nam)• Elbert Mai (graduating senior planning to attend UC San Diego)• Leo Green (BIG student advised by Professor Elisa Franco)• Tyler Backman (honorable mention, BIG student advised by Professor Thomas Girke)


Student Fellows List

NSF Graduate Research Fellowship

2014Jacklyn WhiteheadThien-Toan Tran (Honorable Mention)Brittney McKenzie (Honorable Mention)

2013Thanh Yen NguygenMaricela MaldoradoElbert Mai Leo GreenTyler Backman (Honorable Mention)

2012Jaclyn LockChristian Oh

2011Kaila BennetGabrielle GoodmanPamela JreijVicente NunezNoriko Sausman CAMP-BD 2012 Maricela Maldonado Carla De Los Santos

NSF IGERT

2013Carissa Reynolds

2012Atena ZahediMelissa Eberle

2011Michael OliveiraJillian Larsen

2010Devin McBrideDouglas Hill

NSF EIFP

2013Jaclyn Lock

NIH

2013Erica Freeman

Space Grant Fellowship

2013Karen Low


Advisory Board

AMIR GANDJBAKHCHESection Chief

and Senior InvestigatorNIH

BEN VERSTEEGVP Engineering

TruTouch Technologies

BRUCE TROMBERGProfessor of Bioengineering,

Director Beckmann Laser InstituteUniversity of

California, Irvine

JOHN WATSONProfessor of Bioengineering

Advisory Board ChairUniversity

of California San Diego

RUBEN FLORES-SAAIBAssistant VP

Business DevelopmentLA Bio

Medical Institute

WALT BAXTERSenior Principal

ScientistMedtronic

WARREN GRUNDFESTProfessor of Bioengineering,

Electrical Engineering, and SurgeryUniversity

of California Los Angeles

Medical School

ANDREW CARMENAssociate Director

Business DevelopmentIllumina

MATT CHLUDZINSKIDirector

Abbot Vascular

WILLIAM R. PRATTVice President,

Operations and Director

of Creative DesignKinamed

PUBLICATIONS 2013

AT A GLANCEThe University

of California, Riverside

Bioengineering

professors have taken

part in publishing

in top journals

throughout

the world.


Adini A, Adini I, Ghosh K, Benny O, Pravda E, Hu R, Luyindula D, D’Amato RJ (2013) The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action, Angiogenesis, 16(2):405-416.

Bahmani B, Bacon D, Anvari B (2013) Erythrocyte-derived photo-theranostic agents: hybrid nano-vesicles containing indocyanine green for near infrared imaging and therapeutics applications, Scientific Reports, 3, 2180.

Bahmani B, Lytle CY, Walker AM, Gupta S, Vullev VI, Anvari B (2013) Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs, International Journal of Nanomedicine, 8:1609–1620.

Buettner GR, Wagner BA, Rodgers VGJ (2013) Quantitative Redox Biology: An approach to understanding the role of reactive species in defining the cellular redox environment, Cell Biochemistry and Biophysics, 67(2):477-483.

Chartuprayoon N, Rheem Y, Ng J, Nam J, Chen W, Myung N (2013) Polypyrrole nanoribbon based chemiresistive immunosensors for viral plant pathogen detection, Analytical Methods, 5(14):3497-3502.

Cipriano AF, Zhao T, Johnson I, Guan R, Garcia S, Liu H (2013) In vitro Degradation of Four Magnesium-Zinc-Strontium Alloys and Their Cytocompatibility with Human Embryonic Stem Cells, Journal of Materials Science: Materials in Medicine, 24(4):989-1003.

Delgado FF, Cermak N, Hecht VC, Son S, Li YZ, Knudsen SM, Olcum S, Higgins JM, Chen JZ, Grover WH, Manalis, SR (2013) Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells, PLOS ONE, 8(7):e67590.

Gorham RD, Forest DL, Tamamis P, López de Victoria A, Kraszni M, Kieslich CA, Banna CD, Bellows-Peterson ML, Larive CK, Floudas CA, Archontis G, Johnson LV, Morikis D (2013) Novel Compstatin Family Peptides Prevent Complement-associated Deposit Formation in Human Retinal Pigmented Epithelial Cell Cultures, Experimental Eye Research, 116:96-108.

Guan R, Cipriano AF, Zhao Z, Lock JY, Tie D, Zhao T, Cui T, Liu H (2013) Development and Evaluation of a Magnesium-Zinc-Strontium Alloy for Biomedical Applications - Alloy Processing, Microstructure, Mechanical Properties, and Biodegradation, Materials Science and Engineering: C, 33(7):3661-3669.

Guo S, Bao D, Upadhyayula S, Wang W, Guvenc AB, Kyle JR, Bay H, Bozhilov K, Vullev VI, Ozkan C, Ozkan M (2013) Photoinduced Electron Transfer between Pyridine-Coated Cadmium Selenide Quantum Dots and Single-Sheet Graphene, Advanced Functional Materials, 23 (41): 5199-5211.

Gupta S, Chatni MR, Rao ALN, Vullev VI, Wang LV, Anvari B (2013) Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging, Nanoscale, 5:1772-1776.


Hwang YJ, Granelli J, Tirumalasetty M, Lyubovitsky J (2013) Microscopic imaging of glyceraldehyde-induced tissue glycation with intrinsic second harmonic generation and two-photon fluorescence contrasts, Proc. SPIE, 8587.

Hwang YJ, Lyubovitsky J (2013) The structural analysis of three-dimensional fibrous collagen hydrogels by raman microspectroscopy, Biopolymers, 99:349.

Iskandar ME, Aslani A, Liu H (2013) The Effects of Nanostructured Hydroxyapatite Coating onthe Biodeg-radation and Cytocompatibility of Magnesium Implants, Journal of Biomedical Materials Research Part A, 101(8):2340-2354.

Jiang L, Liu Y, Song Y, Saavedra AN, Pan S, Xiang W, Liao J (2013) Internal calibration Förster resonance energy transfer assay: a real-time approach for determining protease kinetics Sensors, Sensors, 13(4):4553-70.

Johnson I, Liu H (2013) A Study on Factors Affecting the Degradation of Magnesium and A Magnesium-Yttrium Alloy for Biomedical Applications, PLoS ONE, 8(6): e65603.

Jung B, Anvari B (2013) Virus-mimicking optical nano-materials: near infrared absorption and fluorescence char-acteristics, and physical stability in biological environments, ACS Applied Materials & Interfaces, 5: 7492-7450.

Jung B, Vullev VI, Anvari B (2014) Revisiting indocyanine green: effects of serum and physiological temperature on absorption and fluorescence characteristics, IEEE Journal of Selected Topics in Quantum Electronics, 20(2): 7000409/1-7000409/9.

Khatibzadeh N, Spector AA, Brownell WE, Anvari B (2013) Effects of plasma membrane cholesterol level and cytoskeleton F-actin on cell protrusion mechanics, PLoS ONE, 8(2): e57147.

Kieslich CA, Shin D, López de Victoria A, González-Rivera G, Morikis D (2013) A predictive model for HIV-1 coreceptor selection, AIDS Research and Human Retroviruses, 29:1386-1394.

Knapik D, Perera P, Nam J, Blazek A, Rath B, Leblebicioglu B, Das H, Wu L, Hewett T, Agarwal S, Robling A, Flanigan D, Lee B, Agarwal S (2013) Mechanosignaling in Bone Health, Trauma and Inflammation, Antioxidants and Redox Signal, 20(6):970-985.

Liu Y, Liao J (2013) Quantitative FRET (Förster Resonance Energy Transfer) analysis for SENP1 protease kinetics determination, Journal of Visualized Experiments, (72):e4430.

Lock JY, Wyatt E, Upadhyayula S, Whall A, Nuñez V, Vullev VI, Liu H (2014) Degradation and antibacterial properties of magnesium alloys in artificial urine for potential resorbable ureteral stent applications, Journal of Biomedical Materials Research Part A, 102(3):781-792.

Maldonado M, Nam J (2013) The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis, Biomed Research International, 101, 284873.

McBride DW, Rodgers VGJ (2013), Predicting the Activity Coefficients of Water for Concentrated Globular Proteins Solutions Using Independently Determined Physical Parameters, PLoS ONE, 8(12):e81933.


PUBLICATIONS 2013 (Cont.)

McBride D, Rodgers VGJ (2013) Interpretation of Negative Second Virial Coefficients from Non-Attractive Protein Solution Osmotic Pressure Data: An Alternate Perspective, Biophysical Chemistry, 184: 79–86.

Nam J, Perera P, Rath B, Agarwal S (2013) Dynamic regulation of bone morphogenic proteins in osteochondral co-culture by mechanical stimulation, Tissue Engineering Part A, 19(5-6):783-792.

Nguyen TY, Liu H (2013) A Review of Current Advances in Biomaterials for Neural Tissue Regeneration, Recent Patents on Biomedical Engineering, 6:29-39.

Nuñez V, Upadhyayula S, Millare B, Hadian Ali, Shin S, Vandrangi P, Gupta S, Xu H, Lin A, Larsen J, Georgiev GY, Vullev VI (2013) Microfluidic space-domain time-resolved emission spectroscopy of terbium (III) and euro-pium (III) chelates with pyridine-2,6-dicarboxylate, Analytical Chemistry, 85(9): 4567-4577.

Pan Z, Ghosh K, Hung V, Macri LK, Einhorn J, Bhatnagar D, Simon M, Clark RA, Rafailovich MH (2013) Deformation gradients imprint the direction and speed of en masse fibroblast migration for fast healing, Journal of Investigative Dermatology, 133(10):2471-9.

Sun SW, Mei J, Tuel K (2013) Comparison of Mouse Brain DTI Maps Using K-space Average, Image-space Average, or No Average Approach, Magnetic Resonance Imaging, 31(9):1532-1536.

Vandrangi P, Lo DD, Kozaka R, Ozaki N, Carvajal N, Rodgers VGJ (2013) Electrostatic Properties of Confluent Caco-2 Cell Layer Correlates to Their Microvilli Growth and Determines Underlying Transcellular Flow, Biotechnology & Bioengineering, 110(10):2742-2748.

Xia B, Bao D, Upadhyayula S, Jones G, Vullev VI (2013) Anthranilamides as Bioinspired Molecular Electrets: Experimental Evidence for Permanent Ground-State Electric Dipole Moment, Journal of Organic Chemistry, 78(5): 1994-2004.

Zhou X, Hollern D, Liao J, Andrechek E, Wang H (2013) NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors, Cell Death Dis., 2013 Mar 28;4:e560.


BIG ALUMNI

MD SHAHIDUL ISLAM, Ph.D. Advisor: H. Park ThorLabs Advanced Imaging Applications Engineer

YANG SONG, Ph.D. Advisor: J. Liao John Hopkins Res. Scientist

MARLON THOMAS, Ph.D. Advisor: V. Vullev Wichita State University Assistant Professor

SRIGOKUL UPADHYAYULA, Ph.D. Advisor: V. Vullev Harvard University Postdoctoral Researcher

PRASHANTHI VANDRANGI, Ph.D. Advisor: V. Rodgers UC Riverside Postdoc

YAN WANG, Ph.D. Advisor: H. Park Postdoc Massachusetts General Hospital

YIHENG WANG, Ph.D. Advisor: V. Rodgers Danville Comm. C Asst. Professor

JANA BUCOLLA, M.S. Advisor: V. Rodgers Abbott Engineer

JOSEPH FLETCHER, M.S. Biosense Webster Engineer

SEAN GUTHRIE, M.S. Advisor: V. Vullev Humana Inc. Engineer

ALI HAJI HADIAN, M.S. Medtronic Associate Product Design Engineer

JONATHAN MA, M.S. Advisor: H. Park NSCW Corona Engineer

RISHI MATANI, M.S. Advisor: H. Park Boston Scientific Manufacturing Engineer II

AARON NICHOLS, M.S. Corpus Medical R&D Engineer

NORIKO OZAKI, M.S. Advisor: V. Rodgers

RICHARD LAUHEAD, BSMS Advisor: J. Liao Biosense Webster Intern

RANDALL MELLO, BSMS Advisor: J. Liao Univ. of Pacific Pharmacy School

KENNETH SUGERMAN, BSMS PSC Biotech Validation Engineer

2 | annual report 2012-2013

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