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Development and differentiation, example of “sticky” switching

Brief Stimulus

(Fertiliation!Development continues with no additional stimulation

"ow do the development circuits ena#le “sticky” switching$

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Sea %rchin Development &etwork' Davidson, et al., Science, 2002 

Like a microprocessor 

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uorum sensing

Credit: Bonnie Bassler, et al., Princeton U.

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uorum Sensing )ircuit

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Microprocessor 

Chemical and

Biochemical

Processes

Cell-based

Biosensor 

Electro-

mechanical

Processes

Synthetic #iology$

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Band dector (of chemical concentrations!

Credit: S. Basu, et al., Princeton U.

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Credit: M.L. Simpson, M. L., et al. , Oak id!e "ational La#

Compounds Detected* Napthalene* TCE

* Tolulene* Benzene* Xylene

ensiti!ity" #$% ppb

Cells glow when detect toxins. Luminescence is detected by an

integrated photosensor circuit.

Cells

PhotodetectorChip

Biochip for toxin detection

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+rokaryotes

ukaryotes

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)hromatin form depends on cell cycle phase

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 $rom %$ Cro&, "ature evie&s 'enetics, 2000 

+ercentage of recognied pregnancies with

trisomies (- copies of a chromosome!

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