10 antianginal agents upd
DESCRIPTION
PharmacologyTRANSCRIPT
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Nitrates Beta blockers Calcium channel blockers
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When the supply of oxygen and nutrients in the blood is insufficient to meet the demands of the heart, the heart muscle aches.
The heart demands a large supply of oxygen to meet the demands placed on it.
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Chronic stable angina (also called classic or effort angina)
Unstable angina(also called preinfarction or crescendo angina)
Vasospastic angina(also called Prinzmetal’s or variant angina)
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Therapeutic Objectives Increase blood flow to ischemic heart muscle
and/or Decrease myocardial oxygen demand
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Therapeutic Objectives Minimize the frequency of attacks and decrease
the duration and intensity of anginal pain Improve the patient’s functional capacity with as
few side effects as possible Prevent or delay the worst possible outcome, MI
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Available forms:Sublingual OintmentsBuccal Transdermal patchesChewable tablets Inhalable spraysCapsules Intravenous solutions
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Cause vasodilation due to relaxation of smooth muscles
Potent dilating effect on coronary arteries
Used for prophylaxis and treatment of angina
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Nitroglycerin Prototypical nitrate Large first-pass effect with PO forms Used for symptomatic treatment of ischemic
heart conditions (angina) IV form used for BP control in perioperative
hypertension, treatment of CHF, ischemic pain, and pulmonary edema associated with acute MI
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isosorbide dinitrate (Isordil, Sorbitrate, Dilatrate SR)
isosorbide mononitrate (Imdur, Monoket, ISMO)
Used for: Acute relief of angina Prophylaxis in situations that may provoke
angina Long-term prophylaxis of angina
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Side Effects Headache
Usually diminish in intensity and frequency with continued use
Tachycardia, postural hypotension Tolerance may develop
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atenolol (Tenormin) metoprolol (Lopressor) propranolol (Inderal) nadolol (Corgard)
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Mechanism of Action Decrease the HR, resulting in decreased
myocardial oxygen demand and increased oxygen delivery to the heart
Decrease myocardial contractility, helping to conserve energy or decrease demand
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Therapeutic Uses Antianginal Antihypertensive Cardioprotective effects, especially after MI
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Side EffectsBody System EffectsCardiovascular bradycardia, hypotension
second- or third-degree heart blockheart failure
Metabolic Altered glucose and lipidmetabolism
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Side EffectsBody System EffectsCNS dizziness, fatigue,
mental depression, lethargy,drowsiness, unusual
dreamsOther impotence
wheezing, dyspnea
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verapamil (Calan) diltiazem (Cardizem) nifedipine (Procardia)
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Mechanism of Action Cause peripheral arterial vasodilation Reduce myocardial contractility
(negative inotropic action) Result: decreased myocardial oxygen demand
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Therapeutic Uses First-line agents for treatment of angina,
hypertension, and supraventricular tachycardia Short-term management of atrial fibrillation and
flutter Several other uses
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Side Effects Very acceptable side effect and safety profile May cause hypotension, palpitations,
tachycardia or bradycardia, constipation, nausea, dyspnea
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Before administering, perform a complete health history to determine presence of conditions that may be contraindications for use or call for cautious use.
Obtain baseline VS, including respiratory patterns and rate.
Assess for drug interactions.
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Patients should not take any medications, including OTC medications, without checking with the physician.
Patients should report blurred vision, persistent headache, dry mouth, dizziness, edema, fainting episodes, weight gain of 2 pounds in 1 day or 5 or more pounds in 1 week, pulse rates under 60, and any dyspnea.
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Alcohol consumption and hot baths or spending time in jacuzzis, hot tubs, or saunas will result in vasodilation, hypotension, and the possibility of fainting.
Teach patients to change positions slowly to avoid postural BP changes.
Encourage patients to keep a record of their anginal attacks, including precipitating factors, number of pills taken, and therapeutic effects.
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Nursing Implications Instruct patients in proper technique and
guidelines for taking sublingual NTG for anginal pain.
Instruct patients never to chew or swallow the SL form.
Instruct patients that a burning sensation felt with SL forms indicates that the drug is still potent.
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Nursing Implications Instruct patients to keep a fresh supply of NTG
on hand; potency is lost in about 3 months after the bottle has been opened.
Medications should be stored in an airtight, dark glass bottle with a metal cap and no cotton filler
to preserve potency.
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Nursing Implications Instruct patients in the proper application of
nitrate topical ointments and transdermal forms, including site rotation and removal of old medication.
To reduce tolerance, the patient may be instructed to remove topical forms at bedtime, and apply new doses in the morning, allowing for a nitrate-free period.
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Nursing Implications Instruct patients to take prn nitrates at the first
hint of anginal pain.
If experiencing chest pain, the patient taking SL NTG should be lying down to prevent or decrease dizziness and fainting that may occur due to hypotension.
Monitor VS frequently during acute exacerbations of angina and during IV administration.
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Nursing Implications IV forms of NTG must be contained in glass IV
bottles and must be given with infusion pumps. Discard parenteral solution that is blue, green,
or dark red. Follow specific manufacturer’s instructions for IV
administration. Use special IV tubing provided or non-PVC tubing.
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Nursing Implications Blood levels should be monitored to ensure they
are therapeutic. Oral CCBs should be taken before meals and
as ordered. Patients should be encouraged to limit
caffeine intake.
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Nursing Implications Patients taking beta blockers should monitor
pulse rate daily and report any rate lower than 60 beats per minute.
Dizziness or fainting should also be reported. Constipation is a common problem. Instruct
patients to take in adequate fluids and eat high-fiber foods.
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Nursing Implications These medications should never be abruptly
discontinued due to risk of rebound hypertensive crisis.
Inform patients that these medications are for long-term prevention of angina, not for immediate relief.
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Monitor for adverse reactions Allergic reactions, headache, light-
headedness, hypotension, dizziness
Monitor for therapeutic effects Relief of angina, decreased BP, or both