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10 mv 100 ms 5 s 10 mv 5 s transient current injection to the cell can toggle its state

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Page 1: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 2: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 3: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 4: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

10 mV

100 ms

5 s

Page 5: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 6: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 7: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 8: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 9: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

10 mV

5 s

Page 10: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 11: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 12: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 13: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Transient current injection to the cell can toggle its state

Page 14: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

I

V

I

V

Page 15: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Climbing Fiber Parallel Fiber

Page 16: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Climbing fibers response and Ca changes

Page 17: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

LTD: Long Term Depression

Page 18: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

LTD time course

Page 19: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

LTD: specificity

PSTH: Post Stimulus Time Histogram

Page 20: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

LTD: Properties

Page 21: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Involvement of AMPA receptors in LTD induction.

Pairing PF-mediated EPSPs with depolarization of PCs

Pairing quisqualate application with depolarization of cultured PCs

Page 22: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Involvement of mGluR1 and PKC in LTD induction.

In the presence of antibodies inactivating mGluR1

control

The same in knockout mice lacking functional mGluR1

BAPTA

PKC (19¯36)

PKC(glu27) (19¯36)

Control

Page 23: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Mechanism of LTD

Page 24: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

SS activity following vestibular stimulation

CS activity following optical stimulation

Page 25: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Mechanism of VOR gain change

Page 26: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

L7-PKC transgene

Page 27: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Expression of PKC in L7-PKC mice

http://www.neuron.org/content/vol20/issue3/images/large/NEURO.20_3_495.1239.f2.jpeg
Page 28: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Glutamate+Depolarization

LTD in L7-PKC mice

http://www.neuron.org/content/vol20/issue3/images/large/NEURO.20_3_495.1239.f5.jpeg
Page 29: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

VOR gain change in L7-PKC mice

http://www.neuron.org/content/vol20/issue3/images/large/NEURO.20_3_495.1239.f6.jpeg
http://www.neuron.org/content/vol20/issue3/images/large/NEURO.20_3_495.1239.f6.jpeg
Page 30: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
http://www.neuron.org/content/vol20/issue3/images/large/NEURO.20_3_495.1239.f3.jpeg
Page 31: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

Involvement of PKC activation in LTD induction .

BAPTA

PKC (19¯36)

PKC(glu27) (19¯36)Control

NOS inhibitor L-NMMA

Control

Page 32: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 33: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 34: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 35: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state
Page 36: 10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state

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