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AAC Research Symposium“New Directions in Osteoarthritis Research”

Kananaskis, AlbertaOctober 22-23, 2015

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WE HAVE MADE GREAT STRIDES IN OA RESEARCH...

Deborah Marshall, PhDAAC Research Committee Co-chair

University of Calgary

Alberta Bone and Joint Health Institute

and McCaig Institute for Bone and Joint Health

Let’s Keep on Moving: A Call to Action

In tribute to Dr Cy Frank

Cy’s Network andCapacity Building

Data Elsevier’s ScopusVisualization created in NodeXL

88 Graduate students and Postdoctoral fellows supervisedSummer students supervised5

1$28

M In Research Funding

Thanks to AIHS Performance Management and Evaluation Team

4- AIHS Performance Management and Evaluation Team

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- AIHS Performance Management and Evaluation Team

Arthritis Alliance of Canada: History

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Arthritis Alliance of Canada (AAC)

Executive member and Key advisor to co-chairs (Dianne Mosher, Gillian Hawker, Cheryl Koehn and John Esdaile) National Arthritis Summit for Arthritis Prevention and Care, 2000

Key driver, CAN OA Consensus Conference hosted by CAN and chair at the meeting that created the Alliance for a Canadian Arthritis Program (ACAP) that became AAC, 2002

AAC Steering Committee member since its formation in 2002

Introduced CAN consumer-patient participation model into the CIHR

SPOR – the Strategy for Patient Oriented Research

Arthritis Alliance of Canada (AAC)

Spiritual leader in development Canadian Arthritis Network (CAN)

First Scientific Director, CIHR Institute of Musculoskeletal Health and Arthritis, 2000

AN ALLIANCE LANDSCAPE: AAC PUBLISHED REPORTS

Arthritis Standards Report

Arthritis Landscape Report

The Impact of Arthritis Report Joint Action on Arthritis National Framework

A Tool for Developing and Evaluating Models

of Care

A Pan-Canadian Approach to

Inflammatory Arthritis Models of Care

Inflammatory Arthritis Care Path Toolkit

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WE HAVE MADE GREAT STRIDES IN OA RESEARCH...

Let’s Keep on Moving

OARSI Year in Review: Imaging• Focus on MRI-based studies dealing with

epidemiologic and methodological aspects of disease.

• Assessment of bone parameters and interest in inflammatory disease manifestations

• Ultrastructural assessment using compositional MRI – RQ: What is the predictive value of these techniques regarding structural and clinical outcomes?

• RQ - Role of modalities other than MRI (CT and ultrasound?

• RQ - Imaging research in spine, hip and hand OA

Osteoarthritis Year in Review 2014 and 2015: ImagingFW Roemer and A Guermazi (2014); F Cicuttini (2015)

Image Source: http://www.clipartpanda.com/categories/mri-20clipart

OARSI Year in Review: Mechanics

• Four themes: mechanobiology, ambulatory mechanics, biomechanical interventions and mechanical risk factors

• Altering joint loads can induce protective and harmful responses in the joint. RQ: What features distinguish protective from damaging loads and how can this be applied in clinical interventions?

• Call for: Studies that merge research methods across disciplines, for a more complete understanding and application of the role of mechanics in OA

Osteoarthritis Year in Review 2014 and 2015: MechanicsRF Moyer, A Ratneswaran, F Beier, TB Birmingham (2014); AJ Grodzinsky (2015)

OARSI Year in Review:Regenerative Medicine

• Emerging technologies to assess the possibility to generate pluripotent stem cells without genetic modification and genetic engineering of growth factors to enhance tissue repair.

• Future Opportunity: Regeneration in a compromised joint environment. Based on interaction between all joint tissues e.g. bone remodeling and synovial inflammation on cartilage repair.

Regenerative medicineGJVM van Osch (2014); AJ Grodzinsky (2015)

Image Source: http://www.dreamstime.com/stock-illustration-dna-inside-test-tube-double-helix-image48526453

OARSI Year in Review: Biomarkers

• Multiplexed approaches to identify novel OA biomarkers using genomics, proteomics and metabolomics tools

• Call for: Still need robust and validated biomarkers and novel disease modifying OA drugs to support drug development, treatment monitoring, and personalized evidence-based action plans.

We need more biochemical biomarkers in qualification phaseFJ Blanco (2014); AC Bay-Jensen (2015)

OARSI Year in Review:Rehabilitation and Outcomes

• Conservative intervention is a critical component of OA care

• Exercise combined with diet for weight loss should be the mainstays of rehabilitation for people with knee and hip OA to provide benefit to OA disease markers, pain, physical function, and health.

• RQ: What is the impact of reduced lean mass associated with dieting?

Rehabilitation and outcomesMR Maly, SM Robbins (2014); K Bennell and R Hinman (2015)

Image Source: http://nursing-care.org/44-living/040-living.html

OARSI Year in Review: Clinical• OA as a heterogeneous condition with multiple

pathogenic mechanisms and clinical manifestations.

• Theme 1: ‘Metabolic OA’• Theme 2: Personalized medicine in OA

treatment.

• Identification of ‘OA phenotypes’ that are more or less likely to respond to treatments

• RQ: How to target interventions to ‘OA responder’ subgroups to amplify treatment effects?

ClinicalGA Hawker, I Stanaitis (2014); L Sharma (2015)

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AAC Models of Care Working GroupQuality Improvement in OA

Continuing to work on improving quality and access to care, the AAC will work together with key stakeholders on the following quality improvement projects:

1) Engaging Primary Care and developing inter-disciplinary teams

Meeting with the College of Family Physicians of Canada (CFPC) to discuss how we can work together to enhance the diagnosis and effectively manage OA, what are the needs of CFPC and discuss how we can help. November 18, 2015.

Friday, October 23rd Workshop at the Annual Meeting in Kananaskis will focus on “Building Clinical Capacity to Effectively Diagnose and Manage OA”

2) Osteoarthritis Toolkit/

Common Messaging

Working with the Advocacy Committee and the AAC Members to develop hot topic papers and common messaging focused on OA issues, such as; the impact of OA on mobility, rehabilitation, prevention and best practices in OA, injury prevention, sports, etc.

Arthritis Alliance of Canada 3rd Annual Meeting and Research Symposium

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Thursday, October 22nd, 2015Delta Lodge in Kananaskis, Alberta

This year’s Annual Meeting, “Building Capacity for Sustainable Health Care in Canada,” organized in partnership with CIHR’s Institute of Musculoskeletal Health and Arthritis, will pay tribute to the accomplishments and legacy of the late Dr. Cy Frank and:

Feature a Research Symposium, entitled “New Directions in Osteoarthritis Research”

Include a Young Investigator Forum and Trainee Session

Feature several AAC Workshops, focused on building capacity in research and health care sustainability

Present a special Gala Tribute Dinner in honour and memory of our colleague, mentor, scientist, surgeon and dear friend, Dr. Cy Frank

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“New Directions in Osteoarthritis Research”Research Symposium, Thursday, October 22, 1:00-5:00 pm

Session I: Chair – Dr. Jason McDougall, Dalhousie University, Halifax, NS

1:00 pm We have made great strides in OA Research ... Let’s keep it moving : A Call to Action Dr. Deborah Marshall

1:10 pm Consumer action in Canadian Osteoarthritis research: From study participants to knowledge transfer agents

Ms. Alison Hoens, Mr. John Coderre, Ms. Anne Fouillard, Dr. Jean Miller

1:35 pm Setting the Stage: What is OA? Dr. Gillian Hawker

2:00 pm Basic research in OA: why is it important and what have we learned Dr. Frank Beier

2:25 pmThe management of OA from microfracture and osteotomy to stem cell regeneration, using the ACL injured knee as the model

Dr. Nicholas Mohtadi

Session II: Chair: Dr. André Bussières, McGill University, Montreal, QC

3:15 pm Preventing joint injury and subsequent osteoarthritis: A population health perspective

Dr. Carolyn Emery

3:40 pm Knowledge translation of osteoarthritis research: Advances after 15 years

Dr. Linda Li

4:05 pm The evolution of OA management: from late-stage surgery to a comprehensive prevention and treatment strategy

Dr. Ewa Roos

4:30 pm Panel discussion: Prospects for future osteoarthritis researchPanel Chair: Dr. Jeff DixonPanel: Ms. Alison Hoens, Dr. Ewa Roos, Dr. Frank Beier, Dr. Nick Mohtadi, Dr. Carolyn Emery, Dr. Gillian Hawker, Dr. Linda Li

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“Together, we are better.”

One OA team focussed on the end goal – patients, and pain free mobility for life.

What are you going to do to make a difference?