COMPUTER-AIDED CHEMICAL ENGINEERING, 31

11to INTERNATIONAL

SYMPOSIUM ON PROCESS

SYSTEMS ENGINEERING

PART B

Edited by

Iftekhar A. Karimi

Department of Chemical & Biomolecular EngineeringNational University of Singapore, Singapore

Rajagopalan Srinivasan

Department of Chemical & Biomolecular EngineeringNational University of Singapore, Singapore

ELSEVIER

Amsterdam - Boston - Heidelberg -London - New York - OxfordParis - San Diego - San Francisco - Singapore - Sydney - Tokyo

Contents

Bioprocessing & Biotechnology

Integration of market dynamics into the design ofbiofuel processes

Anna Voll, Giovanni Sorda, Felix Optehostert, Reinhard Madlener

and Wolfgang Marquardt 850

Design methodology for bio-based processing:Biodiesel and fatty alcohol productionLida Simasatitkul, Amornchai Arpornwichanop, Rafiqul Gani 855

Multi-objective Optimization of a Fermentation Process Integratedwith Cell Recycling and Inter-stage Extraction

Shivom Sharma, G.P. Rangaiah 860

Integrated Design of High Temperature Steam Electrolysis and Biomass

to Liquid Fuel Process

Quentin Bernical, Xavier Joulia, Isabelle Noirot-Le Borgne, Pascal

Floquet, Pierre Baurens, Guillaume Boissonnet 865

Model-based assessment of algal ponds for biomass production under

temperate plimatesMohammedK Mohammed, AidongYang, Adel Sharif 870

PSE opportunities in biocatalytic process design and developmentPar Tufvesson, Ulrich Kriihne, Krist V. Gernaey, John M. Woodley 875

Optimal Design ofan Algae Oil Transesterification Process

C. Silva, L. A. Fabiano, G. Cameron and W.D. Seider 880

Potential for Bio-based Chemicals Production in Singapore'sPetrochemical Cluster

Josephine Jie Min Tay, Cassandra Tian Hui Seto, AriefAdhityab,Iskandar Halim, Balaji Balagurunathan, Rajagopalan Srinivasan 885

Multi-Objective, Multi-Period Optimization of Renewable Technologies and

storage system Using Evolutionary Algorithms and Mixed Integer Linear

Programming (MILP)Samira Fazlollahi, Stephane Laurent Bungener, Gwenaelle Becker

Francois Marechal 890

Improved Strains for Biological Treatment of Wastewater

Shilpi Aggarwal, Chia Pei Lyn, lAKarimi 895

In silico Simulation for Enhancing Production of OrganicAcids in Zymomonas mobilis

Hanifah Widiastuti, Dong-Yup Lee, and IftekharA. Karimi 900

Computational Fluid Dynamics

CFD simulation ofcracking tube with internal twisted slices

Nan Zhang, Bingzhen Chen, Tong Qiu 905

vi Contents

CFD-Based Optimization ofa Flooded Bed Bioreactor for Algae Production

Justin Smith, Selen Cremaschi, Daniel Crunkleton 910

CPFD Simulation for Particle Deposit Formation in Reactor Cyclone of RFCC

Hyungtae Cho, Bumjoon Cha, JaewookRyu, Sungwon Kim, II Moon 915

CFD-Mass transfer Simulation of an RDC Column

Mark. W. Hlawitschka, Hans-Jorg Bart 920

Parameter Estimation

Estimation of Primary Variables from Combination of Secondary Measurements:

Comparison ofAlternative Methods for Monitoring and Control

Maryam Ghadrdan, Chriss Grimholt, Sigurd Skogestad, IvarJ. Halvorsen 925

Validation ofan absorber model of carbon dioxide capture in an aqueous amine

solvent developed based on the SAFT-VR framework

C. V. Brand, J. Rodriguez, A. Galindo, G. Jackson and C. S. Adjiman 930

EM Algorithm for Parameter Estimation in Batch Process

Zhonggai Zhao, Biao Huang, Fei Liu 935

Continuous Discrete Unscented Kalman Filtering for Nonlinear Differential

Algebraic Equations SystemsS. C. Kadu, Mani Bhushan, Kallol Roy 940

Systematic identification ofcrystallization kinetics within a genericmodelling framework

Noor Asma Fazli Abdul Samad, Kresten Troelstrup Meisler, Krist V. Gernaey,Nicolas Smit von Solms, Rafiqul Gani 945

Generation offirst and higher order derivative information

out ofthe documentation level

Victor Alejandro Merchan, RobertKraus, Tilman Barz,

Harvey Arellano-Garcia, Giinter Wozny 950

Dynamic Model Identification with Uncertain Process Variables usingFuzzy Inference SystemRaony M. Fontes, Cristiano H. Fontes, Ricardo A. Kalid 955

Coalescence Parameter Estimation in Liquid Extraction Column using OPOSPM

Hanin B.Jildeh, Menwer Attarakih, Hans-Jorg Bart 960

Constraint Programming based Input Signal Design for System Identification

Prakash Kotecha, Mani Bhushan, Ravindra Gudi, Sridharkumar

Narasimhan, Raghunathan Rengaswamy 965

Education

Industry Embedded Training in (Bio)Process SystemsElaine Martin, Gary Montague, Bryn Jones 970

Chemical Engineering Education and Industry MegatrendsVictor Heinanen, Timo Seuranen, Markku Hurme 975

Contents

Use of Podcasts for Teaching Process Control

Srinivas Palanki

Energy

Synthesis ofHeat-Integrated Resource Conservation Networks

Y. L. Tan, D. K. S. Ng, M. M. El-Halwagi, Y. Samyudia, D. C. Y. Foo

Impacts ofequipment off-design characteristics on the optimal designand operation of combined cooling, heating and power systemsZhe Zhou, Pei Liu, Zheng Li, Efstratios N. Pistikopoulos, Michael C. Georgiadis

Storage of Renewable Energies via Chemical Conversion using C02:

Energy Systems AnalysisAlexander Zinser, Liisa Rihko-Struckmann, Kai Sundmacher

Integrated Biomass Power Plant and Storage for Peak Load ManagementWai Shin Ho, Haslenda Hashim, Zarina A. Muis

An optimization procedure for retrofitting process energy systems in refineries

Bingjian Zhang, Shengyuan Wu, Qinglin Chen

Optimization ofPerformance ofPhosphoric Acid Fuel Cell (PAFC)Stack using Reduced Order Model with Integrated Space Marchingand Electrolyte Concentration InferencingSaibal Ganguly, Sonali Das, Kajari Kargupta, Dipali Bannerjee

Platform development for studying integrated energy conversion processes:

Application to a power plant process with C02 captureLaurence Tock, Francois Marechal

Robust Optimization of Microgrids - An Application to TaichungIndustrial Park

Jin-SuKang, Chung-Chuan Chang, Dong-Yup Lee, Tai-yongLee

Enterprise Optimization

An optimization of the food quality products throughout the supply chain

Ali Mehdizadeh, Nilay Shah, Neha Raikar, Pfeter M.M. Bongers

i

Single- & Multi-site Production& Distribution Planningin Food Processing Industries

Georgios M. Kopanos, Luis Puigjaner, Michael C. Georgiadis

Hybrid Approach for Multi-stage Logistics Network Optimizationunder Disruption Risk

Yoshiaki Shimizu and Muhammad Rusman

Supply Chain Optimization ofBiomass Production ImprovementMingyen Yu, Franjo Cecelja, Seyed Ali Hosseini

Modular Optimization Approach for Process Synthesis and Integrationofan Integrated BiorefineryDouglas H. S Toy, Rex T. L. Ng, Denny K. S. Ng

viii Contents

Integrated production and distribution management with cross dockingin supply chains

M.E. Coccola, C.A. Mendez, M. Zamarripa, A. Espuha 1050

Semantically-enabled Formalisation to Support and Automate the applicationof Industrial SymbiosisTara Raafat, Nikolaos Trokanas, Franjo Cecelja, Antonis Kokossis,

Aidong Yang 1055

Modeling and Optimization ofSuperstructure-based Stochastic Programsfor Risk-aware Decision SupportJohn D. Siirola, Jean-Paul Watson 1060

Accessing Direct and Indirect Effects within a LCA Based MultiobjectiveSynthesis of Bioproducts Supply Chains

Lidija Cucek,Jin Jaromir Klemes, Zdravko Kravanja 1065

Mitigating Supply Disruption for a Global Chemical SupplyChain- Application of Agent-based ModelingBehzad Behdani, AriefAdhitya, Zofia Lukszo, Rajagopalan Srinivasan 1070

Planning & Scheduling

A Novel Multi-Grid Formulation for Scheduling Semi-Continuous Plants

Naresh Susarla, Jie Li, and IA Karimi 1075

A Continuous-Time Approach for Scheduling Bidirectional Pipeline OperationsVanina G. Cafaro, Diego C. Cafaro, Jaime Cerdd 1080

An iterative MILP-based approach to automated multi-product multi-stagemanufacturing systemsA. M. Aguirre, C. A. Mendez, C. De Prada 1085

Integrated Scheduling and Control ofContinuous-Time Blending Processes

Kathrin Frankl, JosefBeenken, Wolfgang Marquardt 1090

Industrial Applications

De-risking Scale-up ofa High Shear Wet Granulation Process Using Latent

Variable Modeling and Near Infrared SpectroscopyKoji Muteki, Ken Yamamoto, George L. Reid, Mahesh Krishnan 1095

Performance Assessment and Benchmarking of Desalination Plants

N. Bhutani, M. Srinivas, Senthilmurugan S 1100

Process Modeling ofBio-Based Production on InterdisciplinaryAnalysis across Agriculture and Engineering: A Case Studyof Sugarcane-Derived Ethanol Production

Satoshi Ohara, Yasunori Kikuchi, Rumiko Suginobe, Yoichi Kanzaki,Masahiko Hirao 1105

Planning and Scheduling as a Part of a Control System - Implementation AspectsIiro Harjunkoski 1110

Advances in Procedural Automation in the Chemical IndustryMaurice Wilkins, Marcus Tennant 1115

Contents ix

Pharmaceutical Systems

Retrofit design of a pharmaceutical batch process improving

green process chemistry & engineering principlesAlireza Banimostafa, Stavros Papadokonstantakis, Konrad Hungerbuhler 1120

Parallel design of pharmacodynamic experiments for the identification

of antimicrobial-resistant bacterial population models

Carlo C. Ballan, Federico Galvanin, Massimiliano Barolo, Fabrizio Bezzo 1125

Integral Formulation of the Smoluchowski Coagulation Equation usingthe Cumulative Quadrature Method ofMoments (CQMOM)Menwer Attarakih, and Hans-Jorg Bart 1130

Capacity Planning for Continuous Pharmaceutical Manufacturing Facilities

And Sundaramoorthy, Xiang Li, James M.B. Evans, Paul I. Barton 1135

Multivariate Analysis ofAPI Particle Size Distribution Variation

in a Manufacturing Environment

Keeley Stepney, Elaine Martin, Gary Montague 1140

Long-term Scheduling of a Multi-stage MultiproductBio-pharmaceutical Process

Shaurya Kabra, Munawar A. Shaik, Anurag S. Rathore 1145

An advanced model for controlled oral drug deliveryNaresh Pavurala, Luke E.K. Achenie 1150

Model and analysis of pharmaceutical manufacturing systemwith government intervention and emergency supplyChen Wang, Michael Pishko, and Carl Laird 1155

Optimization and Control of Crystal Shape and Size in Protein CrystallisationProcess

Jing J. Liu, Yang D. Hu andXue Z. Wang 1160

Intelligent Decision-Support Tools for Effective and Integrated OperationalPlanning in Pharmaceutical Plants

Naresh Susarla and IA Karimi 1165

Process Design

Embedding Methane Steam Reformer and Methanol Reactor

into a Single Reactor

AmjadRiaz, Gholamreza Zahedi 1170

Characterization and design ofa new crystallization process

using a model-based approachBenny Harjo, Yoshio Fukui, Sean Bermingham 1175

A new graphical representation ofexergy applied to low temperature

process designDanahe Marmolejo-Correa, Truls Gundersen 1180

Model based optimal reactor design applied to a free radical polymerization processP. Klimantos and M. Hillestad 1185

Optimization of carbon dioxide-assisted nanoparticledeposition process with uncertain design space

MichaelJ. Casciato, SungilKim, J.C. Lu, Dennis W. Hess, Martha A. Grover

Process Simulation

Modeling and Simulation of Multi-stream Heat

Exchanger Using Artificial Neural Network

Mohd Shariq Khan, Yuli Amalia Husnil, Mesfin Getu & Moonyong Lee

Modeling and Analysis of Novel Reactive HiGee Distillation

Gudena Krishna, Toy HawMin, G.P. Rangaiah

Simulation and Analysis ofCarbon-in-Leach (CIL) Circuits

Divyamaan Wadnerkar, Ranjeet P. Utikar, Moses O. Tade, Vishnu K. Pareek

The Numerical Simulation ofPneumatic Drying of Polycarbonatein Vertical Tube

Lingqi Kong, Shiqing Zheng

The OPOSPM as a Nonlinear Autocorrelation Population Balance

Model for Dynamic Simulation ofLiquid Extraction Columns

Menwer Attarakih, Hanin B. Jildeh, Matthias Mickler, Hans-Jorg Bart

The Simulation and Analysis of Coal to Liquids Processes

Li Sun, Robin Smith

Agent-Based Simulation Framework for Public Bus

Fleet Electrification Investment AnalysisShisheng Huang, Rajagopalan Srinivasan, Joseph F. Pekny,Gintaras V. Reklaitis

Modeling and Control Challenges in the developmentof Discrete Microfluidic Devices

Jeevan Maddala, Raghunathan Rengaswamy

Simulation of Hydrodynamics and Heat Transfer in Confined Jet Reactors

of Different Size Scales for Nanomaterial Production

Cai YMa, Xue Z Wang, Christopher J Tighe, Robert I Gruar

and Jawaad A Darr

Modeling, Simulation and Experimental Investigation of a Reactive

Hybrid Process for the Production of Dimethyl Carbonate

Johannes Holtbruegge, Philip Lutze, Andrzej Gorak

Process Monitoring

Estimation of Predictive Accuracy of Soft Sensor Models Based

on One-Class Support Vector MachineHiromasa Kaneko, Kimito Funatsu

Methodology for Emergency Shut-Down ofMulti-MegawattWind Turbine Generators

Sebastien Gros, Benoit Chachuat

Data-driven causal inference based on a modified transfer entropyYidan Shu, Jinsong Zhao

Contents xi

Data-based Method for Diagnosing Multiple Blockage Locations

in a Microreactor with Parallelized Microchannels

Masaru Noda andNobuhide Sakamoto 1261

Conceptual Framework for Security Hazard Managementin Critical Infrastructures

Yoshihiro Hashimoto, Takeshi Toyoshima, Shuichi Yogo, Masato Koike,

Sun Jing and Ichiro Koshijima 1266

A simulation based engineering method to support HAZOP studies

Rasmus Enemark-Rasmussen, David Cameron, Per Bagge Angelo and

GurkanSin 1271

Optimal Layout of chemical process using risk index approach to minimize

risk to human

Kyusang Han, Inhyuck Choi, En Sup Yoon 1276

Optimal channel design and sensor placement in flow distributors

for detecting blockage ofparallelized microreactors

Osamu Tonomura, Atsushi Nishida, Lin Wang, Shnji Hasebe 1281

Batch process analysis and monitoring based on an automatic phaseidentification method utilizing process dynamic information

Yuan Yao, Weiwei Dong, Chien-Ching Huang, Yuan-JuiLiu 1286

Data driven fault detection using multi-block PLS based path modeling approachManoj Kandpal, Prem Krishnan, Lakshminarayanan Samavedham 1291

Process Operations

Optimisation of a Power Plant Utility System Using Process IntegrationMkhokheli Ndlovu, Thokozani Majozi 1296

Simplified MFE with power-change adaption strategy for the dynamicoptimization ofHTR-PM

'

Sen Huang, Kexin Wang, Weifeng Chen, Jianghong You, Xi Chen, Jixin

Qian, Zhijiang Shao, Lorenz T. Biegler 1301

A methodology to forecast the price of commodities

Davide Manca 1306

INumerical study ofmixed-feedstock pyrolysisKa Leung Lam, Adetoyese O. Oyedun, Chi Wai Hui 1311

Generating operating procedures using a micro genetic algorithmRafael Batres 1316

Optimal Operation of a Membrane Reactor Network

E. Esche, HArellano-Garcia, G. Wozny, L.T. Biegler 1321

Dynamic Optimization ofSolution Polymerization Process

of Methyl Methacrylate in Batch Reactors

Wan Hanisah B. Wan Ibrahim, Iqbal M. Mujtaba 1326

Optimization of multi-refinery hydrogen networks

Anoop Jagannath, AH Elkamel and I.A.Karimi 1331

xii Contents

Optimizing the PSA process ofpropylene/propane using Neuro-Fuzzy modelingMona Khalighi, S. Farooq, LA. Karimi 1336

Product Design

Rigorous Generation and Model-Based Selection of Future Biofuel Candidates

Manuel Hechinger, Manuel Dahmen, Juan J. Victoria Villeda,

Wolfgang Marquardt 1341

Reducing drying energy consumption by adsorbent property optimizationin multistage systemsJames C. Atuonwu, Gerrit van Straten, Henk C. van Deventer,

Antonius J. B. van Boxtel 1346

Optimizing Protein-Excipient Interactions for the DevelopmentofAggregation-Reducing Lyophilized Formulations

Brock C. Roughton, Anthony I. Pokphanh, E.M. Topp, and Kyle V. Camarda 1351

Signature Descriptors for Process and Molecular Design in Reactive SystemsNishanth G. Chemmangattuvalappil, Christopher B. Roberts, Mario R. Eden 1356

Optimization ofProduct Formulation through Multivariate Statistical AnalysisSubin Hada, Nishanth G. Chemmangattuvalappil, Christopher B. Roberts,

Mario R.Eden 1361

Sustainability & Environment

Control strategies for flexible operation of powerplant integratedwith C02 capture plantYu-JengLin, Chun-Cheng Chang, David Shan-Hill Wong Shi-Shang JangandJenq-Jang Ou 1366

A framework for water footprint optimisation in the bioethanol supply chain

Andrea Bernardi, Sara Giarola and Fabrizio Bezzo 1372

Steady-state multiplicity of a biogas production system based

on anaerobic digestionAstrid Bornhoft, Richard Hanke-Rauschenbach, Kai Sundmacher 1377

A Unified Approach for the Optimization of Energy and Water

in Multipurpose Batch Plants

Omobolanle Adekola, Jane D. Stamp, Thokozani Majozi, Anurag Garg,Santanu Bandyopadhyay 1382

Evaluation of coal-based dimethyl ether production system usinglife cycle assessment in South Korea

Seunghyok Kim, Jaeha Kim, En Sup Yoon 1387

Analysis and Modeling ofInformation Required for Process Assessment

on Environment, Health, and Safety by IDEFO and UMLYasunori Kikuchi, Stavros Papadokonstantakis, Alireza Banimostafa,Hirokazu Sugiyama, Konrad Hungerbiihler, Masahiko Hirao 1392

Correlations among Footprints within Biomass Energy Supply-ChainsLidija Cucek,JifiJ. Klemes, Petar S. Varbanov, Zdravko Kravanja 1397

Contents xiii

Energy Generation and Carbon Footprint of Waste to Energy:Centralised vs. Distributed ProcessingPetar S. Varbanov, Hon Loong Lam, Ferenc Friedler, Jiri Jaromir Klemes 1402

Assessing the environmental potential of carbon dioxide utilization:

A graphical targeting approachMarie-Noelle Dumont, Niklas von derAssen, Andre Sternberg, Andre Bardow 1407

Simultaneous Water and Energy Minimization for Brown Stock Washing SystemIrene Mei Leng Chew, Dominic Chwan Yee Foo, Jean-Christophe Bonhivers,

Paul Stuart, Alberto Alva-Argaez, Luciana Elena Savulescu 1412

Water

A heuristic approach to design batch water-using networks with multiplecontaminants

Bao-HongLi, You-KangLiang,Ckuei-Tin, Chang 1417

Synthesis of Sustainable Property-Based Water Networks

Luis Fernando Lira-Barragdn, Jose Maria Ortega-Ponce,Medardo Serna-Gonzdlez, MahmoudM. El-Halwagi 1422

Modeling and optimization of water-based polygeneration systemTriana Prihatin, Shuhaimi Mahadzir and M. Ibrahim Abdul Mutalib 1427

Multi-objective Optimization for Integrated Water Network SynthesisIskandar Halim, AriefAdhitya, Rajagopalan Srinivasan 1432

Synthesis ofwater networks for processes with mixed batch

and continuous units

Cheng-Liang Chen, Chun-Yen Lin, Hui-chu Chen, Jui-Yuan Lee 1437

Optimal operation ofreverse osmosis plant driven by solar powerwithout batteries

Senthil.K, Shankar Narasimhan, Sridharakumar Narasimhan 1442

Optimization ofthe scheduling and water integration in batch processes

based on the Timed Petri net

Li Huan, Xiao Wu, He GaoHong, Du Jian 1447

A method to find an optimal draw solute fc|r cost-effective FO(forward osmosis)desalination process

Tae-wooKim, Young Kim, Choamun Yun, Hong Jang, Woohyun Kim,

SunwonPark 1452

Optimal water network synthesis with detailed membrane-based

regenerator models

Cheng Seong Khor, Benoit Chachuat, Nilay Shah 1457

A Stochastic Programming Formulation for Disinfectant Booster Station

Placement to Protect Large-Scale Water Distribution SystemsGabriel A. Hackebeil, Angelica V. Mann, William E. Hart, Katherine

A. Klise, Carl D. Laird 1462

xiv Contents

Oil & Gas

Incorporating Complex Fiscal Rules in Strategic Planning ofOffshore

Oil and Gas Fields

Vijay Gupta andlgnacio E. Grossmann 1467

Optimization of Pure-Refrigerant Cycle Compressing Ratio on C3-MR Process

Inkyu Lee, Kyungjae Tak, Wonsub Lim, Kwangho Choi, II Moon IAll

Monitoring and fault diagnosis system for LNG fractionation process

Hahyung Pyun, Hyunseok Jeong, Daeyeon Kim, Daegun Ha, Chonghun Han 1477

Simultaneous Optimal Placement ofInjector and Producer Wells UsingMathematical ProgrammingW.X. Leow, M.S. Tavallali, LA. Karimi, K.M. Teo 1482

Contract selection under uncertainty: LNG buyers' perspectiveRajab Khalilpour, I. A. Karimi 1487

Optimization

A Novel Global Optimization Approach to the Multiperiod Blending Problem

Scott P. Kolodziej, Ignacio E. Grossmann, Kevin C. Furman

and Nicolas W. Sawaya 1492

Finding an optimized set of transformations for convexifying nonconvexMINLP problemsAndreas Lundell and Tapio Westerlund 1497

Structured regularization in barrier NLP for optimization models with dependentconstraints

Kexin Wang, Zhijiang Shao, Lorenz T. Biegler, Yidong Lang, Jixin Qian 1 502

A Progressive Hedging Approach for Parameter Estimation via Stochastic

Nonlinear ProgrammingDaniel P. Word, Jean-Paul Watson, David L. Woodruff, and Carl D. Laird 1507

Performance Analysis of Shooting Algorithms In Chance-Constrained

OptimizationS. Werk, T. Ban, H Arellano-Garcia, G. Wozny 1512

Alarms & Sensors

Multiple Sensor Fault Isolation Using Contribution Plots without SmearingEffect to Non-Faulty Variables

Jialin Liu, Ding-Sou Chen 1517

Integrated Sensor Network DesignNabil M, Sridharakumar Narasimhan 1522

Reallocation Index Based Sensor Network Design for Efficient Fault DiagnosisSuryanarayana Kolluri, Mani Bhushan 1527

A Graphic Processing Unit (GPU) Algorithm for Improved Variable Selection

in Multivariate Process MonitoringLau Mai Chan, Rajagopalan Srinivasan 1532

Contents xv

Proactive Alarms Monitoring using Predictive TechnologiesShichao Xu, Shanqing Yin, Rajagopalan Srinivasan, Martin Helander 1537

Heat Integration

Synthesis of Large-scale Multi-stream Heat Exchanger Network Based

on Pseudo-temperature Enthalpy Diagram Method Combined

with Superstructure Method

Jilong Li, Man Du, Zongchang Zhao, Qingwei Meng, Pingjing Yao 1542

A New Tool for Simultaneous Targeting and Designof Heat Exchanger Networks

Sharifah Rafidah Wan Alwi, Zainuddin Abdul Manan, Misrawati Misman 1547

Heat Exchanger Network Synthesis Using a Hyperstructure of StagewiseStream SuperstructuresKe Feng Huang andI. A. Karimi 1552

Improvement in Strategy for Design of Heat Exchanger Networks usingMultiagent FrameworkNaoki Kimura, Kizuki Yasue, Kei Kobayashi, Yoshifumi Tsuge 1557

Process Heat Exchanger Network Integration and

Decomposition via Clustering ApproachWendy Pei Qin Ng, Hella Tokos, Hon Loong Lam, Yongrong Yang 1562

Distillation

Controllability of three types of dividing wall columns

Chuan-Chen Chao and Jeffrey D. Ward 1567

A systematic procedure for synthesis ofintensified simple columnconfigurations for multicomponent distillations

Ben-Guang Rong, Massimiliano Errico j 1572

Design and Control of a Reactive-Distillation Process for Esterification

of an Alcohol Mixture Containing Ethanol and n-Butanol

Yi-Chang Wu, Hao-Yeh Lee, Chen-Yu Tsai, Hsiao-Ping Huang and I-Lung Chien 1577

Design and Control ofReactive Divided ^all Column for Esterification

with Mixed n-Amyl alcohol and n-Hexan6l Feed

Yi-Chang Wu, Hao-Yeh Lee, Chung-Han Lee,

Hsiao-Ping Huang and I-Lung Chien 1582

Aggregate models based on the wave propagation theory for high-puritydistillation columns

Lingyu Zhu, Dexin Li.Yichen Ren, Xi Chen, Lorenz T. Biegler 1587

An exergy grand composite curve based procedure for arranging side

exchangers on distillation columns

Zhiqiang Wei, Shengyuan Wu, Bingjian Zhang, Qinglin Chen 1592

Optimization of Complex Column Networks with Hybrid Genetic AlgorithmSeon B. Kim andAndreas A. Linninger 1597

xvi Contents

Using PSE to develop innovative cryogenic air separation processesChao Fu, Truls Gundersen 1602

Heterogeneous batch distillation with variable decanter hold-upLdszlo Hegely, Vincent Gerbaud, Peter Lang 1607

Model Predictive Control

Economic NMPC for energy intensive applications with electricity

price predictionRui Huang and Lorenz T. Biegler 1612

A Multivariate Nonlinear Model Predictive Control Framework

for a PEM Fuel Cell System

Chrysovalantou Ziogou, Efstratios N. Pistikopoulos, Spyros Voutetakis,

Michael C. Georgiadis, Simira Papadopoulou 1617

Online Model Predictive Control ofMunicipal Water Distribution Networks

Gokul Siva Sankar, Sridharakumar Narasimhan and Shankar Narasimhan 1622

Multi-fidelity models for model predictive control

Shiva Kameswaran, Niranjan Subrahmanya 1627

A Frequency Domain Approach for MPC TuningLeyla Ozkan, Joris Meijs, A.C.P.M. Backx 1632

Control Strategies

Control Strategy for Thermal Budget and Temperature Uniformityin Spike Rapid Thermal Processing SystemsJyh-Cheng Jeng, Wen-Chung Chen 1637

Systematic Formalization of Control Requirements using Hierarchical

Cause-Effect Charts

Stephan Fischer, Christian Sonntag, Sebastian Engell 1642

Self-optimizing control for hydrogen optimizationin a diesel hydrodesulfurization plantElena G. Sayalero, Sigurd Skogestad, Cesar de Prada, J. Miguel Sola,

Rafael Gonzalez 1647

Reconfigurable stabilizing control applied to a neutralization process

Thiago V. Costa, Ana M. F. Filed, Luis C Oliveira-Lopes, Flavio V. Silva 1652

Robust IMC-PID Design for Optimal Closed-loop Response with SpecifiedGain and Phase Margins for SOPTD Systems

KeyuLi 1657

A New Strategy of Locality Enhancement for Just-in-Time Learning Method

Qing Lin Su, Manabu Kano, Min-Sen Chiu 1662

Modeling and Analysis

Hybrid Dynamic Modeling of4-CBA Hydrogenation Fixed-Bed CatalyticReactor ofPTA Production Plant

Abbas Azarpour, Gholamreza Zahedi 1667

Contents xvii

Integrated Model-Based Support for the Design ofComplex Controlled SystemsMartin Hiifner, Stephan Fischer, Christian Sonntag, Sebastian Engell 1672

Design and modeling of a new periodical-steady state process for the oxidation

of sulfur dioxide in the context ofan emission free sulfuric acid plantR. Giinther, J.C. Schdneberger, H. Arellano-Garcia, H. Thielert, G.Wozny 1677

Thinking OntologiesHeinz A Preisig 1682

The impact of radiation on gas combustion modeling for a Kraft recovery boiler

Daniel J. O. Ferreira, Marcelo Cardoso, Song Won Park 1687

Process Synthesis

Process development in a miniplant scale - A multilevel - multiscale PSE

approach for developing an improved Oxidative Coupling ofMethane process

Steffen Stunkel, Konstantin Bittig, Hamid-Reza Godini, Stanislav Jaso, Walter

Martini, Harvey Arellano-Garcia, Gtinter Wozny 1692

Phenomena-based Process Synthesis and Designto achieve Process Intensification

Philip Lutze, Deenesh K. Babi, John Woodley, Rafiqul Gani 1697

Three-layer solution strategy for multi-objective process synthesisJincaiYue, Shiqing Zheng, Xia Yang 1702

Conceptual process synthesis for isolation and purification ofnatural

products from plants - A case study ofartemisinin from Artemisia annua

Chandrakant Malwade, Haiyan Qu, Ben-Guang Rong, Lars P. Christensen 1707

Synthesis and Optimization ofDistributed Energy Supply Systems usingAutomated Superstructure and Model Generation

Philip Voll, Carsten Klqffke, Maike Hennen, Stefan Kirschbaum, Andre Bardowa 1712

Biomedical Applications

Design of optimal disease and patient-specific chemotherapy protocolsfor the treatment of Acute Myeloid Leukaemia (AML)E. Pefani, N. Panoskaltsis, A. Mantalaris] M.C. Georgiadis, E.N. Pistikopoulos 1717

A Control Engineering Perspective of Calcium Homeostasis

ChristopherR. Christie, LukeE.K. Achenie, Babatunde A. Ogunnaike 1722

Hemodynamics ofcerebral micro vasculature

Ian Gopal Gould, Thomas Marinnan, Maurice Chojecki, Masood Qader,Brian Henry, Mohammed Pervais, Nicholas Va aitis, YiyiZhu, Aaron Rogers and

Andreas Linninger 1727

Medical Image-based Systematic Design of Human Gene Silencing TherapiesYing Hsu, Ashty Karim, Andreas Linninger 1732

Author Index xviii